Category: ethers-buliding-blocks

Galebach, Peter H. published the artcileProduction of Alcohols from Cellulose by Supercritical Methanol Depolymerization and Hydrodeoxygenation, Application of 2-Methoxypropan-1-ol, the publication is ACS Sustainable Chemistry & Engineering (2018), 6(3), 4330-4344, database is CAplus.

The reaction pathway and products of cellulose supercritical methanol depolymerization and hydrodeoxygenation (SCM-DHDO) were investigated. Monoalcs., diols, alc. ethers, and Me esters were produced from cellulose at 300 °C with a CuMgAl mixed metal-oxide catalyst. Time-course experiments show that cellulose is rapidly solubilized and depolymerized within 1 h with C₂-C₄ diols being intermediates. Experiments with glucose-¹³C₆ show that methanol is incorporated in all liquid products accounting for approx. 30-40% of the carbon in these products. Experiments with model compounds (dihydroxyacetone, isosorbide, and 5-hydroxymethylfurfural) indicate that the reaction pathway for cellulose occurs primarily through retro-aldol condensation of solubilized cellulose followed by recondensation with methanol. Methanol produces H₂, CO, and CO₂ through reformation with 30% of the generated H₂ being incorporated into the liquid products. Anal. of the liquid products with Fourier transform ion cyclotron resonance MS (FT-ICR MS) measured C₇-C₁₂ partially oxygenated species with 2-6 double bond equivalence which could not be detected via gas chromatog. (GC). We conclude that the reaction pathway occurs through rapid solubilization and depolymerization of cellulose followed by retro-aldol condensation to C₂-C₄ oxygenates. Retro-aldol condensation products undergo hydrodeoxygenation and extensive carbon-carbon coupling to produce C₂-C₇ alcs. or other oxygenates.

ACS Sustainable Chemistry & Engineering published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Application of 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Thakur, Khalid A. M. published the artcileProton MAS NMR analysis of phenyl silane functionalized silica nanoparticles, Synthetic Route of 1589-47-5, the publication is ACS Symposium Series (2011), 495-508, database is CAplus.

High temperature magic-angle-spinning (MAS) ¹H NMR was used to identify organic components on the surface of functionalized silica nanoparticles. The high temperature data acquisition, by preferential narrowing of resonances, enabled differentiation between species that were adsorbed or weakly bound vs. those that were covalently bound to the surface. MAS NMR of a sample as a slurry with appropriate solvent provided information similar to that obtained at higher temperatures With increasing temperature, gradual separation and up-field shift of silanol proton and water resonances at different rates was observed, possibly a result of diminished hydrogen bonding at increasingly higher temperatures

ACS Symposium Series published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C6H12O2, Synthetic Route of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Panova, Maria V. published the artcileSupramolecular stereoelectronic effect in hemiketals, Quality Control of 1589-47-5, the publication is Mendeleev Communications (2017), 27(6), 595-598, database is CAplus.

Hemiketals are important targets for crystal prediction and mol. modeling. The supramol. stereoelectronic effect (SSE) recently found in carboxylic acid associates occurs in hemiketals: the presence and nature of an H-bond acceptor affect the conformational preference of hemiketals. To provide a structural basis for the multitude of biol. roles played by hemiketal-containing structures, it is important to accurately model their spatial and dynamic properties, so the SSE in hemiketals should be explicitly implemented in future force fields.

Mendeleev Communications published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Quality Control of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yue, Zheng published the artcileSynthesis and physical properties of new fluoroether sulfones, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Journal of Fluorine Chemistry (2018), 118-123, database is CAplus.

Eight new strategically designed fluoroether sulfone solvents have been synthesized through different synthetic pathways for potential applications in lithium-sulfur battery electrolytes. The structures of these compounds have been confirmed by ¹H-NMR, ¹³C-NMR and elemental anal. Several 1,2-dimethoxyethane (DME)-based electrolyte formulations have been prepared with these solvents to derive an electrolyte with good ionic conductivity (>5 mS cm^-1 at 25 °C). The viscosity of these new additives has also been determined as it is directly related to the ionic conductivity Three of these solvents that contain a trifluoromethyl group displayed acceptable ionic conductivity

Journal of Fluorine Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C10H10CoF6P, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Jin, Xiang-xiang published the artcileA chalcone-syringaldehyde hybrid inhibits triple-negative breast cancer cell proliferation and migration by inhibiting CKAP2-mediated FAK and STAT3 phosphorylation, Computed Properties of 134-96-3, the publication is Phytomedicine (2022), 154087, database is CAplus and MEDLINE.

Although triple-neg. breast cancer (TNBC) accounts for only 15% of breast cancer cases, it is associated with a high relapse rate and poor outcome after standard treatment. Currently, the effective drugs and treatment strategies for TNBC remain limited, and thus, developing effective treatments for TNBC is pressing. Several studies have demonstrated that both chalcone and syringaldehyde have anticancer effect, but their potential anti-TNBC bioactivity are still unknown. The present study aimed to synthesize a chalcone-syringaldehyde hybrid (CSH1) and explore its potential anti-TNBC effects and the underlying mol. mechanism. Cell cytotoxicity was determined by 3-(4,5-dimethythiazol)-2,5-diphenyltetrazolium bromide (MTT). The activity of cell proliferation was measured by colony formation assay and 5-ethynyl-2′-deoxyuridine (EdU) staining assay. Cell cycle distribution and cell apoptosis were determined by fluorescence-activated cell sorter (FACS). The situation of DNA damage was observed using fluorescence microscopy. The ability of cell-matrix adhesion, migration and invasion was detected using cell adhesion assay and transwell assay. Transcriptome sequencing was performed to find out the changed genes. Levels of various signaling proteins were assessed by western blotting. CSH1 treatment triggered DNA damage and inhibited DNA replication, cell cycle arrest, and cell apoptosis via suppressing signal transducer and activator of transcription 3 (STAT3) phosphorylation. Whole genome RNA-seq anal. suggested that 4% of changed genes were correlated to DNA damage and repair, and nearly 18% of changed genes were functionally related to cell adhesion and migration. Exptl. evidence indicated that CSH1 treatment significantly affected the distribution of focal adhesion kinase (FAK) and its phosphorylation, resulting in cell-matrix-adhesion reduction and migration inhibition of TNBC cells. Further mechanistic studies indicated that CSH1 inhibited TNBC cell proliferation, adhesion, and migration by inhibiting cytoskeleton-associated protein 2 (CKAP2)-mediated FAK and STAT3 phosphorylation signaling. These results suggest that CKAP2-mediated FAK and STAT3 phosphorylation signaling is a valuable target for TNBC treatment, and these findings also reveal the potential of CSH1 as a prospective TNBC drug.

Phytomedicine published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Computed Properties of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gaucher-Wieczorek, Florence S. published the artcileFluorous Tagged N-Hydroxy Phthalimide for the Parallel Synthesis of O-Aryloxyamines, Name: (3-((2-Chlorobenzyl)oxy)phenyl)boronic acid, the publication is Journal of Combinatorial Chemistry (2010), 12(5), 655-658, database is CAplus and MEDLINE.

The parallel synthesis of O-aryloxyamines remains an unfulfilled need in the field of medicinal chem. and fragment-based approaches. To fill this gap a solution-phase two-step process based on (1) a copper-catalyzed cross-coupling of aryl boronic acids with a fluorous tagged N-hydroxyphthalimide, and (2) a supported aminolysis was designed and optimized using Taguchi’s method. A library of O-aryloxyamines was synthesized in high yields with high purity and diversity.

Journal of Combinatorial Chemistry published new progress about 845551-45-3. 845551-45-3 belongs to ethers-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (3-((2-Chlorobenzyl)oxy)phenyl)boronic acid, and the molecular formula is C13H12BClO3, Name: (3-((2-Chlorobenzyl)oxy)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Singh, Anshu published the artcileDesigned pincer ligand supported Co(II)-based catalysts for dehydrogenative activation of alcohols: Studies on N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Dalton Transactions (2021), 50(24), 8567-8587, database is CAplus and MEDLINE.

Base-metal catalysts Co1, Co2 and Co3 were synthesized from designed pincer ligands L¹, L² and L³ having NNN donor atoms, resp. Co1, Co2 and Co3 were characterized by IR, UV-visible and ESI-MS spectroscopic studies. Single crystal x-ray diffraction studies were studied to authenticate the mol. structures of Co1 and Co3. Catalysts Co1, Co2 and Co3 were used to study the dehydrogenative activation of alcs. for N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines. Under optimized reaction conditions, a broad range of substrates including alcs., anilines and ketones were exploited. Control experiments for N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines were examined to understand the reaction pathway. ESI-MS spectral studies were studied to characterize Co-alkoxide and Co-hydride intermediates. Reduction of styrene by evolved H gas during the reaction was studied to authenticate the dehydrogenative nature of the catalysts. Probable reaction pathways are proposed for N-alkylation of amines, α-alkylation of ketones and synthesis of quinolines from control experiments and detection of reaction intermediates.

Dalton Transactions published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C10H16BNO2, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bartz, Jan published the artcileOrganic sulfur compounds in the iodine-azide reaction. III. Linear and cyclic derivatives of thiourea, Category: ethers-buliding-blocks, the publication is Zeszyty Naukowe Uniwersytetu im. Adama Mickiewicza w Poznaniu, Matematyka, Fizyka, Chemia (1967), 161-7, database is CAplus.

Thiourea and many of the 34 derivatives examined had high induction coefficients due to the mesomeric character of thiourea. The differences in induction coefficients of thiourea and its mono- and di-substituted derivatives were negligible. Introduction of 3 Me groups lowered slightly the induction, and 4 Me groups reduced it by one half. NH2 or NH groups separated from each other by at least 1 C atom promoted the induction, whereas the presence of NHNH2 groups had an inhibiting effect.

Zeszyty Naukowe Uniwersytetu im. Adama Mickiewicza w Poznaniu, Matematyka, Fizyka, Chemia published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Peyronel, Giorgio published the artcileInfrared investigations on the dithioformamidinium dihalides, Name: Formamidine disulfide dihydrochloride, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (1983), 39A(7), 617-20, database is CAplus.

[((H₂N)₂CS)₂]X₂.H₂O (X = Cl, Br, I) and the anhydrous dibromide were investigated by IR spectroscopy. The νNH and δNH₂ bands were identified from the deuterated dithioformamidinium diiodide. With respect to thiourea the νNH and δNH₂ frequencies decreased and increased resp., as in other S-bonded derivatives of thiourea, and the ν_asCN₂ and νCS frequencies increased and decreased resp., in agreement with the increased CN double bond character and the formation of a C-S single bond.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Name: Formamidine disulfide dihydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Barrett, Anthony G. M. published the artcileSynthetic studies on calyculin A: a convenient asymmetric synthesis of anti-vicinal diols, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1994), 1901-5, database is CAplus.

Anti-vicinal diols, e.g. I [R = Ph, cyclohexyl, (CH₂)₅Me] and II, have been prepared with excellent relative and absolute stereocontrol via the reaction of aldehydes with B-{3-[(diisopropylamino)dimethylsilyl]allyl}diisopinocampheylborane in THF and Et₂O and work-up using potassium fluoride, potassium hydrogen carbonate and hydrogen peroxide in aqueous methanol. Absolute stereoselectivities of reactions were determined by conversion of four product diols into bis[(R)-α-methoxy-α-(trifluoromethyl)phenylacetate] esters. The reactions are relevant to the synthesis of the marine phosphatase inhibitor calyculin A.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem