Category: ethers-buliding-blocks

Son, Jung Beom published the artcileEnantioselective total synthesis of (-)-clavosolide A and B, Category: ethers-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2010), 31(3), 653-663, database is CAplus.

Enantioselective total synthesis of proposed and revised structure of (-)-clavosolide A and B by a convergent approach, where syn-selective aldol, hydroxy-directed cyclopropanation, Mitsunobu inversion, Schmidt-type glycosylation, and macrolactonization reactions were utilized as key reactions. The relative and absolute stereochem. of the natural products were confirmed unambiguously by comparing the optical rotation values and ¹H and ¹³C NMR spectra of them.

Bulletin of the Korean Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C9H5ClO2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Pengfei published the artcileSynthesis of the Potent Immunostimulatory Adjuvant QS-21A, Formula: C21H37BO, the publication is Journal of the American Chemical Society (2005), 127(10), 3256-3257, database is CAplus and MEDLINE.

QS-21A is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy, given its exceedingly high level of potency and its favorable toxicity profile. Melanoma, breast cancer, small cell lung cancer, prostate cancer, HIV-1, and malaria are among the numerous maladies targeted in more than 80 recent and ongoing clin. trials involving QS-21A as a critical component for immune response augmentation in microgram doses. Herein is reported the first synthesis and structure verification of QS-21A_api, applying novel glycosylation methodologies in the convergent modular construction of this rare and potent natural product immunostimulant (no biol. data).

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C15H21BO3, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tomioka, Hideo published the artcileButtressing effect in carbene chemistry. Effect of 3-alkyl groups on the reactions of 2-alkoxydiphenylcarbenes, Related Products of ethers-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1991), 471-7, database is CAplus.

Irradiation of 3,2-R(MeO)C₆H₃CPh:N₂ (I; R = H) in Et₂O at 10° gave 3-phenyldihydrofuran (II; R = H) and a small amount of 3,2-R(MeO)C₆H₃CHPhR¹ [III; R¹ = H, R = EtOCHMe (IV)]; IV was the major product when the irradiation was carried out in an Et₂O matrix at -196°. With I (R = alkyl) the reaction patterns were dramatically changed. Only II (R = alkyl) were formed in Et₂O at +10 or -196°. This was due to the buttressing effect of R, which prevents the 2-MeO group from lying in the plane of the Ph ring in the precursor mols. and assists the MeO group in rotating around the C-O bond toward the carbene center after elimination of N. The effect of buttressing on the generation of carbene in MeOH is also discussed.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C8H7ClO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Golovnev, N. N. published the artcileSynthesis and properties of compounds of formamidindium disulfide with d-element tetrahalide anions, COA of Formula: C2H8Cl2N4S2, the publication is Russian Journal of Inorganic Chemistry (2013), 58(6), 701-705, database is CAplus.

Products of reactions of salts of d elements with formamidine disulfide dihydrochloride (FDSH₂Cl₂) in concentrated HCl and HBr solutions were synthesized and characterized. The following compounds were obtained: FDSH₂[CuCl₄]·H₂O, FDSH₂[CoCl₄], FDSH₂[ZnCl₄], FDSH₂[HgCl₄], and FDSH₂[HgBr₄]. The identity of these compounds was confirmed by x-ray diffraction; their compositions were derived from the results of chem. anal. and thermal anal. The IR and Raman scattering spectra of the compounds indicate the presence therein of FDSH cation. FDSH transforms into formamidindium trisulfide cation (NH₂)₂C-S-S-S-C(NH₂) upon storage in air in HCl solution

Russian Journal of Inorganic Chemistry published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, COA of Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bano, Kulsum published the artcileFacile Synthesis of Benzimidazole and Benzothiazole Compounds Mediated by a Zinc Precatalyst Supported by an Iminopyrrole-Morpholine Ligand, Application In Synthesis of 6850-57-3, the publication is European Journal of Inorganic Chemistry (2022), 2022(10), e202200023, database is CAplus.

Three zinc complexes, with the general formula {κ2-C₄H₃NH[2-CH=NCH₂CH₂N(CH₂CH₂)₂O]ZnX₂} [X = Cl, Br, I], supported by a neutral iminopyrrole-morpholine ligand, were synthesized by the reaction between {C₄H₃NH-2-[CH=NCH₂CH₂N (CH₂CH₂)₂O]} and anhydrous zinc dihalides (ZnCl₂, ZnBr₂, ZnI₂) at ambient temperature in dry methanol. The zinc complexes were fully characterized using multinuclear NMR spectroscopic techniques and the mol. structures of complexes in their solid states were determined by single-crystal X-ray diffraction anal. The zinc diiodo complex proved to be a competent precatalyst in the formation of a wide range of benzimidazole and benzothiazole compounds, via aerobic oxidative condensation of several benzylamines with o-phenylenediamine, N-phenyl-o-phenylene-diamine, and o-mercaptoaniline. The benzimidazole and benzothiazole derivatives were successfully characterized using ¹H and ¹³C{1H} NMR spectroscopy.

European Journal of Inorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Saprykin, L. V. published the artcileEvolution of volatile substances during thermal degradation of rice hull organic components. 1. Thermolysis with inorganic catalytic additives, Formula: C10H14O, the publication is Koksnes Kimija (1990), 8-14, database is CAplus.

A comparison of the catalytic effect of NaCl, KCl, CaCl₂, MgCl₂, CsBr, and LiCl on thermolysis of rice hulls for Si showed that LiCl exerted the strongest effect. LiCl significantly changed the composition of the thermolysis products by promoting cleavage of C-C and ether bonds. NH₄Cl catalyzed low-temperature dehydration and secondary resinification reactions of the thermolysis products. Significant amounts of SiO₂ contained in the rice hull and in its hydrolytic lignin leveled the catalytic effect of LiCl. The thermolysis products included 2-methyldioxolane, mesityl oxide, 2-isopropylanisole, PhOH, guaiacol, 2-ethylphenol, veratrole, furfural, formal, coumaran, ethylpyrocatechol, and Me₂CO.

Koksnes Kimija published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Reinisch, Jens published the artcilePredicting Flash Points of Pure Compounds and Mixtures with COSMO-RS, Related Products of ethers-buliding-blocks, the publication is Industrial & Engineering Chemistry Research (2015), 54(51), 12974-12980, database is CAplus.

Flash point (FP) is an important parameter to assess chem. compound safety. Many empirical approaches have been developed to predict FP based on mol. structure, sometimes involving a large number of descriptors and resulting in class-specific equations. This work demonstrated that a satisfying, rather general prediction of saturation pressure at the FP can be achieved using only mol. surface area. This relation in conjunction with any exptl. or computational method to calculate temperature-dependent vapor pressures allows for the FP predictions. In a second step, chem. mixture FP were calculated using COSMO-RS activity coefficients Using the proposed method, FP were calculated without needing data typically generated in experiments (normal b.p., combustion enthalpy), although exptl. pure-compound FP and vapor pressure data can still be used to increase prediction quality.

Industrial & Engineering Chemistry Research published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Woods, Thomas S. published the artcileCleavage of sulfur-sulfur bonds with sodium hydrogen selenide, Computed Properties of 14807-75-1, the publication is Journal of Organic Chemistry (1974), 39(25), 3716-20, database is CAplus.

Sodium hydrogen selenide is shown to be an effective reagent for reduction of alkyl, aryl, aralkyl, and functionally substituted disulfides to thiols under mild conditions in protic solvents. Two-electron transfer from the hydrogen selenide anion, which promotes the cleavage of the S-S bond with concomitant production of elemental selenium, is found to occur only in a narrow pH range. Organic thiosulfates (Bunte salts) also give thiols through the intermediacy of the corresponding disulfide on reaction with sodium hydrogen selenide.

Journal of Organic Chemistry published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C4H6BrN3, Computed Properties of 14807-75-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Oster, Alexander published the artcileBicyclic Substituted Hydroxyphenylmethanone Type Inhibitors of 17 β-Hydroxysteroid Dehydrogenase Type 1 (17 β-HSD1): The Role of the Bicyclic Moiety, Related Products of ethers-buliding-blocks, the publication is ChemMedChem (2011), 6(3), 476-487, database is CAplus and MEDLINE.

An attractive target that has still to be explored for the treatment of estrogen-dependent diseases, such as breast cancer and endometriosis, is the enzyme responsible for the last step in the biosynthesis of estradiol (E2): 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1). It catalyzes the reduction of the weakly active estrone (E1) into E2, which is the most potent estrogen in humans. Inhibition of 17β-HSD1 lowers intracellular E2 concentrations and thus presents a therapeutic target for estrogen-dependent pathologies. Recently, we reported a new class of highly active and selective 17β-HSD1 inhibitors: bicyclic substituted hydroxyphenylmethanones. Here, further structural variations on the bicyclic moiety are described, especially focusing on the exchange of its hydroxy function. Twenty-nine novel inhibitors were synthesized and evaluated for 17β-HSD1 inhibition in a cell-free and cellular assay, for selectivity toward 17βHSD2 and estrogen receptors (ER) alpha and beta, as well as for metabolic stability. The best compound (I) exhibited IC₅₀ values of 12 nM (cell-free assay) and 78 nM (cellular assay), high selectivity for 17β-HSD1, and reasonable metabolic stability. A mol. docking study provided insight into the protein-ligand interactions of this compound with 17β-HSD1.

ChemMedChem published new progress about 845551-45-3. 845551-45-3 belongs to ethers-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (3-((2-Chlorobenzyl)oxy)phenyl)boronic acid, and the molecular formula is C13H12BClO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Elstner, R. published the artcileStudies on the effect of inhibitors in ammonia etching solutions on the depth and pattern in copper etching, Category: ethers-buliding-blocks, the publication is Metalloberflaeche (1982), 36(10), 468-78, database is CAplus.

The effects of inhibitors on the etching of Cu for printed circuits by ammoniacal solutions of Na chlorite and CuCl₂ were studied. The etch rates and elec. conductivity of the different solutions are given. The effects of Cu(I) ions are discussed. The optimum etching conditions are described.

Metalloberflaeche published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem