Category: ethers-buliding-blocks

Reddy, P. Srinivasa published the artcileReductive amination of carbonyl compounds using NaBH₄ in a Bronsted acidic ionic liquid, COA of Formula: C13H14N2O, the publication is Tetrahedron Letters (2007), 48(50), 8807-8810, database is CAplus.

Reductive amination of carbonyl compounds using sodium borohydride is conducted in the Bronsted acidic ionic liquid, 1-methylimidazolium tetrafluoroborate ([HMIm][BF₄]). The ionic liquid plays the dual role of solvent as well as catalyst for efficient conversion of aldehydes and ketones to amines in excellent yields without the formation of side products.

Tetrahedron Letters published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, COA of Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kasama, Kengo published the artcileChemo- and regioselective cross-dehydrogenative coupling reaction of 3-hydroxycarbazoles with arenols catalyzed by a mesoporous silica-supported oxovanadium, Category: ethers-buliding-blocks, the publication is RSC Advances (2021), 11(56), 35342-35350, database is CAplus and MEDLINE.

Cross-dehydrogenative coupling between 3-hydroxycarbazoles I(R = H; R¹ = H, Br, Me; RR¹ = -CH:CH-CH:CH-; R² = H, Me, Ph, benzyl, acetyl, tolyl) and 2-naphthols II (R³ = 6-MeO, 7-Br, 3-Me, etc.) has been achieved by using a mesoporous silica-supported oxovanadium catalyst.

RSC Advances published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Budeev, Anton published the artcileUgi reaction-derived 1H-pyrrol-2(5H)-ones proved as valid precursors to a new class of heterocyclic α-diazocarbonyl compounds, Synthetic Route of 6850-57-3, the publication is Tetrahedron Letters (2022), 153598, database is CAplus.

1H-Pyrrol-2(5H)-ones synthesized via a modified literature procedure from primary amines, 3-substituted propiolic acids, isocyanides and glyoxal underwent a facile Regitz diazo transfer to give novel heterocyclic α-diazocarbonyl compounds – polysubstituted diazo pyrrol-2-ones I [R¹ = Me, n-Pr, Ph, etc.; R² = n-Bu, Bn, 3-FC₆H₄CH₂, etc.; R³ = t-Bu, cyclohexyl] .

Tetrahedron Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, C. Y. published the artcileA New Benzenoid from Liriodendron chinense, Formula: C9H10O4, the publication is Chemistry of Natural Compounds (2022), 58(3), 387-389, database is CAplus.

A new benzenoid, liriodenchic acid (1), along with nine known compounds that include two aporphine alkaloids, liriodenine (2) and (-)-anonaine (3); two lignans, (+)-syringaresinol (4) and (+)-yangambin (5); and five benzenoids, p-hydroxybenzoic acid (6), vanillic acid (7), vanillin (8), syringic acid (9), and syringaldehyde (10), were isolated from the leaves of Liriodendron chinense (Magnoliaceae). These compounds were characterized and identified by phys. and spectral evidences.

Chemistry of Natural Compounds published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Timofeeva, Maria N. published the artcileSynthetic and natural materials with the brucite-like layers as high active catalyst for synthesis of 1-methoxy-2-propanol from methanol and propylene oxide, Quality Control of 1589-47-5, the publication is Journal of Molecular Catalysis A: Chemical (2016), 22-30, database is CAplus.

The aim of this study was to investigate the correlation between the basic and catalytic properties of brucite and Mg,Al-layered double hydroxides (Mg,Al-LDHs) in the reaction of propylene oxide with methanol. The basic properties of the solids were investigated by FT-IR spectroscopy using CDCl₃ as probe mol. and Hammett acidity titration with n-butylamine and benzoic acid. Both the increase in the activation temperature and the decrease in Al content favored the increase in the basicity of Mg,Al-LDH. The nature of “Mⁿ⁺-O^2- Lewis acid-ba se” pairs was a key factor to control the catalytic behavior of the solids. The length of the M-O bond, the basicity of the oxygen ion and the strength of the metal ion on the surface affected the catalytic activity of the solids and their isomer selectivity in the reaction between methanol and propylene oxide to form 1-methoxy-2-propanol. It was demonstrated that brucite(150) can be applied as catalyst for at least four successive cycles without loss of activity.

Journal of Molecular Catalysis A: Chemical published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H6O3, Quality Control of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yigit, Murat published the artcileRuthenium(II)-NHC-catalyzed (NHC = perhydrobenzimidazol-2-ylidene) alkylation of amines using the hydrogen borrowing methodology under solvent-free conditions, Formula: C13H14N2O, the publication is Transition Metal Chemistry (Dordrecht, Netherlands) (2019), 44(6), 565-573, database is CAplus.

New ruthenium(II) complexes with N-heterocyclic carbene ligand were synthesized by transmetalation reactions between silver(I) N-heterocyclic carbene complexes and [RuCl₂(p-cymene)]₂. The complexes were characterized by physicochem. and spectroscopic methods. These ruthenium complexes were applied to the N-monoalkylation of aromatic amines with a wide range of primary alcs. under solvent-free conditions using the hydrogen borrowing strategy. The catalytic reactions using all ruthenium complexes resulted in N-monoalkylated products with high selectivities using furfuryl alc. as the alkylating agent.

Transition Metal Chemistry (Dordrecht, Netherlands) published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C40H35N7O8, Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Karimi Askarani, Hajar published the artcileOne-pot synthesis of polyhydroquinoline derivatives using nano-Fe₃O₄@dextrin/BF₃ as a magnetic biodegradable catalyst, Formula: C9H10O4, the publication is Journal of the Iranian Chemical Society (2022), 19(7), 3189-3203, database is CAplus.

In this study, the magnetized nano-dextrin-supported boron trifluoride (nano-Fe₃O₄@dextrin/BF₃) as a green biopolymer-based catalyst is synthesized in two steps. In the first step, nano-dextrin is magnetized (nano-Fe₃O₄@dextrin), and in the second step, the BF₃ is supported to the obtained nano-Fe₃O₄@dextrin. The structure of nano-Fe₃O₄@dextrin/BF₃ is characterized by different techniques, including Fourier transform IR (FT-IR) spectroscopy, X-ray diffraction (XRD) pattern, energy dispersive X-ray (EDX) anal., SEM (SEM) imaging, mapping, vibrating sample magnetometer (VSM), and thermogravimetric anal. (TGA/DTG). The catalytic efficiency was also investigated in the synthesis of biol. active polyhydroquinoline derivatives via Hantzsch condensation reaction of aromatic aldehydes, dimedone, Et acetoacetate, and ammonium acetate under solvent-free conditions. The structure of products was confirmed by their m.ps. (MP), FT-IR, and ¹H and ¹³C NMR (NMR) spectroscopy. This procedure enjoys advantages such as short reaction time, clean and fast work-up, and easy separation of the catalyst by an external magnet.

Journal of the Iranian Chemical Society published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Aleyasin, Hossein published the artcileAntihelminthic Benzimidazoles Are Novel HIF Activators That Prevent Oxidative Neuronal Death via Binding to Tubulin, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Antioxidants & Redox Signaling (2015), 22(2), 121-134, database is CAplus and MEDLINE.

Aims: Pharmacol. activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurol. conditions, including stroke, Huntington’s disease, and Parkinson’s disease. We screened a drug library with known safety in humans using a hippocampal neuroblast line expressing a reporter of hypoxia-inducible factor (HIF)-dependent transcription. Results: Our screen identified more than 40 compounds with the ability to induce hypoxia response element-driven luciferase activity as well or better than deferoxamine, a canonical activator of hypoxic adaptation. Among the chem. entities identified, the antihelminthic benzimidazoles represented one pharmacophore that appeared multiple times in our screen. Secondary assays confirmed that antihelminthics stabilized the transcriptional activator HIF-1α and induced expression of a known HIF target gene, p21^cip1/waf1, in post-mitotic cortical neurons. The on-target effect of these agents in stimulating hypoxic signaling was binding to free tubulin. Moreover, antihelminthic benzimidazoles also abrogated oxidative stress-induced death in vitro, and this on-target effect also involves binding to free tubulin. Innovation and Conclusions: These studies demonstrate that tubulin-binding drugs can activate a component of the hypoxic adaptive response, specifically the stabilization of HIF-1α and its downstream targets. Tubulin-binding drugs, including antihelminthic benzimidazoles, also abrogate oxidative neuronal death in primary neurons. Given their safety in humans and known ability to penetrate into the central nervous system, antihelminthic benzimidazoles may be considered viable candidates for treating diseases associated with oxidative neuronal death, including stroke. Antioxid. Redox Signal. 22, 121-134.

Antioxidants & Redox Signaling published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hirose, Tomoyasu published the artcileSolution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag, Product Details of C25H23NO4, the publication is Tetrahedron (2011), 67(35), 6633-6643, database is CAplus.

A solution-phase total synthesis of argifin using 3,4,5-tris(octadecyloxy)benzyl tag as a hydrophobic protective group of carboxylic acid was developed to produce 44% overall yield for 16 linear steps. Argifin, a novel class of natural product chitinase inhibitor, is a highly water-soluble cyclic pentapeptide, so hitherto, only solid-phase synthesis techniques have been used to conveniently prepare the compound and its derivatives 3,4,5-Tris(octadecyloxy)benzyl alc. (HO-TAGa) and its esters are highly crystalline materials and highly capable of dissolving in less-polar solvents such as dichloromethane, benzene, THF, etc., but insoluble in polar solvents such as methanol and DMSO. The combination of HO-TAGa and Fmoc-based peptide synthesis, together with simple purification by recrystallization from MeOH solution, furnished an efficient and practical route of argifin production in the liquid-phase.

Tetrahedron published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Product Details of C25H23NO4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Thoma, K. published the artcileColloid association and bioavailability of local anesthetics. Part 6. Mixed micelle formation with polysorbates, Product Details of C17H28ClNO3, the publication is Pharmaceutica Acta Helvetiae (1988), 63(4-5), 102-10, database is CAplus and MEDLINE.

For 19 surface-active local anesthetics, the binding to polyethylene glycol sorbitan fatty acid esters (I) by formation of mixed micelles was determined All surface-active local anesthetics investigated, except procaine-HCl and lidocaine-HCl, form mixed micelles with I. In the presence of 5% I in water, this binding fluctuates between 5.3% for butacaine sulfate and 75% for cyclomethycaine-sulfate. For all local anesthetics the quotient of the total concentration and the free moiety is proportional to the surfactant concentration The surfactant bound moiety of the local anesthetic is constant when it is below its critical micellar concentration (CMC). Above the CMC, deviations from this rule are observed The binding of tetracaine-HCl to I by mixed micelles formation demonstrates that the binding to these surfactants increases with the shortened fatty acid chain (that means an increasing HLB-value). When the pH-value or ionic strength increases, stadacain-HCl exhibits a distinct increase of the binding by a change of the dissociation-rate or a salting-out effect. Changing the solvent of stadacain-HCl from water to saline, for example, increases the binding to 5% I from 38.1 to 68%.

Pharmaceutica Acta Helvetiae published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C19H14N2, Product Details of C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem