Tag: 100-200

Wuttke, Evelyn; Pevny, Florian; Hervault, Yves-Marie; Norel, Lucie; Drescher, Malte; Winter, Rainer F.; Rigaut, Stephane published an article on February 6 ,2012. The article was titled 《Fully Delocalized (Ethynyl)(vinyl)phenylene Bridged Triruthenium Complexes in up to Five Different Oxidation States》, and you may find the article in Inorganic Chemistry.Application In Synthesis of 1,4-Diethynyl-2,5-dimethoxybenzene The information in the text is summarized as follows:

Triruthenium [(dppe)2Ru{-CC-1,4-C6H2-2,5-R2-CH:CH-RuCl(CO)(PiPr3)2}2]n+ (4a, R = H; 4b, R = OMe) containing unsym. (ethynyl)(vinyl)phenylene bridging ligands and displaying five well-separated redox states (n = 0-4) are compared to their bis(alkynyl)ruthenium precursors (dppe)2Ru{-CC-1,4-C6H2-2,5-R2-CCR’} (2a,b: R’ = TMS; 3a,b: R’ = H) and their sym. substituted bimetallic congeners, complexes {Cl(dppe)2Ru}2{μ-CC-1,4-C6H2-2,5-R2-CC} (Aa, R = H; Ab, R = OMe) and {RuCl(CO)(PiPr3)2}2{μ-CH:CH-1,4-C6H2-2,5-R2-CH:CH} (Va, R = H; Vb, R = OMe) as well as the mixed (ethynyl)(vinyl)phenylene bridged [Cl(dppe)2Ru-CC-1,4-C6H4-CH:CH-RuCl(CO)(PiPr3)2] (Ma). Successive 1-electron transfer steps were studied by cyclic voltammetry, EPR and UV-visible-NIR-IR spectroelectrochem. The 1st oxidation mainly involves the central bis(alkynyl) Ru moiety with only limited effects on the appended vinyl Ru moieties. The 2nd to 4th oxidations (n = 2, 3, 4) involve the entire C-rich conjugated path of the mol. with an increased charge uniformly distributed between the two arms of the mols., including the terminal vinyl Ru sites. To assess the charge distribution, the authors judiciously use 13CO labeled analogs to distinguish stretching vibrations due to the acetylide triple bonds and the intense and charge-sensitive Ru(CO) IR probe in different oxidation states. The comparison between complex pairs 4a,bn+ (n = 0-3), Aa,bn+ and Va,bn+ (n = 0-2) serves to elucidate the effect of the methoxy donor substituents on the redox and spectroscopic properties of these systems in their various oxidation states and on the metal/ligand contributions to their frontier orbitals. In the experimental materials used by the author, we found 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Application In Synthesis of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Application In Synthesis of 1,4-Diethynyl-2,5-dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Van Averbeke, Bernard; Beljonne, David published their research in ChemPhysChem on December 7 ,2009. The article was titled 《Energy Transport along Conjugated Polymer Chains with Extended Radiative Lifetimes: A Theoretical Study》.Related Products of 74029-40-6 The article contains the following contents:

The ability to improve exciton diffusion lengths is a key issue in optimizing many opto-electronic devices based on conjugated polymers. On the basis of quantum-chem. calculations, we investigate a strategy consisting of extending the radiative lifetime of energy carriers through incorporation along the polymer backbone of repeating units with forbidden optical transition. The results obtained for poly(p-phenylenebutadiyne), PPE, and poly(p-triphenylenebutadiyne), PTPE, show that the larger number of hops performed by the electronic excitations during their lifetime in PTPE is compensated by the smaller hopping length (associated with the reduced conjugation length), so that similar on-chain diffusion lengths are predicted in both polymers. The results came from multiple reactions, including the reaction of 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Related Products of 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Related Products of 74029-40-6 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Resta, C.; Pescitelli, G.; Di Bari, L. published an article on January 31 ,2018. The article was titled 《Impact and amplification of chirality in the aggregation of leucine-appended poly(p-phenylene ethynylene) (PPE)》, and you may find the article in European Polymer Journal.Related Products of 74029-40-6 The information in the text is summarized as follows:

A leucine-appended poly(p-phenyleneethynylene) (PPE) was prepared in enantiomeric stereoregular (L-1 and D-1) and stereorandom (rac-1) forms. The solution aggregates of L-1, D-1, rac-1, and mixtures of L-1/D-1, were characterized by absorption, electronic CD and emission spectra. Both rac-1 and L-1/D-1 mixtures are more prone to aggregate than L-1 and D-1. Upon aggregating, the enantiomeric mixtures manifest an apparent majority-rules effect, which is mostly due to the greater tendency to form heterochiral aggregates with respect to homochiral ones. The impact of chirality on the aggregation behavior of the aminoacid-appended PPE is demonstrated. The experimental part of the paper was very detailed, including the reaction process of 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Related Products of 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Related Products of 74029-40-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Dalton Transactions included an article by Figueira, Joao; Czardybon, Wojciech; Mesquita, Jose Carlos; Rodrigues, Joao; Lahoz, Fernando; Russo, Luca; Valkonen, Arto; Rissanen, Kari. Recommanded Product: 74029-40-6. The article was titled 《Synthesis, characterization and solid-state photoluminescence studies of six alkoxy phenylene ethynylene dinuclear palladium(II) rods》. The information in the text is summarized as follows:

A rare family of six discrete binuclear [PdCl(PEt3)2] phenylene ethynylene rods with alkoxy side chains (methoxy, ethoxy and heptoxy) were developed, and their solid-state photoluminescence results were presented and discussed. The shorter bridging ligands are H-CC-C6H2(R)2-CC-H, where R = H, OCH3, OC2H5, and OC7H15, whereas the longer ones are based on H-CC-C6H4-CC-C6H2(R)2-CC-C6H4-CC-H, where R = OCH3, OC2H5. These ligands display increasing length in both the main dimension (backbone length) as well as the number of carbons in the side chains (R, alkoxide side chain) that stem from the central phenylene moiety. The x-ray crystal structures of two of the prepared complexes are reported: one corresponds to a shorter rod, 1,4-bis[trans-(PEt3)2ClPd-CC]-2,5-diethoxybenzene (6c), while the 2nd one is associated with a longer rod, the binuclear complex 1,4-bis[trans-(PEt3)2ClPd-4-(-CC-C6H4-CC)]-2,5-diethoxybenzene (7c). All new compounds were characterized by NMR spectroscopy (1H, 13C{1H} and 31P{1H}) as well as ESI-MS(TOF), EA, FTIR, UV-visible, cyclic voltammetry and solid-state photoluminescence. The authors’ work shows the influence of the alkoxy side chains on the electronic structure of the family of binuclear Pd rods by lowering its oxidation potential. In addition to this, the increase of the length of the bridge results in a higher oxidation potential. Solid state photoluminescence results indicate that Pd complexes were characterized by a marked decrease in both the emission intensity and the fluorescence lifetime values as compared to their ligands. This behavior could be due to some degree of ligand-to-metal charge transfer. The experimental part of the paper was very detailed, including the reaction process of 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Recommanded Product: 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 74029-40-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 3-Methoxyphenylboronic acidIn 2021 ,《Modifications on the tetrahydroquinoline scaffold targeting a phenylalanine cluster on GPER as antiproliferative compounds against renal, liver and pancreatic cancer cells》 was published in Pharmaceuticals. The article was written by Mendez-Luna, David; Morelos-Garnica, Loreley Araceli; Garcia-Vazquez, Juan Benjamin; Bello, Martiniano; Padilla-Martinez, Itzia Irene; Fragoso-Vazquez, Manuel Jonathan; Gonzalez, Alfonso Duenas; De Pedro, Nuria; Gomez-Vidal, Jose Antonio; Mendoza-Figueroa, Humberto Lubriel; Correa-Basurto, Jose. The article contains the following contents:

The implementation of chemo- and bioinformatics tools is a crucial step in the design of structure-based drugs, enabling the identification of more specific and effective mols. against cancer without side effects. In this study, three new compounds were designed and synthesized with suitable absorption, distribution, metabolism, excretion and toxicity (ADME-tox) properties and high affinity for the G protein-coupled estrogen receptor (GPER) binding site by in silico methods, which correlated with the growth inhibitory activity tested in a cluster of cancer cell lines. Docking and mol. dynamics (MD) simulations accompanied by a mol. mechanics/generalized Born surface area (MMGBSA) approach yielded the binding modes and energetic features of the proposed compounds on GPER. These in silico studies showed that the compounds reached the GPER binding site, establishing interactions with a phenylalanine cluster (F206, F208 and F278) required for GPER mol. recognition of its agonist and antagonist ligands. Finally, a 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay showed growth inhibitory activity of compounds 4, 5 and 7 in three different cancer cell lines-MIA Paca-2, RCC4-VA and Hep G2-at micromolar concentrations These new mols. with specific chem. modifications of the GPER pharmacophore open up the possibility of generating new compounds capable of reaching the GPER binding site with potential growth inhibitory activities against nonconventional GPER cell models.3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 3-Methoxyphenylboronic acid) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tavakolian, Mina; Keshavarz, Kimia; Hosseini-Sarvari, Mona published their research in Molecular Catalysis in 2021. The article was titled 《Cu2O/TiO2 as sustainable and recyclable photocatalyst for gram-scale synthesis of phenols in water》.Product Details of 150-19-6 The article contains the following contents:

A green and straightforward protocol was developed for the synthesis of phenols from aryl boronic acid using an inexpensive and available Cu2O/TiO2 photocatalyst under visible light and sunlight. This approach proceeded in mild reaction conditions in water and the presence of air as a green oxidant, resulting in the corresponding phenols in good to excellent yields. Sunlight was also a sustainable source for this photochem. reaction. Heterogeneous nano photocatalyst was successfully recovered in 8 consecutive runs. It is noteworthy that, the photocatalyst exhibited high activity for the large-scale synthesis of phenols. The experimental process involved the reaction of m-Methoxyphenol(cas: 150-19-6Product Details of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneProduct Details of 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《GC-MS analysis of N-(bromodimethoxybenzyl)-2-, 3-, and 4-methoxyphenethylamines: Inverse analogues of the psychoactive 25B-NBOMe drug》 was written by Almalki, Ahmad J.; Clark, C. Randall; Abiedalla, Younis; DeRuiter, Jack. Related Products of 135-02-4 And the article was included in Forensic Chemistry in 2020. The article conveys some information:

The substituted phenethylamine analogs in this study are derivatives of N-(2-methoxybenzyl)-4-bromo-2,5-dimethoxyphenethylamine (25B-NBOMe) having the reverse substitution pattern for two aromatic rings. The nine regioisomeric compounds were prepared from the regioisomeric 2-, 3-, and 4- methoxyphenethylamines via N-reductive alkylation with the three regioisomeric 2,4,5-substituted bromodimethoxybenzaldehydes. The EI-MS spectra of these regioisomers gave two major bromine containing ions at m/z 229/231 (base peak) and 258/260 and two non-brominated fragments at m/z 91 and 121. The relative abundance of the m/z 91 was higher for the 2-methoxyphenethylamine substituted isomers and relative abundance of the m/z 121 fragment was higher in the 4-methoxy substituted isomers. The gas chromatog. separation for the regioisomeric methoxyphenethylamines of each bromodimethoxybenzyl aromatic ring substitution pattern showed 2-methoxyphenethylamine substituted isomer eluted first followed by the 3-substituted isomer and 4-methoxyphenethylamine substituted isomer was last to elute and the three bromodimethoxybenzyl regioisomers for the 2-methoxyphenethylamine subseries were resolved as the trifluoroacetamides. The EI-MS for the TFA derivatives of the 2-bromo-4,5-dimethoxybenzyl substituted isomer gave unique fragment ions resulting from displacement of bromine from the mol. ion. This fragmentation pathway was confirmed using the model compounds N-(2-, 3- and 4-bromobenzyl)phenethylamine trifluoroacetamides. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Related Products of 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Related Products of 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Visible-light photoredox-catalyzed C-O bond cleavage of diaryl ethers by acridinium photocatalysts at room temperature》 was published in Nature Communications in 2020. These research results belong to Tan, Fang-Fang; He, Xiao-Ya; Tian, Wan-Fa; Li, Yang. Recommanded Product: 150-19-6 The article mentions the following:

Visible-light photoredox-catalyzed C-O bond cleavage of diaryl ethers by an acidolysis with an aryl carboxylic acid and a following one-pot hydrolysis was reported. Two mols. of phenols were obtained from one mol. of diaryl ether at room temperature The aryl carboxylic acid used for the acidolysis was recovered. The key to success of the acidolysis was merging visible-light photoredox catalysis using an acridinium photocatalyst and Lewis acid catalysis using Cu(TMHD)2. Preliminary mechanistic studies indicated that the catalytic cycle occurred via a rare selective electrophilic attack of the generated aryl carboxylic radical on the electron-rich aryl ring of the di-Ph ether. This transformation was applied to a gram-scale reaction and the model of 4-O-5 lignin linkages.m-Methoxyphenol(cas: 150-19-6Recommanded Product: 150-19-6) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Binding Interaction Between Boronic Acid Derivatives with Monosaccharaides colon Effect of Structural Change of Monosaccharaides Upon Binding Using S hyphen V Plots》 was published in Macromolecular Symposia in 2020. These research results belong to Bhavya, P.; Melavanki, Raveendra; Narayanappa, C. K.; Kusanur, Raviraj; U., Meghana; B., Suma. Application In Synthesis of 3-Methoxyphenylboronic acid The article mentions the following:

Sugar sensing and continuous monitoring of glucose (CGM) play an important and vital role in controlling diabetes. The present enzyme-based sugar sensors have their own drawbacks. Problems associated with them have encouraged alternate approaches to design new sensors. Among many, fluorescent intensity change based sensors are drawing more attention. Fluorescence sensors based on boronic acid derivatives are more popular because of their ability to reversibly bind diol-containing compounds Here, the binding ability of two boronic acid derivatives, namely 2-methylphenyl boronic acid (B1) and 3-methoxyphenyl boronic acid (B2) with mono saccharides (sugars), is under investigation. The sugar concentration is kept nearly 1000 times more than that of boronic acid. The interactions of B1 and B2 with three saccharides (D-sorbitol, dextrose, and fructose) are studied by absorbance and steady-state fluorescence. Both B1 and B2 fluorescence is quenched by formation of esters with saccharides. The results of absorbance and fluorescence measurements indicate that the studied sugars can be ordered by their affinity to B1 as: D-sorbitol > xylose > dextrose and for B2 as: dextrose > xylose > D-sorbitol. In each case, slope of modified S-V plots is nearly one indicating only a single binding site in boronic acids for sugars. After reading the article, we found that the author used 3-Methoxyphenylboronic acid(cas: 10365-98-7Application In Synthesis of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Application In Synthesis of 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Structural characterization of new zinc(II) complexes with N2O2 chelating thiosemicarbazidato ligands; investigation of the relationship between their DNA interaction and in vitro antiproliferative activity towards human cancer cells》 was published in New Journal of Chemistry in 2020. These research results belong to Kaya, Busra; Yilmaz, Zehra Kubra; Sahin, Onur; Aslim, Belma; Ulkuseven, Bahri. Computed Properties of C8H8O3 The article mentions the following:

Two new zinc(II) complexes were synthesized by condensation of 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione-S-methyl-thiosemicarbazone with salicylaldehyde or 4-methoxy-salicylaldehyde. Structures of the N2O2-chelate complexes, Zn1 and Zn2, were explicated by IR, 1H NMR, ESI-MS and X-ray crystallog. Electronic spectral anal. was performed to assign the nature of the interaction between the complexes and calf thymus DNA (CT-DNA). DNA cleavage activities of the complexes were investigated by gel electrophoresis (pBR322 DNA). The results indicated that the complexes bind to CT-DNA via an intercalation mode and the binding of Zn2 is stronger than that of Zn1. Relatively high concentrations of the zinc complexes were found to encourage the cleavage of DNA from supercoiled form (Form I) to nicked circular form (Form II). The antiproliferative activity of the complexes was determined against human colorectal adenocarcinoma (HT-29) and human cervical carcinoma (HeLa) cell lines by MTT assay. The tests revealed that the complex Zn2 exhibited a higher antiproliferative effect than Zn1 on HT-29 and HeLa cells, analogical to the data from DNA interaction experiments The studies demonstrated that complex Zn2 could be a good candidate as a chemotherapeutic drug targeting DNA. In the experiment, the researchers used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Computed Properties of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem