Tag: 100-200

Avcu Altiparmak, Elif; Yazar, Sibel; Ozdemir, Namik; Bal-Demirci, Tulay; Ulkuseven, Bahri published an article in 2021. The article was titled 《Supramolecular Ni(II) complex aggregates with a circular linkage of intermolecular multi-hydrogen bonding frameworks based on thiosemicarbazone, and a Cu(II) complex: Synthesis, structural, DFT, electrochemical and antioxidant studies》, and you may find the article in Polyhedron.Safety of 2-Hydroxy-4-methoxybenzaldehyde The information in the text is summarized as follows:

Copper(II) and nickel(II) mixed ligand complexes were synthesized from 4-methoxysalicylaldehyde-N-phenyl-thiosemicarbazone and 3,5-lutidine. The structures of the complexes were characterized by elemental anal., IR, UV, 1H NMR and ESI-MS spectra, together with magnetic susceptibility measurements. Complex I has a distorted square planar geometry, with coordination of azomethine nitrogen, thiolate sulfur, phenolate oxygen and pyridyl nitrogen atoms, by the single-crystal x-ray diffraction technique. Quantum chem. DFT calculations also were carried out using the DFT/HSEH1PBE method with the cc-pVDZ basis set for C, H, N, O and S atoms, and the LANL2DZ basis set for the metal atom. The antioxidant activities of the ligand and its metal complexes were studied by CUPRAC and DPPH assays and calculated as their trolox equivalent antioxidant capacities (TEAC). Electrochem. properties were performed with cyclic voltammetry and square wave voltammetry. Both the ligand and its metal complexes have antioxidant capacity. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Safety of 2-Hydroxy-4-methoxybenzaldehyde

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Zhu, Zhaoyang; Zhang, Xue; Guo, Xing; Wu, Qinghua; Li, Zhongxin; Yu, Changjiang; Hao, Erhong; Jiao, Lijuan; Zhao, Jianzhang published an article in 2021. The article was titled 《Orthogonally aligned cyclic BODIPY arrays with long-lived triplet excited states as efficient heavy-atom-free photosensitizers》, and you may find the article in Chemical Science.Synthetic Route of C7H9BO3 The information in the text is summarized as follows:

In photosensitizers, long triplet excited state lifetimes are key to their efficient electron transfer or energy transfer processes. Herein, we report a novel class of cyclic trimeric BODIPY arrays which were efficiently generated from easily accessible meso-mesityldipyrrinone and arylboronic acids in one pot. Arylboronic acid, for the first time, was used to provide a boron source for BODIPY derivatives Due to the well-defined and orthogonally aligned BODIPY cores as verified by X-ray crystallog., these BODIPY arrays show strong exciton coupling effects and efficient intersystem crossings, and are novel heavy-atom-free photosensitizers with a long-lived triplet excited state (lifetime up to 257.5 μs) and good reactive oxygen species generation efficiency (up to 0.72) contributed by both 1O2 and O2- under light irradiation The experimental part of the paper was very detailed, including the reaction process of 3-Methoxyphenylboronic acid(cas: 10365-98-7Synthetic Route of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

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Shon, Jong-Hwa; Kim, Dooyoung; Rathnayake, Manjula D.; Sittel, Steven; Weaver, Jimmie; Teets, Thomas S. published their research in Chemical Science in 2021. The article was titled 《Photoredox catalysis on unactivated substrates with strongly reducing iridium photosensitizers》.Formula: C7H7BrO The article contains the following contents:

In this work, the strong bis-cyclometalated iridium photoreductants with electron-rich β-diketiminate (NacNac) ancillary ligands enable high-yielding photoredox transformations of challenging substrates with very simple reaction conditions that require only a single sacrificial reagent. Using blue or green visible-light activation a variety of reactions, which include hydrodehalogenation, cyclization, intramol. radical addition, and prenylation via radical-mediated pathways, with optimized conditions that only require the photocatalyst and a sacrificial reductant/hydrogen atom donor were demonstrated. Many of these reactions involve organobromide and organochloride substrates RX (R = 3-methoxyphenyl, 4-cyanophenyl, {1-[(benzyloxy)carbonyl]piperidin-4-yl}, etc.; X = Br, Cl) which in the past have had limited utility in photoredox catalysis. This work paves the way for the continued expansion of the substrate scope in photoredox catalysis. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Formula: C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Formula: C7H7BrO

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Ether – Wikipedia,
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Gao, Peng-Chao; Wang, Zi-Xuan; Li, Bi-Jie published their research in Organic Letters in 2021. The article was titled 《Iridium-Catalyzed Regioselective Hydroalkynylation of Internal Alkenes Directed by an Oxime》.Reference of 2-(Benzyloxy)acetaldehyde The article contains the following contents:

An iridium-catalyzed hydroalkynylation of allylic alcs. protected by an oxime group was reported. Catalytic alkynylation occurred exclusively at the distal position of the alkene. This method generated γ-alkynyl alc. oximes directly from internal alkenes and terminal alkynes. The oxime group was readily removed to afford a free alc., thus providing an indirect route for the catalytic hydroalkynylation of allylic alcs.2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Reference of 2-(Benzyloxy)acetaldehyde) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Reference of 2-(Benzyloxy)acetaldehyde

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Ether – Wikipedia,
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Liu, Chen-Fei; Wang, Hongyu; Martin, Robert T.; Zhao, Haonan; Gutierrez, Osvaldo; Koh, Ming Joo published their research in Nature Catalysis in 2021. The article was titled 《Olefin functionalization/isomerization enables stereoselective alkene synthesis》.Quality Control of 2-(Benzyloxy)acetaldehyde The article contains the following contents:

The catalytic amounts of a non-precious N-heterocyclic carbene-Ni(I) complex in conjunction with a sterically bulky base promote site- and trans-selective union of monosubstituted olefins CH2=CHC(R1)R2 (R1 = Ph, naphthalen-1-yl, furan-2-yl, etc.; R2 = H, Me, Ph; R1R2 = 1-[(tert-butoxy)(oxo)methane]piperidin-4-yl, 1-[(tert-butoxy)(oxo)methane]azetidin-3-yl) with a wide array of electrophilic reagents R3OTf (R3 = Ph, 1-benzyl-1H-indol-5-yl, 4-methoxyphenyl, etc.) and bis(pinacolato)diboron to deliver tri- and tetrasubstituted alkenes E/Z-R3C(CH3)=CR1R2 in up to 92% yield and >98% regio- and stereoselectivity were demonstrated. The protocol is amenable to the preparation of carbon- and heteroatom-substituted C=C bonds, providing distinct advantages over existing transformations. Utility is highlighted through concise stereoselective synthesis of biol. active compounds In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Quality Control of 2-(Benzyloxy)acetaldehyde) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Quality Control of 2-(Benzyloxy)acetaldehyde

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Dialkylation of 1,3-Dienes by Dual Photoredox and Chromium Catalysis》 was written by Schwarz, J. Luca; Huang, Huan-Ming; Paulisch, Tiffany O.; Glorius, Frank. HPLC of Formula: 60656-87-3 And the article was included in ACS Catalysis in 2020. The article conveys some information:

The direct conversion of feedstock chems. into value-added products is of broad interest in chem. research. Herein, we present a regioselective and diastereoselective three-component dialkylation of feedstock 1,3-dienes with Hantzsch esters and aldehydes for the synthesis of homoallylic alcs. The reaction is enabled by dual photoredox and chromium catalysis and can also be performed enantioselectively by employing chromium-bisoxazoline complexes. In the part of experimental materials, we found many familiar compounds, such as 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3HPLC of Formula: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).HPLC of Formula: 60656-87-3

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Ether – Wikipedia,
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《2′-Fluorinated Hydantoins as Chemical Biology Tools for Base Excision Repair Glycosylases》 was written by Cao, Sheng; Rogers, JohnPatrick; Yeo, Jongchan; Anderson-Steele, Brittany; Ashby, Jonathan; David, Sheila S.. Application In Synthesis of N,N-Dimethylformamide Dimethyl Acetal And the article was included in ACS Chemical Biology in 2020. The article conveys some information:

The guanine oxidation products, 5-guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp), are mutagenic and toxic base lesions that are removed by Fpg, Nei, and the Nei-like (NEIL) glycosylases as the first step in base excision repair (BER). The hydantoins are excellent substrates for the NEIL glycosylases in a variety of DNA contexts beyond canonical duplex DNA, implicating the potential impact of repair activity on a multitude of cellular processes. In order to prepare stable derivatives as chem. biol. tools, oligonucleotides containing fluorine at the 2′-position of the sugar of 8-oxo-7,8-dihydro-2′-deoxyguanosine2′-F-OG) were synthesized in ribo and arabino configuration. Selective oxidation of 2′-F-OG within a DNA oligonucleotide provided the corresponding 2′-F-Gh or 2′-F-Sp containing DNA. The 2′-F-hydantoins in duplex DNA were found to be highly resistant to the glycosylase activity of Fpg and NEIL1 compared to the unmodified lesion substrates. Surprisingly, however, some glycosylase-mediated base removal from both the 2′-F-ribo- and 2′-F-arabinohydantoin duplex DNA was observed Notably, the associated β-lyase strand scission reaction of the 2′-F-arabinohydantoins was inhibited such that the glycosylases were “”stalled”” at the Schiff-base intermediate. Fpg and NEIL1 showed high affinity for the 2′-F-Gh duplexes in both ribo and arabino configurations. However, binding affinity assessed using catalytically inactive variants of Fpg and NEIL1 indicated higher affinity for the 2′-F-riboGh-containing duplexes. The distinct features of glycosylase processing of 2′-F-ribohydantoins and 2′-F-arabinohydantoins illustrate their utility to reveal structural insight into damage recognition and excision by NEIL and related glycosylases and provide opportunities for delineating the impact of lesion formation and repair in cells. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application In Synthesis of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Application In Synthesis of N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
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《Versatile cobalt-catalyzed regioselective chain-walking double hydroboration of 1,n-dienes to access gem-bis(boryl)alkanes》 was published in Nature Communications in 2020. These research results belong to Hu, Ming; Ge, Shaozhong. Name: 2-(Benzyloxy)acetaldehyde The article mentions the following:

Double hydroboration of dienes is the addition of a hydrogen and a boryl group to the two double bonds of a diene mol. and represents a straightforward and effective protocol to prepare synthetically versatile bis(boryl)alkanes, provided that this reaction occurs selectively. However, this reaction can potentially yield several isomeric organoboron products, and it still remains a challenge to control the regioselectivity of this reaction, which allows the selective production of a single organoboron product, in particular, for a broad scope of dienes. By employing a readily available cobalt catalyst, here authors show that this double hydroboration yields synthetically useful gem-bis(boryl)alkanes with excellent regioselectivity. In addition, the scope of dienes for this reaction is broad and encompasses a wide range of conjugated and non-conjugated dienes. Furthermore, mechanistic studies indicate that this cobalt-catalyzed double hydroboration occurs through boryl-directed chain-walking hydroboration of alkenylboronates generated from anti-Markovnikov 1,2-hydroboration of 1,n-diene. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Name: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Visible-light-mediated Minisci C-H alkylation of heteroarenes with 4-alkyl-1,4-dihydropyridines using O2 as an oxidant》 was published in Green Chemistry in 2020. These research results belong to Dong, Jianyang; Yue, Fuyang; Xu, Wentao; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin. COA of Formula: C9H10O2 The article mentions the following:

A protocol for direct visible-light-mediated Minisci C-H alkylation reactions of N-heteroarenes with 4-alkyl-1,4-dihydropyridines for synthesis of alkylated N-heteroarenes such as I at room temperature with mol. oxygen as an oxidant was reported. The protocol permitted efficient functionalization of various N-heteroarenes with a broad range of cyclic and acyclic primary, secondary and tertiary alkyl groups and was scalable to the gram level. This mild protocol used an inexpensive, green oxidant and was suitable for late-stage C-H alkylation of complex nitrogen-containing mols. Its utility was demonstrated by preparing or functionalizing several pharmaceuticals and natural products. After reading the article, we found that the author used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.COA of Formula: C9H10O2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Visible light induced oxidative hydroxylation of boronic acids》 were Ding, Aishun; Zhang, Yanbin; Chen, Yang; Rios, Ramon; Hu, Jianhua; Guo, Hao. And the article was published in Tetrahedron Letters in 2019. HPLC of Formula: 150-19-6 The author mentioned the following in the article:

A visible light-induced aerobic oxidative hydroxylation of boronic acids was reported. The reaction employed 7H-benzo[c]thioxanthen-7-one as metal-free catalyst and di-Me carbonate as green solvent. Scale-up experiment was achieved using 0.1 mol% catalyst in a good yield with column-free purification This reaction showed great green chem. features and potential in synthetic applications. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6HPLC of Formula: 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.HPLC of Formula: 150-19-6

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem