Category: 52189-63-6

52189-63-6, These common heterocyclic compound, 52189-63-6, name is 1-Fluoro-3,5-dimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of aluminum chloride (8.6 g, 64.04 mmol) in toluene (30 mL) was added 1-fluoro-3,5-dimethoxybenzene (301-3) (10.0 g, 64.04 mmol) at 0 C. The reaction mixture was stirred for 2 hours. To the above mixture was added acetyl chloride (5.0 g, 64.04 mmol). The resulting mixture was stirred for an additional 0.5 hours. The reaction mixture was quenched with water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate and evaporated in vacuo. The crude product was purified by column chromatography (hexanes/ethyl acetate: 25/1) to afford the title compound 302-3 as a white solid (2.78 g, 22 % yield). ?H NIVIR (400 1VIHz, CDC13): 2.46 (s, 3H), 3.79 (s, 6H), 6.29 (d, J 10.8 Hz, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52189-63-6.

Reference:
Patent; PHARMAENGINE, INC.; CAI, Xiong; QIAN, Changgeng; WANG, Yanong Daniel; (98 pag.)WO2017/132928; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

52189-63-6, Adding some certain compound to certain chemical reactions, such as: 52189-63-6, name is 1-Fluoro-3,5-dimethoxybenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52189-63-6.

Boron tribromide (1 M in dichloromethane, 9mL, 89.985mmol) was added drop wise to an ice- cooled solution of 3,5-dimethoxy fluorobenzene (3ml, 22,496mmol) in dichloromethane (2OmL) and the mixture was stirred at O0C to room temperature for 4 hours. The solution was cooled to O0C, further boron tribromide (4ml, 44.992mmol) was added and stirring continued, warming to room temperature for an additional 18 hours. The reaction was quenched with 0.88 ammonia solution and stirred at room temperature for 90 minutes. The organic layer was separated and extracted with 2N sodium hydroxide (30ml), which was then acidified to pH1 by drop wise addition of concentrated hydrochloric acid. The aqueous layer was then re- extracted with dichloromethane (3x15mL), the combined organic solution was dried over sodium sulfate and concentrated in vacuo to afford the title compound as a white solid in 54% yield, 1.72g. 1HNMR(400MHz, CD3OD) delta: 3.72(s, 3H), 6.07-6.15(m, 3H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52189-63-6.

Reference:
Patent; PFIZER LIMITED; WO2007/34325; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem