Category: 321-28-8

Hfaiedh, Anoir; Ben Ammar, Hamed; Soule, Jean-Francois; Doucet, Henri published an article in 2017, the title of the article was Palladium-catalyzed regioselective C-H bond arylations at the C3 position of ortho-substituted fluorobenzenes.Computed Properties of 321-28-8 And the article contains the following content:

The influence of an ortho-substituent on fluorobenzene derivatives for palladium-catalyzed C-H bond arylation has been explored. In the presence of 2-bromo, 2-chloro and 2-methoxy substituents, the reaction proceeds nicely using a diphosphine-palladium catalyst and potassium acetate/dimethylacetamide (PivOK/DMA) as the catalytic system. In all cases, a regioselective arylation at the other ortho-position to the fluorine atom (C3) was observed A variety of electron-withdrawing substituents on the aryl bromide coupling partner, such as formyl, nitro, nitrile, and also heteroaryl bromides, was tolerated. Moreover, tri(hetero)aryl derivatives containing a fluorobenzene as the central unit have been prepared from 2-bromofluorobenzene through palladium-catalyzed-successive C-H bond (hetero)arylations. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Computed Properties of 321-28-8

The Article related to fluorobenzene aryl bromide regioselective ch bond activation arylation palladium, fluorobiaryl preparation, palladium regioselective ch bond activation arylation catalyst and other aspects.Computed Properties of 321-28-8

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On March 19, 2020, Bergmann, Katrina; van Wijngaarden, Jennifer published an article.HPLC of Formula: 321-28-8 The title of the article was Rotational Spectroscopic and Ab Initio Investigation of the Rotamer Geometries of 2-Fluoroanisole and 3-Fluoroanisole. And the article contained the following:

The rotational spectra of 2-fluoroanisole and 3-fluoroanisole were investigated using Fourier transform microwave spectroscopy in the 4-26 GHz range. Assigned transitions correspond to the lowest energy rotamer for 2-fluoroanisole which has the O-CH3 group directed away (anti) from the fluorine substituent whereas for 3-fluoroanisole, the spectrum is consistent with the presence of two rotamers arising from syn and anti orientations of the methoxy moiety relative to fluorine. Ab initio calculations at the MP2/cc-pVTZ level were used to estimate the equilibrium (re) geometries of the three observed rotamers. Their assignments were confirmed through the observation of the rotational transitions of eight minor isotopologues (13C and 18O) in natural abundance for each species. The mass dependence (rm(1)) structures derived using the exptl. determined rotational constants compare favorably with the ab initio estimates The resulting sets of geometric parameters suggest that the aromatic ring backbone is distorted by the introduction of the angular methoxy substituent, with a tendency to induce bond length alternation around the ring, and by the electron withdrawing effects of fluorine. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).HPLC of Formula: 321-28-8

The Article related to fluoroanisole regioisomer rotational spectrum mol geometry, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.HPLC of Formula: 321-28-8

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Ether – Wikipedia,
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On June 3, 2015, Cho, Hee Yeon; Scott, Lawrence T. published an article.Application In Synthesis of 1-Fluoro-2-methoxybenzene The title of the article was Oxidative cyclotrimerization of unsaturated compounds with DDQ and triflic acid: An efficient synthetic route to triply-fused benzene rings. And the article contained the following:

Intermol. oxidative cyclotrimerization reactions of alkenes and aromatic compounds with DDQ and trifluoromethanesulfonic acid are described. Scholl-type oxidation reactions involving alkenes have not previously been demonstrated. Moreover, the DDQ/acid system has never been used for intermol. oxidative cyclization reactions. This convenient, metal-free reagent system (DDQ/TfOH) is advantageous with respect to metal-based Scholl-type oxidants because it eliminates the possibility of halogenation of aromatic compounds as a competing side reaction. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application In Synthesis of 1-Fluoro-2-methoxybenzene

The Article related to triply fused benzene ring preparation, oxidative cyclotrimerization alkene aromatic compound, triphenylene alkoxy preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Other Tricyclic and Multicyclic Six-Membered Ring Systems, Including Trypticenes and Helicenes and other aspects.Application In Synthesis of 1-Fluoro-2-methoxybenzene

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Liu, Xiang-Wie; Zarate, Cayetana; Martin, Ruben published an article in 2019, the title of the article was Base-Mediated Defluorosilylation of C(sp2)-F and C(sp3)-F Bonds.Synthetic Route of 321-28-8 And the article contains the following content:

The ability to selectively forge C-heteroatom bonds by C-F scission is typically accomplished by metal catalysts, specialized ligands and/or harsh reaction conditions. Described herein is a base-mediated defluorosilylation of unactivated C(sp2)-F and C(sp3)-F bonds that obviates the need for metal catalysts. This protocol was characterized by its simplicity, mild reaction conditions, and wide scope, even within the context of late-stage functionalization, constituting a complementary approach to existing C-Si bond-forming protocols. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to base mediated defluorosilylation unactivated carbon fluorine bond aryl fluoride, silane preparation, cross-coupling, fluorine, reaction mechanisms, silylation, synthetic methods and other aspects.Synthetic Route of 321-28-8

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On November 25, 2020, Shi, Weimin; Zhang, Jingjie; Zhao, Fengqian; Wei, Wei; Liang, Fang; Zhang, Yin; Zhou, Shaolin published an article.Related Products of 321-28-8 The title of the article was Nucleophilic Aromatic Substitution of Unactivated Aryl Fluorides with Primary Aliphatic Amines by Organic Photoredox Catalysis. And the article contained the following:

A mild and transition-metal-free approach for the nucleophilic aromatic substitution (SNAr) of unactivated fluoroarenes with primary aliphatic amines to form aromatic amines was reported. This reaction is facilitated by the formation of cationic fluoroarene radical intermediates in the presence of an acridinium-based organic photocatalyst under blue-light irradiation Various electron-rich and electron-neutral fluoroarenes are competent electrophiles for this transformation. A wide range of primary aliphatic amines, including amino acid esters, dipeptides and linear and branched amines are suitable nucleophiles. The synthetic utility of this protocol is demonstrated by the late-stage functionalization of several complex drug mols. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Related Products of 321-28-8

The Article related to aryl fluoride aliphatic amine photoredox catalyst nucleophilic aromatic substitution, amines, aryl fluorides, nucleophilic aromatic substitution, visible-light photocatalysis and other aspects.Related Products of 321-28-8

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On July 31, 2021, He, Xiao-Yun published an article.Application of 321-28-8 The title of the article was A general palladium-catalyzed cross-coupling of aryl fluorides and organotitanium (IV) reagents. And the article contained the following:

Pd(OAc)2/1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxy-piperidine was demonstrated to effectively catalyze cross-coupling of aryl fluoride and aryl(alkyl) titanium reagent. Both electron-deficient and electron-rich aryl fluoride reacted effectively with nucleophile and provided extensive functional groups tolerance. 2-Arylated product was realized by selective activation of the C-F bond. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application of 321-28-8

The Article related to haloarene aryltitanium reagent palladium catalyst cross coupling, biaryl preparation, alkyltitanium reagenthaloarene palladium catalyst cross coupling, alkylarene preparation and other aspects.Application of 321-28-8

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On November 5, 2014, Milner, Phillip J.; Kinzel, Tom; Zhang, Yong; Buchwald, Stephen L. published an article.Safety of 1-Fluoro-2-methoxybenzene The title of the article was Studying Regioisomer Formation in the Pd-Catalyzed Fluorination of Aryl Triflates by Deuterium Labeling. And the article contained the following:

Isotopic labeling was used to determine that a portion of the desired product in the Pd-catalyzed fluorination of electron-rich, nonortho-substituted aryl triflates results from direct C-F cross-coupling. In some cases, formation of a Pd-aryne intermediate is responsible for producing undesired regioisomers. The generation of the Pd-aryne intermediate occurs primarily via ortho-deprotonation of a L路Pd(Ar)OTf (L = biaryl monophosphine) species by CsF and thus competes directly with the transmetalation step of the catalytic cycle. D labeling studies were conducted with a variety of aryl triflates. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Safety of 1-Fluoro-2-methoxybenzene

The Article related to palladium complex catalyzed fluorination coupling aryl triflate deuterium labeling, aryne palladacycle intermediate preparation catalyst fluorination coupling aryl triflate and other aspects.Safety of 1-Fluoro-2-methoxybenzene

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On April 19, 2019, Huber, Florian; Roesslein, Joel; Gademann, Karl published an article.HPLC of Formula: 321-28-8 The title of the article was Preparation of Indolenines via Nucleophilic Aromatic Substitution. And the article contained the following:

An unusual aromatic substitution to access indolenines is described. 2-(2-Methoxyphenyl)acetonitrile derivatives are reacted with various alkyl and aryl Li reagents to furnish the corresponding indolenine products, constituents of natural products, and cyanine dyes such as indocyanine green. This new method was used to synthesize 41 indolenines with large functional group tolerance, and selected examples were further converted to the corresponding indolenine dyes. Key experiments provide insight into the mechanism of this nucleophilic aromatic substitution. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).HPLC of Formula: 321-28-8

The Article related to indolenine preparation nucleophilic aromatic substitution methoxyphenyl acetonitrile organolithium, aromatic substitution methoxyphenyl acetonitrile organolithium indolenine cyclization and other aspects.HPLC of Formula: 321-28-8

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On November 16, 2018, Lim, Soobin; Song, Dalnim; Jeon, Seungwon; Kim, Youngsuk; Kim, Hyunseok; Lee, Sanghee; Cho, Hyungdo; Lee, Byung Chul; Kim, Sang Eun; Kim, Kimoon; Lee, Eunsung published an article.Related Products of 321-28-8 The title of the article was Cobalt-Catalyzed C-F Bond Borylation of Aryl Fluorides. And the article contained the following:

A mild and practical Co-catalyzed defluoroborylation of fluoroarenes is presented for the 1st time. The method permits straightforward functionalization of fluoroarenes, with high selectivity for borylation of C-F over C-H bonds, and a tolerance for aerobic conditions. Also, two-step 18F-fluorination was achieved for expanding the scope of 18F-positron emission tomog. probes. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Related Products of 321-28-8

The Article related to aryl fluoride cobalt catalyzed defluoroborylated, borylphenyl indole preparation crystal structure fluorination, mol structure borylphenyl indole, arylborane preparation fluorination and other aspects.Related Products of 321-28-8

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Kaga, Atsushi; Hayashi, Hirohito; Hakamata, Hiroyuki; Oi, Miku; Uchiyama, Masanobu; Takita, Ryo; Chiba, Shunsuke published an article in 2017, the title of the article was Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite.Formula: C7H7FO And the article contains the following content:

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Formula: C7H7FO

The Article related to benzannulated nitrogen heterocycle preparation, methoxy arene amine nucleophilic amination, dft calculations, amination, nitrogen heterocycles, nucleophilic aromatic substitution, sodium hydride and other aspects.Formula: C7H7FO

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Ether – Wikipedia,
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