Tag: 100-200

Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzeneOn June 11, 2001, Dirk, S. M.; Price, D. W.; Chanteau, S.; Kosynkin, D. V.; Tour, J. M. published an article in Tetrahedron. The article was 《Accoutrements of a molecular computer: switches, memory components and alligator clips》. The article mentions the following:

Several second generation memory components consisting of oligo(phenylene ethynylene)s containing easily reducible functionalities consisting of either nitro or quinone cores have been synthesized for incorporation into mol. electronic devices. Addnl., two new types of contacts between organic compounds and a metal surface based on diazonium salts or pyridine have been synthesized and integrated into mols. for use in mol. electronic devices. In the experiment, the researchers used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Discovery of potential Q-marker of traditional Chinese medicine based on plant metabolomics and network pharmacology: Periplocae Cortex as an example》 was written by Li, Zi-ting; Zhang, Feng-xiang; Fan, Cai-lian; Ye, Meng-nan; Chen, Wei-wu; Yao, Zhi-hong; Yao, Xin-sheng; Dai, Yi. Recommanded Product: 673-22-3This research focused ontraditional Chinese medicine plant metabolomic pharmacol Periplocae; Multivariate statistical analysis; Network pharmacology; Periplocae Cortex; Q-marker; Quantification. The article conveys some information:

Quality control exerted great importance on the clin. application of drugs for ensuring effectiveness and safety. Due to chem. complexity, diversity among different producing areas and harvest seasons, as well as unintentionally mixed with non-medicinal parts, the current quality standards of traditional Chinese medicine (TCM) still faced challenges in evaluating the overall chem. consistency. We aimed to develop a new strategy to discover potential quality marker (Q-marker) of TCM by integrating plant metabolomics and network pharmacol., using Periplocae Cortex (GP, the dried root bark of Periploca sepium Bge.) as an example. First, plant metabolomics anal. was performed by UPLC/Q-TOF MS in 89 batches of samples to discover chem. markers to distinguish medicinal parts (GP) and non-medicinal parts (the dried stem bark of Periploca sepium Bge. (JP)), harvest seasons and producing region of Periplocae Cortex. Second, network pharmacol. was applied to explore the initial linkages among chem. constituents, targets and diseases. Last, potential Q-marker were selected by integrating anal. of plant metabolomics and network pharmacol., and the quantification method of Q-marker was developed by using UPLC-TQ-MS. The chem. profiling of GP and JP was investigated. Fifteen distinguishing features were designated as core chem. markers to distinguish GP and JP. Besides, the content of 4-methoxybenzaldehyde-2-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside could be used to identify Periplocae Cortex harvested in spring-autumn or summer. Meanwhile, a total of 15 components targeted rheumatoid arthritis were screened out based on network pharmacol. Taking absorbed constituents into consideration, 23 constituents were selected as potential Q-marker. A simultaneous quantification method (together with 11 semi-quant. anal.) was developed and applied to the anal. of 20 batches of com. Periplocae Cortex on the market. The PLS-DA model was successfully developed to distinguish GP and JP samples. In addition, the artificially mixed GP sample, which contained no less than 10% of the adulterant (JP), could also be correctly identified. Our results indicated that 9 ingredients could be considered as Q-marker of Periplocae Cortex. This study has also demonstrated that the plant metabolomics and network pharmacol. could be used as an effective approach for discovering Q-marker of TCM to fulfill the evaluation of overall chem. consistency among samples from different producing areas, harvest seasons, and even those com. crude drugs, which might be mixed with a small amount of non-medicinal parts. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Asymmetric Total Syntheses of (-)-Fennebricin A, (-)-Renieramycin J, (-)-Renieramycin G, (-)-Renieramycin M, and (-)- Jorunnamycin A via C-H Activation》 was published in Organic Letters in 2020. These research results belong to Zheng, Yu; Li, Xue-Dan; Sheng, Peng-Zhen; Yang, Hong-Dou; Wei, Kun; Yang, Yu-Rong. Recommanded Product: 2-(Benzyloxy)acetaldehyde The article mentions the following:

Collective total synthesis of five tetrahydroisoquinoline alkaloids including the first total synthesis of (-)-fennebricin A and (-)-renieramycin J has been accomplished. The synthesis features employing a single common amino acid to sym. construct the pentacycle of title alkaloids. The palladium-catalyzed arylation of alanine-derived amide developed by Yu was tactically utilized to afford unnatural amino acid building block rapidly and practically. The structure of synthetic (-)-renieramycin M has been confirmed by single crystal X-ray anal. for the first time. The experimental process involved the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Recommanded Product: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Omega included an article by Grattan, Vincent; Vaino, Andrew R.; Prensky, Zachary; Hixon, Mark S.. Application of 4637-24-5. The article was titled 《Antipsychotic benzamides amisulpride and LB-102 display polypharmacy as racemates, S enantiomers engage receptors D2 and D3, while R enantiomers engage 5-HT7》. The information in the text is summarized as follows:

Benzamide antipsychotics such as amisulpride are dosed as racemates though efficacy is assumed to be mediated through S enantiomer binding to D2 receptors. At prescribed doses, the benzamides likely display polypharmacy since brain exposure should be sufficient to engage the 5-HT7 receptors, as well. Curiously, the studies herein reveal that racemic dosing is required to engage both targets since the D2 receptor has an almost 40-fold selectivity for the S enantiomer, while the 5-HT7 receptor has greater than 50-fold preference for the R enantiomer. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Application of 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Green Chemistry included an article by Xu, Yu-Ting; Li, Chen-Yuan; Huang, Xiao-Bo; Gao, Wen-Xia; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue. Synthetic Route of C7H8O2. The article was titled 《Photoinduced hydroxylation of arylboronic acids with molecular oxygen under photocatalyst-free conditions》. The information in the text is summarized as follows:

Photoinduced hydroxylation of boronic acids RB(OH)2 (R = octyl, 1-naphthyl, thianthren-1-yl, benzo[d][1,3]dioxol-5-yl, 9-phenyl-9H-carbazol-2-yl, etc.) with mol. oxygen under photocatalyst-free conditions is reported, providing a green entry to a variety of phenols and aliphatic alcs. ROH in a highly concise fashion. This new protocol features photocatalyst-free conditions, wide substrate scope and excellent functional group compatibility. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Synthetic Route of C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneSynthetic Route of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Investigation of DNA binding and bioactivities of thioether containing Schiff base Copper(II), Cobalt(II) and Palladium(II) complexes: Synthesis, characterization, spectrochemical study, viscosity measurement》 was written by Maiti, Subir Kr; Kalita, Mukul; Singh, Anmol; Deka, Jahnabi; Barman, Pranjit. Recommanded Product: 673-22-3This research focused ontransition metal Schiff salicylaldehyde benzylthioaniline complex preparation bactericide; DNA binding transition metal Schiff salicylaldehyde benzylthioaniline complex; crystal structure transition metal salicylaldehyde benzylthioaniline complex. The article conveys some information:

Three complexes of an ONS donor ligand of the Schiff base [C21H19NO2S] (HL), [Cu(C21H18NO2S)2] (1) [Co(C21H18NO2S)2] (2) and [Pd(C21H18NO2SCl)] (3), were synthesized and characterized by elemental anal., FT-IR, 1H NMR, UV-Visible spectroscopy and single-crystal X-ray diffraction anal. Single crystal X-ray diffraction anal. reveals that the copper complex acquires a distorted pyramidal structure and the palladium complex acquires a square planar structure. All the compounds are stable at room temperature and they show very good antibacterial activities against gram-pos. and gram-neg. bacteria. DNA binding activities of the ligand and its Cu(II), Pd(II) and Co(II) complexes with CT-DNA were carried out in DMF and tris-buffer (5 mM, pH 7.3) solution; all the three complexes along with the ligand show a very good intercalative mode of DNA interaction with Kb values of 1.56(±0.03) x 105 for 1 and 1.02(±0.09) x 105 for 3. The DNA binding activity was confirmed by a hydrodynamic study (viscosity). The order of DNA binding activity is 1 > 3 > 2.2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yamaguchi, Hinano; Kondo, Mizuho; Sasaki, Tomoyuki; Sakamoto, Moritsugu; Ono, Hiroshi; Kawatsuki, Nobuhiro published an article in Langmuir. The title of the article was 《Polarized Fluorescence of N-Salicylideneaniline Derivatives Formed by In Situ Exchange from N-Benzylideneaniline Side Groups in Photoaligned Liquid Crystalline Copolymer Films》.Electric Literature of C8H8O3 The author mentioned the following in the article:

Polarized fluorescence of oriented N-salicylideneaniline (SA) derivatives is explored based on the thermally stimulated photoinduced mol. reorientation of liquid crystalline (LC) copolymethacrylate with N-benzylideneaniline derivative (NBA2) and benzoic acid (BA) side groups. The LC copolymer films show significant cooperative mol. reorientation of the NBA2 and BA side groups (D > 0.7). Subsequent thermal hydrolysis of the NBA2 side groups yields free phenylamine moieties. These moieties can form oriented SA derivatives via in situ condensation with 2-hydroxybenzaldehyde derivatives The excited-state intermol. proton transfer of the oriented SA mols. induces polarized fluorescence at 510-548 nm with a polarization ratio up to 6.2. Direct in situ exchange from the oriented NBA2 to SA derivatives achieves polarized fluorescence similar to that of the SA side groups. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Electric Literature of C8H8O3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Electric Literature of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Moschona, Fotini; Misirlaki, Christina; Karadimas, Nikolaos; Koutiva, Maria; Savvopoulou, Ioanna; Rassias, Gerasimos published an article in Symmetry. The title of the article was 《Organocatalytic Asymmetric Halocyclization of Allylic Amides to Chiral Oxazolines Using DTBM-SEGPHOS-Mechanistic Implications from Hammett Plots》.Product Details of 2398-37-0 The author mentioned the following in the article:

The intramol. halocyclization of alkenes possessing an internal heteroatom nucleophile leads to multifunctional heterocycles which are useful versatile intermediates in organic synthesis. The asym. chlorocyclization of 2-substituted allylic amides ArC(O)NHCH2C(=CH2)R (R = Ph, 4-FC6H4, pyridin-3-yl, naphthalen-1-yl, etc.; Ar = Ph, 4-MeOC6H4, 4-MeC6H4, etc.) gives access to chiral oxazolines I (X = Cl) bearing a chloromethyl moiety for further synthetic manipulation. The literature reports on this transformation involve complex syntheses of the 2-substituted allylic amides and cryogenic temperatures for achieving high enantioselectivities in the organocatalyzed halocyclization step. Based on the Heck reaction of aryl bromides ArBr (Ar = Ph, 4-CNC6H4, pyridin-3-yl, naphthalen-1-yl, etc.;) and Boc-protected allylamine or allylamine benzamides, a practical synthesis of 2-substituted allylic amides that does not require chromatog. was developed and accomplished their asym. halocyclization reaction with 24-92%ee under practical conditions (5°C, CpME) catalyzed by (S)-(+)-DTBM-SEGPHOS. In addition, using appropriately substituted substrates, Hammett plots were generated and formulated a consistent mechanism for the halocyclization reaction which involves two competing modes of formation of the haliranium intermediate whose relative kinetics are governed by the electronic properties of the substrate. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Product Details of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Ma, Na-Na; Ren, Jing-Ao; Liu, Xiang; Chu, Xue-Qiang; Rao, Weidong; Shen, Zhi-Liang published an article in Organic Letters. The title of the article was 《Nickel-Catalyzed Direct Cross-Coupling of Aryl Sulfonium Salt with Aryl Bromide》.Recommanded Product: 1-Bromo-3-methoxybenzene The author mentioned the following in the article:

The direct cross-couplings of aryl sulfonium salts with aryl halides was achieved by using nickel as a reaction catalyst. The reactions proceeded efficiently via C-S bond activation in the presence of magnesium turnings and lithium chloride in THF at ambient temperature to afford the corresponding biaryls in moderate to good yields, potentially served as an attractive alternative to conventional cross-coupling reactions employing preprepared organometallic reagents. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Recommanded Product: 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yimyaem, Jirapat; Chantana, Chayamon; Boonmee, Suthimon; Jaratjaroonphong, Jaray published an article in Synlett. The title of the article was 《Expedient Access to Indolyl-Substituted Tri- and Diarylmethanes and (±)-Colletotryptin E by Silica Sulfuric Acid Catalyzed Transindolylation》.Name: 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:

An expedient access to a series of nonsym. bis(indolyl)methanes (BIMs) through transindolylation of readily available sym. 3,3′-BIMs with various indoles catalyzed by silica-supported sulfuric acid has been established. This approach not only provides a useful strategy for the synthesis of structurally diverse BIMs, but also provides examples of nucleophilic substitution of BIMs with aromatic and nonaromatic π-systems, leading to a library of indolyl-substituted tri- and diarylmethanes. Moreover, this method was successfully applied in the first total synthesis of the 2,3′-BIM alkaloid (±)-colletotryptin E (I) in three steps with an overall yield of 46%. The features of this procedure include a metal-free process, an inexpensive and environmentally friendly catalyst, mild reaction conditions, broad functional-group tolerance, good yields, and gram-scalable preparations In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Name: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem