Category: 622-86-6

Bose, Shubhankar Kumar published the artcileHighly efficient synthesis of alkylboronate esters via Cu(II)-catalyzed borylation of unactivated alkyl bromides and chlorides in air, Application of (2-Chloroethoxy)benzene, the main research area is boronate preparation alkyl halide borylation copper catalyst; alkylboronic ester preparation copper catalyzed boration alkyl bromide chloride.

A copper(II)-catalyzed borylation of alkyl halides with bis(pinacolato)diboron (B2pin2) has been developed, which can be carried out in air, providing a wide range of primary, secondary, and some tertiary alkylboronates in high yields. A variety of functional groups are tolerated and the protocol is also applicable to unactivated alkyl chlorides (including 1,1- and 1,2-dichlorides). Preliminary mechanistic investigations show that this borylation reaction involves one-electron processes.

ACS Catalysis published new progress about Borylation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application of (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gupta, Ramesh C. published the artcileNovel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor, Category: ethers-buliding-blocks, the main research area is piperidine cyanothiazolidinoylmethyl hydrazino derivative preparation dipeptidyl peptidase inhibition activity; hydrazinopiperidine DPPIV inhibitor structure activity relationship insulin release stimulator.

A novel class of N-substituted 4-hydrazino piperidine derivatives containing chiral cyanothiazolidinoyl moieties were designed, synthesized and evaluated for DPP IV inhibition. The SAR studies on the N-substituted piperidines led to the discovery of compound I as a potent DPP IV inhibitor (IC50 88 nM), which is highly selective over other peptidases. In vivo efficacy indicates that compound I stimulates insulin release in response to glucose load and improves glucose tolerance in n5-STZ and Zucker Diabetic Fatty (ZDF) rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Hydrazines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ting, Pauline C. published the artcileThe synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists, Name: (2-Chloroethoxy)benzene, the main research area is benzimidazolyl piperidinylcarbonyl piperidine preparation; H3 receptor antagonist structure activity human.

A structure-activity relationship study of the lead piperazinylcarbonylpiperidine I, resulted in the identification of 4-benzimidazolyl-piperidinylcarbonyl-piperidine II, as a histamine-3 (H3) receptor antagonist. Addnl. optimization of II led to the identification of compounds e.g., III with good in vivo activity.

Bioorganic & Medicinal Chemistry Letters published new progress about Histamine H3 receptor antagonists. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Name: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Erkin, A. V. published the artcileAryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms, Safety of (2-Chloroethoxy)benzene, the main research area is hydroxyethylsulfanyl pyrimidine aryl ether hydrochloride salt preparation fungicidal activity.

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramol. cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

Russian Journal of General Chemistry published new progress about Fungicides. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Safety of (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ting, Pauline C. published the artcileThe synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists, Name: (2-Chloroethoxy)benzene, the main research area is benzimidazolyl piperidinylcarbonyl piperidine preparation; H3 receptor antagonist structure activity human.

A structure-activity relationship study of the lead piperazinylcarbonylpiperidine I, resulted in the identification of 4-benzimidazolyl-piperidinylcarbonyl-piperidine II, as a histamine-3 (H3) receptor antagonist. Addnl. optimization of II led to the identification of compounds e.g., III with good in vivo activity.

Bioorganic & Medicinal Chemistry Letters published new progress about Histamine H3 receptor antagonists. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Name: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gupta, Ramesh C. published the artcileNovel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor, Category: ethers-buliding-blocks, the main research area is piperidine cyanothiazolidinoylmethyl hydrazino derivative preparation dipeptidyl peptidase inhibition activity; hydrazinopiperidine DPPIV inhibitor structure activity relationship insulin release stimulator.

A novel class of N-substituted 4-hydrazino piperidine derivatives containing chiral cyanothiazolidinoyl moieties were designed, synthesized and evaluated for DPP IV inhibition. The SAR studies on the N-substituted piperidines led to the discovery of compound I as a potent DPP IV inhibitor (IC50 88 nM), which is highly selective over other peptidases. In vivo efficacy indicates that compound I stimulates insulin release in response to glucose load and improves glucose tolerance in n5-STZ and Zucker Diabetic Fatty (ZDF) rats.

Bioorganic & Medicinal Chemistry Letters published new progress about Hydrazines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Erkin, A. V. published the artcileAryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms, Safety of (2-Chloroethoxy)benzene, the main research area is hydroxyethylsulfanyl pyrimidine aryl ether hydrochloride salt preparation fungicidal activity.

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramol. cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

Russian Journal of General Chemistry published new progress about Fungicides. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Safety of (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem