Category: ethers-buliding-blocks

Tao, Duan-Jian published the artcileSynthesis of Tetrabutylphosphonium Carboxylate Ionic Liquids and Its Catalytic Activities for the Alcoholysis Reaction of Propylene Oxide, Application of 2-Methoxypropan-1-ol, the publication is Industrial & Engineering Chemistry Research (2013), 52(48), 17111-17116, database is CAplus.

Four tetrabutylphosphonium carboxylate ionic liquids ([P₄₄₄₄]-[CA]) were prepared, characterized, and used as catalysts for the synthesis of propylene glycol Me ether (PGME) from the alcoholysis reaction of propylene oxide (PO) with methanol. The effects of various parameters such as the kind of ILs, temperature, reaction time, catalyst loading, and molar ratio of the reactants on PGME yield and selectivity were also studied in detail. The results indicated that tetrabutylphosphonium butyrate ([P₄₄₄₄]-[Buty]) exhibited the best catalytic activity in comparison to three other carboxylate ILs, and PGME was produced in nearly 94% yield under mild conditions. In addition, [P₄₄₄₄]-[Buty] was found to exhibit good catalytic activities and selectivities in other alcoholysis reactions of epoxides with various alcs., such as PO with n-propanol, PO with n-butanol, 1-(allyloxy)-2,3-epoxypropane with methanol, and 1,2-epoxybutane with methanol. [P₄₄₄₄]-[Buty] could also be recovered easily and used repetitively at least 10 times without an obvious decrease in activity and quantity. Therefore, [P₄₄₄₄]-[Buty] proved to be an effective recyclable homogeneous catalyst for the synthesis of PGME and showed potential application in industry.

Industrial & Engineering Chemistry Research published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C8H5IO, Application of 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sato, Ryota published the artcileInvestigation for the cyclization efficiency of linear tetrapeptides: Synthesis of tentoxin B and dihydrotentoxin, Computed Properties of 77128-73-5, the publication is Tetrahedron (2018), 74(42), 6173-6181, database is CAplus.

Investigation of the cyclization efficiency of N-Me linear tetrapeptides using a mol. modeling study and chem. synthesis is described. The linear peptide with two N-Me groups, MeAla-Leu-MePhe-Gly, forms γ-turn like conformation with the amine at N-terminus and the carbonyl at C-terminus in closer proximity to give the desired cyclic tetrapeptide, dihydrotentoxin. In addition, synthesis of tentoxin B by the combination of Fmoc solid-phase peptide synthesis (Fmoc = 9-fluorenylmethoxycarbonyl) and cyclization in solution phase has been reported. An unusual amino acid, an L-N-methyl-β-hydroxyphenylalanine derivative, which was assembled on solid support, was prepared from Et cinnamate. Cyclic tetrapeptide formation and cleavage of benzyl ether were optimized with DIPCI/HOBt/DIPEA and Et₃SiH/Pd(OH)₂, resp.

Tetrahedron published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Computed Properties of 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tatematsu, Ryoichi published the artcilePreparation and properties of some fluoroalcohol-ethylene oxide adducts, Application In Synthesis of 2358-54-5, the publication is Yukagaku (1977), 26(6), 367-71, database is CAplus.

Surfactants such as CF3CF2CH2O(C2H4O)3H (I) [63693-17-4] and CF3CH2OCH2CH2OH [2358-54-5] were prepared A mixture of 10 g CF3CF2CH2OH [422-05-9], 11.9 g ethylene oxide [75-21-8], and 0.3 mL 50% aqueous NaOH was heated at 80-5° for 2 h to prepare 32.8% I.

Yukagaku published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C40H35N7O8, Application In Synthesis of 2358-54-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yigit, Beyhan published the artcileActive ruthenium(II)-NHC complexes for alkylation of amines with alcohols using solvent-free conditions, Computed Properties of 52818-63-0, the publication is Polyhedron, database is CAplus.

A series of new ruthenium(II) complexes bearing N-heterocyclic carbene ligands with benzylic groups were prepared by transmetallation reactions between silver(I) N-heterocyclic carbene complexes and [RuCl₂(p-cymene)]₂. All of the obtained complexes were characterized by FT-IR, ¹H NMR and ¹³C NMR spectroscopy, and the mol. structure of compound 3c was also determined by x-ray crystallog. These ruthenium complexes were tested for the alkylation of aromatic amines with a wide range of primary alcs. under solvent-free conditions using the hydrogen borrowing strategy. All of the compounds tested here showed excellent catalytic activity for these reactions and N-monoalkylated products were obtained selectively using 2.5 mol% of the ruthenium complexes.

Polyhedron published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C39H35N5O8, Computed Properties of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ratajczak, H. M. published the artcilePolarographic studies on aqueous formamidine disulfide solutions. I, Category: ethers-buliding-blocks, the publication is Electrochimica Acta (1975), 20(6-7), 427-9, database is CAplus.

The polarog. reduction of [H2NC(:NH)S]2 (I) in aqueous solution, prepared by oxidation of CS(NH2)2 with H2O2 and by in situ polarog. oxidation of CS(NH2)2 with Ce(IV), was dependent on the acidity of the solution and 3 reduction waves were observed The wave at lowest limiting current was assigned to reduction of the protonated formamidine disulfide [(NH2)2CS]22+ and the second wave to the reduction of a less protonated form. The wave at highest limiting current was due to the reduction of a polysulfide compound formed by reaction of S, from the minor decomposition of I, with I.

Electrochimica Acta published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Misal, Balu published the artcileSulfated polyborate-H₂O assisted tunable activation of N-iodosuccinimide for expeditious mono and diiodination of arenes, Formula: C11H10O, the publication is Tetrahedron Letters (2021), 153154, database is CAplus.

Owing to both Lewis and Bronsted acid active sites on sulfated polyborate under homogeneous conditions, iodination protocol of arenes was developed, which can meet the requirement of regioselectivity and higher yield. The sulfated polyborate activated N-iodosuccinimide for mono iodination of highly activated substrates viz. phenols, anilines under anhydrous condition. Water tuned sulfated polyborate to generate more Bronsted acid sites resulting in rapid activation of NIS for diiodination. The protocol was equally applicable to diiodination of 4-hydroxyphenylacetic acid to synthesize 4-hydroxy-3,5-diiodophenylacetic acid, an intermediate of tiratricol, a thyroid treatment drug. This protocol was further integrated via one-pot sequential iodination and Sonogashira coupling to synthesize aryl acetylenes, building blocks for the synthesis of a variety of specialty chems., API and natural products.

Tetrahedron Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dalai, Pallaba Ganjan published the artcileGeneration of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C-H Halogenation, Application In Synthesis of 93-04-9, the publication is Advanced Synthesis & Catalysis (2022), 364(5), 1031-1038, database is CAplus.

A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and DMSO (DMSO) for C-H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur ylide, which undergoes pyrolytic elimination of ethylene by affording halonium ions. These ions were accumulated and stabilized by DMSO through coordination by forming halogen cation pools for the halogenation reaction. This protocol was selective for electrophilic monohalogenation of arenes at room temperature; however, polyhalogenated products were formed by raising the reaction temperature Late-stage halogenation of heteroarenes and some commonly marketed drugs signifies the synthetic utility of this protocol in pharmaceutical chem. Unlike the classical methods, the in-situ generated electrophilic bromonium ion was further exploited for the direct synthesis of α-diketones from the alkenes under base-free conditions.

Advanced Synthesis & Catalysis published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Application In Synthesis of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sunagawa, Genshun published the artcileSynthesis of organic bases. VI. Synthesis of thonzylamine, HPLC of Formula: 52818-63-0, the publication is Takamine Kenkyusho Nenpo (1952), 36-9, database is CAplus.

cf. C.A. 48, 8777d. Thonzylamine (I) was prepared by the following 3 routes: (a) Heating anisaldehyde, 2-aminopyridine (Ia), and HCO₂H gave 2-(p-methoxybenzylamino)pyridine (II), m. 108-9°, which, converted to the Na salt and treated with Me₂NCH₂CH₂Cl (III), gave 96% I, b₃ 191-3°. (b) 2-Formylaminopyridine and anisaldehyde in ethylene glycol gave 73.1% II which with III gave I, (lower yield than method a). (c) Ia and III in the presence of NaNH₂ yielded 29.4% N,N-Dimethyl-N’-(2-pyrimidyl)ethylenediamine, b₃ 90-5°, which was converted to the N’-formyl compound, b₆ 121-5° (96.4% yield), and finally heated with anisaldehyde in glycol to give I.

Takamine Kenkyusho Nenpo published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C3H6O2, HPLC of Formula: 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Joshua, C. P. published the artcileOxidation of mixtures of thiocarbamides. II. Oxidation of mixtures of 1-alkyl-3-arylthiocarbamides and thiocarbamide. Formation of 3-amino-5-alkylimino-4-aryl-1,2,4-Δ2-thiadiazolines, Formula: C2H8Cl2N4S2, the publication is Indian Journal of Chemistry (1974), 12(9), 962-5, database is CAplus.

Oxidation of mixtures of 1-alkyl-3-arylthiocarbamides and thiocarbamide yielded 3-amino-5-alkylimino-4-aryl-1,2,4-Δ2-thiadiazolines. The role of 1-amidino-3-alkyl-1-arylthiocarbamide-HCl as intermediates in the oxidation was established by their isolation under mild conditions. The 1-amidino-3-alkyl-1-arylthiocarbamide salts and 3-amino-5-alkylimino-4-aryl-1-2,4-Δ2-thiadiazolines are interconvertible by oxidation-reduction Interactions between bis(N-alkyl-N’-aryl)dithioformamidine dihydrochlorides and dithioformamidine dihydrochloride also lead to 1-amidino-3-alkyl-1-arylthiocarbamide salts.

Indian Journal of Chemistry published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Joshua, C. P. published the artcileOxidation of mixtures of s-diarylthiocarbamides and thiocarbamide. Formation of 3-amino-4-aryl-5-arylimino-1,2,4Δ2-thiadiazolines, Computed Properties of 14807-75-1, the publication is Indian Journal of Chemistry (1973), 11(12), 1272-5, database is CAplus.

Oxidation of an acid alc. solution of a binary mixture of s-diphenyl-, s-di-o-tolyl- or s-di-p-tolylthiocarbamide and thiocarbamide yields the related 3-amino-4-aryl-5-(arylimino)-1,2,4-Δ2-thiadiazoline (I). A mechanism of formation is described.

Indian Journal of Chemistry published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Computed Properties of 14807-75-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem