Tag: 100-200

《Phosphine-Mediated MBH-Type/Umpolung Addition Domino Sequence: Divergent Construction of Coumarins》 was published in Organic Letters in 2020. These research results belong to Deng, Zhi-Xiong; Zheng, Yu; Xie, Zhen-Zhen; Gao, Yue-Heng; Xiao, Jun-An; Xie, Si-Qi; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. Safety of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

A phosphine-mediated domino process of MBH-type reaction/umpolung γ-addition through the rational integration of the privileged reactivities of alkynoate is reported. Simply by manipulating the nucleophilic reagent, the developed protocol offers a facile, diversity-oriented construction of a wide range of three-substituted coumarins. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Safety of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Green-light activatable, water-soluble red-shifted coumarin photocages》 were Bojtar, Marton; Kormos, Attila; Kis-Petik, Katalin; Kellermayer, Miklos; Kele, Peter. And the article was published in Organic Letters in 2019. Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The author mentioned the following in the article:

Easily accessible green-light activatable (>500 nm) photocages based on red-shifted, π-extended coumarin scaffolds are developed with uncaging efficiencies similar to those of recently introduced BODIPY derivatives The photocages possess increased aqueous solubility, high absorption coefficients within the 450-600 nm range, and exceptionally high two-photon cross sections. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Rhenium-Catalyzed Regioselective ortho-Alkenylation and [3 + 2 + 1] Cycloaddition of Phenols with Internal Alkynes》 were Murai, Masahito; Yamamoto, Masaki; Takai, Kazuhiko. And the article was published in Organic Letters in 2019. COA of Formula: C7H8O2 The author mentioned the following in the article:

An operationally simple and direct rhenium-catalyzed ortho-alkenylation (C-alkenylation) of unprotected phenols with alkynes was developed. The protocol provided ortho-alkenylphenols exclusively, and formation of para- or multiply alkenylated phenols and hydrophenoxylation (O-alkenylation) products were not observed The [3 + 2 + 1] cycloaddition of phenols and two alkynes via ortho-alkenylation was also demonstrated, in which the alkynes functioned as both two- and one-carbon units. These reactions proceeded with readily available starting materials under neutral conditions without addnl. ligands. In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6COA of Formula: C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.COA of Formula: C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Omega included an article by Jadhav, Nirajkumar H.; Sakate, Sachin S.; Rasal, Nishant K.; Shinde, Dnyaneshwar R.; Pawar, Ramdas A.. Recommanded Product: m-Methoxyphenol. The article was titled 《Heterogeneously Catalyzed Pechmann Condensation Employing the Tailored Zn0.925Ti0.075O NPs: Synthesis of Coumarin》. The information in the text is summarized as follows:

A novel heterogeneous catalytic method was developed for the synthesis of coumarin and its derivatives using the Ti(IV)-doped ZnO matrix forming catalyst Zn0.925Ti0.075O having a high surface area and good Lewis acidity. The catalyst shows high activity toward a broad spectrum of the substituted phenols with β-ketoesters such as Et acetoacetate, Et butyryl acetate, Et benzoyl acetate, and so forth in good yields over short reaction times during the synthesis of coumarins. The methodol. was further extended for the synthesis of ayapin mols. The catalyst also shows recycle activity up to seven cycles with very good stability. After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ChemistrySelect included an article by Maddila, Suresh; Nagaraju, Kerru; Chinnam, Sampath; Jonnalagadda, Sreekantha B.. Electric Literature of C8H8O2. The article was titled 《Microwave-Assisted Multicomponent Reaction: A Green and Catalyst-Free Method for the Synthesis of Poly-Functionalized 1,4-Dihydropyridines》. The information in the text is summarized as follows:

A facile and an efficient procedure for the synthesis of poly-substituted 1,4-dihydropyridine derivatives under catalyst-free conditions was established by a one-pot multi-component reaction in EtOH solvent under microwave irradiation (150 W). The remarkable benefits of this approach were: simple operation, non-toxic, short reaction time (< 5 min), excellent yields (93-98%), no column chromatog., clean reaction profile and environmentally friendly reaction. In addition to this study using 2-Methoxybenzaldehyde, there are many other studies that have used 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Electric Literature of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic Letters included an article by Peng, Jin-Bao; Li, Da; Geng, Hui-Qing; Wu, Xiao-Feng. Recommanded Product: 10365-98-7. The article was titled 《Palladium-Catalyzed Amide Synthesis via Aminocarbonylation of Arylboronic Acids with Nitroarenes》. The information in the text is summarized as follows:

A palladium-catalyzed aminocarbonylation of aryl boronic acids with nitroarenes for the synthesis of amides was developed. A wide range of substrates were well-tolerated and gave the corresponding amides in moderate to good yields. No external oxidant or reductant was needed in this procedure. This procedure provides a redox-economical process for the synthesis of amides. In addition to this study using 3-Methoxyphenylboronic acid, there are many other studies that have used 3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 10365-98-7) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic Letters included an article by Hoang, Gia L.; Zoll, Adam J.; Ellman, Jonathan A.. Synthetic Route of C9H10O2. The article was titled 《Three-Component Coupling of Aldehydes, 2-Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C-H Activation: Synthesis of Pyrido[1,2-a]pyrimidin-4-ones》. The information in the text is summarized as follows:

Imines formed in situ from 2-aminopyridines and aldehydes undergo Rh(III)-catalyzed imidoyl C-H activation and coupling with diazo esters to give pyrido[1,2-a]pyrimidin-4-ones. Aromatic and enolizable aliphatic aldehydes were both effective substrates, and a broad range of functional groups were incorporated at different sites on the heterocyclic products. In addition, methoxy and dimethylamino functionalities could be directly installed on the pyrimidine ring by employing tri-Me orthoformate or N,N-dimethylformamide di-Me acetal in place of the aldehyde, resp. The results came from multiple reactions, including the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Synthetic Route of C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Synthetic Route of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Molecules included an article by Tsakama, Madalitso; Ma, Xiaochi; He, Yonghuan; Chen, Weihua; Dai, Xiaofeng. Formula: C12H10O2. The article was titled 《A simple mannose-coated poly (p-phenylene ethynylene) for qualitative bacterial capturing》. The information in the text is summarized as follows:

A mannose-functionalized poly (p-phenylene ethynylene) was rationally designed to achieve selective detection of bacteria. The polymer was constructed as a signaling unit and was modified by attaching aminoethyl mannose using the carboxylic acid group at the end of the linker. Incubation of Escherichia coli with the polymer yielded fluorescent bacteria aggregates through polyvalent interactions. The utility of the mannose functionalized polymer to detect E. coli expressing functional FimH mannose-specific lectin on their surface was also demonstrated. The sugar units displayed on the surface of the polymer retained their functional ability to interact with mannose-binding lectin. To determine the optimum binding time, we measured the fluorescence intensity of the polymer-bacteria suspension at intervals. Our results showed that binding in this system will reach an optimum level within 30 min of incubation. The polymers affinity for bacteria has been demonstrated and bacteria with a concentration of 103 CFU mL-1 can be detected by this system. After reading the article, we found that the author used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Formula: C12H10O2)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Formula: C12H10O2 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Cu-Catalyzed four-component polymerization of alkynes, sulfonyl azides, nucleophiles and electrophiles》 was published in Polymer Chemistry in 2021. These research results belong to He, Junnan; Zheng, Nan; Li, Ming; Zheng, YuBin; Song, Wangze. Safety of 1,4-Diethynyl-2,5-dimethoxybenzene The article mentions the following:

Multicomponent polymerization has emerged as a promising strategy to develop functional polymers with versatile structures. In this work, a Cu-catalyzed four-component polymerization was developed using diynes, sulfonyl azides, nucleophiles, and a variety of electrophiles including alkyl glyoxylates, nitroalkenes, and Morita-Baylis-Hillman adducts to successfully synthesize a library of α-functionalized poly(N-sulfonylimidates)s with a wide substrate scope and high mol. weights (up to 20 000 g mol-1) in high yields (up to 86%). Such α-functionalized poly(N-sulfonylimidates)s could be further post-modified or utilized for the design of multi-functional and biodegradable polymers. In the experiment, the researchers used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Safety of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Safety of 1,4-Diethynyl-2,5-dimethoxybenzene They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 2-Hydroxy-4-methoxybenzaldehydeIn 2021 ,《A ratiometric photoelectrochemical microsensor based on a small-molecule organic semiconductor for reliable in vivo analysis》 was published in Chemical Science. The article was written by Xiang, Yunhui; Kong, Yao; Feng, Wenqi; Ye, Xiaoxue; Liu, Zhihong. The article contains the following contents:

Photoelectrochem. (PEC) sensing has been developing quickly in recent years, while its in vivo application is still in the infancy. The complexity of biol. environments poses a high challenge to the specificity and reliability of PEC sensing. We herein proposed the concept of small-mol. organic semiconductor (SMOS)-based ratiometric PEC sensing making use of the structural flexibility as well as readily tunable energy band of SMOS. Xanthene skeleton-based CyOH was prepared as a photoactive mol., and its absorption band and corresponding PEC output can be modulated by an intramol. charge transfer process. As such, the target mediated shift of absorption offered the opportunity to construct a ratiometric PEC sensor. A proof-of-concept probe CyOThiols was synthesized and assembled on a Ti wire electrode (TiWE) to prepare a highly selective microsensor for thiols. Under two monochromatic laser excitation (808 nm and 750 nm), CyOThiols/TiWE offered a ratiometric signal (j808/j750), which exhibited pronounced capacity to offset the disturbance of environmental factors, guaranteeing its reliability for application in vivo. The ratiometric PEC sensor achieved the observation of bio-thiol release induced by cytotoxic edema and fluctuations of thiols in drug-induced epilepsy in living rat brains. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem