Tag: 100-200

Application In Synthesis of 2-(Benzyloxy)acetaldehydeIn 2021 ,《Construction of Enantioenriched 4,5,6,7-Tetrahydrofuro[2,3-b]pyridines through a Multicatalytic Sequence Merging Gold and Amine Catalysis》 was published in Advanced Synthesis & Catalysis. The article was written by Genet, Manon; Takfaoui, Abdelilah; Marrot, Jerome; Greck, Christine; Moreau, Xavier. The article contains the following contents:

A series of enantioenriched 4,5,6,7-tetrahydrofuro[2,3-b]pyridines I (R1 = Ph, 2-MeC6H4, 2-thienyl, etc.; R2 = Me, Pr, Bn, etc.; R3 = Ph, 4-MeOC6H4, 4-FC6H4, etc.) were accessed by a cycloisomerization/cycloaddition strategy. Starting from ynamide derivatives and aldehydes, yields ranging from 27 to 90% and high levels of stereoselectivity (de>95%, 93-99% ee) were obtained through sequential relay catalysis. The concurrent use of a gold complex with a diphenylprolinol silyl ether was applied to a combination of diversely functionalized substrates. The experimental process involved the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Application In Synthesis of 2-(Benzyloxy)acetaldehyde

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Category: ethers-buliding-blocksIn 2020 ,《Ultrasound assisted synthesis of pyrazolo[1,5-a]pyrimidine-antipyrine hybrids and their anti-inflammatory and anti-cancer activities》 appeared in European Journal of Chemistry. The author of the article were Kaping, Shunan; Sunn, Melboureen; Singha, Laishram Indira; Vishwakarma, Jai Narain. The article conveys some information:

A series of antipyrinyl-pyrazolo[1,5-a]pyrimidines have been synthesized by reactions of aminopyrazole (4) with various formylated active proton compounds in the presence of KHSO4 (aqueous media), under ultrasound irradiation The structures of the compounds have been established with the help of spectral and anal. data. N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-7-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide (6a) was further subjected to X-ray crystallog. studies to avoid any ambiguity of the derived structures. Crystal data for compound 6a, C51H46N12O5 (M =907.00 g/mol): triclinic, space group P-1 (number 2), a = 9.9554(3) Å, b = 14.0875(4) Å, c = 17.4572(4) Å, a = 79.676(2)°, β= 85.283(2)°, γ= 72.647(2)°, V = 2297.97(11) Å3, Z = 2, T = 296.15 K, μ(MoKa) = 0.088 mm-1, Dcalc = 1.311 g/cm3, 29732 reflections measured (4.174° = 2T = 57.068°), 10681 unique (Rint = 0.0400, Rsigma = 0.0533) which were used in all calculations The final R1 was 0.0566 (I > 2s(I)) and wR2 was 0.1663 (all data). The novel compounds were also screened for their biol. activities. In the part of experimental materials, we found many familiar compounds, such as N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Category: ethers-buliding-blocks

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Reference of 2-MethoxybenzaldehydeIn 2019 ,《Pyranopyrazoles as efficient antimicrobial agents: Green, one pot and multicomponent approach》 appeared in Bioorganic Chemistry. The author of the article were Reddy, Guda Mallikarjuna; Garcia, Jarem Raul; Zyryanov, Grigory V.; Sravya, Gundala; Reddy, Nemallapudi Bakthavatchala. The article conveys some information:

Innovative therapeutic heterocycles having precisely thiadiazolyl-pyranopyrazole fragments were prepared by using the ecofriendly synthetic route. Entire compounds formed in quant. yields. All the composites tested for their antimicrobial effectiveness against four microbial, two beneficial fungi’s and accurately measured the min. inhibitory concentrations (MIC and MBC/MFC), along with some initial structure activity relationships (SARs) also discussed. From the biol. outcomes, the motif 6f provided an outstanding activity against all six pathogens. The possible presence of a nitro substituent on this composite may undoubtedly enhance the activity. In addition, amalgams 6d, 6g and 6l displayed promising antimicrobial results. This may be justified to the presence of electron capture group attached to the benzene ring, while the combinations 6j and 6k were zero effect towards all bacterial strains. The other compounds were excellent to low antimicrobial efficiency. The intriguing point was observed that all the active compounds had in common immense antibacterial effectiveness on Gram-neg. bacteria than Gram-pos. one and more antifungal activity on A. niger compare to other fungus. All things considered and suggested that this outstanding green synthetic approach is used to develop biol. active compounds On top of that, biol. results confirmed that these biol. energetic motifs suitable for addnl. preclin. examine with the aim of standing novel innovative drugs.2-Methoxybenzaldehyde(cas: 135-02-4Reference of 2-Methoxybenzaldehyde) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Reference of 2-Methoxybenzaldehyde

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In 2022,Kondoh, Azusa; Hirozane, Takayuki; Terada, Masahiro published an article in Chemistry – A European Journal. The title of the article was 《Formal umpolung addition of phosphites to 2-azaaryl Ketones under chiral Broensted base catalysis: enantioselective protonation utilizing [1,2]-phospha-Brook rearrangement》.Product Details of 2398-37-0 The author mentioned the following in the article:

The formal enantioselective umpolung addition of dialkyl phosphites to 2-azaaryl ketones was developed under Broensted base catalysis. The reaction involved the enantioselective protonation of the transient α-oxygenated (2-azaaryl)methyl anion generated through the 1,2-addition of the anion of dialkyl phosphite to the 2-azaaryl ketone and the subsequent [1,2]-phospha-Brook rearrangement. A chiral bis(guanidino)iminophosphorane organosuperbase efficiently catalyzed the reaction to provide enantio-enriched phosphates in high yields with good to high enantioselectivities. This is a rare example of the catalytic enantioselective protonation of transient carbanions other than enolates, constructing a trisubstituted stereogenic center α to 2-azaarenes. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Product Details of 2398-37-0

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Ether – Wikipedia,
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Yang, Qi-Liang; Liu, Ying; Liang, Lei; Li, Zhi-Hao; Qu, Gui-Rong; Guo, Hai-Ming published an article in 2022. The article was titled 《Facilitating Rh-Catalyzed C-H Alkylation of (Hetero)arenes and 6-Arylpurine Nucleosides (Nucleotides) with Electrochemistry》, and you may find the article in Journal of Organic Chemistry.Recommanded Product: 10365-98-7 The information in the text is summarized as follows:

An electrochem. approach to promote the ortho C-H alkylation of (hetero)arenes via rhodium catalysis under mild conditions was described. This approach features mild conditions with high levels of regio- and monoselectivity that tolerated a variety of aromatic and heteroaromatic groups and offered a widely applicable method for late-stage diversification of complex mol. architectures including tryptophan, estrone, diazepam, nucleosides and nucleotides. Alkyl boronic acids, esters and alkyl trifluoroborates were demonstrated as suitable coupling partners. The isolation of key rhodium intermediates and mechanistic studies provided strong support for a rhodium(III/IV or V) regime. The results came from multiple reactions, including the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 10365-98-7

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Pal, Ashutosh published an article in 2021. The article was titled 《Synthesis of salicylate and salicylamide alcohols for the preparation of phosphorodiamidates and ifosfamide prodrugs》, and you may find the article in Oriental Journal of Chemistry.Application In Synthesis of 2-(Benzyloxy)acetaldehyde The information in the text is summarized as follows:

Different types of salicylate and salicylamide alcs. for the preparation of phosphorodiamidates and ifosfamide prodrugs were reported. In drug discovery and development, prodrugs were well-known for pharmacokinetic effects of pharmacol. nimble products. Almost 10% of drugs permitted, whole world were classified as prodrugs, where the application of a prodrug method during initial stages of development was an emergent fashion. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Application In Synthesis of 2-(Benzyloxy)acetaldehyde

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Ether – Wikipedia,
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Wang, Jiaqi; Luo, Yingying; Zhang, Yixuan; Chen, Yue; Gao, Fei; Ma, Yue; Xian, Dongmei; You, Zhonglu published their research in Journal of Coordination Chemistry in 2021. The article was titled 《Synthesis, crystal structure, and urease inhibition of an end-on azido-bridged dinuclear copper(II) complex with an oxidized tridentate Schiff base ligand》.Category: ethers-buliding-blocks The article contains the following contents:

An end-on azido-bridged dinuclear Cu(II) complex, [Cu2L2(μ1,1-N3)2], where L is the deprotonated form of N-(2-hydroxy-4-methoxybenzylidene)picolinamide (HL), was prepared by the reaction of 5-methoxy-2-[(pyridin-2-ylmethylimino)methyl]phenol (HL’) with Cu bromide and Na azide in MeOH. The structure of the complex was characterized by elemental anal., IR and UV-visible spectra, and single crystal x-ray diffraction. The complex possesses crystallog. inversion symmetry, with the two Cu ions (3.36 Å) bridged by two end-on azido bridges. Each Cu ion is in a square pyramidal coordination. The original ligand HL’ was unexpectedly oxidized to HL under mild conditions during preparation of the complex. The complex has excellent urease inhibitory activity. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Category: ethers-buliding-blocks

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《Synthesis and cytotoxicity of (-)-homo-renieramycin G and its derivatives》 was written by Ma, Yantao; Pan, Xuan; Guan, Baohe; Zhang, Guangyan; Liu, Zhanzhu. Electric Literature of C9H10O2 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

(-)-Homo-renieramycin G (I) and its twenty derivatives were prepared from L-tyrosine Me ester via a multi-step route. Their cytotoxicities were tested against four human cancer cell lines (A549, HeLa, KB and BGC-823). (-)-Renieramycin G and (-)-homo-renieramycin G showed comparable cytotoxicity against these four cancer cell lines, which indicated that the expansion of ring C from the six-membered 1,4-piperazinone to the seven-membered 1,4-diazepanone had no obvious impact on the cytotoxicity. The compound with Me side chain and compounds with heterocyclic aromatic side chains at C-23 exhibited the most potent cytotoxicity with the IC50 values at the level of 10-6 M. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Electric Literature of C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Electric Literature of C9H10O2

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Ether – Wikipedia,
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《Steroid compounds. IX. Experiments on the synthesis of conessine. Synthesis of tetracyclic intermediates》 was published in Indian Journal of Chemistry in 1971. These research results belong to Mukharji, P. C.; Sircar, J. C.; Devasthale, V. V.. Application of 33797-34-1 The article mentions the following:

Condensation of 2-(2-methyl-3-methoxyphenyl)ethyl bromide with dimethyl cyclopentanone-2,3-dicarboxylate followed by cyclodehydration, catalytic hydrogenation and conversion of the secondary methoxycarbonyl group to a methyl ketone gave I. This, on Leuckart reaction with MeNHCHO gave stereospecifically II, which on reduction and demethylation gave the III, corresponding to the BCDE rings of conessine. Leuckart reaction of I and IV with HCONH2 gave a mixture of two epimeric lactams, in contrast to complete stereospecificity observed in the reaction with MeNHCHO. In addition to this study using (3-Methoxy-2-methylphenyl)methanol, there are many other studies that have used (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Application of 33797-34-1) was used in this study.

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Application of 33797-34-1

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Ether – Wikipedia,
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《Blue light enhanced Heck arylation at room temperature applied to allenes》 was written by Renzi, Polyssena; Azzi, Emanuele; Bessone, Enrico; Ghigo, Giovanni; Parisotto, Stefano; Pellegrino, Francesco; Deagostino, Annamaria. SDS of cas: 2398-37-0This research focused ontosyl alkdienylamine aryl bromide palladium catalyst Heck photochem arylation; arylvinyl tolylsulfonyl pyrrolidine preparation; aryl vinyl tolylsulfonyl piperidine preparation. The article conveys some information:

An unprecedented visible light enhanced room temperature Heck reaction between aryl halides and allenyl tosyl amines was here reported. A simple catalytic system (Pd(OAc)2/PPh3) was employed to afford arylated vinyl pyrrolidines and piperidines. A broad scope with high tolerance towards functional groups was observed Electronic effects play an important role in the efficiency of this process. Mechanistic studies, both exptl. and computational, indicated no evidence for a radical mechanism and a pivotal role of light in promoting the carbo-palladation step. The results came from multiple reactions, including the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0SDS of cas: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.SDS of cas: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem