Tag: 100-200

In 2021,Cailiao Kexue Yu Gongcheng Xuebao included an article by Yang, Can; Liu, Yang; Fu, Weiqiang; Tong, Bin; Cai, Zhengxu; Dong, Yuping; Shi, Jianbing. Related Products of 74029-40-6. The article was titled 《Preparation of poly(silicon-phenyl-arylacetylene) resin by polymerizing dialkynylarylenes and phenylsilane catalyzed by alkali metal hydroxide》. The information in the text is summarized as follows:

A new method for preparing silicon-containing Ph arylacetylene resin (SPAR) has been developed using aromatic dialkyne derivatives and 1,4-bis(dimethylsilyl) benzene as raw materials in a one-step reaction in air. In addition, NaOH, a nontransition metal catalyst, was used to achieve high yield polymerization The exptl. conditions affecting polymerization, including monomer species, catalyst dosage, polymerization time, reaction solvent and temperature were investigated. Gel permeation chromatog., NMR and Fourier transform IR spectroscopy were used to determine the mol. weight and structure of the SPARs. Thermogravimetric anal. revealed their thermal stability, and the results indicated that most of them had good thermal stability. This polymerization method that employs simple preparation method, less expensive catalysts, and less complicated posttreatment method will provide an efficient preparation of functional SPARs. In the experiment, the researchers used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Related Products of 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Related Products of 74029-40-6 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

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Ether – Wikipedia,
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The author of 《Synthesis, biological evaluation, molecular docking and DFT calculations of novel benzenesulfonamide derivatives》 were Fahim, Asmaa M.; Shalaby, Mona A.. And the article was published in Journal of Molecular Structure in 2019. Reference of N,N-Dimethylformamide Dimethyl Acetal The author mentioned the following in the article:

The reaction of N-(4-acetylphenyl)benzene sulfonamide derivatives with N,N DMF di-Me acetal (DMF-DMA) afford acryloyl(phenyl)benzenesulfonamide derivatives I (R = Me, Cl) resp. The chem. reactivity of enaminones towards hydrazine hydrate or hydroxylamine was studied for synthesizing of pyrazolyl and isoxazolyl-Ph benzenesulfonamide derivatives resp, e.g., II. Also, the treatment of enaminones with thiosemicarbazide or heterocyclic amines derivatives afford the novel sulfonamide derivatives Furthermore, the reactivity of acetylsulfonamide derivatives towards nitrogen nucleophiles and dimedone afforded novel benzene sulfonamide compounds Some of the synthesized chlorinated compounds exhibited excellent in vitro antitumor activity against HepG2 and MCF-7 cell lines. Addnl., further studies were carried out on one of the most effective compounds, II, to evaluate its potential interaction against KSHV thymidylate synthase complex. The optimized mol. structure and the harmonic vibrational frequencies were examined via D. functional theory (DFT)/B3LYP/6-31G(d) and Hartree-Fock HF/6-31G(d) energies. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Reference of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Reference of N,N-Dimethylformamide Dimethyl Acetal

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In 2019,Journal of Molecular Structure included an article by Farag, Ahmad M.; Fahim, Asmaa M.. Product Details of 4637-24-5. The article was titled 《Synthesis, biological evaluation and DFT calculation of novel pyrazole and pyrimidine derivatives》. The information in the text is summarized as follows:

The utility of the enaminonitriles for the synthesis of the pyrazole derivatives, diaminopyrimidine derivatives, pyrazolo[1,5-a]pyrimidines, triazolo[4,3-a]pyrimidines and imidazo[1,2-a]pyrimidine derivatives was explored. Most of the synthesized compounds showed excellent in-vitro antitumor activity against MCF-7 cell line. They also exhibited high antimicrobial and antioxidant activities. D. functional theory (DFT) calculations at the B3LYP/6-31G level of theory have been carried out to investigate the equilibrium geometry of the novel [phenylpyrazolo[1,5-a]pyrimidin-6-yl]methanone derivative and phenylpyrazolo[1,5-a]pyrimidine derivative The structure-activity relationship (SAR) was used to correlate the biol. activity with the appropriate quantum such as total energy. The energy of the HOMO and LUMO and Mulliken at. charges were also calculated In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Product Details of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Product Details of 4637-24-5

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Ether – Wikipedia,
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Application In Synthesis of 1,2,3-Trifluoro-4-methoxybenzeneOn November 2, 2006 ,《Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity》 appeared in Journal of Medicinal Chemistry. The author of the article were Chu, Xin-Jie; DePinto, Wanda; Bartkovitz, David; So, Sung-Sau; Vu, Binh T.; Packman, Kathryn; Lukacs, Christine; Ding, Qingjie; Jiang, Nan; Wang, Ka; Goelzer, Petra; Yin, Xuefeng; Smith, Melissa A.; Higgins, Brian X.; Chen, Yingsi; Xiang, Qing; Moliterni, John; Kaplan, Gerald; Graves, Bradford; Lovey, Allen; Fotouhi, Nader. The article conveys some information:

The cyclin-dependent kinases (CDKs) and their cyclin partners are key regulators of the cell cycle. Since deregulation of CDKs is found with high frequency in many human cancer cells, pharmacol. inhibition of CDKs with small mols. has the potential to provide an effective strategy for the treatment of cancer. The 2,4-diamino-5-ketopyrimidines 6 reported here represent a novel class of potent and ATP-competitive inhibitors that selectively target the cyclin-dependent kinase family. This diaminopyrimidine core with a substituted 4-piperidine moiety on the C2-amino position and 2-methoxybenzoyl at the C5 position has been identified as the critical structure responsible for the CDK inhibitory activity. Further optimization has led to a good number of analogs that show potent inhibitory activities against CDK1, CDK2, and CDK4 but are inactive against a large panel of serine/threonine and tyrosine kinases (Ki > 10 μM). As one of these representative analogs, compound 39 (I; R547) has the best CDK inhibitory activities (Ki = 0.001, 0.003, and 0.001 μM for CDK1, CDK2, and CDK4, resp.) and excellent in vitro cellular potency, inhibiting the growth of various human tumor cell lines including an HCT116 cell line (IC50 = 0.08 μM). An X-ray crystal structure of 39 bound to CDK2 has been determined in this study, revealing a binding mode that is consistent with our SAR. Compound 39 demonstrates significant in vivo efficacy in the HCT116 human colorectal tumor xenograft model in nude mice with up to 95% tumor growth inhibition. On the basis of its superior overall profile, 39 was chosen for further evaluation and has progressed into Phase I clin. trial for the treatment of cancer. In the experimental materials used by the author, we found 1,2,3-Trifluoro-4-methoxybenzene(cas: 203245-16-3Application In Synthesis of 1,2,3-Trifluoro-4-methoxybenzene)

1,2,3-Trifluoro-4-methoxybenzene(cas: 203245-16-3) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Application In Synthesis of 1,2,3-Trifluoro-4-methoxybenzene

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Ether – Wikipedia,
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《Highly Selective Room-Temperature Suzuki-Miyaura Coupling of Bromo-2-sulfonyloxypyridines for Unsymmetrical Diarylpyridines》 was written by Jeon, Young-Kyo; Lee, Jae-Yeon; Kim, Seo-Eun; Kim, Won-Suk. Category: ethers-buliding-blocksThis research focused onunsym diarylpyridine chemoselective preparation Suzuki coupling bromosulfonyloxypyridine boronic acid. The article conveys some information:

A new and mild synthetic approach has been developed for the synthesis of pharmaceutically important unsym. diarylpyridines via chemoselective Suzuki-Miyaura coupling reactions of bromo-2-sulfonyloxypyridines. Most reactions allow for facile access to aryl-2-sulfonyloxypyridines at room temperature in yields of 5-99% with excellent chemoselectivity in the presence of Pd(OAc)2 (2.0 mol %) and Ad2BnP (2.4 mol %). The second arylation of the remaining tosyl or triflyl group in the monoarylpyridine derivatives obtained was successfully accomplished for the synthesis of unsym. 2,3-, 2,4-, 2,5-, and 2,6-diarylpyridine derivatives Furthermore, a one-pot synthesis of unsym. diarylpyridines starting from bromo-2-sulfonyloxypyridine was accomplished to demonstrate the practical convenience. Finally, with this method, an antibacterial agent, a topoisomerase inhibitor, and etoricoxib, a nonsteroidal anti-inflammatory drug, were successfully synthesized from the corresponding bromo-2-hydroxypyridines in overall yields of 80, 86, and 49%, resp. The experimental part of the paper was very detailed, including the reaction process of 3-Methoxyphenylboronic acid(cas: 10365-98-7Category: ethers-buliding-blocks)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Category: ethers-buliding-blocks

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Ether – Wikipedia,
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《Efficient Sensing of Explosives by Using Fluorescent Nonporous Films of Oligophenyleneethynylene Derivatives Thanks to Optimal Structure Orientation and Exciton Migration》 was published in Chemistry – A European Journal in 2014. These research results belong to Caron, Thomas; Pasquinet, Eric; van der Lee, Arie; Pansu, Robert B.; Rouessac, Vincent; Clavaguera, Simon; Bouhadid, Myriam; Serein-Spirau, Francoise; Lere-Porte, Jean-Pierre; Montmeat, Pierre. Related Products of 74029-40-6 The article mentions the following:

The fluorescence of thin films of a diimine-substituted phenyleneethynylene compound can be efficiently quenched by nitroarom. vapors, which is not the case for the unsubstituted parent compound Thin-film porosity is usually considered to be an essential factor for efficient quenching, but in the present case the origin of the quenching is completely different, as both films are nonporous and hermetic to 2,4-dinitrotoluene (DNT) mols. The mol. organization in the two crystallized thin films offers a low level of π stacking for both compounds, but the orientation of the phenylenethynylene fluorophore differs markedly with respect to the surface of the films. For the substituted compound, the fluorophore is almost parallel to the surface, thus making it readily available to mols. of a nitroarom. quencher. This rationale is also observed in the case of a related compound bearing methoxy side chains instead of the long octyloxy moieties. Fluorescence-lifetime experiments show that the efficient quenching process in the nonporous crystallized films of the substituted compound is due to a fast (<70 ps) diffusion of excitons from the bulk of the film toward the surface where they are quenched, thus providing evidence of antenna effects. The experimental part of the paper was very detailed, including the reaction process of 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Related Products of 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Related Products of 74029-40-6

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of 2-Hydroxy-4-methoxybenzaldehydeIn 2019 ,《Synthesis of new TCH/Ni-based nanocomposite supported on SBA-15 and its catalytic application for preparation of benzimidazole and perimidine derivatives》 was published in Applied Organometallic Chemistry. The article was written by Kalhor, Mehdi; Rezaee-Baroonaghi, Fahimeh; Dadras, Akbar; Zarnegar, Zohre. The article contains the following contents:

A stable nickel-decorated SBA-15 nanocomposite (Ni/TCH@SBA-15) was synthesized through surface modification of silica nanoparticles with 3-chloropropyltriethoxysilane (CPTES) and thiocarbohydrazide (TCH) followed by metal-ligand coordination with Ni(II). The structure of this organometallic nanocomposite was characterized by Fourier transform-IR, field emission-SEM, EDAX, transmission electron microscopy, at. absorption spectroscopy and N2 adsorption-desorption (Brunauer-Emmett-Teller) techniques. The catalytic performance of Ni/TCH@SBA-15 (NNTS-15) was determined for synthesis of 2-aryl-substituted benzimidazoles I [R1 = H, Me, NO2; R2 = H, 4-MeO, 2,3-di-Cl, etc.] and 2,3-dihydroperimidines II. The excellent yields within shorter reaction times, simplicity of catalytic methods, non-toxicity and clean reactions, mild reaction conditions and easy work-up procedure were important merits of these synthetic protocols. Moreover, the Ni(II) bonded to SBA-15 surface was stable under catalytic reaction conditions resulting in its efficient recycling and reuse. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Safety of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 135-02-4In 2020 ,《H5BW12O40-Catalyzed syntheses of 1,4-dihydropyridines and polyhydroquinolines via Hantzsch reaction: Joint experimental and computational studies》 appeared in Journal of Molecular Structure. The author of the article were Momeni, Tayebeh; Heravi, Majid M.; Hosseinnejad, Tayebeh; Mirzaei, Masoud; Zadsirjan, Vahideh. The article conveys some information:

A series of polyhydroquinoline derivatives I [RR1 = C(O)CH2C(Me2)CH2; Ar = Ph, 4-OMeC6H4, 3-O2NC6H4, etc.] was effectively synthesized via Hantzsch reaction of benzaldehydes, Et acetoacetate, dimedone and ammonium acetate in high yields in the presence of catalytic amounts of a highly neg. charged borotungstic acid H5BW12O40 in refluxing EtOH under green and mild reaction conditions. This method was also used for the synthesis of 1,4-dihydropyridines I [R = CO2Et; R1 = Me] via reaction of benzaldehydes, Et acetoacetate and ammonium acetate. Borotungstic acid is a Keggin-type heteropoly acid with a higher neg. charge and strong Bronsted acidity. Moreover, a comparative mechanistical anal. of Hantzsch reaction was made based on the structural, thermodynamical and electronic properties along with the reaction pathway using d. functional theory (DFT) and quantum theory of atoms in mols. (QTAIM) approaches.2-Methoxybenzaldehyde(cas: 135-02-4Product Details of 135-02-4) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Product Details of 135-02-4

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In 2022,Zheng, Kaiting; Liu, Yaomei; Zheng, Chenggong; Yan, Fangpei; Xiao, Hua; Feng, Yi-Si; Fan, Shilu published an article in Advanced Synthesis & Catalysis. The title of the article was 《Palladium-Catalyzed Monofluoroalkylation of Aryl Iodides and Aryl Bromides with Nucleophilic Ethyl 2-Fluoro-2-(trimethylsilyl)acetate》.Recommanded Product: 2398-37-0 The author mentioned the following in the article:

A palladium-catalyzed monofluoroalkylation of aryl iodides and aryl bromides was developed using nucleophilic Et 2-fluoro-2-(trimethylsilyl)acetate as a monofluoroalkyl source. The transformation proceeded with excellent substrate scope to afford a range of monofluoroalkylated products ArCH(F)CO2Et [Ar = Ph, 2-naphthyl, 3-thienyl, etc.] in good yields under mild conditions, and it proved feasible in a gram-scale reaction. This protocol was successfully used in late-stage modification of an estrone derivative, providing a facile route for research on the discovery of biol. active compounds and high-performance materials. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Recommanded Product: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Alberca, Saul; Velazquez, Marta; Trujillo-Sierra, Jose; Iglesias-Sigueenza, Javier; Fernandez, Rosario; Lassaletta, Jose M.; Monge, David published an article in Advanced Synthesis & Catalysis. The title of the article was 《Pd(II)-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic N-Carbamoyl Hydrazones》.Recommanded Product: 60656-87-3 The author mentioned the following in the article:

Catalysts generated by combinations of Pd(TFA)2 and 2-pyridinecarbohydrazone ligands have been applied to 1,2 addition of arylboronic acids ArB(OH)2 to aliphatic N-carbamoyl (Cbz) hydrazones RCH:NNR1R2 (R1R2 = phthaloyl; R1 = Cbz, R2 = H), affording protected α-aryl monoalkylhydrazines RCHArNHNR1R2 with high enantioselectivities (37-99% ee). Subsequent removal of the benzyloxy carbonyl protecting group provides a direct entry to free monosubstituted hydrazines, key building blocks for the synthesis of appealing 1,2-diaza-heterocycles, amino acid derived hydrazides and other pharmacophores thereof. The experimental process involved the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Recommanded Product: 60656-87-3

Referemce:
Ether – Wikipedia,
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