Tag: 100-200

《Direct Access to Highly Enantioenriched α-Branched Acrylonitriles through a One-Pot Sequential Asymmetric Michael Addition/Retro-Dieckmann/Retro-Michael Fragmentation Cascade》 was written by Duchemin, Nicolas; Cattoen, Martin; Gayraud, Oscar; Anselmi, Silvia; Siddiq, Bilal; Buccafusca, Roberto; Daumas, Marc; Ferey, Vincent; Smietana, Michael; Arseniyadis, Stellios. Computed Properties of C9H10O2 And the article was included in Organic Letters in 2020. The article conveys some information:

A highly enantioselective synthesis of α-branched acrylonitriles is reported featuring a one-pot sequential asym. Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which relies on a solid, bench-stable, and com. available acrylonitrile surrogate, is practical, scalable, and highly versatile and provides a direct access to a wide range of enantioenriched nitrile-containing building blocks. Most importantly, the method offers a new tool to incorporate an acrylonitrile moiety in an asym. fashion. In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Computed Properties of C9H10O2) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Computed Properties of C9H10O2

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《Derivatization of Perfluorocarboxylic Acids with N,N-Dimethylformamide Dimethylacetal Prior to GC-MS Analysis》 was published in Chromatographia in 2020. These research results belong to Strozynska, Monika; Schuhen, Katrin. Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article mentions the following:

A simple derivatization reaction with N,N-dimethylformamide di-Me acetal (DMF-DMA) was developed for the anal. of perfluorocarboxylic acids (PFCA, C4-C12) in solid samples by gas chromatog.-mass spectrometry (GC-MS). After extraction with Me tert-Bu ether (MTBE), the samples are mixed with derivatizing agent and injected into GC. The derivatization reaction takes place in injection block forming corresponding N,N,N’,N’-tetramethyl diamines. The method provides excellent separation of nine PFCA (C4-C12) in 15 min and is characterized by good precision (maximum RSD = 6.21% for 10 ng/mL, n = 6), linearity and detection limits in the range of 0.15-0.38 ng/mL. The main aim of the study was to develop a quick and easy GC-MS screening for PFCA. The method was successfully applied for sewage sludge, textiles and dental flosses. To confirm the laboratory evaluation, two samples were measured by an external laboratory using LC-MS/MS and showed comparable results. The proposed method is very promising, taking into account its simplicity, mild conditions and application of cost-effective GC-MS system. Addnl., a comparison with two other derivatization methods for PFCA: reaction with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and benzyl bromide is presented. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
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《Carbamates: A Directing Group for Selective C-H Amidation and Alkylation under Cp*Co(III) Catalysis》 was published in Organic Letters in 2020. These research results belong to Bera, Sourav Sekhar; Maji, Modhu Sudan. Quality Control of m-Methoxyphenol The article mentions the following:

The selective reactivity of carbamate and thiocarbamate toward alkylation and amidation corresponding alkyl-carbamates e.g., I and amidyl-thiocarbamates e.g., II to get was reported under stable, high-valent, cost-effective cobalt(III) catalysis. This method revealed the wide possibility of designing a different branch of synthetically challenging yet highly promising asym. catalysts based on BINOL and SPINOL scaffolds. Late-stage C-H functionalization of L-tyrosine and estrone was also achieved through this approach. The mechanistic study shows that a base-assisted internal electrophilic substitution mechanism is operative here. After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

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Ether – Wikipedia,
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In 2019,Organic Communications included an article by Celik, Hulya; Kuzu, Muslum. Safety of 2-Methoxybenzaldehyde. The article was titled 《Microwave assisted synthesis of N-(methyl and methoxy)benzylidene-4-fluoroaniline derivatives and their carbonic anhydrase I and II inhibition properties》. The information in the text is summarized as follows:

In this study, few Schiff base derivatives I (R = 2-Me, 4-Me, 3-OMe, etc.) were synthesized from Me or methoxy substituted benzaldehydes and 4-fluoroaniline using a microwave method. Their inhibitory effects were studied on carbonic anhydrase isoenzymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulfanilamide affinity chromatog. Among the synthesized compounds I (R = 3-Me, 4-Me, 2-OMe) showed moderate activity on hCA II in the range of IC50 values. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxybenzaldehyde(cas: 135-02-4Safety of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Safety of 2-Methoxybenzaldehyde

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The author of 《Bimetallic ruthenium complexes bridged by divinylphenylene bearing oligo(ethylene glycol)methylether: synthesis, (spectro)electrochemistry and the lithium cation effect》 were Tian, Li Yan; Liu, Yuan Mei; Tian, Guang-Xuan; Wu, Xiang Hua; Li, Zhen; Kou, Jun-Feng; Ou, Ya-Ping; Liu, Sheng Hua; Fu, Wen-Fu. And the article was published in Dalton Transactions in 2014. Category: ethers-buliding-blocks The author mentioned the following in the article:

1,4-Disubstituted Ru-vinyl complexes, (E,E)-[{(PMe3)3(CO)ClRu}2(μ-HC:CHArCH:CH)] (Ar = C6H2(OR)2, OR = (OCH2CH2)nOMe, n = 0-3), in which the 1,4-diethenylphenylene bridge bears two oligo(ethylene glycol)methyl ether side chains at different positions (2,5- and 2,3-positions), were prepared The resp. products were characterized by elemental analyses and NMR spectroscopy. The structures of complexes (E,E)-[{(PMe3)3(CO)ClRu}2(μ-HC:CHC6H2(OR)2CH:CH)] (1b, n = 1; 2,5-positions) and (E,E)-[{(PMe3)3(CO)ClRu}2(μ-HC:CHC6H2(OR)2CH:CH)] (1e, n = 0; 2,3-positions) were established by x-ray crystallog. The electronic properties of the complexes were studied by cyclic voltammetry, IR, and UV-visible/NIR spectroscopies. Electrochem. studies showed that the 2,5-substituents better stabilized the mixed-valence states; the electrochem. behavior was greatly affected by Li cations, especially for complex (E,E)-[{(PMe3)3(CO)ClRu}2(μ-HC:CHC6H2(OR)2CH:CH)] (1g, n = 2) with 2,3-substituents, which was further supported by IR and UV-visible/NIR spectra changes. Spectroelectrochem. studies showed that the redox chem. was dominated by the noninnocent character of the bridging fragment. In the experimental materials used by the author, we found 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Category: ethers-buliding-blocks)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Category: ethers-buliding-blocks They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of 1,4-Diethynyl-2,5-dimethoxybenzeneOn May 3, 2019 ,《Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates》 appeared in Organic Letters. The author of the article were Kanemoto, Kazuya; Yoshida, Suguru; Hosoya, Takamitsu. The article conveys some information:

A mild and odorless copper-catalyzed thiolation of terminal alkynes with thiosulfonates is described. The broad substrate scope provides convenient access to a wide variety of sulfur-containing heterocycles. In particular, divergent benzoheteroles are efficiently prepared in a simple manner by thiolation of ethynylbenzenes bearing ortho-nucleophilic functional groups followed by iodocyclization. In the experiment, the researchers used many compounds, for example, 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Safety of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Safety of 1,4-Diethynyl-2,5-dimethoxybenzene

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Ether – Wikipedia,
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HPLC of Formula: 4637-24-5In 2019 ,《Scalable Sonochemical Synthetic Strategy for Pyrazolo[1,5-a]pyridine Derivatives: First Catalyst-Free Concerted [3 + 2] Cycloaddition of Alkyne and Alkene Derivatives to 2-Imino-1H-pyridin-1-amines》 was published in ACS Omega. The article was written by Ibrahim, Hamada Mohamed; Behbehani, Haider; Mostafa, Noha S.. The article contains the following contents:

A highly efficient and convenient one-pot sonochem. synthetic strategy has been sophisticated for synthesizing a novel class of polysubstituted pyrazolo[1,5-a]pyridines via [3 + 2] cycloaddition of dialkyl acetylenedicarboxylates, Et propiolate, and alkenes to 2-imino-1H-pyridin-1-amines under catalyst-free conditions. A series of uniquely substituted pyrazolo[1,5-a]pyridines has been synthesized with a very good to excellent yield, and the mechanistic pathway that involves a [3 + 2] annulation process was also proposed. In this study, several spectroscopic tools of analyses were employed for structure elucidation, and the X-ray single-crystal technique was utilized to confirm the proposed mechanism and the regioselectivity.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5HPLC of Formula: 4637-24-5) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.HPLC of Formula: 4637-24-5

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Synthetic Route of C5H13NO2In 2020 ,《New facile method for synthesis of 5-[(dimethylamino)methylene]pyrimidine-2,4,6-trione as potential template for barbiturate drugs》 appeared in Pharma Chemica. The author of the article were Sarhan, Alaadin E.. The article conveys some information:

New eco-friendly rapid synthesis of 5-[(dimethylamino)methylene]pyrimidine-2,4,6-trione was achieved by new method with efficient yield as potential template in synthesis of many biol. important organic compounds In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Synthetic Route of C5H13NO2

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Ether – Wikipedia,
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In 2022,Sharapov, Ainur D.; Fatykhov, Ramil F.; Khalymbadzha, Igor A.; Sharutin, Vladimir V.; Santra, Sougata; Zyryanov, Grigory V.; Chupakhin, Oleg N.; Ranu, Brindaban C. published an article in Green Chemistry. The title of the article was 《Mechanochemical synthesis of coumarins via Pechmann condensation under solvent-free conditions: an easy access to coumarins and annulated pyrano[2,3-f] and [3,2-f]indoles》.Safety of m-Methoxyphenol The author mentioned the following in the article:

A green protocol has been developed for the synthesis of simple coumarins, e.g., I linear pyrano[2,3-f] and [3,2-f]indoles by the reaction of phenol derivatives ROH (R = 3,5-(OH)2C6H3, 4-Br-3-OHC6H3, 3-OMeC6H4) with β-ketoesters, e.g., cyclohexanecarboxylic acid, 2-oxo-, Et ester under ball milling at ambient temperature in the presence of methanesulfonic acid as a mild acid catalyst. The significant advantages of this procedure are high yields, scalability, no use of hazardous acids or solvents, shorter reaction time, ambient temperature, low cost, and straightforward purification without column chromatog. This procedure is associated with high EcoScale metrics and a low E-factor. In contrast to traditional Pechmann condensation procedures, the mechanochem. protocol leads to the synthesis of pyranoindoles with excellent regioselectivity and high yields.m-Methoxyphenol(cas: 150-19-6Safety of m-Methoxyphenol) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneSafety of m-Methoxyphenol

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《Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite as a novel and efficient catalyst for the synthesis of 2-amino-4H-pyrans and spirochromenes》 was published in Scientific Reports in 2020. These research results belong to Saneinezhad, Sara; Mohammadi, Leila; Zadsirjan, Vahideh; Bamoharram, Fatemeh F.; Heravi, Majid M.. Category: ethers-buliding-blocks The article mentions the following:

Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite (PC/AgNPs) was prepared and fully characterized by FTIR, UV-vis, SEM, and TEM techniques. The preparation of PC/AgNPs was studied systematically to optimize the processing parameters by Taguchi method using the amount of PC, reaction temperature, concentration of silver nitrate and pH of medium. Taguchi’s L9 orthogonal (4 parameters, 4 level) was used for the exptl. design. The SEM anal. confirmed the presence of the Preyssler as a white cloud as well as spherical AgNPs on the surface of cellulose. The formation of AgNPs on the surface was observed by changing of the color from yellow to deep brown and confirmed by UV-vis spectroscopy. The best yield of AgNPs forming was obtained in pH 12.5 at 80°C in 20 min. TEM anal. confirmed the formation of spherical AgNPs with a size of 50 nm, at the 1% weight loading of Preyssler. This easily prepared PC/AgNPs was successfully employed as an efficient, green, and reusable catalyst in the synthesis of a wide range of 2-amino-4H-pyran I (R = Ph, 3-nitrophenyl, 4-chlorophenyl, etc.; X = CN, CO2Et), II (R1 = Ph, 2-methoxyphenyl, 4-chlorophenyl, etc.), III (R2 = Ph, 4-hydroxyphenyl, 4-chlorophenyl, etc.), IV (R3 = Ph, 2-nitrophenyl, 3-bromophenyl, etc.) and V and functionalized spirochromene derivatives via a one-pot, multicomponent reaction. The chief merits realized for this protocol were the utilization of com. available or easily accessible starting materials, operational simplicity, facile work-up procedure, obtaining of high to excellent yields of the products and being done under green conditions. The catalyst could be easily separated from the reaction mixture and reused several times without observing any appreciable loss in its efficiency. In the experiment, the researchers used many compounds, for example, 2-Methoxybenzaldehyde(cas: 135-02-4Category: ethers-buliding-blocks)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem