Tag: 100-200

In 2019,Advanced Synthesis & Catalysis included an article by Kim, Seongwoo; Kim, Youngik; Jin, Hyomin; Park, Myung Hwan; Kim, Youngjo; Lee, Kang Mun; Kim, Min. Computed Properties of C8H8O2. The article was titled 《Europium-catalyzed aerobic oxidation of alcohols to aldehydes/ketones and photoluminescence tracking》. The information in the text is summarized as follows:

Europium-catalyzed aerobic oxidation of alcs. to aldehydes/ketones with external catalytic oxidants utilizing the redox cycle of Eu2+/Eu3+ was developed. The oxidation reaction was performed under mild conditions and it showed good substrate tolerance. The photoluminescence spectra clearly demonstrated the oxidation state changes that occur during the presented europium-catalyzed aerobic oxidation In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Computed Properties of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Computed Properties of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Chunlei; Wang, Xiu; Shen, Lei; Deng, Wenping; Liu, Haiyun; Ge, Shenguang; Yan, Mei; Song, Xianrang published an article in Biosensors & Bioelectronics. The title of the article was 《An aldehyde group-based P-acid probe for selective fluorescence turn-on sensing of cysteine and homocysteine》.HPLC of Formula: 74029-40-6 The author mentioned the following in the article:

A highly sensitive and selective turn on fluorescent probe P-acid-aldehyde (P-CHO) is developed for the determination of cysteine (Cys) and homocysteine (Hcy). The probe is designed and synthesized by incorporating the specific functional group aldehyde group for thiols into a stable p-conjugated material 4,4′-(2,5-dimethoxy-1,4-phenylene) bis(ethyne-2,1-diyl) dibenzoic acid (P-acid). The probe fluorescence is quenched through donor photoinduced electron transfer (d-PET) between the fluorophore (P-acid) and the recognition group (aldehyde group). In the presence of thiols, Cys and Hcy can selectively react with aldehyde group of the probe because the inhibition of d-PET between fluorophore and recognition group. Therefore, a turn-on fluorescent sensor was established for the fluorescence recovery. Under the optimized conditions, the fluorescence response of probe is directly proportional to the concentration of Cys in the range of 4-95 nM L-1, with a detection limit 3.0 nM. In addition, the sensing system exhibits good selectively toward Cys and Hcy in the presence of other amino acids. It has been successfully applied for bioimaging of Cys and Hcy in living cells with low cell toxicity. After reading the article, we found that the author used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6HPLC of Formula: 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.HPLC of Formula: 74029-40-6Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Journal of Chemistry included an article by Basinger, Corinne A.; Sullivan, Kaitlin; Siemer, Sarah; Oehrle, Stuart; Walters, Keith A.. Application of 74029-40-6. The article was titled 《Synthesis and preliminary characterization of a PPE-type polymer containing substituted fullerenes and transition metal ligation sites》. The information in the text is summarized as follows:

A substituted fullerene was incorporated into a PPE-conjugated polymer repeat unit. This subunit was then polymerized via Sonogashira coupling with other repeat units to create polymeric systems approaching 50 repeat units (based on GPC characterization). Bipyridine ligands were incorporated into some of these repeat units to provide sites for transition metal coordination. Photophys. characterization of the absorption and emission properties of these systems shows excited states located on both the fullerene and aromatic backbone of the polymers that exist in a thermally controlled equilibrium Future work will explore other substituted polyaromatic systems using similar methodologies. In addition to this study using 1,4-Diethynyl-2,5-dimethoxybenzene, there are many other studies that have used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Application of 74029-40-6) was used in this study.

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Application of 74029-40-6 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《β-1,3-glucan (schyzophyllan) can act as a one-dimensional host for creating chirally twisted poly(p-phenylene ethynylene)》 was written by Numata, Munenori; Fujisawa, Tomohisa; Li, Chun; Haraguchi, Shunichi; Ikeda, Masato; Sakurai, Kazuo; Shinkai, Seiji. Synthetic Route of C12H10O2 And the article was included in Supramolecular Chemistry in 2007. The article conveys some information:

It has been demonstrated that a chiral, insulated poly(p-phenylene ethynylene) (PPE) nano-wire can be created by a polymer wrapping method utilizing natural β-1,3-glucan polysaccharide schizophyllan (SPG). Spectroscopic and microscopic measurements have revealed that PPE adopts a rigid conformation and exists as one piece in the helical hollow constructed by two SPG chains. Moreover, the inherent helical structure of SPG can induce the chiral twisting of the insulated PPE backbone. It is believed that the present system is really applicable for designing novel chiral sensors based on PPE. In the experimental materials used by the author, we found 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Synthetic Route of C12H10O2)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Synthetic Route of C12H10O2Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Reactivity of 1,2,3- and 1,2,4-Trifluorobenzenes in Palladium-Catalyzed Direct Arylation》 was written by Shi, Xinzhe; Mao, Shuxin; Soule, Jean-Francois; Doucet, Henri. Category: ethers-buliding-blocks And the article was included in Journal of Organic Chemistry on April 6 ,2018. The article conveys some information:

The higher reactivity of the C4-H bond as compared to the C5-H bond of 1,2,3-trifluorobenzene in palladium-catalyzed direct arylation allows the selective synthesis of 4-aryl-1,2,3-trifluorobenzenes in moderate to high yields. In most cases, phosphine-free Pd(OAc)2 catalyst and inexpensive KOAc base were employed. Then, from these 4-aryl-1,2,3-trifluorobenzenes, the palladium-catalyzed C-H bond functionalization of the C6-position allows the synthesis of the corresponding 4,6-diarylated 1,2,3-trifluorobenzenes. We also applied these reaction conditions to the regioselective direct C3-arylation of 1,2,4-trifluorobenzene.1,2,3-Trifluoro-4-methoxybenzene(cas: 203245-16-3Category: ethers-buliding-blocks) was used in this study.

1,2,3-Trifluoro-4-methoxybenzene(cas: 203245-16-3) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1-Bromo-3-methoxybenzeneIn 2020 ,《Synthesis of Tetrahydropyridazines via Pd-Catalyzed Carboamination of Alkenyl Hydrazones》 was published in Advanced Synthesis & Catalysis. The article was written by Guo, Yajing; Zhao, Jinbo; Zhang, Qian. The article contains the following contents:

Herein a facile approach to tetrahydropyridazines, a scaffold found in many natural products and biol. active entities, via Pd-catalyzed carboamination of readily available alkenyl hydrazones with aryl and alkenyl halides was reported. Preliminary studies showed its promise for enantioselective synthesis. This work offers an expedient access to the tetrahydropyridazine scaffold bearing substitution patterns, thus significantly increasing the availability of these derivatives for downstream evaluation. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Reference of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Reference of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 2-Hydroxy-4-methoxybenzaldehydeIn 2019 ,《High in Vitro and in Vivo Tumor-Selective Novel Ruthenium(II) Complexes with 3-(2′-Benzimidazolyl)-7-fluoro-coumarin》 was published in ACS Medicinal Chemistry Letters. The article was written by Qin, Qi-Pin; Wang, Zhen-Feng; Huang, Xiao-Ling; Tan, Ming-Xiong; Shi, Bei-Bei; Liang, Hong. The article contains the following contents:

Three novel Ru(II) complexes, namely, (RuCl2[La][DMSO]2)·H2O (Ru1), (RuCl2[Lb][DMSO]2) (Ru2), and (RuCl2[Lc][DMSO]2) (Ru3), which resp. contain 3-(2′-benzimidazolyl)coumarin (La), 3-(2′-benzimidazolyl)-7-fluoro-coumarin (Lb), and 3-(2′-benzimidazolyl)-7-methoxyl-coumarin (Lc), were first designed and characterized. Ru2 showed potent antitumor activity against NCI-H460 cells (IC50 = 0.30 ± 0.02 μM) and high selectivity between NCI-H460 cancer cells and normal HL-7702 cells. Ru2 induced NCI-H460 apoptosis via telomerase inhibition, which involved DNA damage, cell-cycle distribution, and S phase-protein down-regulation. However, Ru1 did not demonstrate such effects in NCI-H460 cells, which is undoubtedly associated with the key regulatory role of the 7-fluoro substituted group in the Lb ligand of Ru2. Ru2 exhibited considerably higher anticancer efficacy (inhibition rate [IR] = 61.3%) compared with cisplatin (IR= 25.5%) in a NCI-H460 xenograft mouse model. Thus, this coumarin Ru(II) compound is a promising Ru2-targeting telomerase anticancer agent. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Reference of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Reference of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SDS of cas: 673-22-3In 2020 ,《Visible-light-induced radical cascade cyclization of pyrazoles bearing a coumarin unit》 appeared in New Journal of Chemistry. The author of the article were Sharma, Amit Kumar; Jaiswal, Anjali; Mishra, Anu; Tiwari, Jyoti; Jaiswal, Deepali; Singh, Shailesh; Singh, Jaya; Singh, Jagdamba. The article conveys some information:

Herein, an efficient, eco-friendly, metal free, visible light catalyzed synthesis of coumarin based pyrazoles I (R1 = H, OH, OMe; R2 = H, Cl, Br, NO2; R3 = H, OMe; R4 = H, Br, F; R5 = H, F) under an open atm. involving a photoredox catalyst, which is an inexpensive organic dye have been described. The present strategy is the first example of visible light promoted, aerobic, oxidative cyclization of pyrazoles bearing a coumarin unit via the formation of C-C, C-O and C-N bonds to afford excellent yields of the products I in a simple one-pot operation under mild reaction conditions. The major advantages of the present methodol. include short reaction time, cost effectiveness, easy work-up, broad substrate scope and high atom economy. In the experiment, the researchers used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3SDS of cas: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.SDS of cas: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Kaya, Busra; Kalindemirtas, Ferdane Danisman; Ertik, Onur; Yanardag, Refiye; Kuruca, Serap Erdem; Ulkuseven, Bahri published an article in Chemico-Biological Interactions. The title of the article was 《New thiosemicarbazone-based Zinc(II) complexes. In vitro cytotoxicity competing with cisplatin on malignant melanoma A375 cells and its relation to neuraminidase inhibition》.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde The author mentioned the following in the article:

New thiosemicarbazone-based zinc(II) complexes were synthesized to study their cytotoxicity on A375 malignant melanoma cells. The complexes containing salicylidene (Zn1a), 3-methoxy-salicylidene (Zn1b) or 4-methoxy-salicylidene (Zn1c) moiety were characterized by anal. and spectroscopic methods. Anticancer potential of the complexes was determined by MTT test and HUVEC endothelial cells line was used to comprehend the effect on normal cells. Zn1b with an IC50 of 13 μM was found to be highly cytotoxic against A375 cancer cells, more effective than cisplatin (IC50: 37 μM). Zn1a and Zn1c did not have a neg. effect on cell viability in the normal cells and gave the impression that they are more advantageous than cisplatin in this respect. Further, the ability of Zn1a-c to inhibit neuraminidase enzyme and its role in cytotoxicity was discussed. The test revealed that the Zn1b with 3-methoxy substituent exhibited higher inhibition activity against the neuraminidase than the Zn1a and Zn1c as analogical to the cytotoxicity results. In neuraminidase inhibition, IC50 values of Zn1b and Zn1c were 14 and 66 μM, resp. These concentrations were very close to the cytotoxicity concentrations for Zn1b and Zn1c. The findings may indicate the role of neuraminidase enzyme inhibition in cell death for Zn1b and Zn1c. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yi, Bing; Wang, Qiang; Tan, Jian-Ping; Yi, Ziqi; Li, Daiguang; Kang, Shiyuan; Zhang, Wenhui; Tang, Huan; Xie, Yanjun published an article in Asian Journal of Organic Chemistry. The title of the article was 《Visible Light-mediated, Iodine-catalyzed Radical Cascade Sulfonylation/Cyclization for the Synthesis of Sulfone-containing Coumarin under Photocatalyst-free Conditions》.COA of Formula: C7H8O2 The author mentioned the following in the article:

A visible-light mediated, iodine catalyzed radical cascade sulfonylation/cyclization reaction by employing iodine as catalyst without addition of any of photocatalyst and oxidant was presented. A number of sulfone-containing coumarin derivatives with different substituent and functional groups were obtained in moderate to good yields. Besides, the practicality and utility of this protocol were demonstrated by the scale up synthesis. Furthermore, mechanistic investigations including control experiments and light on/off studies indicated that visible-light irradiation and iodine catalyst were the essential elements to fulfill the radical cascade sulfonylation/cyclization process. This protocol featured green, economical and efficient, and opens a new opportunity for accessing to structurally diverse sulfone-containing coumarin derivatives In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6COA of Formula: C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneCOA of Formula: C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem