Tag: 100-200

On February 29, 2020, Song, Song; Li, Xinyao; Wei, Jialiang; Wang, Weijin; Zhang, Yiqun; Ai, Lingsheng; Zhu, Yuchao; Shi, Xiaomeng; Zhang, Xiaohui; Jiao, Ning published an article.Application of 578-58-5 The title of the article was DMSO-catalysed late-stage chlorination of (hetero)arenes. And the article contained the following:

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Application of 578-58-5

The Article related to arene heteroarene chlorination dimethyl sulfoxide catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Application of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 29, 2020, Song, Song; Li, Xinyao; Wei, Jialiang; Wang, Weijin; Zhang, Yiqun; Ai, Lingsheng; Zhu, Yuchao; Shi, Xiaomeng; Zhang, Xiaohui; Jiao, Ning published an article.Safety of 2-Methoxynaphthalene The title of the article was DMSO-catalysed late-stage chlorination of (hetero)arenes. And the article contained the following:

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Safety of 2-Methoxynaphthalene

The Article related to arene heteroarene chlorination dimethyl sulfoxide catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 26, 2022, Yang, Tao; Li, Xiaoqian; Deng, Shuang; Qi, Xiaotian; Cong, Hengjiang; Cheng, Hong-Gang; Shi, Liangwei; Zhou, Qianghui; Zhuang, Lin published an article.Electric Literature of 578-58-5 The title of the article was From N-H Nitration to Controllable Aromatic Mononitration and Dinitration-The Discovery of a Versatile and Powerful N-Nitropyrazole Nitrating Reagent. And the article contained the following:

Herein,the identification of a powerful nitrating reagent, 5-methyl-1,3-dinitro-1H-pyrazole, from the N-nitro-type reagent library constructed using a practical N-H nitration method was reported. This nitrating reagent behaved as a controllable source of the nitronium ion, enabling mild and scalable nitration of a broad range of (hetero)arenes with good functional group tolerance. Of note, this nitration method was controlled by manipulating the reaction conditions to furnish mononitrated or dinitrated product selectively. The value of this method in medicinal chem. was well established by its efficient late-stage C-H nitration of complex biorelevant mols. D. functional theory (DFT) calculations and preliminary mechanistic studies reveal that the powerfulness and versatility of this nitrating reagent were due to the synergistic “nitro effect” and “methyl effect”. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Electric Literature of 578-58-5

The Article related to arene nitropyrazole nitration, nitroarene preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhao, Meng; Li, Changjun; Shan, Xiaotao; Han, Huijing; Zhao, Qiuhua; Xie, Meiran; Chen, Jianzhuang; Liao, Xiaojuan published an article in 2021, the title of the article was A stretchable pillararene-containing supramolecular polymeric material with self-healing property.Application of 150-78-7 And the article contains the following content:

Constructing polymeric materials with stretchable and self-healing properties arise increasing interest in the field of tissue engineering, wearable electronics and soft actuators. Herein, a new type of supramol. crosslinker was constructed through host-guest interaction between pillar[5]arene functionalized acrylate and pyridinium functionalized acrylate, which could form supramol. polymeric material via photo-polymerization of Bu acrylate (BA). Such material exhibited excellent tensile properties, with maximum tensile strength of 3.4 MPa and strain of 3000%, resp. Moreover, this material can effectively dissipate energy with the energy absorption efficiency of 93%, which could be applied in the field of energy absorbing materials. In addition, the material showed self-healing property after cut and responded to competitive guest. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Application of 150-78-7

The Article related to stretchable pillararene supramol polymeric material self healing property, host-guest chemistry, pillararene, supramolecular chemistry, supramolecular polymer, Placeholder for records without volume info and other aspects.Application of 150-78-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gui, Jingjing; Cai, Xin; Chen, Lingyun; Zhou, Yuxin; Zhu, Wenjing; Jiang, Yuanrui; Hu, Min; Chen, Xiaobei; Hu, Yanwei; Zhang, Shilei published an article in 2021, the title of the article was Facile and practical hydrodehalogenations of organic halides enabled by calcium hydride and palladium chloride.Safety of 2-Methoxynaphthalene And the article contains the following content:

Herein, a convenient hydrodehalogenation method was described by employing less-explored calcium hydride as the reductant. A wide range of organic halides such as aromatic bromides RBr (R = 4-(dimethylamino)phenyl, 4-aminonaphthalen-1-yl, quinolin-5-yl, etc.), aromatic chlorides R1Cl (R1 = naphthalen-1-yl, 3-carboxy-5-methoxyphenyl, 2-[2-(cyclohexa-1,5-dien-1-yl)ethenyl]phenyl, etc.), aromatic triflates R2Otf (R2 = 2-methylquinolin-8-yl, 2-nitrophenyl, 2-acetylnaphthalen-1-yl, etc.), 1-(2-(4-bromo/chlorobutoxy)phenyl)ethan-1-one were efficiently and selectively reduced to obtain the corresponding hydrocarbons e.g., Phenyl(pyrrolidin-1-yl)methanone. More importantly, monodehalogenation of trihalomethyl compounds R3CXY2 (R3 = benzenesulfonyl, 3-oxo-1-phenyl-3-(thiophen-3-yl)propyl, N-(naphthalen-1-yl)carbamoyl, etc.; X = Br, Cl; Y = Br, Cl, F) in THF could provide various useful dihalomethyl products R3CHY2. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Safety of 2-Methoxynaphthalene

The Article related to hydrocarbon preparation, aromatic halide hydrodehalogenation calcium hydride palladium chloride catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 20, 2022, Liu, Bin; Wang, Guanyu; Xu, Zhenhao; Wang, Menglin; Nie, Yangleiyu; Luo, Zhibin published an article.Reference of 2-Methoxynaphthalene The title of the article was Ionic liquid/boronic acid system enabled deuteration with D2O. And the article contained the following:

The development of transition-metal free systems for multi-sites deuteration is important for the preparation of deuterium-labeled drugs and intermediates e.g, d-agomelatine. The ionic liquid [bmim]PF6, which was able to promote highly efficient deuterodeborylation of boronic acids RB(OH)2 [R = thianthren-1-yl, 1-benzothiophen-2-yl, 4-formyl-2-methoxyphenyl, etc.] with D2O was reported. The ionic liquid/boronic acid system was successfully applied to the selective H/D exchange at various sp2/sp3 C-H positions. Moreover, unusual nucleophilic behaviors of nitrogen-containing heteroaromatics in ionic liquid were observed The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Reference of 2-Methoxynaphthalene

The Article related to deuterium compound preparation, boronic acid deuterium oxide deuterodeborylation ionic liquid catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 19, 2018, Tang, Ren-Jin; Milcent, Thierry; Crousse, Benoit published an article.Quality Control of 1-Fluoro-2-methoxybenzene The title of the article was Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol. And the article contained the following:

Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcs. is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Addnl., the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Quality Control of 1-Fluoro-2-methoxybenzene

The Article related to haloarene haloheterocycle regioselective preparation, arene heterocycle regioselective halogenation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 22, 1994, Garret, Claude; Montier, Francois published a patent.HPLC of Formula: 81616-80-0 The title of the patent was Pharmaceutical compositions containing synergistic Nk1 and NK2 receptor antagonists. And the patent contained the following:

Pharmaceutical compositions containing synergistic Nk1 and NK2 receptor antagonists are used for the treatment of diseases caused by substance P and/or neurokinine A. I.v. injection of [imino-1-(methoxy-2-phenyl)-2-ethyl]-2-diphenyl-7,7-perhydroisoindolone-4-(3aR,7aR) (preparation given) and N-methyl[(phenyl-4-acetamido-4-piperidinyl)-4-(dichloro-3,4-phenyl)-2-butyl]benzamide (I) at 0.5mg/kg did not inhibit the capsaicin-induced bladder contractions in rats, while the combination of both decreased the contractions by 74%. A tablet contained [diphenyl-7,7-(methoxy-2-phenyl)-2-propionyl-(S)]-2-perhydroisoindolol-4-(3aS,4S, 7aS) 12.5, I 12.5, starch 83, silica 30, and Mg stearate 3 mg. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).HPLC of Formula: 81616-80-0

The Article related to pharmaceutical synergism nk1 nk2 receptor antagonist, tablet synergism nk1 nk2 receptor antagonist, Pharmaceuticals: Formulation and Compounding and other aspects.HPLC of Formula: 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 1, 2020, Van Velthoven, Niels; Henrion, Mickael; Dallenes, Jesse; Krajnc, Andraz; Bugaev, Aram L.; Liu, Pei; Bals, Sara; Soldatov, Alexander V.; Mali, Gregor; De Vos, Dirk E. published an article.Safety of 1,2-Dimethoxybenzene The title of the article was S,O-Functionalized Metal-Organic Frameworks as Heterogeneous Single-Site Catalysts for the Oxidative Alkenylation of Arenes via C-H activation. And the article contained the following:

Heterogeneous single-site catalysts can combine the precise active site design of organometallic complexes with the efficient recovery of solid catalysts. Based on recent progress on homogeneous thioether ligands for Pd-catalyzed C-H activation reactions, a scalable metal-organic framework-based heterogeneous single-site catalyst containing S,O-moieties that increase the catalytic activity of Pd(II) for the oxidative alkenylation of arenes has been developed. The structure of the Pd@MOF-808-L1 catalyst was characterized in detail via solid-state NMR spectroscopy, N2 physisorption, and high-angle annular dark field scanning transmission electron microscopy, and the structure of the isolated palladium active sites could be identified by X-ray absorption spectroscopy. A turnover frequency (TOF) of 8.4 h-1 was reached after 1 h of reaction time, which was 3 times higher than the TOF of standard Pd(OAc)2, ranking Pd@MOF-808-L1 among the most active heterogeneous catalysts ever reported for the nondirected oxidative alkenylation of arenes. Finally, the single-site catalyst promotes the oxidative alkenylation of a broad range of electron-rich arenes, and the applicability of this heterogeneous system was demonstrated by the gram-scale synthesis of industrially relevant products has been reported. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Safety of 1,2-Dimethoxybenzene

The Article related to arene oxidative alkenylation metal organic framework catalyst regioselective stereoselective, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 1,2-Dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 13, 2020, Yurino, Taiga; Hachiya, Asuka; Suzuki, Keisuke; Ohkuma, Takeshi published an article.Category: ethers-buliding-blocks The title of the article was Selective Conversion of Benzylic Phosphates into Diarylmethanes Through Al(OTf)3-Catalyzed Friedel-Crafts-Type Benzylation. And the article contained the following:

Al(OTf)3 was identified as a high-performance catalyst for Friedel-Crafts-type benzylation using benzylic phosphates as electrophiles. The reaction proceeded even with 0.2 mol-% of the catalyst. A series of diarylmethanes (21 examples) was obtained in moderate to high yield. The catalyst showed unique chemoselectivity, preferentially converting the benzylic phosphate motif, even with a benzylic acetate group existed in the same mol. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Category: ethers-buliding-blocks

The Article related to diarylmethane preparation benzylic phosphate aluminum catalyst friedel crafts benzylation, General Organic Chemistry: Synthetic Methods and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem