Category: 321-28-8

On May 31, 2019, Gobbi, Silvia; Hu, Qingzhong; Foschi, Giacomo; Catanzaro, Elena; Belluti, Federica; Rampa, Angela; Fimognari, Carmela; Hartmann, Rolf W.; Bisi, Alessandra published an article.Application In Synthesis of 1-Fluoro-2-methoxybenzene The title of the article was Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing. And the article contained the following:

The inhibition of steroidogenic cytochrome P 450 enzymes has been shown to play a central role in the management of life-threatening diseases such as cancer, and indeed potent inhibitors of CYP19 (aromatase) and CYP17 (17伪 hydroxylase/17,20 lyase) are currently used for the treatment of breast, ovarian and prostate cancer. In the last few decades CYP11B1 (11-尾-hydroxylase) and CYP11B2 (aldosterone synthase), key enzymes in the biosynthesis of cortisol and aldosterone, resp., have been also investigated as targets for the identification of new potent and selective agents for the treatment of Cushing’s syndrome, impaired wound healing and cardiovascular diseases. In an effort to improve activity and synthetic feasibility of our different series of xanthone-based CYP11B1 and CYP11B2 inhibitors, a small series of imidazolylmethylbenzophenone-based compounds, previously reported as CYP19 inhibitors, was also tested on these new targets, in order to explore the role of a more flexible scaffold for the inhibition of CYP11B1 and -B2 isoforms. Compound 3 proved to be very potent and selective towards CYP11B1, and was thus selected for further optimization via appropriate decoration of the scaffold, leading to new potent 4′-substituted derivatives In this second series, 4 and 8, carrying a methoxy group and a Ph ring, resp., proved to be low-nanomolar inhibitors of CYP11B1, despite a slight decrease in selectivity against CYP11B2. Moreover, unlike the benzophenones of the first series, the 4′-substituted derivatives also proved to be selective for CYP11B enzymes, showing very weak inhibition of CYP19 and CYP17. Notably, the promising result of a preliminary scratch test performed on compound 8 confirmed the potential of this compound as a wound-healing promoter. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application In Synthesis of 1-Fluoro-2-methoxybenzene

The Article related to benzophenone cyp11b1 cyp11b2 inhibitor wound healing cortisol steroidogenesis, benzophenone, cyp11b1 (11-尾-hydroxylase), cyp11b2 (aldosterone synthase), cortisol, steroidogenesis, wound healing and other aspects.Application In Synthesis of 1-Fluoro-2-methoxybenzene

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Ether – Wikipedia,
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Svejstrup, Thomas D.; Ruffoni, Alessandro; Julia, Fabio; Aubert, Valentin M.; Leonori, Daniele published an article in 2017, the title of the article was Synthesis of Arylamines via Aminium Radicals.Electric Literature of 321-28-8 And the article contains the following content:

Arylamines constitute the core structure of many therapeutic agents, agrochems., and organic materials. The development of methods for the efficient and selective construction of these structural motifs from simple building blocks is desirable but still challenging. We demonstrate that protonated electron-poor O-aryl hydroxylamines give aminium radicals in the presence of Ru(bpy)3Cl2. These highly electrophilic species undergo polarized radical addition to aromatic compounds in high yield and selectivity. We successfully applied this method to the late-stage modification of chiral catalyst templates, therapeutic agents, and natural products. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Electric Literature of 321-28-8

The Article related to arene aryl hydroxylamine aminium radical photocatalytic regioselective amination, arylamine preparation, n-arylation, aminium radicals, aryl amines, late-stage amination, synthetic methods and other aspects.Electric Literature of 321-28-8

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Ether – Wikipedia,
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On February 19, 2021, Falk, Eric; Gasser, Valentina C. M.; Morandi, Bill published an article.SDS of cas: 321-28-8 The title of the article was Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C-H Amination. And the article contained the following:

We report both an intermol. C-H amination of arenes to access N-methylanilines and an intramol. variant for the synthesis of tetrahydroquinolines. A newly developed, highly electrophilic aminating reagent was key for the direct synthesis of unprotected N-methylanilines from simple arenes. The reactions display a broad functional group tolerance and employ catalytic amounts of a benign iron salt under mild reaction conditions. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).SDS of cas: 321-28-8

The Article related to arene oxymethylammonium triflate iron catalyst regioselective amination, methyl arylamine preparation, tosyloxy phenylpropyl carbamate iron catalyst regioselective amination, tetrahydroquinoline preparation and other aspects.SDS of cas: 321-28-8

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Ether – Wikipedia,
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On December 23, 2014, Dubbaka, Srinivas Reddy; Narreddula, Venkateswara Reddy; Gadde, Satyanarayana; Mathew, Thresen published an article.COA of Formula: C7H7FO The title of the article was Silver-mediated fluorination of potassium aryltrifluoroborates with Selectfluor. And the article contained the following:

A simple and practical procedure for the silver-mediated fluorination of aryl- and heteroaryltrifluoroborates with electrophilic fluorine from Selectfluor and LiOH路H2O is presented. The reaction procedure is simple and easy to set up, the process produces fluorinated arenes and heteroarenes in good to excellent yields and a wide range of electronically and structurally diverse substrates are tolerated. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).COA of Formula: C7H7FO

The Article related to silver mediated fluorination potassium aryltrifluoroborate heteroaryltrifluoroborate electrophilic fluorine selectfluor, fluorinated arene heteroarene preparation fluorination selectfluor lithium hydroxide and other aspects.COA of Formula: C7H7FO

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On February 5, 2021, Tlahuext-Aca, Adrian; Lee, Sarah Yunmi; Sakamoto, Shu; Hartwig, John F. published an article.Recommanded Product: 321-28-8 The title of the article was Direct Arylation of Simple Arenes with Aryl Bromides by Synergistic Silver and Palladium Catalysis. And the article contained the following:

The direct, catalytic arylation of simple arenes in small excess with aryl bromides was disclosed. The developed method did not require the assistance of directing groups and relies on a synergistic catalytic cycle in which phosphine-ligated silver complexes cleave the aryl C-H bond, while palladium catalysts enable the formation of the biaryl products. Mechanistic experiments, including kinetic isotope effects, competition experiments, and hydrogen-deuterium exchange, support a catalytic cycle in which cleavage of the C-H bond by silver is the rate-determining step. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 321-28-8

The Article related to arene aryl bromide synergistic palladium silver catalyst regioselective arylation, biaryl preparation, c鈥揾 activation, aryl bromides, direct arylation, palladium and silver catalysts, synergistic catalysis and other aspects.Recommanded Product: 321-28-8

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Ether – Wikipedia,
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On May 10, 2021, Jiang, Zhong-Tao; Huang, Jiangkun; Zeng, Yaxin; Hu, Fangdong; Xia, Ying published an article.Synthetic Route of 321-28-8 The title of the article was Rhodium Catalyzed Regioselective C-H Allylation of Simple Arenes via C-C Bond Activation of Gem-difluorinated Cyclopropanes. And the article contained the following:

Herein, we report a rhodium catalyzed directing-group free regioselective C-H allylation of simple arenes. Readily available gem-difluorinated cyclopropanes can be employed as highly reactive allyl surrogates via a sequence of C-C and C-F bond activation, providing allyl arene derivatives in good yields with high regioselectivity under mild conditions. The robust methodol. enables facile late-stage functionalization of complex bioactive mols. The high efficiency of this reaction is also demonstrated by the high turnover number (TON, up to 1700) of the rhodium catalyst on gram-scale experiments Preliminary success on kinetic resolution of this transformation is achieved, providing a promising access to enantio-enriched gem-difluorinated cyclopropanes. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to arene cyclopropane geminal difluorinated rhodium regioselective allylation catalyst, fluorinated allylarene preparation, c−c bond activation, c−h allylation, directing-group-free, gem-difluorinated cyclopropane, rhodium catalysis and other aspects.Synthetic Route of 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hofer, Manuel; Genoux, Alexandre; Kumar, Roopender; Nevado, Cristina published an article in 2017, the title of the article was Gold-Catalyzed Direct Oxidative Arylation with Boron Coupling Partners.Name: 1-Fluoro-2-methoxybenzene And the article contains the following content:

An efficient synthesis of biaryls through a gold-catalyzed oxidative cross-coupling of arenes with strong electron-deprived aryl boronates is presented herein. Regio- and chemocontrol are achieved by the selective activation of these coupling partners by gold at different oxidation states. Under reaction conditions devoid of basic additives or directing groups, the role of acetato ligand as an internal base has been revealed as a key parameter for expanding the reaction scope in these transformations. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Name: 1-Fluoro-2-methoxybenzene

The Article related to arene aryl boronate direct oxidative arylation cross coupling gold, biaryl preparation mol crystal structure, gold oxidative arylation cross catalyst, arylation, cross-coupling, gold, homogeneous catalysis, reaction mechanisms and other aspects.Name: 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 31, 2015, Sun, Kai; Li, Yan; Zhang, Qian published an article.Name: 1-Fluoro-2-methoxybenzene The title of the article was Copper-catalyzed arenes amination with saccharins. And the article contained the following:

Synthesis of N-arylsaccharins I [R = 4-C6H5C6H4, C6H5, 1-naphthyl, etc.] and N-arylisothioazolones e.g. II [R1 = CH3, R2 = 4-ClC6H4] via copper-catalyzed direct C-N bond formation of simple arenes with saccharins/isothiazolones under relatively mild conditions was developed. This work provided a new method for oxidative coupling of aromatic C(sp2)-H bonds and N-H bonds by using arenes as limiting reagents. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Name: 1-Fluoro-2-methoxybenzene

The Article related to arylsaccharin regioselective preparation mechanism, saccharin arene copper catalyst amination regioselective, arylisothiazolone regioselective preparation mechanism, isothiazolone arene copper catalyst amination regioselective and other aspects.Name: 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 10, 2021, Jiang, Zhong-Tao; Huang, Jiangkun; Zeng, Yaxin; Hu, Fangdong; Xia, Ying published an article.Synthetic Route of 321-28-8 The title of the article was Rhodium Catalyzed Regioselective C-H Allylation of Simple Arenes via C-C Bond Activation of Gem-difluorinated Cyclopropanes. And the article contained the following:

Herein, we report a rhodium catalyzed directing-group free regioselective C-H allylation of simple arenes. Readily available gem-difluorinated cyclopropanes can be employed as highly reactive allyl surrogates via a sequence of C-C and C-F bond activation, providing allyl arene derivatives in good yields with high regioselectivity under mild conditions. The robust methodol. enables facile late-stage functionalization of complex bioactive mols. The high efficiency of this reaction is also demonstrated by the high turnover number (TON, up to 1700) of the rhodium catalyst on gram-scale experiments Preliminary success on kinetic resolution of this transformation is achieved, providing a promising access to enantio-enriched gem-difluorinated cyclopropanes. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to arene cyclopropane geminal difluorinated rhodium regioselective allylation catalyst, fluorinated allylarene preparation, c−c bond activation, c−h allylation, directing-group-free, gem-difluorinated cyclopropane, rhodium catalysis and other aspects.Synthetic Route of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hofer, Manuel; Genoux, Alexandre; Kumar, Roopender; Nevado, Cristina published an article in 2017, the title of the article was Gold-Catalyzed Direct Oxidative Arylation with Boron Coupling Partners.Name: 1-Fluoro-2-methoxybenzene And the article contains the following content:

An efficient synthesis of biaryls through a gold-catalyzed oxidative cross-coupling of arenes with strong electron-deprived aryl boronates is presented herein. Regio- and chemocontrol are achieved by the selective activation of these coupling partners by gold at different oxidation states. Under reaction conditions devoid of basic additives or directing groups, the role of acetato ligand as an internal base has been revealed as a key parameter for expanding the reaction scope in these transformations. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Name: 1-Fluoro-2-methoxybenzene

The Article related to arene aryl boronate direct oxidative arylation cross coupling gold, biaryl preparation mol crystal structure, gold oxidative arylation cross catalyst, arylation, cross-coupling, gold, homogeneous catalysis, reaction mechanisms and other aspects.Name: 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem