Category: 6298-96-0

Related Products of 6298-96-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6298-96-0 name is 1-(4-Methoxyphenyl)ethylamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of (S)-(-)-1-(4-methoxyphenyl)ethylamine (25.0 g, 166 mmol) and 6,7-dihydro-8(5f/)-quinolinone (24.0 g, 166 mmol, J. Org. Chem., 2002, 67, 2197-2205) in dichloromethane was treated with glacial acetic acid (14.0 mL, 249 mmol) and sodium triacetoxyborohydride (53.0 g, 249 mmol). The reaction mixture was stirred at room temperature for 15 hours and then treated with sodium carbonate (106 g, 996 mmol) dissolved in water. The resulting mixture was stirred for 30 minutes and then diluted with dichloromethane. The phases were separated and the aqueous solution extracted with an additional portion of dichloromethane. The combined organic solutions were dried over MgSO4 and concentrated to dryness at reduced pressure. The crude product was purified by flash chromatography (silica gel, gradient elution of dichloromethane to 97:3 dichloromethane/2M ammonia in MeOH) followed by recrystallization from hexane to afford 33 g (70%) of (8S)-Lambda/-{(1 S)-1-[4-(methyloxy)phenyl]ethyl}-5,6,7,8-tetrahydro-8- quinolinamine as a white crystalline solid. 1H NMR (CDCI3): delta 8.40 (m, 1 H), 7.33 (m, 3H), 7.04 (m, 1 H), 6.84 (d, 2H), 4.02 (m, 1 H), 3.83-3.78 (m, 4H), 2.73-2.62 (m, 2H), 1.82 (m, 1H), 1.72 (m, 1 H), 1.57 (m, 2H), 1.43 (d, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Methoxyphenyl)ethylamine, and friends who are interested can also refer to it.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; SVOLTO, Angilique, Christina; WO2007/87548; (2007); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 6298-96-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Examrle 22-[(S)-1 -(4-methoxyphenyl)-ethylamino]-cyclopent-1 -ene-carboxylic acid methylester(compound of formula (IV) wherein Ar = 4-methoxyphenyl, R1 = CO2Me) 10.37 g (70.0 mmol) of 2-oxo-cyclopentane-carboxylic acid methylester (purity 96%, Aldrich) were dissolved in 30 ml of toluene and 10.00 g (65.5 mmol) of (S)-1 -(4- methoxyphenyl)-ethylamine (purity >99%, BASE) were stirred under argon for 12 hours at ca. 25C. Water was completely removed by evaporation of toluene (3 x 50 ml) andthe product was dried at 80C/i mbar to give 18.1 g (100%) of the title product asyellow oil.LC-MS: MH 276;1H NMR: 1 .40 (d, 3H, Me), 1 .65 (m, 2H, H-4), 2.25, 2.37, 2.62 (3m, 4H, H-3, H-5), 3.57(5, 3H, CO2Me), 3.73 (5, 3H, OMe), 4.60 (m, 1 H, CHN), 6,90, 7.20 (2m, 4H, Ar-H), 7.70(d, 1H, NH).

The synthetic route of 1-(4-Methoxyphenyl)ethylamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; KRETZSCHMAR, Gerhard; OEHME, Jan; ROSSEN, Kai; WO2015/189108; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 6298-96-0, A common heterocyclic compound, 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation Example 174 To 713 mg of methyl 1-oxoindane-5-carboxylate were added 612 mg of (1S)-1-(4-methoxyphenyl)ethanamine, 0.23 ml of acetic acid, 600 mg of Molecular Sieves 4A, and 12 ml of toluene, followed by heating to reflux using a Dean-Stark type reflux device for 4 hours under reduced pressure (213 mbar). Then, 0.23 ml of acetic acid and 300 mg of Molecular Sieves 4A were added thereto, followed by heating to reflux using a Dean-Stark type reflux device for 4 hours under reduced pressure (213 mbar). The insoluble material was removed by filtration and the solvent was then evaporated under reduced pressure to obtain an intermediate product. To a solution of the obtained intermediate product in 13 ml of ethanol was added 161 mg of sodium borohydride under ice-cooling, followed by stirring for 1 hour under ice-cooling. The solvent was evaporated under reduced pressure, and to the obtained residue were added water, a saturated aqueous sodium hydrogen carbonate solution, and ethyl acetate to carry out a layer separation operation. The organic layer was washed with water and saturated brine in this order, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 452 mg of methyl (1S)-1-{[(1S)-1-(4-methoxyphenyl)ethyl]amino}indane-5-carboxylate.

The synthetic route of 6298-96-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTELLAS PHARMA INC.; KOGA, Yuji; MAENO, Kyoichi; SATO, Ippei; IMAMURA, Yoshimasa; HANAZAWA, Takeshi; IIDA, Maiko; OHNE, Kazuhiko; IMAMURA, Kenichiro; WATANABE, Tsubasa; NOZAWA, Eisuke; SHIBATA, Hiroshi; US2014/88080; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem