Tag: 100-200

《Titania-silica nanoparticles ensemblies assisted heterogeneous catalytic strategy for the synthesis of pharmacologically significant 2,3-diaryl-3,4-dihydroimidazo[4,5-b]indole scaffolds》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Geedkar, Deepika; Kumar, Ashok; Reen, Gagandeep Kour; Sharma, Pratibha. Recommanded Product: 673-22-3 The article mentions the following:

Present paper elicits the multicomponent reaction (MCR) strategy assisted by titania nanoparticles hosted on silica (TiO2.SiO2 NPs) as heterogeneous catalyst to synthesize a series of pharmacol. significant 2,3-diaryl-3,4-dihydroimidazo[4,5-b]indole derivatives The decrease in reaction time, low catalyst loading, high product yield (up to 92%), and excellent reusability of the catalyst (up to 7 cycles) put this protocol under the umbrella of green chem. tenets. Characterization of catalysts was achieved through a number of techniques viz., energy-dispersive X-ray (EDX) spectroscopy, field emission SEM (FESEM), powder X-ray diffraction (XRD), fourier transform IR (FTIR) spectra of adsorbed pyridine, temperature-programmed desorption of ammonia, and porosity measurements by nitrogen adsorption (Brunauer-Emmett-Teller [BET] method). Also, the structures of synthesized compounds were corroborated on the basis of FTIR, NMR (NMR), mass, and elemental analyses data. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Triethylammonium Hydrogen Sulfate [Et3NH][HSO4] as an Efficient Ionic Liquid Catalyst for the Synthesis of Coumarin Derivatives》 was published in Polycyclic Aromatic Compounds in 2020. These research results belong to Karimi-Jaberi, Zahed; Masoudi, Behzad; Rahmani, Atefeh; Alborzi, Kiana. Computed Properties of C7H8O2 The article mentions the following:

Triethylammonium hydrogen sulfate [Et3NH][HSO4] has been studied to be an efficient ionic liquid catalyst for the synthesis of biol. potent coumarin derivatives Thus, 4-substituted coumarins have been synthesized through the Pechmann condensation of phenols with β-ketoesters in the presence of [Et3NH][HSO4]. Also, 4-hydroxycoumarin was reacted with various aldehydes using this catalyst to obtain the α,α’-benzylidene bis(4-hydroxycoumarin) derivatives In addition, this efficient and privileged ionic liquid catalyst has been described in the synthesis of pyrano[3,2-c]coumarin derivatives by condensation of 4-hydroxycoumarin with chalcones. The optimization conditions carried out in the present study revealed that 20 mol% of ionic liquid catalyst under solvent-free condition at 110° are the best conditions for the synthesis of coumarin-derivatives in good to excellent yields. The present methodol. is a facile and green approach offering several advantages, such as excellent yield of products, minimizing production of chem. wastes, shorter reaction profile, mild reaction conditions, simple operational procedure, and easy preparation/separation of catalyst as a non-corrosive and stable ionic liquid After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Computed Properties of C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneComputed Properties of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Multiwalled carbon nanotubes crowned with nickel-ferrite magnetic nanoparticles assisted heterogeneous catalytic strategy for the synthesis of benzo[d]imidazo[2,1-b]thiazole scaffolds》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Geedkar, Deepika; Kumar, Ashok; Sharma, Pratibha. Recommanded Product: 673-22-3 The article mentions the following:

Present manuscript elicits an account of the sonication promoted multicomponent reactions strategy assisted by multiwalled carbon nanotubes embraced with nickel-ferrite (NiFe2O4-CNTs) magnetic nanoparticles, as a heterogeneous catalyst to synthesize a novel series of pharmacol. active benzo[d]imidazo[2,1-b]thiazole scaffolds I [R1 = H, 4-OH, 4-Cl, etc.; R2 = H, 4-Me, 2-OH, etc.]. The synthesis of these biol. active derivatives was achieved via A3 coupling involving 2-aminobenzothiazole, pertinent aryl aldehydes and Ph acetylene derivatives, proceeded in PEG 400 as green solvent under aerobic conditions to afford the products in good to excellent yields. The higher environmental compatibility and sustainability factors such as higher ecoscale score, smaller E-factor and appreciable atom economy put this etiquette under the parasol of green chem. precepts. The characterization of synthesized catalysts was attained through varied techniques viz. powder X-ray diffraction, field emission SEM with energy-dispersive X-ray spectroscopy, Raman, FT-IR, VSM and TGA-DTA-DTG analyzes, dispersion studies, and nitrogen porosimetry analyzes. The structures of the synthesized compounds were also endorsed by extensive spectroscopic studies (FT-IR, 1H and 13C NMR, mass) and elemental analyzes. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Plant Cell, Tissue and Organ Culture included an article by Ahmad, Zishan; Shahzad, Anwar; Sharma, Shiwali. Recommanded Product: 673-22-3. The article was titled 《Chitosan versus yeast extract driven elicitation for enhanced production of fragrant compound 2-hydroxy-4-methoxybenzaldehyde (2H4MB) in root tuber derived callus of Decalepis salicifolia (Bedd. ex Hook.f.) Venter》. The information in the text is summarized as follows:

Decalepis salicifolia (Bedd. ex Hook.f.) Venter is a new source of the com. important flavor compound 2-hydroxy-4-methoxybenzaldehyde (2H4MB), a structural isomer of vanillin, with high pharmacol. value and used as a flavoring agent at industrial level for making soft drink and bakery products. The natural availability of this high-valued plant is not able to meet the ever-increasing demands due to limited studies. Considering the importance of suspension culture over excised root culture, present communication provides a protocol for the suspension culture of root tuber derived callus of D. salicifolia for the first time. Maximum frequency (84.8%) callus induction was obtained on Murashige and Skoog (MS) medium augmented with (1.0μM) thidiazuron (TDZ) + (1.0μM) α-naphthalene acetic acid (NAA). Two important biotic elicitors, chitosan (CH) and yeast extract (YE) at different concentrations (50, 100, 200 and 300μM) were used as elicitor to investigate the effects on biomass content, 2H4MB content, total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity in cell suspension culture with different contact periods i.e. 24, 48 72 and 96 h. The results showed the supremacy of CH over YE and maximum biomass was 9.7 DW g/l at optimum contact period of 72 h when suspension culture was treated with 200μM CH. Maximum content of 2H4MB was14.8μg/g at 200μM CH and it was found to be 1.4-fold increase in relation to the control (10.8μg/g). The maximum TPC and TFC were 4.8 mg/g and 4.0 mg/g resp. at 200μM CH and 72 h of the contact period. The DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity (RSA) had also been evaluated and most of the suspension culture showed the correlation with TPC and TFC. The maximum RSA (63.8%) and hydroxyl radical scavenging activity (HRSA) (55.2%) were revealed the ability of plant as a potent antioxidant agent. Thus, a new protocol has been developed for the elicitors-induced enhancement of metabolites and antioxidant activity in suspension culture of D. salicifolia. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Microwave-assisted Single Step Cinnamic Acid Derivatization and Evaluation for Cytotoxic Potential》 was published in Current Pharmaceutical Biotechnology in 2020. These research results belong to Mishra, Sonali; Singh, Shilpi; Ali, Arif; Gupta, Amit C.; Shanker, Karuna; Bawankule, Dnyaneshwar U.; Luqman, Suaib. Related Products of 673-22-3 The article mentions the following:

Background: Phenylpropylene biosynthesis pathway plays a crucial role in the vanillin and their derivative(s) production in the plants. The intermediate of vanillin synthesis i.e. cinnamic acid (CA) is converted into 2-Hydroxy 4-MethoxyBenzaldehyde (HMB) in Decalepis arayalpathra having a number of therapeutic value. Objective: Microwave-assisted modifications in cinnamic acid were planned for potential anticancer properties with better yield and efficiency. The present study also confirms the presence of HMB and its precursor i.e. cinnamic acid in D. arayalpathra tubers. Methods: We used a single step Microwave Assisted Synthesis (MAS) to modify cinnamic acid, and then examined the synthetic and natural cinnamic acid derivatives anticancer potential against six human cancer (K-562, WRL-68, A549, A431, MCF-7, and COLO-201) and two normal (L-132 and HEK-293) cell lines at 2, 10 and 50μg/mL concentrations Results: β-bromostyrene and β -nitrostyrene have shown inhibition with IC50 values ranging 0.10-21μM and 0.03-0.06μM, resp. to the cancer cell lines. β-bromostyrene was the most potent anticancer derivative of CA with better cellular safety and biocompatibility. Conclusion: The present study of microwave-assisted synthesis demonstrates a single-step modification in cinnamic acid. MAS is a fast, reliable, and robust method. The resultant compounds have shown in-vitro anticancer activity against human lung carcinoma and breast adenocarcinoma. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Related Products of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Related Products of 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《An efficient base and H2O2 free protocol for the synthesis of phenols in water and oxygen using spinel CuFe2O4 magnetic nanoparticles》 was published in Journal of Coordination Chemistry in 2020. These research results belong to Chutia, Rituparna; Chetia, Bolin. Recommanded Product: m-Methoxyphenol The article mentions the following:

An efficient base and H2O2 free protocol was used for the synthesis of phenols from boronic acids using biogenic CuFe2O4 magnetic nanoparticles as catalyst at room temperature in water and oxygen. The catalyst was prepared using the flowers of Lantana camara. The size of the nanoparticles was 4.27 nm. Base free and ligand free protocol, less time, excellent yields, room temperature, biogenic synthesis of the catalyst, use of O2 as an environmentally friendly oxidant are the advantages of the present protocol. The recyclability of the catalyst was for 5 cycles without loss of magnetic property or catalytic activity. The experimental process involved the reaction of m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Miscible-Immiscible Transition of Deep Eutectic Solvents in Water Switched by CO2》 were Wan, Wenrui; Xiong, Dazhen; Zhang, Qian; Wang, Jianji. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. Application of 150-19-6 The author mentioned the following in the article:

It is very important to develop “”smart”” solvents that can integrate the advantages of homogeneous and heterogeneous reactions into one chem. process for enhanced reaction rate and minimal environmental impact. In designing these solvents, the applicability of the systems to real processes strongly depends on the phase behavior of the systems. In this work, a novel class of CO2 driven miscible-immiscible transition of deep eutectic solvents (DESs) have been explored. These DESs are composed of alkanolamine compounds as hydrogen bond acceptor (HBA) and phenolic compounds as hydrogen bond donor (HBD). They exhibit unique phase behavior with H2O: miscible with water in the absence of CO2, but immiscible with water in the presence of CO2 at room temperature and ambient pressure. Reversible liquid-liquid phase transition of such DESs-H2O mixtures can be realized by alternatively bubbling of CO2 and N2 under ambient conditions. Spectroscopic investigations show that the mechanism behind miscible-immiscible transition of DESs involves breaking of the hydrogen bonds between HBD and HBA by H2CO3 generated by bubbling CO2 through aqueous solution, because the acidity of H2CO3 is stronger than that of HBAs. And then HBAs react with H2CO3 to form ammonium salts. The salting-out effect of ammonium salts leads to the formation of an ammonium-salts-rich top phase and an HBD-rich bottom phase. When CO2 is removed by bubbling of N2, reversible process is achieved. The experimental process involved the reaction of m-Methoxyphenol(cas: 150-19-6Application of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application of 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Improved Synthetic Process of Dimethyl 4-Oxo-4H-pyran-3,5-dicarboxylate》 were Hu, Xinquan; Ding, An; Sun, Nan; Hu, Baoxiang; Shen, Zhenlu; Jin, Liqun. And the article was published in Organic Process Research & Development in 2019. Product Details of 4637-24-5 The author mentioned the following in the article:

A reported two-step procedure for preparing di-Me 4-oxo-4H-pyran-3,5-dicarboxylate was extensively optimized. It was found that the reactions can be carried out in toluene as a single solvent and the product was directly obtained by a simple filtration. More importantly, considering potential solvent recovering and recycling, the effluent of the process can be remarkably reduced. This new process facilitated the potential scale-up with com. significance. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Product Details of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Product Details of 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Chen, Jie; Guo, Pan; Zhang, Jianguo; Rong, Jiaxin; Sun, Wangbin; Jiang, Yaojia; Loh, Teck-Peng. Name: N,N-Dimethylformamide Dimethyl Acetal. The article was titled 《Synthesis of Functionalized α-Vinyl Aldehydes from Enaminones》. The information in the text is summarized as follows:

An efficient RhII-catalyzed synthesis of functionalized α-vinyl aldehydes with high E/Z stereoselectivity was developed. The reaction mediates the cyclopropanation of enaminones with vinyl carbenoids that are generated from cyclopropenes in situ to give the aminocyclopropane intermediates. Selective C-C bond cleavage of the cyclopropane intermediates leads to formation of α-vinyl aldehyde derivatives with high E/Z selectivity. This method proceeds at room temperature under very mild reaction conditions and works with a broad substrate scope.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: N,N-Dimethylformamide Dimethyl Acetal

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Research on Chemical Intermediates included an article by Salami, Masoumeh; Ezabadi, Ali. Application In Synthesis of 2-Methoxybenzaldehyde. The article was titled 《A caffeine-based ionic liquid as a novel and eco-friendly catalyst for the synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions》. The information in the text is summarized as follows:

A new Bronsted acidic ionic liquid has been synthesized using caffeine and p-toluenesulfonic acid as precursors. The IL was fully characterized by FT-IR, 1H NMR, 13C NMR, MS, elemental anal., as well as Hammett acidity function. The prepared reagent is efficiently able to catalyze the synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions. Various advantages associated with this method include novelty and easy preparation of catalyst, simple work-up procedure and purification, short reaction times, high product yields, and easy recovery and reusability of the catalyst. After reading the article, we found that the author used 2-Methoxybenzaldehyde(cas: 135-02-4Application In Synthesis of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Application In Synthesis of 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem