Tag: 100-200

On October 1, 2020, Blanco, E.; Sepulveda, C.; Cruces, K.; Garcia-Fierro, J. L.; Ghampson, I. T.; Escalona, N. published an article.Product Details of 578-58-5 The title of the article was Conversion of guaiacol over metal carbides supported on activated carbon catalysts. And the article contained the following:

The preparation and use of new supported transition metal carbides as catalyst for the conversion of guaiacol was studied. Several metals (Mo, Re, Ru, Ni, Fe, and Cu) were impregnated over activated C and carburized under a mixture of H2/C2H4 at 700°. Catalysts were characterized by XRD, N2 physisorption, XPS, CO chemisorption, and TPR-MS. Evidence for carbide formation was obtained in the case of Mo, Re, Ni and Ru, based primarily on CO formation during the TPR-MS anal. Carbides were mainly active for primary guaiacol conversion to phenol and catechol through demethoxylation and demethylation. Completely deoxygenated products such as benzene and cyclohexane were also formed. The highest selectivity in benzene was obtained for the Re-TPR catalyst while Ni-TPR was the most hydrogenative one. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Product Details of 578-58-5

The Article related to guaiacol conversion transition metal carbide supported activated carbon catalyst, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalytic Reactions and other aspects.Product Details of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adilina, Indri Badria; Widjaya, Robert Ronal; Hidayati, Luthfiana Nurul; Supriadi, Edi; Safaat, Muhammad; Oemry, Ferensa; Restiawaty, Elvi; Bindar, Yazid; Parker, Stewart F. published an article in 2021, the title of the article was Understanding the Surface Characteristics of Biochar and Its Catalytic Activity for the Hydrodeoxygenation of Guaiacol.Formula: C8H10O2 And the article contains the following content:

Biochar (BCR) was obtained from the pyrolysis of a palm-oil-empty fruit bunch at 773 K for 2 h and used as a catalyst for the hydrodeoxygenation (HDO) of guaiacol (GUA) as a bio-oil model compound Brunauer-Emmet-Teller surface area anal., NH3 and CO2-temperature-programmed desorption, scanning electron microscope-dispersive X-ray spectroscopy, CHN anal. and X-ray fluorescence spectroscopy suggested that macroporous and mesoporous structures were formed in BCR with a co-presence of hydrophilic and hydrophobic sites and acid-base behavior. A combination of IR, Raman and inelastic neutron scattering (INS) was carried out to achieve a complete vibrational assignment of BCR. The CH-OH ratio in BCR is ∼5, showing that the hydroxyl functional groups are a minority species. There was no evidence for any aromatic C-H stretch modes in the IR, but they are clearly seen in the INS and are the majority species, with a ratio of sp3-CH:sp2-CH of 1:1.3. The hydrogen bound to sp2-C is largely present as isolated C-H bonds, rather than adjacent C-H bonds. The Raman spectrum shows the characteristic G band (ideal graphitic lattice) and three D bands (disordered graphitic lattice, amorphous carbon, and defective graphitic lattice) of sp2 carbons. Adsorbed water in BCR is present as disordered layers on the surface rather than trapped in voids in the material and could be removed easily by drying prior to catalysis. Catalytic testing demonstrated that BCR was able to catalyze the HDO of GUA, yielding phenol and cresols as the major products. Phenol was produced both from the direct demethoxylation of GUA, as well as through the demethylation pathway via the formation of catechol as the intermediate followed by deoxygenation. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Formula: C8H10O2

The Article related to biochar hydrodeoxygenation catalyst guaiacol phenol cresol, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalytic Reactions and other aspects.Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 9, 1995, Achard, Daniel; Grisoni, Serge; James-Surcouf, Evelyne; Malleron, Jean-Iuc; Morgat, Anne; Peyronel, Jean-Francois; Sabuco, Jean-Francois; Tabart, Michel published a patent.Related Products of 81616-80-0 The title of the patent was Preparation of N-acyl-4-hydroxyperhydroisoindoles as substance P antagonists. And the patent contained the following:

Title compounds [I; 1 of R = H, OH, (hydroxy)alkyl and the other = H, (hydroxy)alkyl, Ph; R1 = Ph, alkyl, alkoxy, etc.; R2 = H, halo, OH, alkyl,alkoxy, etc.; R3 = (un)substituted Ph; R4 = OH; R4 = F when R5,R15 = H or alkyl; 1 of R5,R15 = H, OH, alkyl and the other = H or alkyl; R4R5 = bond; R6 = H, OH, (hydroxy)alkyl] were prepared Thus, 5-methylcyclohex-2-en-1-one was cyclocondensed with PhCH2N(CH2OBu)CH2SiMe3 and the product condensed with BuLi-treated PhOMe to give, after deprotection and N-acylation by (S)-2-(MeO)C6H4CHMeCO2H, title compound (3aR*,4R*,6S*,7aS*)-II which had ED50 of 0.07mg/kg i.v. for inhibition of substance P-induced capillary permeability in monkeys. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Related Products of 81616-80-0

The Article related to acylhydroxyperhydroisoindole preparation substance p antagonist, isoindole acylhydroxyperhydro preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 28, 1993, Achard, Daniel; Grisoni, Serge; Malleron, Jean Luc; Peyronel, Jean-francois; Tabart, Michel published a patent.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the patent was Perhydroisoindole derivatives as substance P antagonists and their preparation. And the patent contained the following:

Title compounds I [R = Ph optionally substituted with halogen or Me in position 2 or 3; R1 = (un)substituted Ph, cyclohexadienyl, naphthyl, indenyl, heterocyclyl; R2 = H, halo, OH, alkyl, aminoalkyl, CO2H, amino, etc.; R3 = Ph optionally substituted in position 2 by C1-2 alkyl or alkoxy; R4 = F, OH; R5 = H; or R4 = R5 = OH; or R4R5 = bond] and their stereoisomers, isomer mixtures, and salts, are claimed (40 synthetic examples). For example, N-acylation of [3a(S),4(S),7a(S)]-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol (prepared in 4 steps) with (S)-2-(MeO)C6H4CHMeCO2H (prepared in 3 steps) using EDCI in CH2Cl2 gave title compound II. The ED50 of II for inhibition of increased capillary permeability induced by septide (a substance P agonist) in guinea pigs was 0.04 mg/kg i.v. or 3.5 mg/kg p.o. II also countered hypotension and bronchoconstriction induced by substance P in guinea pigs. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

The Article related to perhydroisoindole preparation substance p antagonist, isoindole perhydro preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Fan; Smith, Myles W. published an article in 2021, the title of the article was A general approach to 2,2-disubstituted indoxyls: total synthesis of brevianamide A and trigonoliimine C.Related Products of 578-58-5 And the article contains the following content:

The indoxyl unit is a common structural motif in alkaloid natural products and bioactive compounds Herein, a general method that transforms readily available 2-substituted indoles into 2,2-disubstituted indoxyls via nucleophile coupling with a 2-alkoxyindoxyl intermediate and showcase its utility in short total syntheses of the alkaloids brevianamide A (7 steps) and trigonoliimine C (6 steps) is reported. The developed method is operationally simple and demonstrates broad scope in terms of nucleophile identity and indole substitution, tolerating 2-alkyl substituents and free indole N-H groups, elements beyond the scope of most prior approaches. Spirocyclic indoxyl products are also accessible via intramol. nucleophilic trapping. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Related Products of 578-58-5

The Article related to indoxyl preparation, indole nucleophile coupling, brevianamide a trigonoliimine c total synthesis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 17, 2021, Khan, Jabir; Tyagi, Aparna; Yadav, Naveen; Mahato, Rina; Hazra, Chinmoy K. published an article.Formula: C8H10O2 The title of the article was Lambert Salt-Initiated Development of Friedel-Crafts Reaction on Isatin to Access Distinct Derivatives of Oxindoles. And the article contained the following:

Herein, a mild metal-free and efficacious route for the synthesis of biol. important 3-aryl oxindole derivatives I [R = H, OH, 4-MeOC6H4, etc.; R1 = H, Me, Br, etc.; R2 = H, NO2, Cl; R3 = H, Me, Bn, Ts; Ar = 4-HOC6H4, 2,4,6-tri-MeOC6H2, 1H-indol-3-yl, etc.] was described. Using Lambert salt-initiated hydroarylation of isatin, a diverse array of monoarylated products, sym./unsym. double-arylated products and deoxygenated hydroarylated products could be synthesized from the single starting substrate in good to excellent yields. A preliminary mechanistic study revealed that the reaction proceeded via a monoarylated product followed by a nucleophilic attack by another electron-rich arene nucleophile under mild conditions. The potential of newly synthesized sym./unsym. 3,3-disubstituted oxindole, 3-substituted 3-hydroxy oxindoles, 3,3-di(indolyl)indolin-2-ones, and α-aryl oxindoles as valuable building blocks was further illustrated. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Formula: C8H10O2

The Article related to aryl oxindole preparation, isatin arene nucleophile hydroarylation lambert salt initiated, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 9, 1995, Achard, Daniel; Grisoni, Serge; James-Surcouf, Evelyne; Malleron, Jean-Iuc; Morgat, Anne; Peyronel, Jean-Francois; Sabuco, Jean-Francois; Tabart, Michel published a patent.Related Products of 81616-80-0 The title of the patent was Preparation of N-acyl-4-hydroxyperhydroisoindoles as substance P antagonists. And the patent contained the following:

Title compounds [I; 1 of R = H, OH, (hydroxy)alkyl and the other = H, (hydroxy)alkyl, Ph; R1 = Ph, alkyl, alkoxy, etc.; R2 = H, halo, OH, alkyl,alkoxy, etc.; R3 = (un)substituted Ph; R4 = OH; R4 = F when R5,R15 = H or alkyl; 1 of R5,R15 = H, OH, alkyl and the other = H or alkyl; R4R5 = bond; R6 = H, OH, (hydroxy)alkyl] were prepared Thus, 5-methylcyclohex-2-en-1-one was cyclocondensed with PhCH2N(CH2OBu)CH2SiMe3 and the product condensed with BuLi-treated PhOMe to give, after deprotection and N-acylation by (S)-2-(MeO)C6H4CHMeCO2H, title compound (3aR*,4R*,6S*,7aS*)-II which had ED50 of 0.07mg/kg i.v. for inhibition of substance P-induced capillary permeability in monkeys. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Related Products of 81616-80-0

The Article related to acylhydroxyperhydroisoindole preparation substance p antagonist, isoindole acylhydroxyperhydro preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 28, 1993, Achard, Daniel; Grisoni, Serge; Malleron, Jean Luc; Peyronel, Jean-francois; Tabart, Michel published a patent.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid The title of the patent was Perhydroisoindole derivatives as substance P antagonists and their preparation. And the patent contained the following:

Title compounds I [R = Ph optionally substituted with halogen or Me in position 2 or 3; R1 = (un)substituted Ph, cyclohexadienyl, naphthyl, indenyl, heterocyclyl; R2 = H, halo, OH, alkyl, aminoalkyl, CO2H, amino, etc.; R3 = Ph optionally substituted in position 2 by C1-2 alkyl or alkoxy; R4 = F, OH; R5 = H; or R4 = R5 = OH; or R4R5 = bond] and their stereoisomers, isomer mixtures, and salts, are claimed (40 synthetic examples). For example, N-acylation of [3a(S),4(S),7a(S)]-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol (prepared in 4 steps) with (S)-2-(MeO)C6H4CHMeCO2H (prepared in 3 steps) using EDCI in CH2Cl2 gave title compound II. The ED50 of II for inhibition of increased capillary permeability induced by septide (a substance P agonist) in guinea pigs was 0.04 mg/kg i.v. or 3.5 mg/kg p.o. II also countered hypotension and bronchoconstriction induced by substance P in guinea pigs. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

The Article related to perhydroisoindole preparation substance p antagonist, isoindole perhydro preparation substance p antagonist, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of (S)-2-(2-Methoxyphenyl)propanoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Fan; Smith, Myles W. published an article in 2021, the title of the article was A general approach to 2,2-disubstituted indoxyls: total synthesis of brevianamide A and trigonoliimine C.Related Products of 578-58-5 And the article contains the following content:

The indoxyl unit is a common structural motif in alkaloid natural products and bioactive compounds Herein, a general method that transforms readily available 2-substituted indoles into 2,2-disubstituted indoxyls via nucleophile coupling with a 2-alkoxyindoxyl intermediate and showcase its utility in short total syntheses of the alkaloids brevianamide A (7 steps) and trigonoliimine C (6 steps) is reported. The developed method is operationally simple and demonstrates broad scope in terms of nucleophile identity and indole substitution, tolerating 2-alkyl substituents and free indole N-H groups, elements beyond the scope of most prior approaches. Spirocyclic indoxyl products are also accessible via intramol. nucleophilic trapping. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Related Products of 578-58-5

The Article related to indoxyl preparation, indole nucleophile coupling, brevianamide a trigonoliimine c total synthesis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 7, 2013, Chen, Shaoqing; De Vicente Fidalgo, Javier; Hamilton, Matthew Michael; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Li, Hongju; Lovey, Allen John; Lucas, Matthew C.; Luk, Kin-Chun Thomas; Lynch, Stephen M.; O’Yang, Counde; Padilla, Fernando; Schoenfeld, Ryan Craig; Sidduri, Achyutharao; Soth, Michael; Wang, Ce; Wovkulich, Peter Michael; Zhang, Xiaohu published a patent.Safety of (S)-1-Methoxypropan-2-amine hydrochloride The title of the patent was Pyrrolopyrazines as kinase inhibitors and their preparation. And the patent contained the following:

The invention relates to the use of pyrrolopyrazine derivatives of formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases. Compounds of formula I wherein R is H; R’ is lower alkoxy and (un)substituted alkyl; RR’ can be taken together to form (un)substituted heterocycloalkyl; Q is (un)substituted bicyclic heteroaryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their kinase inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 0.00172 μM. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Safety of (S)-1-Methoxypropan-2-amine hydrochloride

The Article related to pyrrolopyrazine preparation kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of (S)-1-Methoxypropan-2-amine hydrochloride

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem