Tag: 100-200

Name: N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types》 appeared in Journal of Medicinal Chemistry. The author of the article were Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai, Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel, Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola. The article conveys some information:

A new class of pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, e.g. was synthesized for the treatment of hyperproliferative pathologies, including neoplasms. The new compounds were screened in the 60 human cancer cell lines of the NCI drug screen and showed potent activity with GI50 values reaching the nanomolar level, with mean graph midpoints of 0.08-0.41μM. All compounds were further tested on six lymphoma cell lines, and eight showed potent growth inhibitory effects with IC50 values lower than 500 nM. Mechanism of action studies showed the ability of the new [1,2]oxazoles to arrest cells in the G2/M phase in a concentration dependent manner and to induce apoptosis through the mitochondrial pathway. The most active compounds inhibited tubulin polymerization, with IC50 values of 1.9-8.2μM, and appeared to bind to the colchicine site. The G2/M arrest was accompanied by apoptosis, mitochondrial depolarization, generation of reactive oxygen species, and PARP cleavage. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Name: N,N-Dimethylformamide Dimethyl Acetal

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Recommanded Product: 4637-24-5In 2020 ,《Synthesis of novel pyrido[2,1-b]benzothiazole and N-substituted 2-pyridylbenzothiazole derivatives showing remarkable fluorescence and biological activities》 appeared in Journal of Molecular Structure. The author of the article were Azzam, Rasha A.; Elgemeie, Galal H.; Osman, Rokia R.. The article conveys some information:

The synthesis of novel pyrido[2,1-b]benzothiazole and pyrido[2,1-b]benzoimidazole derivatives was achieved via the reaction of N-aryl-2-cyano-3,3-bis(methylthio)acrylamide with benzothiazoleylacetonitrile and benzoimidazoleylacetonitrile, resp., while N-substituted 2-pyridylbenzothiazole derivatives were synthesized by reacting 2-(benzo[d]thiazol-2-yl)-3-(dimethylamino)acrylonitrile with either cyanoacetamide, aryl cyanoacetamides or 2-cyano-N’-(4-substituted benzylidene)acetohydrazide. Based on the steady state fluorescence measurements, the newly synthesized N-substituted 2-pyridylbenzothiazole derivatives exhibited remarkable fluorescence properties with considerably high quantum yields (0.25-0.29). In addition, the antimicrobial and antiviral activities were evaluated for all the newly synthesized derivatives The antimicrobial examination revealed that triazolo-pyridone I (Ar = 4-FC6H4, 4-ClC6H4, 4-MeOC6H4, 4-MeC6H4) had the highest potency among all tested compounds against Escherichia coli, Klebsiella pneumonia and Staphylococcus aureus while pyrido[2,1-b]benzoimidazole derivatives II (Ar = 4-ClC6H4, 4-MeC6H4, 3-MeC6H4) had the highest potency over other compounds against Candida albicans fungus. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Recommanded Product: 4637-24-5

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HPLC of Formula: 135-02-4In 2019 ,《1,1′-Butylenebis(3-sulfo-3H-imidazol-1-ium) hydrogensulfate: a versatile task-specific ionic liquid catalyst for the synthesis of 4H-pyran scaffolds through non-conventional process》 appeared in Monatshefte fuer Chemie. The author of the article were Khaligh, Nader Ghaffari; Ling, Ong Chiu; Mihankhah, Taraneh; Johan, Mohd Rafie; Ching, Juan Joon. The article conveys some information:

In the present study, the catalytic efficiency of 1,1′-butylenebis(3-sulfo-3H-imidazol-1-ium)hydrogensulfate (BBSI-HSO4) as a versatile sulfonic acid-functionalized ionic liquid was demonstrated for the one-pot mechanosynthesis of pyrano[4,3-b]-pyrans I (R = C6H5, 4-FC6H4, 2-MeOC6H4, etc.) using planetary ball mill at room temperature under solvent-free conditions. This efficient mechanosynthesis approach to the 4H-pyran scaffolds displays a combination of the structure-activity relationship of ionic liquids with ecol. benefits of a mechanocatalytic procedure. The ionic liquid was easily recycled and reused several times with no significant loss of its catalytic activity.2-Methoxybenzaldehyde(cas: 135-02-4HPLC of Formula: 135-02-4) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.HPLC of Formula: 135-02-4

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In 2022,Zhou, Zongtao; Cai, Zongyu; Zhang, Congzi; Yang, Benhui; Chen, Lianru; He, Yepu; Zhang, Luyong; Li, Zheng published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold》.Product Details of 2398-37-0 The author mentioned the following in the article:

The free fatty acid receptor 1 (FFA1/GPR40) and peroxisome proliferator-activated receptor δ (PPARδ) have been widely considered as promising targets for type 2 diabetes mellitus (T2DM) due to their resp. roles in promoting insulin secretion and improving insulin sensitivity. Hence, the dual FFA1/PPARδ agonists may exert synergistic effects by simultaneously activating FFA1 and PPARδ. The present study performed systematic exploration around previously reported FFA1 agonist compound I (lead compound), leading to the identification of a novel dual FFA1/PPARδ agonist compound II (the optimal compound), which displayed high selectivity over PPARα and PPARγ. In addition, the docking study provided detailed binding modes of the optimal compound II in FFA1 and PPARδ. Furthermore, the optimal compound II exhibited greater glucose-lowering effects than lead compound I, which might attribute to its synergistic effects by simultaneously modulating insulin secretion and resistance. Moreover, the optimal compound II has an acceptable safety profile in the acute toxicity study at a high dose of 500 mg/kg therefore, the results provided a novel dual FFA1/PPARδ agonist with excellent glucose-lowering effects in vivo. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Product Details of 2398-37-0

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In 2022,Hu, Yijie; Wang, Xiaoli; Ren, Nan; Li, Na; Li, Jianyang; Chen, Jie; Zhang, Hui; Deng, Hongmei; Cao, Weiguo; Lin, Jin-Hong published an article in European Journal of Organic Chemistry. The title of the article was 《A Convenient Synthesis of Fluoroalkylated Benzimidazole- or Indole-fused Benzoxazines》.Reference of 2-Hydroxy-4-methoxybenzaldehyde The author mentioned the following in the article:

Herein, the first synthesis of fluoroalkylated benzimidazole- or indole-fused benzoxazines I (R = CF3, C2F5, C3H7; R1 = 2-OMe, 2-Br, 4-Cl, etc.) or II (R2 = H, F; R3 = H, 10-Me, 10-Br, 9,11-(Me)2) by using fluoroalkylated propiolates RCCC(O)2Me as building blocks is described. The reactions proceeded smoothly under mild conditions to give the desired products I and II in moderate to high yields. Notably, benzimidazole-fused products I were obtained by a convenient one-pot two-step process. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Reference of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Reference of 2-Hydroxy-4-methoxybenzaldehyde

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Tang, Zhiqiong; Li, Dongdong; Yue, Yidi; Peng, Dan; Liu, Lu published an article in 2021. The article was titled 《Bronsted acid catalysed chemo- and ortho-selective aminomethylation of phenol》, and you may find the article in Organic & Biomolecular Chemistry.Name: m-Methoxyphenol The information in the text is summarized as follows:

A Bronsted acid-catalyzed highly ortho-selective functionalization of free phenols e.g., Estrone with readily available N, O-acetals e.g., N-(methoxymethyl)-N-(phenylmethyl)-Benzenemethanamine under mild conditions, furnishes various corresponding aminomethylated phenol e.g., I products in moderate to excellent yields. The salient features of this transformation include mild conditions, good substrate scope, excellent ortho-selectivity, high efficiency, and ease of further transformation. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Name: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Name: m-Methoxyphenol

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Park, Yunjeong; Lee, Ji Sun; Ryu, Jae-Sang published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Gold(I)-Catalyzed Intramolecular Dehydrative Amination of Sulfamate Esters Tethered to Allylic Alcohols: A Strategy for the Synthesis of Cyclic Sulfamidates》.COA of Formula: C9H10O2 The article contains the following contents:

An efficient synthesis protocol for cyclic sulfamidates I [R1 = t-Bu, n-pentyl, cyclohexyl, etc.; R2 = H; R3 = H, Me; R4 = H, Me; R5 = H, Me] was developed via catalytic intramol. cyclizations of sulfamate esters tethered to allylic alcs. The reactions proceeded smoothly at room temperature in the presence of (IPr)AuCl (5 mol%) and AgBF4 (5 mol%). This protocol featured good to excellent yields, high selectivity, broad substrate scope, and mild reaction conditions. This method was also applicable to the synthesis of a seven-membered sulfamidate.2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.COA of Formula: C9H10O2

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《Mechanistic investigation into phenol oxidation by IBX elucidated by DFT calculations》 was written by Kaur, Amritpal; Ariafard, Alireza. Product Details of 150-19-6 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

D. functional theory (DFT) at the SMD/M06-2X/def2-TZVP//SMD/M06-2X/LANL2DZ(d),6-31G(d) level was used to explore the regioselective double oxidation of phenols by a hypervalent iodine(V) reagent (IBX) to give o-quinones. The oxidative dearomatization commences with the ligand exchange between IBX and phenol, yielding a phenolate complex, followed by the first redox process, which reduces iodine(V) to iodine(III). Both the processes (the ligand exchange and the first redox reaction) were found to be mediated by a less stable isomer of iodine(V) species. We found that although the first redox process preferentially proceeds via an associative pathway, an electron withdrawing substituent on the phenol ring decreases its accessibility. The inspection of the electronic structure of the redox transition state indicates that the phenolate involved in the iodine(V) reduction has some phenoxenium character. The intrinsic stability of a phenoxenium ion is calculated to be highly sensitive to the substituent on the phenol ring. Since the electron withdrawing substituents considerably decrease the stability of the phenoxenium, they render the iodine(V) to iodine(III) reduction energy consuming. Once the first redox step has completed, a catechol-iodine(III) complex is formed, from which the second redox process produces the final o-quinone product via a carboxylate-assisted transition structure. This transition structure gains stability by hydrogen bond interaction between the catechol OH and carboxylate group. Such an interaction results in the phenolate not having any phenoxenium character in the transition structure, thus making the activation barrier to the second redox step independent from the substituent on the phenol ring. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6Product Details of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Product Details of 150-19-6

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《Novel commercial scale synthetic approach for 5-cyanoindole: a potential intermediate for vilazodone hydrochloride, an antidepressant drug》 was published in Asian Journal of Chemistry in 2020. These research results belong to Venkatanarayana, M.; Nuchu, Ravi; Babu, H. Sharath; Garrepalli, Ganga Sravanthi; Tangallapall, Sudhakar. Synthetic Route of C5H13NO2 The article mentions the following:

Present work described the synthesis of title compound I, a common intermediate used in various synthetic route of the antidepressant vilazodone hydrochloride. The protocol was both robust and com. viable, utilizing readily available and low-cost materials and the isomers are environmental friendly than previously reported routes through its evading use of cyanide reagents and heavy metals. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Synthetic Route of C5H13NO2

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《Synthesis, structural and anticorrosion properties of diethyl(methoxyphenyl(phenylamino)methyl)phosphonate derivatives: Experimental and theoretical study》 was published in Journal of Molecular Structure in 2020. These research results belong to Moumeni, Ouahiba; Chafaa, Salah; Kerkour, Rachida; Benbouguerra, Khalissa; Chafai, Nadjib. COA of Formula: C8H8O2 The article mentions the following:

The authors synthesized three di-Et (phenylamino) Me phosphonate derivatives: Diethyl(phenyl(phenylamino)methyl)phosphonate (DEPAMP), Diethyl(2-methoxyphenyl(phenylamino)methyl)phosphonate (o-DEPAMP), Diethyl(4-methoxyphenyl(phenylamino)methyl)phosphonate (p-DEPAMP), whose the yields were 92%, 86% and 88%, resp. After confirmation of their structures by UV-visible, FTIR and NMR spectroscopic methods, the synthesized compounds were studied as corrosion inhibitors of XC48 C steel in 1 mol L-1 HCl medium. P-DEPAMP is a better inhibitor in 10-3 mol L-1. Atomic Force Microscopy (AFM) was required for metallic surface characterization and the quantum chem. parameters were calculated using the D. Functional Theory (DFT) method. The adsorption energies of the inhibitors on Fe (110) surface in gas and aqueous phases were premeditated adopting the Mol. Dynamics Simulation (MDS) method. This study described the successful performance of these compounds in corrosion using weight loss measurements, Potentiodynamic Polarization and Electrochem. Impedance Spectroscopy (EIS), and discusses the correlation between exptl. and theor., presumed DFT and MDS finding. The adsorption studies on surface were in agreement with the Langmuir adsorption isotherm model. The effects of position of OCH3 group located at ortho and para or without in chem. structure of aminophosphonates on the corrosion inhibition efficiencies of the compounds were also studied. The experimental process involved the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4COA of Formula: C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.COA of Formula: C8H8O2

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