Category: 3929-47-3

Study on the removal and depolymerization of lignin from corn stover through the synergistic effect of Bronsted acid, Lewis acid and hydrogenation sites was written by Zhang, Baikai;Li, Wenzhi;Zhang, Tingwei;Li, Xu;Ogunbiyi, Ajibola T.;Chen, Kun;Shen, Changcheng. And the article was included in Fuel in 2021.Electric Literature of C11H16O3 This article mentions the following:

The effective transformation of lignin is an essential part of realizing the comprehensive utilization of biomass. In this study, a one-pot method for the depolymerization of corn stover lignin used aluminum phosphate (NiAPO-5) zeolite catalyst contained Bronsted acid, Lewis acid and hydrogenation sites was proposed. It was found that the number of Bronsted acid sites was increased after NiAPO-5 was reduced with H₂. The yield of monomers and residue were 35.70% and 38.09% at 235鎺矯 for 3 h, resp. The result of 2D HSQC NMR showed that the NiAPO-5 (H₂) catalyst significantly affected the cleavage of 灏?O-4 bonds. The distribution of products and the stability of catalyst revealed that NiAPO-5 (H₂) was an efficient catalyst for the depolymerization of lignin. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Electric Literature of C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Electric Literature of C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pharmacokinetic profiling of anticancer phytocompounds using computational approach was written by Sharma, Ashish;Sharma, Shilpa;Gupta, Mansi;Fatima, Shehnaz;Saini, Ravi;Agarwal, Subhash Mohan. And the article was included in Phytochemical Analysis in 2018.Computed Properties of C11H16O3 This article mentions the following:

Introduction : Natural products exhibit diverse scaffolds and are considered as suitable candidates for development of leads. However, poor pharmacokinetics often acts as a hindrance during the drug discovery process. Objective : With a view of exploring the absorption, distribution, metabolism, excretion and toxicity (ADMET) profile of plant-based anticancer compounds, open-access databases (NPACT, CancerHSP and TaxKB) were analyzed to identify mols. having properties favorable for drug ability. Methodol. : Our workflow involved identification of mols. capable of passing each of the ADMET barriers based on physicochem. properties of mols., and physiol. barriers and factors. Results : The results revealed that out of 5086 phytomols., 63% were orally absorbable and 52% distributable. Also, an appreciable proportion of these compounds (45%) could be metabolised and excreted. Furthermore, 28% were found to be non-toxic for cardio toxicity and central nervous system (CNS) activity. Addnl., comparison against known anticancer drugs (reference dataset) revealed that the three libraries exhibit similar trends, thus providing addnl. confidence to the predictions. Overall, 28% of the mol. dataset was found to have suitable pharmacokinetic properties. We have also discussed a few natural products which exhibit favorable ADMET as well as low nano-micromolar in vitro anticancer activity. Conclusion : We have created an interactive database (ADMETCan), which provides access to predicted ADMET of these anticancer phytomols. The ease of availability of this dataset is expected to minimise failure rate of these compounds and thus is expected to be beneficial to the scientific community involved in anticancer identification and development. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Computed Properties of C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Computed Properties of C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-Catalyzed Intermolecular Enantioselective Radical Oxidative C(sp³)-H/C(sp)-H Cross-Coupling with Rationally Designed Oxazoline-Derived N,N,P(O)-Ligands was written by Liu, Lin;Guo, Kai-Xin;Tian, Yu;Yang, Chang-Jiang;Gu, Qiang-Shuai;Li, Zhong-Liang;Ye, Liu;Liu, Xin-Yuan. And the article was included in Angewandte Chemie, International Edition in 2021.Related Products of 3929-47-3 This article mentions the following:

Here, a copper-catalyzed asym. C(sp³)-C(sp) cross-coupling of (hetero)benzylic and (cyclic)allylic C-H bonds with terminal alkynes that occurs with high to excellent enantioselectivity was reported. Critical to the success is the rational design of chiral oxazoline-derived N,N,P(O)-ligands that not only tolerate the strong oxidative conditions which were requisite for intermol. hydrogen atom abstraction (HAA) processes but also induce the challenging enantiocontrol. Direct access to a range of synthetically useful chiral benzylic alkynes and 1,4-enynes, high site-selectivity among similar C(sp³)-H bonds, and facile synthesis of enantioenriched medicinally relevant compounds make this approach very attractive. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Use of high-frequency conductometry in organic chemistry. IV. Acid-base properties of aromatic alcohols of the phenylpropane and guaiacylpropane series was written by Cemeris, M.;Galochkin, A. I.. And the article was included in Koksnes Kimija in 1974.Reference of 3929-47-3 This article mentions the following:

The acidities of phenylalkanols decreased in the order p-O2NC6H4CH2OH > PhCH2OH > PhCH:CHCH2OH > PhCH2CH2OH > PhCHEtOH > Ph(CH2)3OH; those of veratryl alcs. decreased in the order ZCH:CHCH2OH [Z = 3,4-(MeO)2C6H3] > Z(CH2)3OH > ZCHEtOH; those of guaiacylpropanols were comparable with that of PhCH2OH. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Reference of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Reference of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D₂-like dopamine receptors was written by Stark, Daniela;Piel, Markus;Huebner, Harald;Gmeiner, Peter;Gruender, Gerhard;Roesch, Frank. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Recommanded Product: 3929-47-3 This article mentions the following:

Benzamide derivatives as radiotracers have played an important role in diagnosing malfunction in dopaminergic neurotransmission. A variety of halogenated and two unsubstituted benzamide derivatives were synthesized and their in vitro affinities to dopaminergic, serotonergic and adrenergic receptors and their lipophilicities were determined As references IBZM (3), raclopride (4) and FLB457 (5) were tested as well. The two iodinated compounds NAE (27) and NADE (28) displayed K_i values of 0.68 and 14 nM for the D₂ receptor. The well-established radiotracers FP (1) and DMFP (2) showed affinities in the same range as did the brominated compounds NABrE (29) and NABrDE (30). The log D_7.4 values of 2.91 for NAE (27) and of 2.81 for NADE (28) are in the range of those found for IBZM (3), FP (1) and DMFP (2). These facts allow to expect good properties for the two iodinated compounds NAE (27) and NADE (28) regarding in vivo imaging with SPECT. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Recommanded Product: 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

High hypolipidemic activity of saturated side-chain α-asarone analogs was written by Cruz, Adriana;Garduno, Leticia;Salazar, Maria;Martinez, Elizdath;Diaz, Francisco;Chamorro, German;Tamariz, Joaquin. And the article was included in Medicinal Chemistry Research in 2001.SDS of cas: 3929-47-3 This article mentions the following:

With the aim of evaluating the pharmacophore potential of the side chain of α-asarone regarding its high hypolipidemic activity, α-asarone analogs (I) were evaluated pharmacol. For I, with a variable-size side chain, significant decreases in serum cholesterol, LDL-cholesterol, and triglyceride levels and significant increases in HDL-cholesterol levels were observed in mice. I were even more active than α-asarone in reducing cholesterol. The results suggested that the length and saturated character of the side chain seem to be a key feature in improving hypolipidemic activity of I. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3SDS of cas: 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.SDS of cas: 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ru-Catalyzed Hydrogenolysis of Lignin: Base-Dependent Tunability of Monomeric Phenols and Mechanistic Study was written by Li, Helong;Song, Guoyong. And the article was included in ACS Catalysis in 2019.Electric Literature of C11H16O3 This article mentions the following:

Substantial attention has been given to depolymerization of lignin into monomeric phenols in recent years because lignin is a renewable and CO₂-natural aromatic resource. Recent results indicated that the base can shift the selectivity from C3-fragmented phenols to C2-fragmented phenols partially in transition metal-catalyzed lignin hydogenolysis, while reaction mechanisms have remained elusive. Using a series of dimeric, trimeric, and polymeric β-O-4 lignin mimics, as well as their deuterated analogs, we now report an in-depth exptl. study on the mechanism of Ru/C-catalyzed hydogenolysis lignin. Exptl. evidence based on substrate probes, reactivity examination of possible intermediates, and isotopic labeling experiments confirmed that the reported pathways, such as enol ether generated via α,β-dehydration reaction or C_α carbonyl compounds generated via dehydrogenation or consecutive C_β-O and C_γ-OH bonds hydrogenolysis, are irrelevant to current reactions. For C3-fragmented phenols with Ru/C catalyst under neutral condition, we deduced that the monolignol such as coniferyl alc. is formed primarily through a concerted hydrogenolysis process, where C_α-O and C_β-O bonds are ruptured synchronously. For C2-fragmented phenols generated by the combination of Ru/C and Cs₂CO₃, the reaction should start from quinone methide specie generated from the dehydration (or demethanolization) reaction between phenolic proton and C_α-OH (or C_α-OMe). The followed deprotonation of C_γ-OH and the coordination of oxygen with Ru results in a Ru specie, which undergoes C_β-H, C_β-O, and C_β-C_γ bonds cleavage to release 4-vinylphenol. In the case of Ru/C-catalyzed hydrogenolysis of an enzymic mild acidolysis lignin (EMAL) derived from birch tree, the effects of some key parameters such as temperature, reaction time, as well as the type and dosage of base were also examined in terms of monomer yields and selectivity. We found the formation of C2-phenols is a base-dependent process, which is in line with the proposed mechanism. Under optimized conditions, a high proportion of C2-phenols (44%) could be obtained with 26.6 weight % total monomers yield. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Electric Literature of C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Electric Literature of C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A novel and direct synthesis of chroman derivatives using a hypervalent iodine(III) reagent was written by Hamamoto, Hiromi;Hata, Kayoko;Nambu, Hisanori;Shiozaki, Yukiko;Tohma, Hirofumi;Kita, Yasuyuki. And the article was included in Tetrahedron Letters in 2004.SDS of cas: 3929-47-3 This article mentions the following:

The direct aromatic carbon-oxygen bond-formation reaction was described and the novel and simple synthetic method for chroman derivatives involving aromatic cation radical intermediates was developed using the hypervalent iodine(III) reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA). In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3SDS of cas: 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.SDS of cas: 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M was written by Rusch, Marion;Zimmermann, Tobias J.;Buerger, Marco;Dekker, Frank J.;Goermer, Kristina;Triola, Gemma;Brockmeyer, Andreas;Janning, Petra;Boettcher, Thomas;Sieber, Stephan A.;Vetter, Ingrid R.;Hedberg, Christian;Waldmann, Herbert. And the article was included in Angewandte Chemie, International Edition in 2011.Formula: C11H16O3 This article mentions the following:

Activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Formula: C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mo-Based Oxidizers as Powerful Tools for the Synthesis of Thia- and Selenaheterocycles was written by Franzmann, Peter;Beil, Sebastian B.;Schollmeyer, Dieter;Waldvogel, Siegfried R.. And the article was included in Chemistry – A European Journal in 2019.Reference of 3929-47-3 This article mentions the following:

A highly efficient synthetic protocol for the synthesis of thia- and selenaheterocycles has been developed. By employing a MoCl₅-mediated intramol. dehydrogenative coupling reaction, a broad variety of structural motifs was isolated in yields up to 94 % [e.g., bis(2-(3,4-dimethoxyphenyl)ethyl) disulfide → 4,5-dimethoxybenzothiophene (65 %) in the presence of MoCl₅ + TiCl₄ (2 equiv)]. The electrophilic key transformation is tolerated by several labile moieties like halides and tertiary alkyl groups. Due to the use of disulfide or diselenide precursors, a high atom efficiency was achieved. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Reference of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem