Tag: 100-200

On March 31, 2022, Wang, Mingqi; Zhou, Jingjing; Zhang, Guoxian; Liu, Qing; Zhang, Qiuyu published an article.Computed Properties of 929-37-3 The title of the article was Pyrrolidinyl ligand motif-assisted bovine serum albumin molecularly imprinted polymers with high specificity. And the article contained the following:

Ideal binding ligands for anchoring proteins are essential for the design and assembly of desirable molecularly imprinted polymers (MIPs). In this study, bovine serum albumin-MIPs (BSA-MIPs) were successfully prepared by orchestrating the involvement of orientation-controllable binding ligands via sequential thiol-ene click and thiol-ene-amine conjugation. We showed that the optimal thiol-ene-amine conjugates and binding ligands were decisive in determining the rebinding capacity and selectivity. The pyrrolidinyl MIPs exhibited the best adsorption capacity of 352 卤 22 mg/g and a superior imprinting factor of 4.72 among MIPs with various binding ligands. These favorable results were further studied by computational simulation and isothermal titration calorimetry (ITC). Mol. docking revealed the preferential binding free energy and H-bonds between BSA residues and the thiol-ene-amine conjugates. Meanwhile, the pyrrolidinyl ligand motif enabled entropy-favorable affinity to be achieved via hydrophobic effects with the BSA template by ITC thermodn. Because of these favorable bindings, the MIPs exhibited excellent adsorption specificity to BSA over competing proteins. The proof-of-concept of MIPs with orientation-controllable conjugates and proven binding ligands for target proteins demonstrates that this material is promising for use with a real biol. sample. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Computed Properties of 929-37-3

The Article related to pyrrolidinyl ligand bovine serum albumin molecularly imprinted polymer, adsorption capacity, hydrophobic effect, molecularly imprinted polymers (mips), pyrrolidinyl group, thiol-ene-amine conjugation and other aspects.Computed Properties of 929-37-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 30, 2013, Dong, Xiaomei; Wang, Qingxia; Zhang, Qian; Xu, Shuai; Wang, Zhihong published an article.Application of 929-37-3 The title of the article was Construction of dihydropyran-bridged macrocycles by inverse-electron-demand Diels-Alder reaction. And the article contained the following:

A variety of dihydropyran-bridged macrocyclic structures were constructed by the inverse-electron-demand Diels-Alder reaction of 2-oxo-4-aryl-but-3-enoates. Controlling of the tether length and the position of the activating substituent in the substrates would guide the reaction to the formation of four different types of polycyclic frames, namely bicyclic [n.3.1], bicyclic [n.2.2], tricyclic [n.3.1.1], and tricyclic [n.2.2.2] macrocycles. The intermol./intramol. selectivity of the Diels-Alder reaction was virtually governed by the tether length. The reactions were carried out rapidly under mild conditions, and offered a practical method for creating bridged polycyclic structures with large rings from acyclic precursors. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Application of 929-37-3

The Article related to oxoarylbutenoate inverse electron demand diels alder reaction, dihydropyran bridged bicyclic tricyclic macrocycle preparation, tether length control selectivity cyclization dimerization trimerization and other aspects.Application of 929-37-3

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Ether – Wikipedia,
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On December 9, 2021, Zhang, Shaofei; Vayer, Marie; Noel, Florent; Vukovic, Vuk D.; Golushko, Andrei; Rezajooei, Nazanin; Rowley, Christopher N.; Leboeuf, David; Moran, Joseph published an article.Safety of 1,4-Dimethoxybenzene The title of the article was Unlocking the Friedel-Crafts arylation of primary aliphatic alcohols and epoxides driven by hexafluoroisopropanol. And the article contained the following:

The limitations thar easily overcome using Bronsted acid catalysis in hexafluoroisopropanol (HFIP) as a solvent were reported. Electron-poor aromatic epoxides and aliphatic epoxides undergo stereospecific arylation to give alcs. RC(R1)(Ar)CH2OH/RCH(OH)CH(Ar)OH, and based on the reaction conditions, it can partake in a second nucleophilic substitution with a different arene ArH in one pot. Ph ethanols R3(CH2)2OH (R3 = Ph, 2,6-dichlorophenyl, 2,4,6-trimethylphenyl, etc.) react through a phenonium intermediate, whereas simple aliphatic alcs. e.g., cyclopentanol participate in a rare intermol. SN2 Friedel-Crafts process, delivering linear products e.g., 1,3,5-trimethyl-2-phenethylbenzene exclusively. In this work, an alternative to metal-catalyzed cross-couplings was provided for accessing important scaffolds, and widening the range of applications of the Friedel-Crafts reaction. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Safety of 1,4-Dimethoxybenzene

The Article related to alc preparation regioselective, epoxide arene ring opening friedel crafts arylation bronstedacid catalyst, arylethane preparation, aliphatic alc arene friedel crafts arylation bronsted acid catalyst and other aspects.Safety of 1,4-Dimethoxybenzene

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Ether – Wikipedia,
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Sarapas, Joel M.; Tew, Gregory N. published an article in 2016, the title of the article was Thiol-Ene Step-Growth as a Versatile Route to Functional Polymers.Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol And the article contains the following content:

A new use of the thiol-ene reaction to generate functional, redox-tunable polymers is described. To illustrate the versatility of this approach, tailored divinyl ether monomers were polymerized with triethylene glycol dithiol to yield polymers containing either a carbonate or zwitterionic phosphocholine within the polymer backbone. Similarly, dithioerythritol was polymerized with triethylene glycol divinyl ether to yield a polymer with pendant diols and show how functional groups can be designed into either the divinyl ether or dithiol monomer. Using the thioether functional group inherent to this polymerization, all three polymers were selectively and quant. oxidized to either sulfoxides or sulfones by treatment with dilute hydrogen peroxide or mCPBA, resp. With these illustrative examples, it is shown that the thiol-ene polymerization is a broad-reaching method to access a class of new redox-active polymers which contain varied and dense functional-group compositions The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol

The Article related to thiol ene step growth polymerization oxidation sulfoxide sulfone, carbonate zwitterionic phosphocholine polyether backbone preparation, click chemistry, diols, oxidation, polymerization, zwitterions and other aspects.Application In Synthesis of 2-(2-(Vinyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 4, 2021, Bartlett, Mark J.; Chin, Gregory F.; Clarke, Michael O.; Cosman, Jennifer L.; Ensan, Deeba; Goyal, Bindu; Ho, Stephen; Hui, Hon C.; Mackman, Richard L.; Mish, Michael R.; Schroeder, Scott D.; Shapiro, Nathan; Siegel, Dustin S.; Tang, Doris T.; Yang, Hai published a patent.Electric Literature of 1162054-86-5 The title of the patent was Preparation of CD73 inhibiting 2,4-dioxopyrimidine compounds. And the patent contained the following:

The present disclosure provides pyrimidine dione compounds I [Y = a bond, alkyl, cycloalkyl, etc.; one or two of Z1-Z3 = CR2 and the remaining one or two of Z1-Z3 = N; one of W1 and W2 = N and the other = C; R1 = H, CN, alkyl, etc.; R2 = (independently) H, halo, CN, etc.] or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. E.g., a multi-step synthesis of II, starting from 8-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine and cyclopropylboronic acid, was described. Exemplified compounds I were tested in the CD73 biochem. IC50 assay and in the MDA-MB-231 cell based CD73 activity assay (data given). The compounds I can be used alone or in combination with other anti-cancer agents. The experimental process involved the reaction of (S)-1-Methoxypropan-2-amine hydrochloride(cas: 1162054-86-5).Electric Literature of 1162054-86-5

The Article related to dioxopyrimidine pyrimidinedione imidazopyridazinyl preparation cd73 inhibitor antitumor solid tumor, combination chemotherapy cd73 inhibitor antitumor pyrimidinedione imidazopyridazinyl preparation and other aspects.Electric Literature of 1162054-86-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 7, 2020, Blum, Stephan P.; Schollmeyer, Dieter; Turks, Maris; Waldvogel, Siegfried R. published an article.Computed Properties of 91-16-7 The title of the article was Metal- and Reagent-Free Electrochemical Synthesis of Alkyl Arylsulfonates in a Multi-Component Reaction. And the article contained the following:

This work presents the first electrochem. preparation of alkyl arylsulfonates RS(O)2OR1 (R = 3,4,5-trimethoxyphenyl, 2,5-dimethoxyphenyl, 4-methoxy-2,6-dimethylphenyl, etc.; R1 = Me, Et, t-Bu, etc.) by direct anodic oxidation of electron-rich arenes RH. The reaction mechanism features a multi-component reaction consisting of electron-rich arenes, an alc. of choice and excess SO2 in an acetonitrile-HFIP reaction mixture In-situ formed monoalkyl sulfites are considered as key intermediates with bifunctional purpose. Firstly, this species functions as nucleophile and secondly, excellent conductivity is provided. Several primary and secondary alcs. R1OH and electron-rich arenes are implemented in this reaction to form the alkyl arylsulfonates in yields up to 73% with exquisite selectivity. Boron-doped diamond electrodes (BDD) are employed in divided cells and separated by a simple com. available glass frit. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Computed Properties of 91-16-7

The Article related to arylsulfonate alkyl preparation electrochem green chem regioselective, arene alc anodic oxidation multicomponent reaction, c鈭抙 activation, electrochemistry, green chemistry, oxidation, radical ions and other aspects.Computed Properties of 91-16-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 7, 2020, Blum, Stephan P.; Schollmeyer, Dieter; Turks, Maris; Waldvogel, Siegfried R. published an article.Application In Synthesis of 1,4-Dimethoxybenzene The title of the article was Metal- and Reagent-Free Electrochemical Synthesis of Alkyl Arylsulfonates in a Multi-Component Reaction. And the article contained the following:

This work presents the first electrochem. preparation of alkyl arylsulfonates RS(O)2OR1 (R = 3,4,5-trimethoxyphenyl, 2,5-dimethoxyphenyl, 4-methoxy-2,6-dimethylphenyl, etc.; R1 = Me, Et, t-Bu, etc.) by direct anodic oxidation of electron-rich arenes RH. The reaction mechanism features a multi-component reaction consisting of electron-rich arenes, an alc. of choice and excess SO2 in an acetonitrile-HFIP reaction mixture In-situ formed monoalkyl sulfites are considered as key intermediates with bifunctional purpose. Firstly, this species functions as nucleophile and secondly, excellent conductivity is provided. Several primary and secondary alcs. R1OH and electron-rich arenes are implemented in this reaction to form the alkyl arylsulfonates in yields up to 73% with exquisite selectivity. Boron-doped diamond electrodes (BDD) are employed in divided cells and separated by a simple com. available glass frit. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Application In Synthesis of 1,4-Dimethoxybenzene

The Article related to arylsulfonate alkyl preparation electrochem green chem regioselective, arene alc anodic oxidation multicomponent reaction, c鈭抙 activation, electrochemistry, green chemistry, oxidation, radical ions and other aspects.Application In Synthesis of 1,4-Dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 10, 2021, Jiang, Zhong-Tao; Huang, Jiangkun; Zeng, Yaxin; Hu, Fangdong; Xia, Ying published an article.Synthetic Route of 321-28-8 The title of the article was Rhodium Catalyzed Regioselective C-H Allylation of Simple Arenes via C-C Bond Activation of Gem-difluorinated Cyclopropanes. And the article contained the following:

Herein, we report a rhodium catalyzed directing-group free regioselective C-H allylation of simple arenes. Readily available gem-difluorinated cyclopropanes can be employed as highly reactive allyl surrogates via a sequence of C-C and C-F bond activation, providing allyl arene derivatives in good yields with high regioselectivity under mild conditions. The robust methodol. enables facile late-stage functionalization of complex bioactive mols. The high efficiency of this reaction is also demonstrated by the high turnover number (TON, up to 1700) of the rhodium catalyst on gram-scale experiments Preliminary success on kinetic resolution of this transformation is achieved, providing a promising access to enantio-enriched gem-difluorinated cyclopropanes. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to arene cyclopropane geminal difluorinated rhodium regioselective allylation catalyst, fluorinated allylarene preparation, c−c bond activation, c−h allylation, directing-group-free, gem-difluorinated cyclopropane, rhodium catalysis and other aspects.Synthetic Route of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hofer, Manuel; Genoux, Alexandre; Kumar, Roopender; Nevado, Cristina published an article in 2017, the title of the article was Gold-Catalyzed Direct Oxidative Arylation with Boron Coupling Partners.Name: 1-Fluoro-2-methoxybenzene And the article contains the following content:

An efficient synthesis of biaryls through a gold-catalyzed oxidative cross-coupling of arenes with strong electron-deprived aryl boronates is presented herein. Regio- and chemocontrol are achieved by the selective activation of these coupling partners by gold at different oxidation states. Under reaction conditions devoid of basic additives or directing groups, the role of acetato ligand as an internal base has been revealed as a key parameter for expanding the reaction scope in these transformations. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Name: 1-Fluoro-2-methoxybenzene

The Article related to arene aryl boronate direct oxidative arylation cross coupling gold, biaryl preparation mol crystal structure, gold oxidative arylation cross catalyst, arylation, cross-coupling, gold, homogeneous catalysis, reaction mechanisms and other aspects.Name: 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yan, Boyu; Zhou, Yutong; Wu, Jieliang; Ran, Maogang; Li, Huihui; Yao, Qiuli published an article in 2021, the title of the article was Catalyst-free reductive hydrogenation or deuteration of aryl-heteroatom bonds induced by light.Recommanded Product: 93-04-9 And the article contains the following content:

A simple and catalyst-free photochem. strategy for the direct reduction of aryl trimethylammonium salts ArNMe3OTf (Ar = biphenyl-4-yl, 2-naphthyl, quinolin-3-yl, etc.), aryl triflates Ar1OTf (Ar1 = biphenyl-3-yl, 1,6-dimethylpyridin-4-yl, benzothiazol-5-yl, etc.), and haloarenes Ar2X (Ar2 = biphenyl-4-yl, 2-naphthyl, quinolin-4-yl, etc.; X = Cl, Br, I) to arenes ArH/Ar1H or deuterium-labeled arenes ArD/Ar1D/Ar2D was described. A broad range of substrate scope was demonstrated with high yields and deuterium incorporations. Radical clock experiments indicate the formation of aryl radical intermediates that can also be trapped by phenols. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Recommanded Product: 93-04-9

The Article related to aromatic hydrocarbon preparation, aryl deuterated compound preparation, quaternary arylammonium salt reductive hydrogenation deuteration, triflate aryl reductive hydrogenation deuteration, arylhalide dehalogenation deuteration and other aspects.Recommanded Product: 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem