Category: 4637-24-5

Shao, Chenwen; Hedberg, Christian; Qian, Yong published an article in 2021. The article was titled 《In Vivo Imaging of the Macrophage Migration Inhibitory Factor in Liver Cancer with an Activity-Based Probe》, and you may find the article in Analytical Chemistry (Washington, DC, United States).Application of 4637-24-5 The information in the text is summarized as follows:

The macrophage migration inhibitory factor (MIF), a vital cytokine and biomarker, has been suggested to closely associate with the pathogenesis of liver cancer. However, a simple and effective approach for monitoring the change and distribution of cellular MIF is currently lacking and urgently needed, which could be helpful for a better understanding of its role in the progression of cancer. Herein, we report a novel activity-based probe, TPP2 (I), which allows for direct labeling and imaging of endogenous MIF activity within live cells, clin. tissues, and in vivo in a mouse model of liver cancer. With this probe, we have intuitively observed the dynamic change of intracellular MIF activity by both flow cytometry and confocal imaging. We further found that TPP2 permits the identification and distinguishing of liver cancer in vitro and in vivo with high sensitivity and selectivity toward MIF. Our observations indicate that TPP2 could provide a promising new imaging approach for elucidating the MIF-related biol. functions in liver cancer. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Application of 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Journal of Polymer Science, Part A: Polymer Chemistry included an article by Yamauchi, Akira; Sudo, Atsushi; Endo, Takeshi. COA of Formula: C5H13NO2. The article was titled 《Polymer with Zwitterionic Structure in Main Chain via Polyaddition of Bifunctional Cyclic Amidine and Diisothiocyanate》. The information in the text is summarized as follows:

Another mode of application for the addition reaction of cyclic amidine and isothiocyanate to the construction of polymers with zwitterionic moieties, i.e., polyaddition of a bifunctional cyclic amidine monomer and diisothiocyanate. The thermal properties and ionic conductivity of the resulting polymer were investigated. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5COA of Formula: C5H13NO2) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.COA of Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Alnaja, Alaa M. A.; Farghaly, Thoraya A.; El-zahabi, Heba S. A.; Shaaban, Mohamed R. published an article in 2021. The article was titled 《Cytotoxicity, Docking Study of New Fluorinated Fused Pyrimidine Scaffold: Thermal and Microwave Irradiation Synthesis》, and you may find the article in Medicinal Chemistry (Sharjah, United Arab Emirates).Synthetic Route of C5H13NO2 The information in the text is summarized as follows:

Azolopyrimidines are imposed on the arena of drugs treated for cancer. The urgent need to discover new selective anticancer agents, paved the way to explore the antitumor significance of such fused systems. From the synthetic point of view, Microwave facilitated technique for synthesis is very strongly associated with green method in chem. field. Our aim is to synthesize bioactive compounds using docking simulation run by MOE program to explore the binding mode of the most active enzyme inhibitor among the target compounds In addition to the use of conventional heating, the MARS system of CEM utilized for Microwave irradiation that is equipped with a multi-mode platform with a magnetic stirring plate and a rotor that allows the parallel processing of many vessels per batch. All the synthesized compounds were tested for their anticancer activity against hepatic cancer (HepG-2), breast cancer (MCF-7) and colon cancer (HCT-116). Screening against the cancer cell lines was performed, using doxorubicin as a reference drug. Docking studies were conducted using MOE software. A novel series of fluorinated fused-pyrimidine namely, pyrazolopyrimidine, triazolopyrimidine and pyrimidobenzimidazole were designed and synthesized conventionally and under microwave irradiations. The mechanistic pathways as well as the structure of all products were debated and demonstrated based on all possible spectral data. In-vitro examination of the novel prepared derivatives vs. the three different human cancer cell lines [hepatic cancer (HepG-2), breast cancer (MCF-7) and colon cancer (HCT-116)] was evaluated to estimate their actual activity. We have developed a simple, facile, and efficient procedure for the formation of new series of azolopyrimidines. All spectra of all products were investigated deliberately to confirm their structures. The anti-cancer activity has been examined against three cancer cell lines e.g. HepG-2, MCF-7 and HCT116. Mol. modeling study was carried out in order to rationalize the in vitro anti-tumor results. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Synthetic Route of C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Crystal structure of (E)-N′-((4-aminophenyl)sulfonyl)-N,N-dimethylformimidamide, C9H13N3O2S》 was published in Zeitschrift fuer Kristallographie – New Crystal Structures in 2020. These research results belong to Abdel-Aziz, Alaa A.-M.; El-Azab, Adel S.; Ghabbour, Hazem A.; Obaidullaha, Ahmad J.. Name: N,N-Dimethylformamide Dimethyl Acetal The article mentions the following:

C9H13N3O2S, monoclinic, P21/c (number 14), a = 8.0984(4) Å, b = 17.3203(10) Å, c = 9.6802(4) Å, β = 124.031(3)°, V = 1125.26(10) Å3, Z = 4, Rgt(F) = 0.0504, wRref(F2) = 0.1275, T = 293(2) K. CCDC number: 1514612. A mixture of benzenesulfonamide (344 mg, 2 mmol) and N, N-dimethylformamide di-Me acetal (476 mg, 4 mmol) in ethanol (10 mL) was heated under reflux for 10 h. The reaction mixture was cooled and the separated solid was filtered, dried and recrystallized from ethanol. Yield 96%; 1H NMR (DMSO-de; 500 MHz): δ 8.10 (s, 1H, N-C(H)=N), 7.39-7.37 (d, 2H, j = 8.5 Hz, Ar-H), 6.58-6.56 (d, 2H, j = 9.0 Hz, Ar- H), 5.82 (s, 2H, NH2), 3.10 (s, 3H, CH3), 2.87 (s, 3H, CH3) ppm; 13C NMR (DMSO-de; 125 MHz): δ 35.30 (CH3), 41.14 (CH3), 113.01, 128.20, 129.03, 152.41, 159.43 (N-CH=N) ppm; MS: m/z = 227.1.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Name: N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of 5-(aminomethylidene)imidazol-4-ones by using N,N-dialkylformamide acetals》 was published in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020. These research results belong to Zaitseva, Elvira R.; Smirnov, Alexander Yu.; Ivanov, Igor A.; Mineev, Konstantin S.; Baranov, Mikhail S.. Category: ethers-buliding-blocks The article mentions the following:

A simple methodol. for the synthesis of various 5-(aminomethylidene)imidazol-4-ones I [R = NMe2, pyrrolidin-1-yl, piperidin-1-yl, 4-[ethoxy(oxo)methane]piperidin-1-yl, morpholin-4-yl; R1 = Me, Et] by condensation reactions of imidazol-4-one that was prepared in situ and acetals of N,N-dialkylformamides RCH(OR2)2 (R2 = Me, Et) has been described. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem