Tag: 100-200

《Synthesis of some chalcone derivatives, in vitro and in silico toxicity evaluation》 was published in Rasayan Journal of Chemistry in 2020. These research results belong to Kristanti, A. N.; Suwito, H.; Aminah, N. S.; Haq, K. U.; Hardiyanti, H. D.; Anggraeni, H.; Faiza, N.; Anto, R. S.; Muharromah, S.. Electric Literature of C8H8O2 The article mentions the following:

The objevtives of this study was to synthesize some chalcone derivatives I [R = 4-F, 4-N(Me)2, 2-OMe, etc.] using conventional Claisen-Schmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing mol. docking on p53 and MDM2 interaction. Cytotoxicity test exhibited that 2,5-dimethoxy-2′-hydroxychalcone and 4-chloro-2′-hydroxychalcone gave very low IC50, but both did not showed potential apoptosis activity, while in docking anal. 4-chloro-2′-hydroxychalcone showed the best results. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Electric Literature of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Molecularly imprinted polymer and computational study of (E)-4-(2-cyano-3-(dimethylamino)acryloyl)benzoic acid from poly(ethylene terephthalate) plastic waste》 was published in Current Analytical Chemistry in 2020. These research results belong to Fahim, Asmaa M.; Wasiniak, Bartlomiej; Lukaszewicz, Jerzy P.. Safety of N,N-Dimethylformamide Dimethyl Acetal The article mentions the following:

Molecularly imprinted polymers (MIPs) are utilized in the separation of a pure compound from complex matrixes. A stable template-monomer complex generates MIPs with the highest affinity and selectivity for the template. In this investigation, degradation of poly(ethylene terephthalate) PET afforded the (E)-4-(2-cyano-3-(dimethylamino) acryloyl) benzoic acid (TAM) which used TAM as template which interacts with methacrylic Acid (MAA) monomer, in the presence of CH3CN as progen. The TAM-MMA complex interactions are dependent on stable hydrogen bonding interaction between the carboxylic acid group of TAM and the hydroxyl group of MMA with minimal interference of porogen CH3CN. The DFT/B3LYP/6-31+G model chem. was used to optimize their structures and frequency calculations The binding energies between TAM with different monomers showed the most stable molar ratio of 1:4 which was confirmed through exptl. anal. The present work describes the synthesis of (E)-4-(2-cyano-3-(dimethylamino) acryloyl) benzoic acid (TAM) from PET waste and formation of molecularly imprinted polymer from TAM with the methacrylic acid monomer. The optimization of mol. imprinted was stimulated via DFT/B3LYP/6-31G (d). The imprinted polymer film was characterized via thermal anal., pore size, FT-IR and SEM. The most stable molecularly imprinted polymers (MIPs) showed binding energy of TAM(MMA4) = -2063.456 KJ/mol with a small value of mesopores (10-100 Å). Also, the sorption capability of TAM-MIPs showed 6.57 mg/g using STP-MIP-9VC. Moreover, the average pore size ranged between 0.2-1 nm with the BET surface about 300 m2/g. The proposed TAM exhibited a high degree of selectivity for MMA in comparison with other different monomers through hydrogen bond interaction, which was thermally stable, good reproducibility and excellent regeneration capacity and elucidated in the computational study and anal. anal. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Safety of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Safety of N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Lewis Acid-Catalyzed Vinyl Acetal Rearrangement of 4,5-Dihydro-1,3-dioxepines: Stereoselective Synthesis of cis- and trans-2,3-Disubstituted Tetrahydrofurans》 was published in Journal of Organic Chemistry in 2020. These research results belong to Ghosh, Arun K.; Belcher, Miranda R.. COA of Formula: C9H10O2 The article mentions the following:

Lewis acid-catalyzed rearrangements of 4,5-dihydro-1,3-dioxepines have been investigated. Rearrangement of vinyl acetals under a variety of conditions resulted in cis- and trans-2,3-disubstituted THF derivatives in a highly stereoselective manner. Rearrangements at lower temperatures typically provided the cis-2,3-disubstituted THF carbaldehydes. At higher temperatures, the corresponding trans-2,3-disubstituted THF carbaldehydes are formed. The requisite substrates for the vinyl acetal rearrangement were synthesized via ring-closing olefin metathesis of bis(allyoxy)methyl derivatives using Grubbs second-generation catalyst followed by olefin isomerization using a catalytic amount of RuCl2(PPh3)3. We examined the substrate scope using substituted aromatic and aliphatic derivatives Addnl., the rearrangement was utilized in the synthesis of a stereochem.-defined bis-tetrahydrofuran (bis-THF) derivative, which is one of the key structural elements of darunavir, an FDA-approved drug for the treatment of HIV/AIDS. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.COA of Formula: C9H10O2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Excited-State Kinetics of an Air-Stable Cyclometalated Iron(II) Complex》 were Steube, Jakob; Burkhardt, Lukas; Paepcke, Ayla; Moll, Johannes; Zimmer, Peter; Schoch, Roland; Woelper, Christoph; Heinze, Katja; Lochbrunner, Stefan; Bauer, Matthias. And the article was published in Chemistry – A European Journal in 2019. Formula: C5H13NO2 The author mentioned the following in the article:

The title complex class with an Earth-abundant metal ion has been repeatedly suggested as a chromophore and potential photosensitizer on the basis of quantum chem. calculations Synthesis and photophys. properties of the parent complex [Fe(pbpy)(tpy)]+ (Hpbpy=6-phenyl-2,2′-bipyridine and tpy=2,2′:6′,2′′-terpyridine) of this new chromophore class are now reported. Ground-state characterization by X-ray diffraction, electrochem., spectroelectrochem., UV/Vis, and X-ray spectroscopy in combination with DFT calculations proves the high impact of the cyclometalating ligand on the electronic structure. The photophys. properties are significantly improved compared to the prototypical [Fe(tpy)2]2+ complex. In particular, the metal-to-ligand absorption extends into the near-IR and the 3MLCT lifetime increases by 5.5, whereas the metal-centered excited triplet state is very short-lived. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Applied Organometallic Chemistry included an article by Varzi, Zahra; Maleki, Ali. Synthetic Route of C8H8O2. The article was titled 《Design and preparation of ZnS-ZnFe2O4: a green and efficient hybrid nanocatalyst for the multicomponent synthesis of 2,4,5-triaryl-1H-imidazoles》. The information in the text is summarized as follows:

In the present work, a new protocol was introduced for the preparation of an efficient hybrid nanocatalyst ZnS-ZnFe2O4 via the co-precipitation method as well as its application in the synthesis of 2,4,5-triaryl-1H-imidazoles derivatives, e.g., I, starting from various aromatic aldehydes, benzil and ammonium acetate under ultrasonic irradiation in ethanol. ZnS-ZnFe2O4 was characterized by Fourier transform IR (FT-IR) spectroscopy, energy-dispersive X-ray spectroscopy (EDS) anal., SEM (SEM) image, X-ray diffraction (XRD) pattern and vibrating sample magnetometer (VSM) curve. This method has advantages such as high efficiency of the heterogeneous catalyst, the use of environmentally-friendly solvent, high yields, short reaction times and easy isolation of the products and chromatog.-free purification Our outcomes illustrated that the present nanocatalyst with nearly spherical and Cauliflower-like morphol. and average particle size of 36 nm could be applied as an effective and magnetically recyclable catalyst without any significant decreasing of activity. Furthermore, the synergic effect of bimetallic Lewis acids was studied for the synthesis of imidazole derivatives In the part of experimental materials, we found many familiar compounds, such as 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Synthetic Route of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Journal of Organic Chemistry included an article by Luo, Zhongfeng; Xiong, Li; Liu, Tingting; Zhang, Yuqi; Lu, Siqi; Chen, Yuwen; Guo, Weijie; Zhu, Yulin; Zeng, Zhuo. HPLC of Formula: 10365-98-7. The article was titled 《Palladium-Catalyzed Decarbonylative Suzuki-Miyaura Coupling of Amides To Achieve Biaryls via C-N Bond Cleavage》. The information in the text is summarized as follows:

The palladium-catalyzed decarbonylative Suzuki-Miyaura coupling of amides via selective amide C-N bond cleavage was reported, which afforded mild access to substitute biaryl products in the presence of low catalyst loading with NaHCO3 as the base in good yields within 4 h (29 examples). The experimental process involved the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7HPLC of Formula: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.HPLC of Formula: 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Khan, Muhammad S.; Al-Mandhary, Muna R. A.; Al-Suti, Mohammed K.; Corcoran, Timothy C.; Al-Mahrooqi, Yaqoub; Attfield, J. Paul; Feeder, Neil; David, William I. F.; Shankland, Kenneth; Friend, Richard H.; Koehler, Anna; Marseglia, Elisabeth A.; Tedesco, Emilio; Tang, Chiu C.; Raithby, Paul R.; Collings, Jonathan C.; Roscoe, Karl P.; Batsanov, Andrei S.; Stimson, Lorna M.; Marder, Todd B. published an article on January 31 ,2003. The article was titled 《Synthesis and optical characterisation of platinum(II) poly-yne polymers incorporating substituted 1,4-diethynylbenzene derivatives and an investigation of the intermolecular interactions in the diethynylbenzene molecular precursors》, and you may find the article in New Journal of Chemistry.Name: 1,4-Diethynyl-2,5-dimethoxybenzene The information in the text is summarized as follows:

A series of 1,4-diethynylbenzene derivatives, H-CC-R-CC-H with R = C6H3NH2 (I), C6H3F (II), C6H2F2-2,5 (III), C6F4 (IV), C6H2(OMe)2-2,5 (V) and C6H2(OC8H17-n)2-2,5 (VI) were synthesized and their crystal structures were determined by single crystal (I, II, III, IV) or powder (V, VI) x-ray diffraction. The CCH···πCC hydrogen bonds dominating structure H-CC-R-CC-H are gradually replaced by CC-H···F ones with the increase of fluorination (II → IV), or completely replaced by CCH···N and NH···πCC bonds in I, and CCH···O in V and VI. The related platinum-based polymers, trans-[-Pt(PnBu3)2-CC-R-CC-]n (R = as above and C6H4,) were prepared and characterized by spectroscopic methods and thermogravimetry, which show that the amino and methoxy derivatives have lowest thermal stability whereas the fluorinated ones exhibit increasing thermal stability with increasing fluorination. Optical spectroscopic measurements reveal that substituents on the aromatic spacer group do not create strong donor-acceptor interactions along the rigid backbone of the organometallic polymers. In addition to this study using 1,4-Diethynyl-2,5-dimethoxybenzene, there are many other studies that have used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Name: 1,4-Diethynyl-2,5-dimethoxybenzene) was used in this study.

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Name: 1,4-Diethynyl-2,5-dimethoxybenzene They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 673-22-3In 2020 ,《Colorimetric textile sensor for the simultaneous detection of NH3 and HCl gases》 was published in Polymers (Basel, Switzerland). The article was written by Park, Young Ki; Oh, Hyun Ju; Bae, Jong Hyuk; Lim, Jee Young; Lee, Hee Dong; Hong, Seok Il; Son, Hyun Sik; Kim, Jong H.; Lim, Seung Ju; Lee, Woosung. The article contains the following contents:

For the immediate detection of strong gaseous alkalis and acids, colorimetric textile sensors based on halochromic dyes are highly valuable for monitoring gas leakages. To date, colorimetric textile sensors for dual-gas detection have usually been fabricated by electrospinning methods. Although nanofibrous sensors have excellent pH sensitivity, they are difficult to use com. because of their low durability, low productivity, and high production costs. In this study, we introduce novel textile sensors with high pH sensitivity and durability via a facile and low-cost screen-printing method. To fabricate these textiles sensors, Dye 3 and RhYK dyes were both incorporated into a polyester fabric. The fabricated sensors exhibited high detection rates (<10 s) and distinctive color changes under alk. or acidic conditions, even at low gas concentrations Furthermore, the fabricated sensors showed an outstanding durability and reversibility after washing and drying and were confirmed to contain limited amounts of hazardous materials. Thus, our results show that the fabricated textile sensors could be used in safety apparel that changes its color in the presence of harmful gases. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C7H7BrOIn 2021 ,《Visible Light Mediated Photocatalytic N-Radical Cascade Reactivity of γ,δ-Unsaturated N-Arylsulfonylhydrazones: A General Approach to Structurally Diverse Tetrahydropyridazines》 was published in Journal of Organic Chemistry. The article was written by Azzi, Emanuele; Ghigo, Giovanni; Parisotto, Stefano; Pellegrino, Francesco; Priola, Emanuele; Renzi, Polyssena; Deagostino, Annamaria. The article contains the following contents:

The photocatalytic synthesis of different tetrahydropyridazines I (R = H, Me; R1 = Me, Ph; R2 = Me, Ph, naphthalen-2-yl, pyridin-2-yl, etc.), II (Ar = Ph, 4-methylphenyl, 2,4,6-trimethylphenyl; R3 = H, Me), III and (7R)-2-(mesitylsulfonyl)-3,4,4,7-tetramethyl-2,3,4,4a,5,6,7,8-octahydrocinnoline starting from γ,δ-unsaturated N-arylsulfonylhydrazones ArS(O)2NHN=C(R2)CH2C(CH3)(R1)CH=CHR3 were described. Simple structural changes of substrates result into three different pathways beginning from a common N-hydrazonyl radical, which evolves through a domino carboamination/dearomatization, a HAT process, or a photoinduced radical Smiles rearrangement to afford diverse tetrahydropyridazines I, II, III and (7R)-2-(mesitylsulfonyl)-3,4,4,7-tetramethyl-2,3,4,4a,5,6,7,8-octahydrocinnoline. All reactions are carried out in very mild conditions, and the quite inexpensive [Ru(bpy)3]Cl2 is used as the catalyst. Preliminary mechanism studies about luminescence and electrochem. characterization of the involved species are presented. Computational studies allow to rationalize the mechanism in accord with the exptl. findings. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0Synthetic Route of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Synthetic Route of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《An acetohydroxamate-coordinated oxidovanadium(V) complex derived from pyridinohydrazone ligand with urease inhibitory activity》 was written by Li, Yanmin; Xu, Luyao; Duan, Mengmeng; Wu, Jiahui; Wang, Yinghui; Dong, Kexin; Han, Moxuan; You, Zhonglu. Name: 2-Hydroxy-4-methoxybenzaldehydeThis research focused onvanadyl hydroxybenzylidenenicotinohydrazide acetohydroxamato complex preparation crystal structure enzyme. The article conveys some information:

A new acetohydroxamate coordinated oxidovanadium(V) complex derived from the pyridinohydrazone ligand 2′-(2-hydroxy-4-methoxybenzylidene)nicotinohydrazide (H2L), was prepared and characterized by elemental anal., IR, UV-visible and 1H NMR spectra, and single crystal x-ray diffraction. Thermal anal. of the complex was performed. The V atom is in octahedral coordination. The complex has remarkable inhibitory activity on Jack bean urease with IC50 value of 14.9 μmol·L-1. The interaction mode of the complex with the urease was studied by mol. docking technique. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Name: 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Name: 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem