Tag: 100-200

In 2022,Basson, Ashley J.; Halcovitch, Nathan R.; McLaughlin, Mark G. published an article in Chemistry – A European Journal. The title of the article was 《Unified Approach to Diverse Fused Fragments via Catalytic Dehydrative Cyclization》.Synthetic Route of C7H7BrO The author mentioned the following in the article:

A range of highly functionalized polycyclic fragments have been synthesized, employing a catalytic dehydrative cyclization. A range of nucleophiles are shown to be successful, with the reaction producing numerous high value motifs. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Synthetic Route of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Synthetic Route of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hoshikawa, Shoki; Yanai, Hikaru; Martin-Mejias, Irene; Lazaro-Milla, Carlos; Aragoncillo, Cristina; Almendros, Pedro; Matsumoto, Takashi published an article in 2021. The article was titled 《Synthesis of Polycyclic Aromatic Hydrocarbons Decorated by Fluorinated Carbon Acids/Carbanions》, and you may find the article in Chemistry – A European Journal.Related Products of 10365-98-7 The information in the text is summarized as follows:

The carboarylation reaction of biphenyl-alkynes was successfully triggered by electrophilic attack of 1,1-bis(triflyl)ethylene on the alkyne moiety to give polycyclic aromatic hydrocarbons (PAHs), e.g., I, decorated by superacidic carbon acid functionality. Neutralization of thus obtained acids with NaHCO3 yielded the corresponding sodium salts, e.g., II•Na+, which showed improved solubility in both aqueous and organic solvents. The experimental process involved the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Related Products of 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Related Products of 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Salihovic, Mirsada; Pazalja, Mirha; Spirtovic Halilovic, Selma; Veljovic, Elma; Mahmutovic-Dizdarevic, Irma; Roca, Suncica; Novakovic, Irena; Trifunovic, Snezana published their research in Journal of Molecular Structure in 2021. The article was titled 《Synthesis, characterization, antimicrobial activity and DFT study of some novel Schiff bases》.Related Products of 135-02-4 The article contains the following contents:

Two new Schiff bases I (R = Cl, OMe) derived from L-cysteine and substituted benzaldehyde were synthesized. DFT calculations were based on global chem. reactivity indexes calculated using the B3LYP/6-31G*, B3LYP/6-31G**, and B3LYP/6-31+G* theory levels. Exptl. and theor. obtained values for FT-IR and NMR (1H, 13C) of test compounds showed good agreement. The reactivity descriptors of B3LYP (E, EHOMO, ELUMO, dipole moment, Δε, μ, η, ω) were calculated to predict the stability of newly synthesized compounds The microbiol. activity of the compounds was tested on several Gram-pos. bacteria: Staphylococcus aureus, Bacillus subtilis, Clostridium sporogenes, Microccocus luteus and Microccocus flavus. The following Gram-neg. bacteria were used to test the compounds: Escherichia coli, Pseudomonas aeruginosa Proteus hauseri, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Enteritidis. Also, the activity on the following yeasts was examined: Candida albicans, Saccharomyces cerevisiae and fungal strain Aspergillus brasilliensis. The Schiff base with chlorine in the structure has the best antimicrobial action against all tested microorganisms. The selected quantum chem. descriptors calculated for both compounds have a close relationship with the antimicrobial activity. After reading the article, we found that the author used 2-Methoxybenzaldehyde(cas: 135-02-4Related Products of 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Related Products of 135-02-4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Bo; Yang, Chenxin; Wang, Xinhao; Li, Guangwu; Peng, Wangwang; Xiao, Huiping; Luo, Shenglian; Xie, Sheng; Wu, Jishan; Zeng, Zebing published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Synthesis and Structural Elucidation of Bisdibenzocorannulene in Multiple Redox States》.Reference of 3-Methoxyphenylboronic acid The article contains the following contents:

An anti-folded bowl-shaped bisdibenzocorannulene (BDBC) featuring a new chair-cyclohexane-like hexagon as a bridge of two dibenzocorannulene moieties was reported. The neutral compound showed multiple redox-active properties and could be converted to the corresponding redox states through chem. reduction or oxidation Chem. reduction of BDBC by stoichiometric addition of metallic potassium in the presence of [18]crown-6 ether, provided a radical anion BDBC.- and a dianion BDBC2-, resp.; while chem. oxidation by silver hexafluoroantimonate(V), converted the neutral compound to an open-shell singlet diradical dication (BDBC••)2+. The structural consequences of both electron-reduction and oxidation were closely related to the release of ring-strain of the bowl-shaped π-scaffold and imposed steric hindrance of the hexagonal bridge. In addition, the unusual open-shell nature of the dication could mainly be attributed to the changing of localized antiaromaticity in the closed-shell structure to delocalized character in the biradical, and thus the emergence of weakly bonded π-electrons.3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Hang; Yan, Zhong-zuo; Guo, Meng-bi; An, Ran; Wang, Xin; Zhang, Rui; Mou, Yan-hua; Hou, Zhuang; Guo, Chun published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections》.Application In Synthesis of 1-Bromo-3-methoxybenzene The article contains the following contents:

A series of selenium-containing miconazoles. compounds I, II [R = H, 3-F, 2-Me, etc. ; X= F, Cl], III [R = H, 3-F, 2-Me, etc.; X= F, C] were identified as potent antifungal drugs in our previous study. Representative compound I (MIC = 0.01μg/mL against C.alb. 5314) proved efficacious in inhibiting the growth of fungal pathogens. However, further study showed lead compound I exhibited potential hemolysis, significant cytotoxic effect and unfavorable metabolic stability and was therefore modified to overcome these drawbacks. In this article, the further optimization of selenium-containing miconazole derivatives resulted in the discovery of similarly potent compound II [R = 4-F ; X= F] (MIC = 0.02μg/mL against C.alb. 5314), exhibiting a superior pharmacol. profile with decreased rate of metabolism, cytotoxic effect and hemolysis. Furthermore, compound II [R = 4-F ; X= F] showed fungicidal activity against Candida albicans and significant effects on the treatment of resistant Candida albicans infections. Meanwhile, compound II [R = 4-F ; X= F] not only could reduce the ergosterol biosynthesis pathway by inhibiting CYP51, but also inhibited biofilm formation. More importantly, compound II [R = 4-F ; X= F] also shows promising in vivo efficacy after i.p. injection and the PK study of compound II [R = 4-F ; X= F] was evaluated. In addition, mol. docking studies provide a model for the interaction between the compound II [R = 4-F ; X= F] and the CYP51 protein. Overall, it was believed that these selenium-containing miconazole compounds can be further developed for the potential treatment of fungal infections. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application In Synthesis of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Application In Synthesis of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of C9H10O2In 2021 ,《Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery》 appeared in Nature (London, United Kingdom). The author of the article were Pipal, Robert W.; Stout, Kenneth T.; Musacchio, Patricia Z.; Ren, Sumei; Graham, Thomas J. A.; Verhoog, Stefan; Gantert, Liza; Lohith, Talakad G.; Schmitz, Alexander; Lee, Hsiaoju S.; Hesk, David; Hostetler, Eric D.; Davies, Ian W.; MacMillan, David W. C.. The article conveys some information:

Positron emission tomog. (PET) radioligands (radioactively labeled tracer compounds) are extremely useful for in vivo characterization of central nervous system drug candidates, neurodegenerative diseases and numerous oncol. targets1. Both tritium and carbon-11 radioisotopologues are generally necessary for in vitro and in vivo characterization of radioligands2, yet there exist few radiolabelling protocols for the synthesis of either, inhibiting the development of PET radioligands. The synthesis of such radioligands also needs to be very rapid owing to the short half-life of carbon-11. Here we report a versatile and rapid metallaphotoredox-catalyzed method for late-stage installation of both tritium and carbon-11 into the desired compounds via methylation of pharmaceutical precursors bearing aryl and alkyl bromides. Me groups are among the most prevalent structural elements found in bioactive mols., and so this synthetic approach simplifies the discovery of radioligands. To demonstrate the breadth of applicability of this technique, we perform rapid synthesis of 20 tritiated and 10 carbon-11-labeled complex pharmaceuticals and PET radioligands, including a one-step radiosynthesis of the clin. used compounds [11C]UCB-J and [11C]PHNO. We further outline the direct utility of this protocol for preclin. PET imaging and its translation to automated radiosynthesis for routine radiotracer production in human clin. imaging. We also demonstrate this protocol for the installation of other diverse and pharmaceutically useful isotopes, including carbon-14, carbon-13 and deuterium. In the experimental materials used by the author, we found 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Electric Literature of C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Electric Literature of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

HPLC of Formula: 135-02-4In 2019 ,《Aqueous hydrotropic solution: green reaction medium for synthesis of pyridopyrimidine carbonitrile and spiro-oxindole dihydroquinazolinone derivatives》 appeared in Research on Chemical Intermediates. The author of the article were Patil, Audumbar; Mane, Ananda; Kamat, Siddharth; Lohar, Trushant; Salunkhe, Rajashri. The article conveys some information:

An efficient multicomponent domino approach for synthesis of pyridopyrimidine carbonitriles I [R = 2-NO2, 4-Me, 3-Cl, etc.] and spiro-oxindole dihydroquinazolinones II [R1 = 3-NO2, 4-CN, 3-OH, etc.] by one-pot reaction in 50 % aqueous sodium p-toluene sulfonate (NaPTS) solution at ambient reaction condition was reported. The merits of present protocol were short reaction time, excellent product yield with high purity, easy workup procedure and reusability of reaction medium. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4HPLC of Formula: 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.HPLC of Formula: 135-02-4

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Ether – Wikipedia,
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Recommanded Product: 3-Methoxyphenylboronic acidIn 2019 ,《Heterogeneous Chiral Diene-Rh Complexes for Asymmetric Arylation of α,β-Unsaturated Carbonyl Compounds, Nitroalkenes, and Imines》 appeared in Advanced Synthesis & Catalysis. The author of the article were Kuremoto, Tatsuya; Yasukawa, Tomohiro; Kobayashi, Shu. The article conveys some information:

A chiral diene ligand with tertiary alkyl amine-derived secondary amide moiety was immobilized on cross-linked polystyrene (PS) by radical polymerization, which was combined with Rh to form heterogeneous chiral Rh complexes (PS-diene Rh-Cl). PS-diene Rh-Cl catalyzed asym. arylation reactions of α,β-unsaturated carbonyl compounds (ketones, esters, and amides), nitroalkenes, and imines afforded the desired products in high yields with excellent enantioselectivities. PS-diene Rh-Cl is stable in air, can be stored for several months, and can be reused more than 10 times without any reduction of either yield or enantioselectivity. We also developed a method of activation of PS-diene Rh-Cl to generate more active species. In the experimental materials used by the author, we found 3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Song, Xue; Zhang, Jie; Wu, Yu-Xing; Ouyang, Qin; Du, Wei; Chen, Ying-Chun published an article in Journal of the American Chemical Society. The title of the article was 《Asymmetric Formal Nucleophilic o-Cresolylation with Morita-Baylis-Hillman Carbonates of 2-Cyclohexenones via Palladium Catalysis》.Computed Properties of C8H8O3 The author mentioned the following in the article:

Here Authors report an asym. formal nucleophilic o-cresolylation reaction with the Morita-Baylis-Hillman (MBH) carbonates from 2-cyclohexanones and diverse aldehydes under palladium catalysis, by in situ generation of electron-neutral and HOMO-raised η2-Pd(0)-dienone complexes via an oxidative insertion/π-σ-isomerization/β-H elimination activation sequence. The subsequent umpolung vinylogous addition to a variety of imines is realized upon Pd(0)-mediated π-Lewis base catalysis, finally furnishing o-cresolylated products followed by another cascade of a π-σ-isomerization/β-H elimination/aromatization process. Moderate to excellent diastereo- and enantioselectivity are achieved for substantial substrate assemblies by employing a newly designed bulky chiral phosphonamidite ligand, and the resultant multifunctional products can be facilely elaborated to access diverse enantioenriched architectures. In addition, the catalytic reaction pathway is finely illuminated by control experiments In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Computed Properties of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A near-infrared excitation/emission fluorescent probe for imaging of endogenous cysteine in living cells and zebrafish》 was written by Xie, Ruihua; Li, Yaqian; Zhou, Zile; Pang, Xiao; Wu, Cuiyan; Yin, Peng; Li, Haitao. Quality Control of 2-Hydroxy-4-methoxybenzaldehyde And the article was included in Analytical and Bioanalytical Chemistry in 2020. The article conveys some information:

The fluorescence imaging technique provides an essential tool for studying biol. systems. However, due to the interference of autofluorescence of biol. tissues, the application of short-wavelength fluorescent probes in biol. imaging was limited. The near-IR (NIR) excitation/emission fluorescent probe possesses unique advantages in optical imaging in vivo, including less light scattering, minimal photo-damage to biol. samples, deep tissue penetration, and weak autofluorescence interference from complicated biol. systems. A convenient fluorophore (E)-2-[2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl]-3- methylbenzo[d]thiazol-3-ium iodide (DXM-OH) with NIR excitation and emission was rationally designed and developed. What′s more, DXM-OH was applied to construct an “”OFF-ON”” fluorescent probe (E)-2-{2-[6-(acryloyloxy)-2,3-dihydro-1H- xanthen-4-yl]vinyl}-3-methylbenzo[d]thiazol-3-ium iodide (DXM) for sensitive and selective detection of cysteine (Cys). DXM had the advantages of good cell permeability, low toxicity, and excellent optical properties (NIR excitation/emission) and it was successfully applied to image Cys of living cells and zebrafish. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Quality Control of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Quality Control of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem