Tag: 100-200

On June 6, 1996, Achard, Daniel; Peyronel, Jean-Francois; Tabart, Michel published a patent.Formula: C10H12O3 The title of the patent was Perhydroisoindole derivatives as antagonists of substance p. And the patent contained the following:

New perhydroinsoindoles having the general formula I wherein R1 is optionally substituted Ph or is cyclohexadienyl, naphthyl, indenyl or mono or polycyclic heterocyclyl, saturated or unsaturated 5 to 9C and optionally substituted, R2 is H or halogen, OH, alkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, alkyloxycarbonyl, dialkylaminoalcyloxycarbonyl, benzyloxycarbonyl, amino or acylamino, R3 is Ph optionally substituted in position -2 by a radical alkyl or alkyloxy 1 or 2C or by OH or F, or disubstituted by CF3, and R4 is an alkyl radical containing 1 or 2C substituted by halogen or CN, N3 or -NHCN, and the radicals R which are similar or different represent H, alkyl or Ph, in their isomer forms having the structure II or mixtures thereof, optionally their salts when they exist and preparation thereof. The new derivatives of the invention are particularly useful as antagonists of substance P. The derivative II (R = H, R1 = Me, R2 = R3 = 2-MeOC6H4, R4 = CH2OH) was prepared via acylation of (卤)-III with (S)-(2-MeOC6H4)CHMeCO2H in CH2Cl2 containing hydroxybenzotriazole hydrate and EtN:C:N(CH2)3NMe2. The antiinflammatory activity of several II were tested with a DE50 mg/kg p.o. range of 0.004-1. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).Formula: C10H12O3

The Article related to substance p antagonist preparation, perhydroisoindole derivative preparation bioactivity, isoindole perhydro derivative preparation bioactivity, nk2 receptor antagonist preparation and other aspects.Formula: C10H12O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 7, 2016, Miyanaga, Wataru; Kawahira, Mizuki; Matsumoto, Kayo; Nakagawa, Tadakiyo; Tokumasu, Munetaka; Takeshita, Sen published a patent.SDS of cas: 1162054-86-5 The title of the patent was Preparation of heterocyclic amidocarboxylic acid compounds as glycogen synthase activators and pharmaceutical compositions containing them. And the patent contained the following:

The purpose of the present invention is to provide a novel compound that is capable of activating glycogen synthase but hardly activates receptor PPAR and shows high safety. Provided is a compound represented by general formula I (all variables are defined in the specification) or a pharmaceutically acceptable salt thereof. Thus, 2-[[5-[[4-(4,5-difluoro-2-methylsulfanylphenyl)phenoxy]methyl]furan-2-carbonyl]-(2-methoxyethyl)amino]acetic acid (preparation given) activated human glycogen synthase with EC50 <0.003 渭M. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).SDS of cas: 1162054-86-5

The Article related to heterocyclic amidocarboxylic acid compound glycogen synthase activator treatment diabetes, phenylphenoxymethylfuranecaraboxamidoacetic acid preparation glycogen synthase activator and other aspects.SDS of cas: 1162054-86-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Qiu, Youai; Scheremetjew, Alexej; Finger, Lars H.; Ackermann, Lutz published an article in 2020, the title of the article was Electrophotocatalytic Undirected C-H Trifluoromethylations of (Het)Arenes.HPLC of Formula: 150-78-7 And the article contains the following content:

Electrophotochem. had enabled arene C-H trifluoromethylation with the Langlois reagent CF3SO2Na under mild reaction conditions. The merger of electrosynthesis and photoredox catalysis provided a chem. oxidant-free approach for the generation of the CF3 radical. The electrophotochem. was carried out in an operationally simple manner, setting the stage for challenging C-H trifluoromethylations of unactivated arenes and heteroarenes. The robust nature of the electrophotochem. manifold was reflected by a wide scope, including electron-rich and electron-deficient benzenes, as well as naturally occurring heteroarenes. Electrophotochem. C-H trifluoromethylation was further achieved in flow with a modular electro-flow-cell equipped with an in-operando monitoring unit for online flow-NMR spectroscopy, providing support for the single electron transfer processes. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).HPLC of Formula: 150-78-7

The Article related to trifluoromethylarene preparation regioselective, arene trifluoromethylation electrophotocatalytic, c鈭抙 trifluoromethylation, arenes, catalysis, electrophotochemistry, oxidant-free and other aspects.HPLC of Formula: 150-78-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 7, 2021, Richards, Kenza; Petit, Eddy; Legrand, Yves-Marie; Grison, Claude published an article.Application of 578-58-5 The title of the article was Eco-Friendly Methodology for the Formation of Aromatic Carbon-Heteroatom Bonds by Using Green Ionic Liquids. And the article contained the following:

A new sustainable method is reported for the formation of aromatic carbon-heteroatom bonds under solvent-free and mild conditions (no co-oxidant, no strong acid and no toxic reagents) by using a new type of green ionic liquid The bromination of methoxy arenes was chosen as a model reaction. The reaction methodol. is based on only using natural sodium bromine, which is transformed into an electrophilic brominating reagent within an ionic liquid, easily prepared from the melted salt FeCl3 hexahydrate. Bromination reactions with this in-situ-generated reagent gave good yields and excellent regioselectivity under simple and environmentally friendly conditions. To understand the unusual bromine polarity reversal of sodium bromine without any strong oxidant, the mol. structure of the reaction medium was characterized by Raman and direct infusion electrospray ionization mass spectroscopy (ESI-MS). An extensive computational investigation using d. functional theory methods was performed to describe a mechanism that suggests indirect oxidation of Br- through new iron adducts. The versatility of the methodol. was successively applied to nitration and thiocyanation of methoxy arenes using KNO3 and KSCN in melted hexahydrated FeCl3. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Application of 578-58-5

The Article related to haloarene green preparation melted ferric chloride ionic liquid, dft-hf calculation, aromatic electrophilic substitution, ionic liquids, mixed melted salts, sustainable chemistry and other aspects.Application of 578-58-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 7, 2021, Yu, Tianliang; Wang, Youfu; Jiang, Kaiyue; Zhai, Guangqun; Ke, Changchun; Zhang, Jichao; Li, Jiantong; Tranca, Diana; Kymakis, Emmanuel; Zhuang, Xiaodong published an article.Reference of 1,2-Dimethoxybenzene The title of the article was Catechol-Coordinated Framework Film-based Micro-Supercapacitors with AC Line Filtering Performance. And the article contained the following:

Coordination polymer frameworks (CPFs) have broad applications due to their excellent features, including stable structure, intrinsic porosity, and others. However, preparation of thin-film CPFs for energy storage and conversion remains a challenge because of poor compatibility between conductive substrates and CPFs and crucial conditions for thin-film preparation In this work, a CPF film was prepared by the coordination of the anisotropic four-armed ligand and CuII at the liquid-liquid interface. Such film-based micro-supercapacitors (MSCs) are fabricated through high-energy scribing and electrolytes soaking. As-fabricated MSCs displayed high volumetric specific capacitance of 121.45 F cm-3. Besides, the volumetric energy d. of MSCs reached 52.6 mWh cm-3, which exceeds the electrochem. performance of most reported CPF-based MSCs. Especially, the device exhibited a.c. (AC) line filtering performance (-84.2掳 at 120 Hz) and a short resistance capacitance (RC) constant of 0.08 ms. This work not only provides a new CPF for MSCs with AC line filtering performance but also paves the way for thin-film CPFs preparation with versatile applications. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Reference of 1,2-Dimethoxybenzene

The Article related to copper catechol coordination polymer framework microsupercapacitor alternating current, alternating current line filtering, catechol, coordination polymer framework, copper, micro-supercapacitor and other aspects.Reference of 1,2-Dimethoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kaga, Atsushi; Hayashi, Hirohito; Hakamata, Hiroyuki; Oi, Miku; Uchiyama, Masanobu; Takita, Ryo; Chiba, Shunsuke published an article in 2017, the title of the article was Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite.Formula: C7H7FO And the article contains the following content:

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Formula: C7H7FO

The Article related to benzannulated nitrogen heterocycle preparation, methoxy arene amine nucleophilic amination, dft calculations, amination, nitrogen heterocycles, nucleophilic aromatic substitution, sodium hydride and other aspects.Formula: C7H7FO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 31, 2021, Trusiano, Giuseppe; Vitale, Alessandra; Bonneaud, Celine; Pugliese, Diego; Dalle Vacche, Sara; Joly-Duhamel, Christine; Friesen, Chadron M.; Bongiovanni, Roberta published an article.Quality Control of 2-(2-(Vinyloxy)ethoxy)ethanol The title of the article was Vinyl ethers and epoxides photoinduced copolymerization with perfluoropolyalkylether monomers. And the article contained the following:

New perfluoropolyalkylether (PFPAE) monomers, chain extended with different alkyl groups and functionalized with vinyl ether or epoxide end-groups, were employed, together with trimethylolpropane trivinyl ether or trimethylolpropane triglycidyl ether, to produce fluorinated copolymers. The photoinduced cationic polymerization was investigated, and the PFPAE-based copolymer properties were thoroughly characterized. Interesting surface properties and two different values of refractive index were observed: thus, these fluorinated copolymers can be suitable materials for the manufacture of self-cleaning coatings and optical waveguides. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Quality Control of 2-(2-(Vinyloxy)ethoxy)ethanol

The Article related to perfluoropolyalkylether monomer vinyl ether epoxide photoinduced copolymerization thermal property, cationic polymerization, perfluoropolyalkylethers, refractive index, sliding angle, uv curing and other aspects.Quality Control of 2-(2-(Vinyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 31, 2019, Gobbi, Silvia; Hu, Qingzhong; Foschi, Giacomo; Catanzaro, Elena; Belluti, Federica; Rampa, Angela; Fimognari, Carmela; Hartmann, Rolf W.; Bisi, Alessandra published an article.Application In Synthesis of 1-Fluoro-2-methoxybenzene The title of the article was Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing. And the article contained the following:

The inhibition of steroidogenic cytochrome P 450 enzymes has been shown to play a central role in the management of life-threatening diseases such as cancer, and indeed potent inhibitors of CYP19 (aromatase) and CYP17 (17伪 hydroxylase/17,20 lyase) are currently used for the treatment of breast, ovarian and prostate cancer. In the last few decades CYP11B1 (11-尾-hydroxylase) and CYP11B2 (aldosterone synthase), key enzymes in the biosynthesis of cortisol and aldosterone, resp., have been also investigated as targets for the identification of new potent and selective agents for the treatment of Cushing’s syndrome, impaired wound healing and cardiovascular diseases. In an effort to improve activity and synthetic feasibility of our different series of xanthone-based CYP11B1 and CYP11B2 inhibitors, a small series of imidazolylmethylbenzophenone-based compounds, previously reported as CYP19 inhibitors, was also tested on these new targets, in order to explore the role of a more flexible scaffold for the inhibition of CYP11B1 and -B2 isoforms. Compound 3 proved to be very potent and selective towards CYP11B1, and was thus selected for further optimization via appropriate decoration of the scaffold, leading to new potent 4′-substituted derivatives In this second series, 4 and 8, carrying a methoxy group and a Ph ring, resp., proved to be low-nanomolar inhibitors of CYP11B1, despite a slight decrease in selectivity against CYP11B2. Moreover, unlike the benzophenones of the first series, the 4′-substituted derivatives also proved to be selective for CYP11B enzymes, showing very weak inhibition of CYP19 and CYP17. Notably, the promising result of a preliminary scratch test performed on compound 8 confirmed the potential of this compound as a wound-healing promoter. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application In Synthesis of 1-Fluoro-2-methoxybenzene

The Article related to benzophenone cyp11b1 cyp11b2 inhibitor wound healing cortisol steroidogenesis, benzophenone, cyp11b1 (11-尾-hydroxylase), cyp11b2 (aldosterone synthase), cortisol, steroidogenesis, wound healing and other aspects.Application In Synthesis of 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 30, 2021, Deng, Xiujuan; Huang, Ganghua; Tu, Qing; Zhou, Hongjie; Li, Yali; Shi, Hongyuan; Wu, Xianxue; Ren, Hongtao; Huang, Kunlun; He, Xiaoyun; Xu, Wentao published an article.COA of Formula: C8H10O2 The title of the article was Evolution analysis of flavor-active compounds during artificial fermentation of Pu-erh tea. And the article contained the following:

For the urgent need for fermentation control and product quality improvement of Pu-erh tea, gas chromatog.-mass spectrometry and odor activity value (OAV) were used to comprehensively investigate the flavor-active compounds during artificial fermentation of Pu-erh tea. A flavor wheel was constructed to expound the sensory attributes evolution during fermentation With an increased total volatiles content, 43 were significantly up-regulated and 30 were down-regulated among 131 detected volatiles. Key active compounds of three aroma types, namely fresh fragrance, fruit-fungus fragrance and stale-Qu fragrance, were analyzed based on OAV. 尾-damascenone was firstly found contributing most to the aroma of Pu-erh tea, followed by 1,2,3-methoxybenzene and (E,E)-2,4-nonadienal. 纬-terpinene, linalool, 1,2,4-trimethoxybenzene, 1,2,3-trimethoxybenzene, and 4-ethylveratrol were identified as the potential markers responsible for aroma differences among three fermentation stages. Finally the metabolic evolution of key flavor-active compounds were systematically summarized. This study provides significant guidance in fermentation control and new product development of Pu-erh tea. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).COA of Formula: C8H10O2

The Article related to betadamascenone gammaterpinene linalool artificial fermentation pu erh tea, aroma profile, artificial fermentation, flavor-active compounds, metabolic evolution, odor activity value, pu-erh tea and other aspects.COA of Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem