Tag: 100-200

Yuan, Tao; Zheng, Meifang; Antonietti, Markus; Wang, Xinchen published an article in 2021, the title of the article was Ceramic boron carbonitrides for unlocking organic halides with visible light.COA of Formula: C8H10O And the article contains the following content:

Here, boron carbonitride (BCN) ceramics were such a system and can reduce organic halides, including (het)aryl and alkyl halides, with visible light irradn was reported. Cross-coupling of halides to afford new C-H, C-C, and C-S bonds was proceeded at ambient reaction conditions. Hydrogen, (het)aryl, and sulfonyl groups were introduced into the arenes and heteroarenes at the designed positions by means of mesolytic C-X (carbon-halogen) bond cleavage in the absence of any metal-based catalysts or ligands. BCN was used not only for half reactions, like reduction reactions with a sacrificial agent, but also redox reactions through oxidative and reductive interfacial electron transfer. The BCN photocatalyst showed tolerance to different substituents and conserved activity after five recycles. The apparent metal-free system opened new opportunities for a wide range of organic catalysts using light energy and sustainable materials, which were metal-free, inexpensive and stable. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).COA of Formula: C8H10O

The Article related to boron carbonitride preparation surface structure, aryl halide boron carbonitride photocatalyst hydrodehalogenation, aromatic hydrocarbon preparation, arene aryl halide boron carbonitride photocatalyst cross coupling arylation, biaryl preparation, haloarene sodium sulfinate boron carbonitride photocatalyst cross coupling sulfonylation, arylsulfone preparation and other aspects.COA of Formula: C8H10O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yuan, Tao; Zheng, Meifang; Antonietti, Markus; Wang, Xinchen published an article in 2021, the title of the article was Ceramic boron carbonitrides for unlocking organic halides with visible light.Quality Control of 2-Methoxynaphthalene And the article contains the following content:

Here, boron carbonitride (BCN) ceramics were such a system and can reduce organic halides, including (het)aryl and alkyl halides, with visible light irradn was reported. Cross-coupling of halides to afford new C-H, C-C, and C-S bonds was proceeded at ambient reaction conditions. Hydrogen, (het)aryl, and sulfonyl groups were introduced into the arenes and heteroarenes at the designed positions by means of mesolytic C-X (carbon-halogen) bond cleavage in the absence of any metal-based catalysts or ligands. BCN was used not only for half reactions, like reduction reactions with a sacrificial agent, but also redox reactions through oxidative and reductive interfacial electron transfer. The BCN photocatalyst showed tolerance to different substituents and conserved activity after five recycles. The apparent metal-free system opened new opportunities for a wide range of organic catalysts using light energy and sustainable materials, which were metal-free, inexpensive and stable. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Quality Control of 2-Methoxynaphthalene

The Article related to boron carbonitride preparation surface structure, aryl halide boron carbonitride photocatalyst hydrodehalogenation, aromatic hydrocarbon preparation, arene aryl halide boron carbonitride photocatalyst cross coupling arylation, biaryl preparation, haloarene sodium sulfinate boron carbonitride photocatalyst cross coupling sulfonylation, arylsulfone preparation and other aspects.Quality Control of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 17, 2001, Blackwell, Helen E.; Perez, Lucy; Schreiber, Stuart L. published an article.Recommanded Product: 2-(2-(Vinyloxy)ethoxy)ethanol The title of the article was Decoding products of diversity pathways from stock solutions derived from single polymeric macrobeads. And the article contained the following:

A combinatorial library of nonracemic dihydropyrancarboxamides such as I [prepared on solid phase by the enantioselective Diels-Alder cycloaddition of resin-bound vinyl ethers with allyl β,γ-unsaturated-α-ketoesters in the presence of nonracemic bisoxazoline ligands and copper (II) triflate] using a novel tagging technique for the labeling and identification of members of combinatorial libraries. Chloroarom. diazoketones II (n = 1, 7, 14; R = H, Cl) were used as tagging agents to identify the sequence of reactions to which a resin bead had been subjected; treatment of a resin bead with II in the presence of dirhodium tetrakis(triphenylacetate) yielded a polystyrene resin containing a fraction of chloroaralkyl cycloheptatriene moieties (formed by ring expansion of the polystyrene Ph groups). Oxidative cleavage of the tags with ceric ammonium nitrate liberated the chloroarom. portion of the tags; treatment of the tags with N,O-bis(trimethylsilyl)acetamide and gas chromatog. yielded masses corresponding to the sequence of reactions to which beads were subjected and thus their identities. The tags could be decoded either directly from a bead before compound cleavage, from a bead after compound cleavage, or from compound stock solutions (generated by compound cleavage and dissolution of a fraction of the liberated compounds in THF/H2O). Decoding compound stock solutions was the most effective method of identifying library members; compounds were identified by tag cleavage of solutions containing 1 or 5% of the compound cleaved from a single bead. Stock solutions were decoded most effectively because a fraction of the library member on a given bead was tagged with the chloroarom. diazoketone in addition to the polystyrene resin (due to the high-loading resin used) and because oxidative cleavage of the tags with CAN proceeded more readily in solution than on solid support. A sublibrary of 108 beads chosen from the larger combinatorial library was decoded by this procedure; of the 108 compounds, 107 were successfully decoded. Four different synthetic pathways were found to be compatible with the diazoketone tagging methodol. (no data). The use of stock solutions for the decoding and deconvolution of combinatorial libraries is amenable to robotic methods for combinatorial library synthesis and testing, minimizes the storage requirements for combinatorial libraries, and allows for simpler and faster compound identification. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Recommanded Product: 2-(2-(Vinyloxy)ethoxy)ethanol

The Article related to polymeric macrobead decoding stock solution, dihydropyrancarboxamide combinatorial library stereoselective enantioselective preparation, chloroarom diazoketone tag decoding identification member combinatorial library, decoding product diversity pathway stock solution polymeric macrobead, oxidative cleavage chloroarom diazoketone tag polymeric macrobead and other aspects.Recommanded Product: 2-(2-(Vinyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 31, 2000, Coalter, Joseph N. III; Bollinger, John C.; Huffman, John C.; Werner-Zwanziger, Ulrike; Caulton, Kenneth G.; Davidson, Ernest R.; Gerard, Helene; Clot, Eric; Eisenstein, Odile published an article.Safety of 2-(2-(Vinyloxy)ethoxy)ethanol The title of the article was Coordinated carbenes from electron-rich olefins on RuHCl(PPri3)2. And the article contained the following:

Dehydrohalogenation of RuH2Cl2L2 (L = PPri3) gives (RuHClL2)2, shown to be a halide-bridged dimer by x-ray crystallog.; the fluoride analog is also a dimer. (RuHClL2)2 reacts with N2, pyridine and C2H4 (L’) to give RuHClL’L2, but with vinyl ether and vinyl amides, H2C:CH(E) [E = OR, NRC(O)R’] such olefin binding is followed by isomerization to the heteroatom-substituted carbene complex L2HClRu:CMe(E). The reaction mechanism for such rearrangement was established by DFT (B3PW91) computations, for C2H4 as olefin (it is endothermic), and the structures of intermediates are calculated for H2C:C(H)(OCH3) and for cyclic and acyclic amide-substituted olefins. It is found, both exptl. and computationally, that the amide O is bonded to Ru, with a calculated bond energy of ∼9 kcal mol-1 for an acyclic model. Less electron-rich vinyl amides or amines form η2-olefin complexes, but do not isomerize to carbene complexes. Calculated ΔE values for selected competition reactions reveal that donation by both Ru and the heteroatom-substituted X are necessary to make the carbene complex L2HClRu:C(X)Me more stable than the olefin complex L2HClRu(η2-H2C:CHX). This originates in part from a diminished endothermicity of the olefin → carbene transformation when the sp2 C bears a π-donor substituent. The importance of a hydride on Ru in furnishing a mechanism for this isomerization is discussed. The compositional characteristics of Schrock and Fischer carbenes are detailed, it is suggested that reactivity will not be uniquely determined by these characteristics, and these new carbenes RuHCl[C(X)CH3]L2 are contrasted to Schrock and Fischer carbenes. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Safety of 2-(2-(Vinyloxy)ethoxy)ethanol

The Article related to crystal structure ruthenium hydrido dinitrogen carbene complex, mol structure ruthenium hydrido dinitrogen carbene complex, electron rich olefin ruthenium coordinated regioselective rearrangement, vinyl amide ether ruthenium coordinated regioselective rearrangement, density functional ruthenium coordinated olefin regioselective rearrangement and other aspects.Safety of 2-(2-(Vinyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On June 18, 2021, Selmani, Aymane; Schoenebeck, Franziska published an article.Recommanded Product: 321-28-8 The title of the article was Transition-Metal-Free, Formal C-H Germylation of Arenes and Styrenes via Dibenzothiophenium Salts. And the article contained the following:

We report an operationally simple, selective, and transition-metal-free germylation of arenes and styrenes at room temperature, using a robust and bench-stable Ge source (R3Ge-SiR3) and dibenzothiophenium salts as enabling intermediates. The first direct engagement in cross-coupling of the newly made E-alkenyl germanes is also presented, allowing the chemoselective arylation under air-tolerant nanoparticle catalysis. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 321-28-8

The Article related to dibenzothiophenylation arene styrene stereoselective germylation, dibenzothiophenium salt preparation intermediate silylgermane germylation stereoselective, alkenyl germane preparation coupling arylation chemoselective nanoparticle palladium catalyst, mol structure optimized dft germylation dibenzothiophenium salt energy regioselective and other aspects.Recommanded Product: 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shi, Jiale; Yuan, Tao; Wang, Rong; Zheng, Meifang; Wang, Xinchen published an article in 2021, the title of the article was Boron carbonitride photocatalysts for direct decarboxylation: the construction of C(sp3)-N or C(sp3)-C(sp2) bonds with visible light.Application In Synthesis of 2-Methoxynaphthalene And the article contains the following content:

A metal-free protocol was established for the decarboxylative N-H or C(sp2)-H functionalization of acids via metal-free boron carbon nitride (BCN) photocatalysis, delivering the desired products under ambient conditions. This methodol.was applicable to the late-stage modification of pharmaceutical mols. and gram-scale experiments as well as in the recovery and reuse of the photocatalysts without the loss of reactivity. The developed photochem. reaction system fulfills the requirements of green and sustainable chem. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Application In Synthesis of 2-Methoxynaphthalene

The Article related to boroncarbonitride photocatalyst preparation pore size distribution, pyrazole phenylacetic acid heterogeneous catalyst decarboxylation c n activation, benzyl pyrazole preparation green chem, methoxybenzene phenylacetic acid heterogeneous catalyst decarboxylation c h activation, benzylmethoxyarylbenzene preparation green chem and other aspects.Application In Synthesis of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 29, 2022, Li, Yang; Wang, Yanan; Ye, Zhegao; Zhang, Shangbiao; Ye, Xiaodong; Yuan, Zheliang published an article.Computed Properties of 93-04-9 The title of the article was Trifluoromethyl Selenoxides: Electrophilic Reagents for C-H Trifluoromethylselenolation of (Hetero)Arene. And the article contained the following:

Herein, designed and synthesized the new electrophilic trifluoromethylselenolation reagents, trifluoromethyl selenoxides I [X = H, CF3, CN], which were easy to prepare and easy-to-handle and were not moisture or air sensitive. The selenoxides are successfully applied to metal-free C-H trifluoromethylselenolation of a series of (hetero)arenes to gave ((trifluoromethyl)selanyl)aryl ArSeCF3 [Ar = 4-HOC6H4, 1H-indol-3-yl, (5-methoxycarbonyl-1H-pyrrol-3-yl), etc.]. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Computed Properties of 93-04-9

The Article related to selanyl hetero aryl trifluoromethyl regioselective preparation, hetero aryl methyl oxido trifluoromethyl selenonium carbon hydrogen trifluoromethylselenolation, trifluoromethyl selanyl aryl regioselective preparation, aromatic compound aryl methyl oxido trifluoromethyl selenonium carbon hydrogen, trifluoromethylselenolation and other aspects.Computed Properties of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 4, 2021, Hofmann, Julian; Ginex, Tiziana; Espargaro, Alba; Scheiner, Matthias; Gunesch, Sandra; Arago, Marc; Stigloher, Christian; Sabate, Raimon; Luque, F. Javier; Decker, Michael published an article.Recommanded Product: 91-16-7 The title of the article was Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress and Neuroinflammation. And the article contained the following:

Many (poly-)phenolic natural products, for example, curcumin and taxifolin, had been studied for their activity against specific hallmarks of neurodegeneration, such as amyloid-β 42 (Aβ42) aggregation and neuroinflammation. Due to their drawbacks, arising from poor pharmacokinetics, rapid metabolism and even instability in aqueous medium, the biol. activity of azobenzene compounds carrying a pharmacophoric catechol group I [R = H, Cl, NO2, MeO, EtO, Oi-Pr; R1 = OH, MeO], which had been designed as bioisoteres of curcumin had been examined Mol. simulations revealed the ability of these compounds to form a hydrophobic cluster with Aβ42, which adopts different folds, affecting the propensity to populate fibril-like conformations. Furthermore, the curcumin bioisosteres exceeded the parent compound in activity against Aβ42 aggregation inhibition, glutamate-induced intracellular oxidative stress in HT22 cells and neuroinflammation in microglial BV-2 cells. The most active compound prevented apoptosis of HT22 cells at a concentration of 2.5μM (83% cell survival), whereas curcumin only showed very low protection at 10μM (21% cell survival). The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Recommanded Product: 91-16-7

The Article related to azobioisostere curcumin diastereoselective preparation intracellular oxidative stress neuroinflammation, amyloid aggregation neurotoxicity neuroprotection docking azobioisostere curcumin diastereoselective preparation, amyloid beta, bioisosterism, natural products, neuroprotectivity, replica-exchange molecular dynamics and other aspects.Recommanded Product: 91-16-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Roesner, Stefan; Buchwald, Stephen L. published an article in 2016, the title of the article was Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes.Reference of 1-Fluoro-2-methoxybenzene And the article contains the following content:

A continuous-flow method for the regioselective arylation of fluoroarenes and fluoropyridines has been developed. The telescoped procedure reported here consists of a three-step metalation, zincation, and Negishi cross-coupling sequence, providing efficient access to a variety of functionalized 2-fluorobiaryl products. Precise temperature control of the metalation step, made possible by continuous-flow technol., allowed for the efficient preparation of the arylated products in high yields and short residence times. Addnl., several examples of the regioselective arylation of benzotrifluoride derivatives are also provided. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Reference of 1-Fluoro-2-methoxybenzene

The Article related to fluorinated biaryl continuous flow synthesis sonication regioselective arylation, metalation zincation negishi coupling sequence fluoroarene bromoarene sonication, fluoropyridine metalation zincation negishi coupling sequence bromoarene sonication, biaryls, cross-coupling, flow chemistry, palladium, synthetic methods and other aspects.Reference of 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 30, 2022, Toupalas, Georgios; Morandi, Bill published an article.Recommanded Product: 93-04-9 The title of the article was Non-innocent electrophiles unlock exogenous base-free coupling reactions. And the article contained the following:

Introduced a unifying strategy that eliminates the need for an exogenous base through the use of non-innocent electrophiles (NIE), which were equipped with a masked base that was released in a controlled fashion during the reaction. The universal applicability of this concept were demonstrated by turning multiple, traditionally base-dependent, catalytic reactions into exogenous base-free homogeneous processes. Furthermore, the advantageous features of NIEs were demonstrated in multiple applications, such as in a micromole-scale fluorescence-based assay. This led to the discovery of a Ni-catalyzed deoxygenation reaction of aryl carbamates using isopropanol as a benign reductant. In a broader context, this work provided a conceptual blueprint for the strategic utilization of NIEs in catalysis. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Recommanded Product: 93-04-9

The Article related to aryl isopropylcarbamate amine nickel catalyst buchwald hartwig amination fluorescence, arylamine preparation, terminal alkene aryl isopropylcarbamate nickel catalyst mizoroki heck reaction, arylalkene preparation, arylboronic acid aryl isopropylcarbamate nickel catalyst suzuki miyaura coupling, biaryl preparation and other aspects.Recommanded Product: 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem