Related Products of 887267-47-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 887267-47-2 name is 2-Bromo-5-(trifluoromethoxy)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2-bromo-5-(trifluoromethoxy)aniline (1.00 g, 3.91 mmol, 1.0 eq) in DCM (10 mL) was added TEA (800.0 mg, 7.91 mmol, 1.10 mL, 2.02 eq) and acetyl chloride (620.0 mg, 7.90 mmol, 563.6 muL, 2.02 eq) at 0 C. After 5 h at 0 C, the mixture was warmed to 40 C and stirred for another 7 h under N2. The reaction mixture was poured into H2O (150 mL), and extracted with EtOAc (50 mL*3). The combined organic layers were washed with brine (80 mL), dried over anhydrous Na2SO4, filtered and the filtrate was concentrated in vacuum. The residue was purified by column chromatography (SiO2) to give compound 06-59-1 (900.0 mg, 2.33 mmol, 60% yield). M+H+ = 297.0 (LCMS).1H NMR (CDCl3, 400 MHz): delta 8.41 (br s, 1H), 7.55 (d, J = 8.8 Hz, 1H), 6.88 (dd, J = 1.8, 8.8 Hz, 1H), 2.27 (s, 3H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5-(trifluoromethoxy)aniline, and friends who are interested can also refer to it.
Reference:
Patent; KYRAS THERAPEUTICS, INC.; VACCA, Joseph P.; LI, Dansu; (587 pag.)WO2017/96045; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem