Tag: 100-200

In 2022,Li, Wen-Xin; Yang, Bo-Wen; Ying, Xuan; Zhang, Zhuo-Wen; Chu, Xue-Qiang; Zhou, Xiaocong; Ma, Mengtao; Shen, Zhi-Liang published an article in Journal of Organic Chemistry. The title of the article was 《Nickel-Catalyzed Direct Cross-Coupling of Diaryl Sulfoxide with Aryl Bromide》.Recommanded Product: 2398-37-0 The author mentioned the following in the article:

The direct cross-couplings of diaryl sulfoxides with aryl bromides via C-S bond cleavage could be readily accomplished using nickel(II) as the catalyst, 1,2-bis(diphenylphosphino)ethane (dppe) as the ligand, and magnesium turnings as the reducing metal in THF, leading to the corresponding biaryls RR1 [R = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = 4-MeOC6H4, 2-pyridyl, benzofuran-5-yl, etc.] in moderate to good yields. The reaction exhibited a broad substrate scope and could be applied to a gram-scale synthesis. The ”one-pot” reaction, which avoided the utility of presynthesized and moisture-labile organometallic compounds, was operationally simple and step-economic.1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 2398-37-0) was used in this study.

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Recommanded Product: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yuan, Sitian; Ye, Xiaoling; Cai, Jingyu; Song, Zhibin; Tan, Yuxing; Peng, Yiyuan; Ding, Qiuping published an article in Journal of Organic Chemistry. The title of the article was 《DMF-Assisted Radical Cyclization of o-Isocyanodiaryl Ethers via 1,5-Aryl Migration: Construction of 2-Arylbenzoxazoles》.Quality Control of m-Methoxyphenol The author mentioned the following in the article:

A novel DMF-assisted radical cyclization of o-isocyanodiaryl ethers 2-CN-3-R1-4-R2 -5-R3 C6HOR (R = 2-tert-butylphenyl, 2-phenylphenyl, pyridin-2-yl; R1 = H, Me, Cl; R2 = H, Me, Cl; R3 = H, Me) via 1,5-aryl migration has been developed for the synthesis of a series of 2-arylbenzoxazoles I and 2-phenyloxazolo[4,5-b]pyridine by the FeCl3/TBHP/Et3N catalytic system in DMF. However, N,N-dimethylbenzo[d]thiazole-2-carboxamide and N,N-dimethylbenzo[d]selenazole-2-carboxamide were obtained from the corresponding substrate 2-isocyanophenyl p-methoxyphenyl thioether and 2-isocyanodiphenyl selenoether under the same conditions. A possible mechanism may involve aryl 1,5-migration and DMF-assisted radical cyclization of o-isocyanodiaryl ethers I. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xiong, Biquan; Xu, Shipan; Xu, Weifeng; Liu, Yu; Zhang, Limin; Tang, Ke-Wen; Yin, Shuang-Feng; Wong, Wai-Yeung published an article in 2022. The article was titled 《Silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides with anilines and phenols》, and you may find the article in Organic Chemistry Frontiers.Quality Control of m-Methoxyphenol The information in the text is summarized as follows:

A simple and efficient method for the silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides (p-QMs) with anilines and phenols has been established. Without the need for pre-protection, a broad range of anilines (primary amine, secondary amine and tertiary amine), phenols and para-quinone methides are well tolerated under mild conditions, giving the corresponding 1,6-hydroarylation products with moderate to good yields. Moreover, a series of modified natural products can be synthesized via this simple method. Control experiments were also performed to gain insights into the plausible reaction mechanism. This protocol has high atom economy, and may have significant implications for the formation of C(sp3)-C(sp2) bonds in organic synthesis.m-Methoxyphenol(cas: 150-19-6Quality Control of m-Methoxyphenol) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneQuality Control of m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huang, Huoming; Li, Xinwei; Guo, Wei; Zhu, Chen; Qian, Yuanyuan; Shen, Qing; Xu, Xuejun; Li, Wei; Wang, Yujun; Fu, Wei published an article in 2021. The article was titled 《Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists》, and you may find the article in ACS Chemical Neuroscience.Application of 2398-37-0 The information in the text is summarized as follows:

Pain was implicated in many diseases. Despite effectiveness to treat moderate to severe pain, opioid analgesics elicited many side effects, greatly limiting their prescription in clinics. Based on M1, an active metabolite of tramadol, 3-((dimethylamino)methyl)-4-(3-hydroxyphenyl)piperidin-4-ol analogs were designed, synthesized, and evaluated in vitro. Among all the compounds tested, compound 23 was found to be a novel, highly selective, and potent MOR agonist (Ki MOR = 0.0034 nM, EC50 MOR = 0.68 nM, Emax = 206.5%; Ki DOR = 41.67 nM; Ki KOR = 7.9 nM). Structure-activity relationship exploration showed that the linker between the piperidine ring and the Ph ring as well as substituent pattern of the Ph ring played a pivotal role in binding affinity and selectivity. (3R, 4S)-23(I) (Ki MOR = 0.0021 ± 0.0001 nM, EC50 MOR = 0.0013 ± 0.0001 nM, Emax = 209.1 ± 1.4%; Ki DOR = 18.4 ± 0.7 nM, EC50 DOR = 74.5 ± 2.8 nM, Emax = 267.1 ± 1.4%; Ki KOR = 25.8 ± 0.2 nM, EC50 DOR = 116.2 ± 4.4 nM, Emax = 209.5 ± 1.4%) had more potent activity for opioid receptors than its enantiomer (3S, 4R)-23 and was found to be a potent, highly selective MOR agonist with novel scaffold. High binding affinity and selectivity of (3R, 4S)-23 for MOR over KOR and DOR and its mechanism of activating MOR were proposed by docking and mol. dynamics simulations, resp. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Application of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Wangchao; Zhang, Hanyu; Sun, Jianjun; Ghadari, Rahim; Zhang, Zhengguo; Pan, Fei; Lv, Kai; Sun, Xun; Guo, Fuling; Shi, Chengwu published an article in 2021. The article was titled 《Molecular tailor-making of zinc phthalocyanines as dopant-free hole-transporting materials for efficient and stable perovskite solar cells》, and you may find the article in Journal of Power Sources.Synthetic Route of C7H9BO3 The information in the text is summarized as follows:

Four Zinc (II) phthalocyanines (ZnPcs) derivatives, ZnPH13, ZnPH14, ZnPH15 and ZnPH22, decorated with elaborate mol. tailor-making on the phenyl-based peripheral substituents of Pc scaffolds are synthesized and acted as dopant-free hole-transporting materials (HTMs) in perovskite solar cells (PSCs). The detailed electrochem., photophys. characteristics, theor. geometric/electronic features, hole mobility, charge carrier extraction, collection and transporting dynamic processes of these HTMs are cautiously unveiled. The heuristic probe into the substantial relations and dependences between the Pc organic scaffold structure and properties at mol. level are investigated. The mixed-ion PSC utilizing the ZnPH22 containing the benzo[d] [1,3]dioxole peripheral substituent with cyclic/planar conformation presents a most competitive power conversion efficiency (PCE) of 18.3% associating with excellent reproducibility and superior long-period stability. These results reveal that the eventual solar cell performance can be decipherable through the intrinsic electronic and structural effects originating from the peripheral substituents modifications. This work thus exploits the new insights into the advanced mol. building of efficient phthalocyanines HTMs for high performance and stable PSCs. In the experiment, the researchers used many compounds, for example, 3-Methoxyphenylboronic acid(cas: 10365-98-7Synthetic Route of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Schlegel, Mark K.; Matsuda, Shigeo; Brown, Christopher R.; Harp, Joel M.; Barry, Joseph D.; Berman, Daniel; Castoreno, Adam; Schofield, Sally; Szeto, John; Manoharan, Muthiah; Charisse, Klaus; Egli, Martin; Maier, Martin A. published an article in 2021. The article was titled 《Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs》, and you may find the article in Nucleic Acids Research.Category: ethers-buliding-blocks The information in the text is summarized as follows:

We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc-siRNA conjugates in rodents, and that these findings could be mitigated by seed-pairing destabilization using a single GNA nucleotide placed within the seed region of the guide strand. Here, we report further investigation of the unique and poorly understood GNA/RNA cross-pairing behavior to better inform GNA-containing siRNA design. A reexamination of published GNA homoduplex crystal structures, along with a novel structure containing a single (S)-GNA-A residue in duplex RNA, indicated that GNA nucleotides universally adopt a rotated nucleobase orientation within all duplex contexts. Such an orientation strongly affects GNA-C and GNA-G but not GNA-A or GNA-T pairing in GNA/RNA heteroduplexes. Transposition of the hydrogen-bond donor/acceptor pairs using the novel (S)-GNA-isocytidine and -isoguanosine nucleotides could rescue productive base-pairing with the complementary G or C ribonucleotides, resp. GalNAc-siRNAs containing these GNA isonucleotides showed an improved in vitro activity, a similar improvement in off-target profile, and maintained in vivo activity and guide strand liver levels more consistent with the parent siRNAs than those modified with isomeric GNA-C or -G, thereby expanding our toolbox for the design of siRNAs with minimized off-target activity. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Decalepis salicifolia (Bedd. ex Hook. f.) Venter: A steno-endemic and critically endangered medicinal and aromatic plant from Western Ghats, India.》 was written by Rodrigues, Vereena; Kumar, Amit; Gokul, Sivaraman; Shukla, Ashutosh K; Ravikumar, Kaliamoorthy; Sundaresan, Velusamy. Computed Properties of C8H8O3 And the article was included in Journal of biosciences in 2021. The article conveys some information:

Decalepis salicifolia (Bedd. ex Hook. f.) Venter is a potential medicinal and highly aromatic plant species confined to the southernmost part of the Western Ghats of India. The plant is well known for its traditional uses among the various tribal communities of south India. The tubers of the plant possess characteristic vanillin-like aroma due to the presence of the compound 2-hydroxy-4-methoxybenzaldehyde. The tubers are used to substitute Hemidesmus indicus in various herbal formulations. The plants in the wild are continuously uprooted for their roots, leading to the irreversible destruction of the whole plant. The resulting tremendous loss of populations in the wild led to the species being declared as critically endangered by IUCN. Our group is working on the various aspects of this species including population status, distribution mapping, prospection, and conservation management. In the present review, we have brought out the available information till date on D. salicifolia, including taxonomy, ethno-medicinal uses, phytochemistry, pharmacology, population status, and conservation efforts along with research gap and lacunae to provide direction for further research into this less explored medicinal and aromatic plant. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Computed Properties of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cervi, Aymeric; Vo, Yen; Chai, Christina L. L.; Banwell, Martin G.; Lan, Ping; Willis, Anthony C. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2H-Chromenes》.Recommanded Product: 150-19-6 The article contains the following contents:

Methods are reported for the efficient assembly of a series of phenol-derived propiolates, including the parent system, and their Au(I)-catalyzed cyclization (intramol. hydroarylation) to give the corresponding coumarins. Simple syntheses of natural products such as ayapin and scoparone have been realized by such means, and the first of these subject to single-crystal X-ray anal. A related process is described for the conversion of propargyl ethers into the isomeric 2H-chromene precocene I, a naturally occurring inhibitor of juvenile hormone biosynthesis. In the part of experimental materials, we found many familiar compounds, such as m-Methoxyphenol(cas: 150-19-6Recommanded Product: 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kargar, Hadi; Aghaei-Meybodi, Fariba; Behjatmanesh-Ardakani, Reza; Elahifard, Mohammad Reza; Torabi, Vajiheh; Fallah-Mehrjardi, Mehdi; Tahir, Muhammad Nawaz; Ashfaq, Muhammad; Munawar, Khurram Shahzad published their research in Journal of Molecular Structure in 2021. The article was titled 《Synthesis, crystal structure, theoretical calculation, spectroscopic and antibacterial activity studies of copper(II) complexes bearing bidentate Schiff base ligands derived from 4-aminoantipyrine: Influence of substitutions on antibacterial activity》.COA of Formula: C8H8O3 The article contains the following contents:

A novel series of Cu(II) complexes, including: [Cu(L1)2]: C1, [Cu(L2)2]: C2, [Cu(L3)2]: C3, [Cu(L4)2]: C4, with four bis-N,O-bidentate Schiff base ligands (HL1: (E)-4-[(2-hydroxy-3-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one; HL2: (E)-4-[(2-hydroxy-4-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one; HL3: (E)-4-[(2-hydroxy-5-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one; HL4: (E)-4-[(2-hydroxy-6-methoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one) were synthesized and characterized by elemental analyses, FTIR, 1H NMR and 13C NMR spectroscopic techniques. Furthermore, the crystal structures of HL4 and C2 were determined by single crystal x-ray anal. Single crystal x-ray analyses, the structure of C2 confirmed the bidentate coordination mode. The metal center possesses a distorted tetrahedral geometry with bis-N,O donor atoms coordinating from Schiff base ligand. Theor. calculation of the synthesized compounds were carried out by DFT using B3LYP method with employing the Def2-SVPD (for ligands) and Def2-SV(P) (for complexes) basis sets. Calculated data are in good accordance with the exptl. studies. The in vitro biol. activities of the synthesized ligands and their copper(II) complexes were evaluated against Staphylococcus aureus and Escherichia coli. The activity data showed that the metal complexes have a promising biol. potential comparable with the parent Schiff base ligands against bacterial species. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3COA of Formula: C8H8O3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.COA of Formula: C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Menard, Travis; Laverny, Aragorn; Denmark, Scott E. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Synthesis of Enantioenriched 3,4-Disubstituted Chromans Through Lewis-Base Catalyzed Carbosulfenylation》.COA of Formula: C7H8O2 The article contains the following contents:

A method for the catalytic, enantioselective, carbosulfenylation of alkenes to construct 3,4-disubstituted chromans was described. Alkene activation proceeded through the intermediacy of enantioenriched, configurationally stable, thiiranium ions generated from catalytic Lewis-base activation of an electrophilic sulfenylating agent. The transformation affords difficult to generate enantioenriched 3,4-disubstituted chromans in moderate to high yields and excellent enantioselectivities. A variety of substituents are compatible including electronically diverse functional groups as well as several functional handles such as aryl halides, esters, anilines, and phenols. The resulting thioether moiety was amenable to a number of functional group manipulations and transformations. Notably, the pendant sulfide was successfully cleaved to furnish a free thiol which readily provides access to most sulfur-containing functional groups which are present in natural products and pharmaceuticals. The experimental part of the paper was very detailed, including the reaction process of m-Methoxyphenol(cas: 150-19-6COA of Formula: C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneCOA of Formula: C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem