Tag: 100-200

In 2022,Xie, Huilin; Lin, Chuankai; Wang, Ruixiang; Liu, Jin-Biao published an article in Tetrahedron Letters. The title of the article was 《Synthesis of salicylates from anionically activated aromatic trifluoromethyl group》.Application of 150-19-6 The author mentioned the following in the article:

An efficient approach to salicylates via a novel transformation of anionically activated aromatic trifluoromethyl group is described. 2-(Trifluoromethyl)phenol reacts with phenols/alcs. under alk. conditions to afford the corresponding aryl/alkyl salicylates in high yields. Mechanism studies indicated that the carbonyl oxygen atom of ester is from the H2O in the solvent. The experimental process involved the reaction of m-Methoxyphenol(cas: 150-19-6Application of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application of 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Wang, Zheng-Hai; Wang, Dong-Hui published an article in Organic Letters. The title of the article was 《Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime》.Electric Literature of C7H8O2 The author mentioned the following in the article:

A Cu-catalyzed straightforward synthesis of benzoxazoles I [R = 5-iPr, 5-NHAc, 7-Bn, etc.; Ar = Ph, 1-naphthyl, 2-furyl, etc.] from free phenols and cyclic oxime esters was reported. The mild reaction conditions tolerate various electron-withdrawing and electron-donating functional groups on both substrates, affording benzoxazoles in moderate to good yields. With this protocol, large-scale syntheses of Ezutromid and Flunoxaprofe in one or two steps were demonstrated. A catalytic mechanism, which included Cu-catalyzed amination via inner-sphere electron transfer and consequent annulation, was proposed. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6Electric Literature of C7H8O2) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneElectric Literature of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dong, Yubao; Zhu, Li; Yin, Bing; Zhu, Xinrui; Li, Dongfeng published their research in Dalton Transactions in 2021. The article was titled 《Regulating the magnetic properties of seven-coordinated Dy(III) single-ion magnets through the effect of positional isomers on axial crystal-field》.Category: ethers-buliding-blocks The article contains the following contents:

Six Dy(III) single-ion magnets (SIMs) [Dy(n-OMe-bbpen)X] were synthesized by a solvothermal reaction with three positional isomers (ortho, meta, and para) of ligands n-OMe-H2bbpen and dysprosium halides DyX3, (n-OMe-H2bbpen = N,N′-bis(2-hydroxy-n-methoxybenzyl)-N,N′-bis(2-methylpyridyl)ethylenediamine; n = 3, X = Cl, 1; n = 3, X = Br, 2; n = 4, X = Cl, 3; n = 4, X = Br, 4; n = 5, X = Cl, 5; n = 5, X = Br, 6). Dynamic magnetic measurements revealed that the six complexes possess notably different effective barriers of magnetic reversal: 872.0 K (1), 1210.1 K (2), 137.9 K (3), 602.6 K (4), 907.0 K (5) and 1216.7 K (6). 6 showed the best performance as SIMs among the six Dy(III) complexes. Moreover, the magnetic hysteresis loops of 6 remained open at 21 K. The crystal structures indicate the switching of local symmetry around Dy(III) ion, aroused by the variation in intermol. interactions and steric effects. This switch is primarily correlated with the distinction of magnetic properties. In addition, ab initio calculations confirmed that the different electrostatic potential around Dy(III) ion stemming from the electronic effect of the OMe-substituted group is another factor leading to the distinction in magnetic properties. This work warns us that when designing ligands for Dy-SIMs, the effect of positional isomerism on magnetic performance must be considered, which is one of the factors that can easily be overlooked.2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pramanik, Milan; Mathuri, Ashis; Sau, Sudip; Das, Monojit; Mal, Prasenjit published their research in Organic Letters in 2021. The article was titled 《Chlorinative Cyclization of Aryl Alkynoates Using NCS and 9-Mesityl-10-methylacridinium Perchlorate Photocatalyst》.Electric Literature of C7H8O2 The article contains the following contents:

In a chlorinative cyclization, Mes-Acr-MeClO4 acted as a visible-light photocatalyst to obtain 3-chlorocoumarins I [Ar = Ph, 4-ClC6H4, 1-naphthyl, etc.; R = H, 7-Me, 6-MeO, etc.] from aryl alkynoates and N-chlorosuccinimide (NCS). The radical initiated reaction proceeded in a cascading manner via Cl- addition to alkynoates. Next, 5-exo-trig spirocyclization and subsequent 1,2-ester migration led to the formation of C-C and C-Cl bonds. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Electric Literature of C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneElectric Literature of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Ni-Catalyzed reductive amination of phenols with ammonia or amines into cyclohexylamines》 was written by Cuypers, Thomas; Morias, Thomas; Windels, Simon; Marquez, Carlos; Van Goethem, Cedric; Vankelecom, Ivo; De Vos, Dirk E.. Computed Properties of C7H8O2 And the article was included in Green Chemistry in 2020. The article conveys some information:

Phenol and its derivatives, which naturally occur in lignocellulose, can be considered as a renewable feedstock not only for aromatic, but also for alicyclic compounds, such as primary and N-substituted cyclohexylamines. So far, the latter are mostly produced from non-renewable starting materials like benzene via problematic nitration/reduction or cross-coupling routes. Herein, an efficient reductive amination of phenol with ammonia or amines is demonstrated, for the first time without the need for rare and expensive noble metals and without using any additives. Various supported Ni catalysts were screened and we elucidated the influence of the key parameters, including the acid-base properties of the supporting material. Acquired knowledge was then applied to different phenol-ammonia/amine combinations, resulting in the synthesis of various primary, secondary and tertiary cyclohexylamines in fair to very high yields. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6Computed Properties of C7H8O2) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Computed Properties of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Diastereoselective olefin amidoacylation via photoredox PCET/nickel-dual catalysis: reaction scope and mechanistic insights》 was written by Zheng, Shuai; Zhang, Shuo-Qing; Saeednia, Borna; Zhou, Jiawang; Anna, Jessica M.; Hong, Xin; Molander, Gary A.. Formula: C9H10O2 And the article was included in Chemical Science in 2020. The article conveys some information:

Synthesis of cyclic amides such as I via regio- and diastereoselective amidoacylation of unactivated olefins by using photoredox proton-coupled electron transfer (PCET)/Ni dual-catalysis was developed. Various acyl electrophiles were compatible, including alkyl- and aryl acyl chlorides and anhydrides, as well as in situ activated carboxylic acids. Hammett studies and other mechanistic experiments to elucidate features of the diastereoselectivity, a transient absorption study of the PCET step, as well as computational evidence, provide an in-depth understanding of the disclosed transformation. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper-catalyzed arylated etherification of 2,2-difluoroethanol and its mechanistic study》 was written by Huang, Shuaishuai; Nie, Yixue; Yang, Jingjing; Zheng, Zhanjiang; Cao, Jian; Xu, Zheng; Xu, Liwen. SDS of cas: 2398-37-0 And the article was included in Youji Huaxue in 2020. The article conveys some information:

A mild and efficient method for the preparation of difluoroethyl aryl ethers was developed by the copper-catalyzed Ullmann-type arylated etherification reaction of aryl bromides or iodides with 2,2-difluoroethanol. This reaction proceeded smoothly in the presence of CuI and 8-hydroxyquinoline/t-BuOK and has a broad substrate scope. ESI-MS anal. supported the existence of LCu(III)Ar(OR) species during this catalytic reaction. Further d. functional theory (DFT) calculations suggested a proposed mechanism of arylated etherification reaction involving oxidative addition, followed by nucleophile substitution and reductive elimination would be rational. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3-methoxybenzene(cas: 2398-37-0SDS of cas: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.SDS of cas: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2020 ,《Enamines and Dimethylamino Imines as Building Blocks in Heterocyclic Synthesis: Reactions of DMF-DMA Reagent with Different Functional Groups》 appeared in ChemistrySelect. The author of the article were Guemues, Mehmet; Koca, Irfan. The article conveys some information:

A review. Herein, the reactions of DMF-DMA reagent with different functional groups were categorized in four classes (methylene, Me, amino, other groups) and the reactions of obtained enamine and dimethylamino imine compounds were investigated in detail such as nucleophilic addition, intramol. cyclization or condensation reactions. The synthesis and continuation reactions of the enamine and dimethylamino imine compounds were also examined in terms of exptl. conditions and reagents used.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Hebade, Madhav J.; Shimpi, Ravindra P.; Chavan, Omprakash S. published an article in Pharma Chemica. The title of the article was 《Microwave assisted, fly ash catalyzed synthesis of coumarin derivatives: green approach》.Synthetic Route of C7H8O2 The author mentioned the following in the article:

Solvent free synthesis of substituted coumarin by Von Pechmann condensation of phenols with β-ketoesters catalyzed by fly ash as a byproduct from thermal power station by microwave irradiation method is reported. Authors present protocol is economical and clean comprise of green reagent, solvent and catalyst. The experimental process involved the reaction of m-Methoxyphenol(cas: 150-19-6Synthetic Route of C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneSynthetic Route of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Jia, Le; Li, Chao-Jun; Zeng, Huiying published an article in Chinese Chemical Letters. The title of the article was 《Cleavage/cross-coupling strategy for converting β-O-4 linkage lignin model compounds into high valued benzyl amines via dual C-O bond cleavage》.Quality Control of m-Methoxyphenol The author mentioned the following in the article:

Lignin is the most recalcitrant of the three components of lignocellulosic biomass. The strength and stability of the linkages have long been a great challenge for the degradation and valorization of lignin biomass to obtain bio-fuels and com. chems. Up to now, the selective cleavage of C-O linkages of lignin to afford chems. contains only C, H and O atoms. Authors’ group has developed a cleavage/cross-coupling strategy for converting 4-O-5 linkage lignin model compounds into high value-added compounds Herein, a palladium-catalyzed cleavage/cross-coupling of the β-O-4 lignin model compounds with amines via dual C-O bond cleavage for the preparation of benzyl amine compounds and phenols is presented. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem