Category: 52818-63-0

Arora, Vinay published the artcileSolvent-Free N-Alkylation and Dehydrogenative Coupling Catalyzed by a Highly Active Pincer-Nickel Complex, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Organometallics (2020), 39(11), 2162-2176, database is CAplus.

The synthesis and characterization of a pincer-Ni complex (^iPr2NNN)NiCl₂(MeCN) is reported here. The authors demonstrated the utility of this pincer-Ni complex (0.02 mol % and 0.002 mol %) for the catalytic N-alkylation of amines using various alcs. Under solvent-free conditions, while the highest yield (âˆ?0%) was obtained for alkylation of 2-amino pyridine with naphthyl-1-methanol, excellent turnovers (34000 TONs) was observed for alkylation of 2-amino pyridine with 4-methoxy benzyl alc. To demonstrate the synthetic utility of these systems, high yield reactions (up to 98%) were probed for representative substrates with a higher loading of the pincer-Ni catalyst (4 mol %). DFT studies indicate that while β-hydride elimination is the RDS for alc. dehydrogenation, the N-alkylated product can be formed either via hydrogenation with a rate-determining σ-bond metathesis or by alcoholysis that has imine insertion as RDS. All the corresponding resting states were observed by HRMS(ESI) anal. The labeling experiments are also complementary to DFT studies and show evidence for the involvement of benzylic C-H bond in RDS with a k_CHH/k_CHD of âˆ?.5. This method was applied to accomplish efficient (2000 TONS) dehydrogenative coupling leading to various benzimidazoles.

Organometallics published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Archibald, John L. published the artcileBenzamidopiperidines. 2. Heterocyclic compounds related to indoramin, Category: ethers-buliding-blocks, the publication is Journal of Medicinal Chemistry (1974), 17(7), 736-9, database is CAplus and MEDLINE.

A series of 19 title compounds prepared from 4-benzamidopiperidine [33953-37-6] by alkylation, acylation, Mannich or Michael-type reactions, or ring closure reactions were evaluated for hypotensive activity in anesthetized normotensive rats and antihypertensive activity in conscious renal hypertensive rats. The most active hypotensive compounds were I, R = 2-hydroxy-2-pyrrol-2-ylethyl [36793-50-7] and I, R = 2-(2-quinolyl)ethyl [36793-54-1]. The most active antihypertensive compounds were I, R = 2-(4-pyridyl)ethyl [36793-45-0], I, R = 2-(2-pyridyl)ethyl [36806-71-0], I, R = 2-(3-benzo[b]thienyl)ethyl [36793-52-9], and I, R = 2-(3-benz[g]indolyl)ethyl [36806-70-9]. None of the compounds were as potent as indoramin [26844-12-2] in either test. I, R = 2-phenothiazin-10-ylethyl [52818-64-1] caused noncompetitive antagonism of histamine in an isolated guinea-pig ileum preparation Structure-activity relations were discussed.

Journal of Medicinal Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fioravanti, Rossella published the artcileSynthesis and microbiological evaluations of (N-heteroaryl)arylmethanamines and their Schiff bases, HPLC of Formula: 52818-63-0, the publication is Farmaco (1996), 51(10), 643-652, database is CAplus.

The synthesis as well as the antimicrobial and antiviral activities of new (N-heteroaryl)arylmethanamines and their Schiff bases are reported. None of the tested compounds shown activity against Herpes simplex virus type 2 and against Gram-pos. and Gram-neg. bacteria. Weak or moderate activity on poliovirus Sabin type 1, on reverse transcriptase, and against Cryptococcus neoformans was shown by some of the tested compounds Several synthesized compounds exhibited a moderate or good activity against strains of Candida albicans, whereas only some of the tested compounds were found moderately active against strains of Candida sp. Instead numerous new compounds I or II were active against isolates of plant pathogenic fungi. The obtained results are discussed on the basis of structure-activity relationships.

Farmaco published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, HPLC of Formula: 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem