As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59557-91-4 name is 4-Bromo-2-methoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 59557-91-4
(0900) Under the protection of nitrogen gas, 4-bromo-2-methoxyaniline (15 g, 74.24 mmol) was dissolved in 1,4-dioxane (250 mL), and a solution of sodium bicarbonate (15.8 g, 188.07 mmol) in water (150 mL) was added. At 0 C., carbobenzoxy chloride (19.1 g, 111.96 mmol) was added dropwisely to the reaction system. After the addition, the reaction was carried out at room temperature for 20 min. TLC detection showed that raw materials disappeared. The mixture was extracted with ethyl acetate (100 mL¡Á3). The organic phases were combined, washed with saturated saline solution (100 mL¡Á2), dried with anhydrous sodium sulfate, and concentrated in vacuum. The crude product was purified by silica gel column chromatography (ethyl acetate: petroleum ether=1:5) to get the title compound as a white solid (15 g, yield: 60%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-methoxyaniline, and friends who are interested can also refer to it.
Reference:
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; (117 pag.)US2017/112833; (2017); A1;,
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