Tag: 100-200

The author of 《Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Bronsted Acidic NO2+ Generation》 were Juarez-Ornelas, Kevin A.; Jimenez-Halla, J. Oscar C.; Kato, Terumasa; Solorio-Alvarado, Cesar R.; Maruoka, Keiji. And the article was published in Organic Letters in 2019. Related Products of 150-19-6 The author mentioned the following in the article:

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Bronsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. D. functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G*) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions. After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Related Products of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Related Products of 150-19-6

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Visible Light-Initiated Catalyst-Free One-Pot, Multicomponent Construction of 5-Substituted Indole Chromeno[2,3-b]pyridines》 were Zhang, Mo; Chen, Meng-Nan; Zhang, Zhan-Hui. And the article was published in Advanced Synthesis & Catalysis in 2019. Category: ethers-buliding-blocks The author mentioned the following in the article:

A visible light-initiated pseudo four-component reaction of salicylaldehydes, indole and malononitrile in aqueous Et lactate is described. This pot, at. and step economic (PASE) methodol. provides a practical approach for the preparation of various 5-substituted indole chromeno[2,3-b]pyridines from readily available starting materials at ambient temperature without any catalyst. High yields and excellent functional groups tolerance are observed In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks

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Ether – Wikipedia,
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《Condensation of ninhydrin with phenols: Regioselective formation of diverse organic scaffolds and crystal structure studies》 was written by Das, Purak; Maity, Suvendu; Ghosh, Prasanta; Dutta, Arpita; Das, Suven. Name: m-Methoxyphenol And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

A range of phenolic compounds were reacted with ninhydrin in acid medium to afford different indanone-based mols. via regioselective C-C bond formation were studied. Ninhydrin reacts with 2,7-Dihydroxynaphthalene and 4-cyanophenol in AcOH producing ortho selective adducts in cyclic hemiketal structure and ring-opened diketo forms. On the other hand, ortho-substituted phenols like o-cresol, guaiacol, o-chloro/iodophenol condense with ninhydrin to accomplish para selective diarylated adducts, whereas 3-methoxy phenol provided corresponding monoarylated adduct as the major product. Different hydroxy benzoic acids delivered versatile scaffolds like diarylated indanone, indenofuran, benzofuran or spirolactone depending upon the substitution pattern and acidity of the reaction medium. All the compounds are characterized by 1H and 13C NMR spectra. In the solid state, scissors-shaped mol. diarylated adduct has been found to form inclusion complex with disordered o-cresol mol. and function as building unit of supramol. network. In the crystal structure of spirolactone, anti-parallel motif of dipolar···dipolar (C=O(δ-)···C(δ+) = O) interaction results ladder-like arrangement. In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6Name: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Name: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《meta-Selective C-H functionalisation of aryl boronic acids directed by a MIDA-derived boronate ester》 was written by Williams, Alexander F.; White, Andrew J. P.; Spivey, Alan C.; Cordier, Christopher J.. Formula: C7H9BO3 And the article was included in Chemical Science in 2020. The article conveys some information:

N-Methyliminodiacetic acid (MIDA) boronates are boronic acid derivatives which are stable to reduction, oxidation and transmetalation. This has led to their widespread use as boronic acid protecting groups (PGs) and in iterative cross-couplings. authors describe herein the development of a novel MIDA derivative that acts in a dual manner, as a protecting group and a directing group (DG) for meta C(sp2)-H functionalisation of arylboronic acids. Palladium catalyzed C-H alkenylations, acetoxylations and arylations are possible, at room temperature and under aerobic conditions. Deprotection to reveal the functionalized boronic acids is rapid and allows for full recovery of the DG. The technique allows the facile diversification of aryl boronic acids and their subsequent use in a range of reactions or in iterative processes. After reading the article, we found that the author used 3-Methoxyphenylboronic acid(cas: 10365-98-7Formula: C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Formula: C7H9BO3

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Ether – Wikipedia,
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《Natural carbolines inspired the discovery of chiral CarOx ligands for asymmetric synthesis and antifungal leads》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Lai, Jixing; Li, Wei; Wei, Sanyue; Li, Shengkun. Synthetic Route of C7H9BO3 The article mentions the following:

The unprecedented β-CarOx ligands were conceived by the hybridization of alangiobussinine and the privileged pyridine-oxazoline scaffold. It is well performed in the highly enantioselective Pd-catalyzed Michael addition of arylboronic acids to nitrostyrenes and β-substituted cyclic enone (up to 99% ee). The β-CarOx ligands also showed an enhanced antifungal effect compared to alangiobussinine, demonstrating promising antifungal leads against Sclerotinia sclerotiorum. The experimental process involved the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Synthetic Route of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of a carbon-11 radiolabeled BACE1 inhibitor》 was published in Medicinal Chemistry Research in 2020. These research results belong to Zhu, Yiwei; Fiedler, Stephanie A.; Hibert, Matthew L.; Wang, Changning. Reference of 3-Methoxyphenylboronic acid The article mentions the following:

Beta-secretase (BACE1), a transmembrane aspartyl protease, can cleave membrane-bound β-amyloid precursor proteins (APPs) to initiate the accumulation of amyloid-β (Aβ). The inhibition of BACE-1 to limit the accumulation of neurotoxic Aβ peptides could offer a potential treatment for Alzheimer’s Disease (AD). However, little is known about the distribution and d. of BACE1 in the central nervous system. As a step toward filling this gap in knowledge, we have evaluated a potential radiotracer for the imaging of BACE1 using positron emission tomog. (PET). A BACE1 inhibitor, 5, is reported with blood-brain barrier (BBB) permeability and high binding affinity. To characterize the pharmacokinetics and distribution of 5 in the brain, we radiolabeled 5 with carbon-11. Using PET, we found that [11C]5 shows moderate uptake in the brain when administered i.v. to rodents and further work will be performed in animal models to test its application as a PET imaging probe for the central nervous system. Our study demonstrates the effectiveness of PET at providing brain pharmacokinetic data for BACE1 inhibitors, crucial for the development of treatments for AD where CNS penetration is critical3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid

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Ether – Wikipedia,
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The author of 《Substituent-Oriented Synthesis of Substituted Pyrazoles/Chromeno[3,2-c]pyrazoles via Sequential Reactions of Chromones/3-Chlorochromones and Tosylhydrazones》 were Dai, Tianzi; Li, Qunyi; Zhang, Xiaofei; Yang, Chunhao. And the article was published in Journal of Organic Chemistry in 2019. Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The author mentioned the following in the article:

A facile and efficient synthetic strategy for the chemoselective synthesis of monocyclic/tricyclic-fused pyrazoles was developed, and it was oriented by different 3-position substituents (H or Cl) on the chromones. The reaction proceeded in a one-pot sequential way with a broad substrate scope and moderate to excellent yields. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
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In 2019,ChemistrySelect included an article by Karimi-Chayjani, Reyhaneh; Daneshvar, Nader; Tajik, Hassan; Shirini, Farhad. Electric Literature of C8H8O2. The article was titled 《Introduction of a New Magnetic Nanocatalyst as an Organic-inorganic Hybrid Framework for the Synthesis of Pyrano[2,3-d]pyrimidinone(thiones) and Pyrido[2,3-d]pyrimidines》. The information in the text is summarized as follows:

In this work, the preparation of bis-[(3-aminopropyl)triethoxysilane]dichloride immobilized on magnetic nano γ-Fe2O3@SiO2 is reported. This reagent can be obtained via the reaction of two mols. of 3-(aminopropyl)triethoxysilane with 1,4-dichlorobutane followed by immobilization of the resulted di-cationic compound on silica coated nano γ-Fe2O3. After characterization using FT-IR, XRD, FE-SEM and TGA techniques, the prepared reagent was used as a highly efficient catalyst for the promotion of the synthesis of pyrano[2,3-d]pyrimidinones(thiones) I (R = H, 2-Cl, 2-NO2, etc.; X = O, S) and pyrido[2,3-d]pyrimidine derivs II (R = H, 2-Cl, 4-F, etc.). The rates and especially the yields of the reactions were excellent in comparison to the reported catalyst for these reactions. Also, the recovery and reusability of the catalyst were excellent for both of the reactions using an external magnet.2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Electric Literature of C8H8O2

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In 2019,Journal of Organic Chemistry included an article by Liu, Shuai; Xu, Liang; Wei, Yu. Synthetic Route of C7H9BO3. The article was titled 《One-Pot, Multistep Reactions for the Modular Synthesis of N,N’-Diarylindazol-3-ones》. The information in the text is summarized as follows:

The pot-economic synthesis of N,N’-diarylindazol-3-ones has been developed using readily available isatoic anhydrides, aryl amines, and aryl boronic acids. A Cu-catalyzed oxidative C-N cross-coupling and dehydrogenative N-N formation sequence under an air atm. affords indazol-3-one derivatives in good to excellent yields. Such process merges well with the preceding decarboxylative amination reaction, resulting in a more modular and straightforward approach. In the experiment, the researchers used 3-Methoxyphenylboronic acid(cas: 10365-98-7Synthetic Route of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,New Journal of Chemistry included an article by Balakrishna, C.; Gudipati, Ramakrishna; Kandula, Venu; Yennam, Satyanarayana; Uma Devi, P.; Behera, Manoranjan. Electric Literature of C5H13NO2. The article was titled 《T3P mediated domino C(sp2)-H sulfenylation/annulation of enaminones and methylsulfinyls for the synthesis of chromone thioether derivatives》. The information in the text is summarized as follows:

A new regioselective method for the synthesis of 3-(methylthio)-4H-chromen-4-one I (R = H, 6-Br, 6-F, etc.) and 3-(phenylthio)-4H-chromen-4-one derivatives II (R = H, 8-F, 6-Cl, etc.; R1 = H, 4-Me, 4-Cl) has been developed. The reaction between o-hydroxy-phenyl-functionalized enaminones and methylsulfinyl derivatives using T3P gave good yields of chromone thioether derivatives The reaction proceeds via domino chromone ring construction and C(sp2)-H bond sulfenylation under transition-metal-free conditions. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Electric Literature of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Electric Literature of C5H13NO2

Referemce:
Ether – Wikipedia,
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