Tag: 100-200

Monteith, John J.; Rousseaux, Sophie A. L. published their research in Organic Letters in 2021. The article was titled 《Ni-Catalyzed C(sp3)-O Arylation of α-Hydroxy Esters》.Recommanded Product: 2398-37-0 The article contains the following contents:

A synthesis of α-aryl ester products I [R1 = Et, Bn, Cy, etc.; R2 = H, Me, CH2Bn; R3 = Ph, 4-MeOC6H4, 4-FC6H4, etc.] via Negishi cross-coupling of α-hydroxy ester derivativesof thiocarbonyl imidazolide and aryl zinc reagents was developed. This reaction tolerated both primary and secondary C(sp3)-O alc. precursors and achieved efficient cross-coupling under Ni catalysis without the need for added external metal reductant, photocatalyst or additives. The arylation of readily accessible C(sp3)-O electrophiles in this operationally simple, rapid, and mild reaction provided a complementary way of accessing desirable α-aryl ester products I. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Recommanded Product: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Chemical Science included an article by Zhou, Tongliang; Ji, Chong-Lei; Hong, Xin; Szostak, Michal. SDS of cas: 10365-98-7. The article was titled 《Palladium-catalyzed decarbonylative Suzuki-Miyaura cross-coupling of amides by carbon-nitrogen bond activation》. The information in the text is summarized as follows:

The first palladium-catalyzed decarbonylative Suzuki-Miyaura cross-coupling of amides RC(O)NR1R2 [R = Ph, naphth-2-yl, benzo[d][1,3]dioxol-5-yl, etc.; R1 = Ac, Ms, Ts, Boc; R2 = Me, Ph, Boc; R1R2 = -C(O)(CH2)3C(O)-, -C(O)(CH2)2C(O)-] and N-benzoylphthalimide for the synthesis of biaryls RR3 (R3 = cyclopropyl, thiophen-3-yl, dimethyl-1,2-oxazol-4-yl, etc.) through the selective activation of the N-C(O) bond of amides has been reported. This new method relies on the precise sequence engineering of the catalytic cycle, wherein decarbonylation occurs prior to the transmetalation step. The reaction is compatible with a wide range of boronic acids R3B(OH)2 and amides, providing valuable biaryls in high yields (>60 examples). DFT studies support a mechanism involving oxidative addition, decarbonylation and transmetalation and provide insight into high N-C(O) bond activation selectivity. Most crucially, the reaction establishes the use of palladium catalysis in the biaryl Suzuki-Miyaura cross-coupling of the amide bond and should enable the design of a wide variety of cross-coupling methods in which palladium rivals the traditional biaryl synthesis from aryl halides and pseudohalides. In addition to this study using 3-Methoxyphenylboronic acid, there are many other studies that have used 3-Methoxyphenylboronic acid(cas: 10365-98-7SDS of cas: 10365-98-7) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.SDS of cas: 10365-98-7

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quality Control of (3-Methoxy-2-methylphenyl)methanolOn May 4, 2018 ,《α-Ketocarbenium Ions Derived from Orthoquinone-Containing Polycyclic Aromatic Compounds》 appeared in Organic Letters. The author of the article were Urakawa, Kazuki; Kawabata, Yuta; Matsuda, Masaki; Sumimoto, Michinori; Ishikawa, Hayato. The article conveys some information:

α-Ketocarbenium ions derived from synthesized orthoquinone-containing polycyclic aromatic compounds were generated in the presence of Bronsted acids such as sulfuric acid, trifluoromethanesulfonic acid, and fluorosulfonic acid. The prepared α-ketocarbenium ions were stabilized by conjugation of the aromatic moiety. In addition, unique absorption properties of the α-ketocarbenium ions were observed and identified on the basis of the calculated absorption spectra. It was suggested that the zigzag-shaped architecture stabilizes the newly discovered α-ketocarbenium ions derived from orthoquinone-containing polycyclic aromatic compounds The experimental process involved the reaction of (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Quality Control of (3-Methoxy-2-methylphenyl)methanol)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Quality Control of (3-Methoxy-2-methylphenyl)methanolAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

HPLC of Formula: 2398-37-0In 2019 ,《Pd nanoparticles at N-heterocyclic carbene at ZIF-8 as an ultrafine, robust and sustainable heterogeneous system for Suzuki-Miyaura cross coupling processes》 was published in Materials Letters. The article was written by Azad, Mohammad; Rostamizadeh, Shahnaz; Nouri, Fatemeh; Estiri, Hamid; Fadakar, Younes. The article contains the following contents:

Producing nanoparticles with controlled size without any aggregation is an important challenge for enhancing the catalytic activities of the metal nanoparticles (MNPs) supported on metal-organic frameworks (MOFs). In this work, a new hybrid nanoporous material, Pd nanoparticles at N-heterocyclic carbene at zeolitic imidazolate framework (Pd NPs at NHC at ZIF-8), with a high internal surface area was successfully prepared by immobilizing anionic sulfonated N-heterocyclic carbene-palladium(II) precursor inside the cavities of ZIF-8 using “”impregnation approach”” followed by reduction with NaBH4. The as-prepared new Pd NPs at NHC at ZIF-8 composite proved to be highly active and showed excellent stability as a heterogeneous catalyst for Suzuki-Miyaura cross-coupling reaction. The results came from multiple reactions, including the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0HPLC of Formula: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.HPLC of Formula: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

HPLC of Formula: 673-22-3In 2021 ,《Radical induced quartet photosensitizers with high 1O2 production for in vivo cancer photodynamic therapy》 was published in Science China: Chemistry. The article was written by Xu, Feng; Ge, Haoying; Xu, Ning; Yang, Cheng; Yao, Qichao; Long, Saran; Sun, Wen; Fan, Jiangli; Xu, Xinsheng; Peng, Xiaojun. The article contains the following contents:

Singlet oxygen (1O2) is a strong oxidant which plays important roles in photodynamic therapy (PDT). The exploitation of photosensitizers with high 1O2 production is crucial to improve PDT efficiency. In this study, a radical labeled quartet photosensitizer Cy-DENT is reported with high singlet oxygen quantum yield (ΦΔ=32.3%) due to a radical enhanced inter-system crossing (ISC) process. After the introduction of 2,2,6,6-tetramethylpiperidinyloxy (TEMPO) radical, quartet state 4[R,T] of Cy-DENT could be formed to give an over 20-fold enhancement of singlet oxygen quantum yield compared to Cy-DEN (without TEMPO radical) under irradiation of near IR (NIR) light. In addition, the 1O2 production is well controlled by varying the electron-donating ability of the terminal substituent group. Cy-DENT possesses good cell permeability and is localized in mitochondria. Under the irradiation of 700 nm light, Cy-DENT can produce high levels of ROS to destroy the mitochondria membrane potential and induce cell apoptosis. Through the encapsulation of PEG-SS-PCL micelle, Cy-DENT can be effectively delivered to tumors and suppresses the tumor growth after PDT treatment.2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3HPLC of Formula: 673-22-3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.HPLC of Formula: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C8H8O2In 2019 ,《Investigation of Photocatalytic Activity of Anchored Dysprosium and Praseodymium Complexes on CoFe2O4 in Synthesis of Pyrano[2,3-d]pyrimidine Derivatives》 appeared in ChemistrySelect. The author of the article were Daraie, Mansoureh; Heravi, Majid M.; Tamoradi, Taiebeh. The article conveys some information:

Two hitherto unknown magnetic nanoparticles were prepared through the immobilization of dysprosium (Dy) and praseodymium (Pr) Complexes on the surface of CoFe2O4, using com. available or easily accessible materials under green conditions. They were fully characterized, using, FT-IR, SEM, EDX, ICP-OES, XRD and TGA techniques. Photocatalytic activity of these nanocomposites were successfully examined in the high yielding synthesis of pyrano[2,3-d]pyrimidines I (R = H, 4-F, 2-Cl, 3-OMe, etc.), via MCR, involving, barbituric acid, malononitrile and differently substituted benzaldehydes RC6H4CHO in the UV region (250 nm) at room temperature The above-mentioned photocatalysts showed excellent recoverability and reusability under the optimal reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Methoxybenzaldehyde(cas: 135-02-4Formula: C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Formula: C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Zoukimian, Claude; Beroud, Remy; Boturyn, Didier published an article in Organic Letters. The title of the article was 《2-hydroxy-4-methoxybenzyl as a thiol-protecting group for directed-disulfide bond formation》.Synthetic Route of C8H8O3 The author mentioned the following in the article:

The chem. synthesis of disulfide-rich peptides such as toxins can be accomplished by using numerous orthogonal cysteine-protecting groups. Herein we report the use of the Hmboff/on protecting group for directed disulfide bond formation. Its combination with classical Trt, Acm, and Mob groups was studied for the synthesis of NMB-1 and phlotoxin-1 toxins highlighting new orthogonal strategies for directed disulfide bond formation. The results came from multiple reactions, including the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Synthetic Route of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Synthetic Route of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Patil, Rupesh C.; Jagdale, Ashutosh A.; Patil, Uttam P.; Ghodake, Jeevan S.; Mali, Sawanta S.; Hong, Chang K.; Patil, Suresh S. published their research in Catalysis Letters in 2021. The article was titled 《Agro-Waste Generated Pd/CAP-Ash Catalyzed Ligand-Free Approach for Suzuki-Miyaura Coupling Reaction》.Quality Control of 1-Bromo-3-methoxybenzene The article contains the following contents:

We converted agro-waste custard apple peels (CAP) to ash via thermal treatment, on which Pd(OAc)2 was immobilized easily that produced a low-cost, highly efficient Pd/CAP-ash catalyst. The prepared catalyst was fully characterized by using FT-IR, SEM, EDX, XRF, DSC-TGA, BET, HR-TEM, and XPS techniques. The Pd/CAP-ash catalyst was conveniently applied for the Suzuki-Miyaura coupling reaction under external base free and ligand-free conditions in an aqueous-organic solvent to produce biphenyls in good to excellent yields. The main attraction of our protocol an application of palladium-supported agro-waste material which is easily recoverable and recyclable provides mono and bis-coupled derivatives in a short reaction time. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Quality Control of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Quality Control of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Asadi, Mahboubeh; Naimi-Jamal, M. Reza; Panahi, Leila published their research in Scientific Reports in 2021. The article was titled 《Green synthesis of carbamates and amides via Cu@Sal-Cs catalyzed C-O and C-N oxidative coupling accelerated by microwave irradiation》.Recommanded Product: 673-22-3 The article contains the following contents:

A new nano-scale Cu@salicylaldehyde-modified-chitosan (Cu@Sal-CS) was synthesized through a green, eco-friendly and cost-effective technique. The prepared catalyst was characterized using Fourier transform IR spectroscopy (FT-IR), SEM (SEM), Energy-dispersive X-ray spectroscopy (EDXS), and inductively coupled plasma (ICP) anal. The synthesized Cu@Sal-CS catalyst indicated its performance in the C-O and C-N oxidative coupling using the reaction of 1,3-dicarbonyl derivatives/2-substituted phenols with amides for the preparation of carbamates, as well as in the reaction of aldehydes and various amines in the synthesis of amides. The significant features of this work are operational simplicity of catalyst synthesis, in situ and new modification method, use of an efficient, recoverable, frequently reused and stable catalyst without any loss of catalytic activity, and high yields of the products in short times. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shelp, Russell A.; Ciro, Anthony; Pu, Youge; Merchant, Rohan R.; Hughes, Jonathan M. E.; Walsh, Patrick J. published their research in Chemical Science in 2021. The article was titled 《Strain-release 2-azaallyl anion addition/borylation of [1.1.1]propellane: synthesis and functionalization of benzylamine bicyclo[1.1.1]pentyl boronates》.Reference of 1-Bromo-3-methoxybenzene The article contains the following contents:

A three-component reaction between N-benzyl ketimines (C6H5)2C=NCH2Ar (Ar = 4-chlorophenyl, pyridin-3-yl, 1-benzothiophen-2-yl, etc.), [1.1.1]propellane, and pinacol boronates such as bis(pinacolato)diboron and i-PrOBpin to generate benzylamine bicyclo[1.1.1]pentane (BCP) pinacol boronates I was reported. These structures are analogs to highly sought diarylmethanamine cores, which are common motifs in bioactive mols. The versatility of the boronate esters I (Ar = Ph, 3,5-difluorophenyl, 4-trifluoromethoxyphenyl) handle via downstream functionalization through a variety of reactions, including a challenging Pd-catalyzed (hetero)arylation that exhibits a broad substrate scope was demonstrated. These methods enable the synthesis of high-value BCP benzylamines II (R1 = naphthalen-2-yl, 4-(dimethylsulfamoyl)phenyl, pyridin-4-yl, etc.) and were inaccessible by existing methods. Furthermore, the successful application of these newly developed (hetero)arylation conditions to a variety of challenging tertiary pinacol boronates, including nitrogen-containing heterocycles, 1,1-disubstituted cyclopropanes, and other BCP cores e.g., 4,4,5,5-tetramethyl-2-(1-phenylcyclopropyl)-1,3,2-dioxaborolane were demonstrated. In addition to this study using 1-Bromo-3-methoxybenzene, there are many other studies that have used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Reference of 1-Bromo-3-methoxybenzene) was used in this study.

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Reference of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem