Tag: 100-200

Vagh, Sandip Sambhaji; Hou, Bo-Jhih; Edukondalu, Athukuri; Wang, Pin-Ching; Lin, Wenwei published their research in Organic Letters in 2021. The article was titled 《Phosphine-Mediated MBH-Type/Acyl Transfer/Wittig Sequence for Construction of Functionalized Furo[3,2-c]coumarins》.HPLC of Formula: 673-22-3 The article contains the following contents:

A new method for the construction of functionalized furo[3,2-c]coumarins via MBH-type/acyl-transfer/Wittig reaction was reported. The current approach would open a new route for the simultaneous formation of two rings in a one-pot reaction which was accompanied by incorporation of a keto functionality on the furan ring by activating the terminal alkynoates with phosphine. Furthermore, this protocol could also be applicable to the internal alkynoates/propiolamides to generate the 2,3-disubstituted furo[3,2-c]coumarins/furo[3,2-c]quinolinones by excluding the acyl-transfer reaction. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3HPLC of Formula: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.HPLC of Formula: 673-22-3

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《Palladium Nanoparticle-Bentonite Hybrid Using Leaves of Syzygium aqueum Plant from India: Design and Assessment in the Catalysis of -C-C- Coupling Reaction》 was written by Manjare, Satish B.; Chaudhari, Rajendra A.. HPLC of Formula: 10365-98-7 And the article was included in Chemistry Africa in 2020. The article conveys some information:

An environment-friendly synthesis process has been developed with the aid of Syzygium aqueum (water apple) leaves extract Pulverized leaves of Syzygium aqueum (water apple) are mixed with a universal solvent such as water for the preparation of Pd nanoparticle supported on activated bentonite. The extract from the plant leaves acts both as a reducing agent and also as a capping agent for converting the PdCl2 to PdNPs. The synthesized PdNPs are supported on modified clay and they are characterized by using FTIR, BET, HR-TEM, ICP-MS, TGA, XRD, and FE-SEM/EDX. It is found that the supported PdNPs give high rate of conversions of Suzuki-Miyaura coupling products and give greater than 90% products in universal solvent i.e. water at fairly low temperature It shows the potential for the environment-friendly synthesis of prime organic mols. like excellent biaryl derivatives with TONs and TOFs with economical and efficient catalyst loading. We recorded high activity, chemoselectivity and excellent TONs (15,061-20,537) and TOFs (100,407-136,919) by using a small catalyst loading in short reaction time only 15 min. The catalyst shows a long lifetime (ten times). Experiments are performed, recycling it, which demonstrate the sustainability and efficiency of the catalytic process. The prepared catalyst gives a higher percentage of coupling product in the lower time. The supported PdNPs help to form good selectivity and efficacy. The catalyst is found highly stable and can be recycled ten times with no appreciable loss in the efficiency. The experimental process involved the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7HPLC of Formula: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.HPLC of Formula: 10365-98-7

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《Population Genetics Coupled Chemical Profiling for Conservation Implications of Decalepis salicifolia (Bedd. ex Hook.f.) Venter, an Endemic and Critically Endangered Species of Western Ghats, India》 was published in Biochemical Genetics in 2020. These research results belong to Gokul, Sivaraman; Rodrigues, Vereena; Kumar, Amit; Verma, Ram S.; Shukla, Ashutosh K.; Sundaresan, Velusamy. Quality Control of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

Information on the genetic diversity and population structure is essential for developing conservational management programs, especially for threatened species. Decalepis salicifolia (Bedd. ex Hook.f.) Venter is a steno-endemic and critically endangered species of the south Western Ghats of India. The present study used ISSR markers as well as essential oil profiling to reveal the extent and distribution of genetic as well as the chem. diversity of all the twelve known populations of D. salicifolia. A total of 84 amplicons generated using 17 ISSR primers represented an overall 72.34% polymorphism. The highest percentage of polymorphic loci was recorded in the population of Theemalai (40.48%) and lowest in Kokanmalai (4.76%) with an average of 20.04% across all the studied populations. At the species level, the Nei’s genetic diversity observed was 0.255 ∓ 0.186, while Shannon’s information index observed was 0.385 ∓ 0.260. The genetic similarity-based unweighted pair-group method with arithmetic average dendrogram grouped the populations according to their geog. locations, which was corroborated by principal component anal. and Bayesian clustering. Distribution of genetic variance through anal. of mol. variance indicated that 38% variance resides within the population, and 62% variance resides among the populations (P < 0.001). Gas chromatog. analyses of root volatiles showed significant variation in the percent content of 2-hydroxy-4-methoxybenzaldehyde. The Mantel test analyses showed a pos. correlation between the genetic vs. geog. distances. Based on the results, both ex situ and in situ conservation strategies are suggested to maximally preserve the genetic resources of this endangered species. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Quality Control of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Quality Control of 2-Hydroxy-4-methoxybenzaldehyde

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The author of 《Graphene Oxide Incorporated Strontium Nanoparticles as a Highly Efficient and Green Acid Catalyst for One-Pot Synthesis of Tetramethyl-9-aryl-hexahydroxanthenes and 13-Aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraones Under Solvent-Free Conditions》 were Mousavi, Seyyed Rasul; Rashidi Nodeh, Hamid; Zamiri Afshari, Elham; Foroumadi, Alireza. And the article was published in Catalysis Letters in 2019. Category: ethers-buliding-blocks The author mentioned the following in the article:

An efficient, inexpensive and recyclable graphene oxide/strontium nanocatalyst was synthesized and applied in a pseudo three-component, one-pot cyclocondensation of aromatic aldehydes and dimedone/lawsone to afford the corresponding 3,3,6,6-tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-diones and 13-aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraones (e.g., I and II, resp.) in high yields under solvent-free conditions. To the best of our knowledge, there are no literature reports on applying graphene oxide/strontium as a nanocatalyst for xanthene derivatives synthesis. The key potential benefits of the present method are including high yields, short reaction time, easy workup, recyclability of catalyst and ability to tolerate a variety of functional groups which gives economical as well as ecol. rewards. The nanocatalyst easily separated from the reaction mixture easily by applying an external magnet and reused at least six times without noticeable degradation in catalytic activity.2-Methoxybenzaldehyde(cas: 135-02-4Category: ethers-buliding-blocks) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Category: ethers-buliding-blocks

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In 2019,Bioorganic Chemistry included an article by Eldehna, Wagdy M.; Abo-Ashour, Mahmoud F.; Berrino, Emanuela; Vullo, Daniela; Ghabbour, Hazem A.; Al-Rashood, Sara T.; Hassan, Ghada S.; Alkahtani, Hamad M.; Almehizia, Abdulrahman A.; Alharbi, Amal; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.. Name: N,N-Dimethylformamide Dimethyl Acetal. The article was titled 《SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX》. The information in the text is summarized as follows:

SLC-0111, an ureido substituted benzenesulfonamide, is a selective carbonic anhydrase (CA, EC 4.2.1.1) IX inhibitor that is currently in Phase I/II clin. trials for the treatment of advanced hypoxic tumors complicated with metastases. Herein we report the synthesis of two series of 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides 5a-i and 6a-j as SLC-0111 enaminone congeners. The prepared enaminones were in vitro investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, IV and IX, using a stopped-flow CO2 hydrase assay. All these isoforms were inhibited by the enaminones reported here in variable degrees. The target tumor-associated isoform hCA IX was undeniably the most affected one (KIs: 0.21-7.1 nM), with 6- to 21-fold enhanced activity than SLC-0111 (KI = 45 nM). All the prepared enaminones displayed interesting selectivity towards hCA IX over hCA I (SI: 32 – >35714), hCA II (SI: 2 – 1689) and hCA IV (SI: 11 – >45454). Of particular interest, bioisosteric replacement of Ph tail with the bulkier 2-naphthyl tail, sulfonamide 6h, achieved the higher II/IX selectivity herein reported with SI of 1689. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Name: N,N-Dimethylformamide Dimethyl Acetal

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In 2019,Methods and Protocols included an article by Martins, Ines S.; Coelho, Jaime A. S.. Application In Synthesis of N,N-Dimethylformamide Dimethyl Acetal. The article was titled 《Solvent-free synthesis of 2,5-bis((dimethylamino)methylene)cyclopentanone》. The information in the text is summarized as follows:

The important feature in synthesis of ketocyanine dyes precursor 2,5-bis((dimethylamino)methylene)cyclopentanone I through organocatalyzed condensation of cyclopentanone and N,N-dimethylformamide di-Me acetal was removal of methanol produced during the reaction. By studying reaction profile, in particular selectivity for formation of mono- and bis-condensation products, a high yield of desired product could be obtained through an operationally simple and solvent-free protocol.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application In Synthesis of N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application In Synthesis of N,N-Dimethylformamide Dimethyl Acetal

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In 2019,Organic Chemistry Frontiers included an article by Song, Zehua; Wang, Guotong; Li, Wei; Li, Shengkun. Recommanded Product: m-Methoxyphenol. The article was titled 《Innate pharmacophore assisted selective C-H functionalization to therapeutically important nicotinamides》. The information in the text is summarized as follows:

The application of the pre-validated pharmacophore 2-(2-oxazolinyl)anilines (R)/(S)-I (R = H, Me, Et, benzyl) as an innate directing group in the C-H etherification and amination of nicotinamides II for the efficient synthesis of drug- and agrochem.-like mols. was determined An operationally simple, and regioselective C-H functionalization of nicotinamides (R)/(S)-II was first accomplished using a complicated variation of copper salts. All the specific procedures used were easy to utilize, without external oxidants or ligands. The feasibility is highlighted using an alternative synthesis of diflufenican with a rapid synthesis of niacin related pharmaceuticals or analogs III (R1 = H, 3-CH3OC6H4O, 2-methoxy-4-(prop-2-en-1-yl)phenyl, 4-methylpiperidin-1-yl, etc.; R2 = H, 2-methoxy-4-(prop-2-en-1-yl)phenyl, 3-methylpiperidin-1-yl, etc.). In the experiment, the researchers used many compounds, for example, m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol

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《Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products》 was written by Gilmartin, Philip H.; Kozlowski, Marisa C.. Computed Properties of C9H12O2 And the article was included in Organic Letters on April 17 ,2020. The article conveys some information:

A mild and efficient method for the vanadium-catalyzed intramol. coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor. The experimental part of the paper was very detailed, including the reaction process of (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Computed Properties of C9H12O2)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Computed Properties of C9H12O2Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

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Application In Synthesis of m-MethoxyphenolIn 2019 ,《Development of an efficient phenolic sensor based on facile Ag2O/Sb2O3 nanoparticles for environmental safety》 was published in Nanoscale Advances. The article was written by Rahman, Mohammed M.; Alam, M. M.; Asiri, Abdullah M.. The article contains the following contents:

The facile hydrothermal method was used to prepare low-dimensional doped Ag2O/Sb2O3 nanoparticles (NPs) at low temperature in alk. medium. The calcined NPs were characterized in detail by FTIR, UV/vis, FESEM, XPS, EDS, and XRD. A thin layer of Ag2O/Sb2O3 NPs was deposited onto a glassy carbon electrode (GCE) using Nafion (5% Nafion suspension in ethanol) conducting binder, which formed the working electrode of the selective 3-methoxyphenol electrochem. sensor probe. The proposed chem. sensor exhibits high sensitivity, long-term stability, and enhanced electrochem. responses towards 3-methoxyphenol. Response to 3-methoxyphenol is linear over the concentration range (LDR) of 0.09 nM to 0.09 mM. The anal. parameters of the sensor such as sensitivity, stability, response time, linearity, LDR, robustness, selectivity etc. were evaluated by an electrochem. approach. The sensor probe fabricated with Ag2O/Sb2O3 NPs seems to be a promising candidate for effective and reliable electrochem. detection of hazardous and carcinogenic chems. in the environment and health care fields in large scales. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6Application In Synthesis of m-Methoxyphenol) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application In Synthesis of m-Methoxyphenol

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In 2022,Gu, Jia; Xiao, Pan-Lei; Wang, Jie; Zhong, Liang; Nie, Xu-Liang; Peng, Da-Yong published an article in Journal of Molecular Structure. The title of the article was 《Synthesis, crystal structure, spectroscopic characterization and anti-fungal activity of Ethyl 2-Oxo-2H-chromene-3-carboxylate Derivatives》.Quality Control of m-Methoxyphenol The author mentioned the following in the article:

A series of Et 2-oxo-2H-chromene-3-carboxylate derivatives I [R1 = H, CH3, Br, etc.; R2 = H, OCH3] was synthesized by the ester cyclization of di-Et malonate and salicylaldehydes which was obtained from corresponding phenols. The single crystal of compounds I [R1 = OCF3, OCH3; R2 = H] were obtained and characterized by X-ray. Compound I [R1 = OCF3; R2 = H] crystallized in the triclinic system with space group P-1 and compound I [R1 = OCH3; R2 = H] crystallized in the monoclinic system with space group P21/c. The potential anti-fungal activities of the synthesized compounds was studied against five kinds of common fungi at concentrations of 200 ppm and 500 ppm and results showed that the target compounds exhibited certain anti-fungal activity against tested strains. The inhibition rate of compound I [R1 = CH3; R2 = H] was the highest against Fusarium oxysporum, up to 60.29% at 500 ppm. Compound I [R1 = CH3; R2 = H] was promising to become the lead compound of pesticide in the future. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

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