These common heterocyclic compound, 702-24-9, name is 4-Methoxy-N-methylbenzylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 702-24-9
N-methyl-4-methoxybenzylamine (30.2 mg, 0.2 mmol), molybdenum disulfide (4 mg, 0.025 mmol), and oneThe pellet was placed in a reaction tube, and after replacing the inert gas, 1 ml of DMF was added to seal the reaction tube. The reaction tube was placed in a 150 ¡ã C oil bath reaction pot, and the reaction was stirred for 18 hours; after cooling to room temperature, the catalyst was removed by filtration, the filtrate was diluted with 15 mL of water, and extracted with ethyl acetate three times, each time 15 mL; The organic layer was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The crude product was purified by column chromatography with ethyl acetate: petroleum ether = 1:2 (1percent triethylamine). Yellow oil in 96percent yield.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 702-24-9.
Reference:
Patent; Xiangtan University; Gong Xing; Xie Guilin; Cai Changqun; Ma Juan; (19 pag.)CN107827817; (2018); A;,
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