Tag: 100-200

Accurate and simple method for simultaneous determination of restricted ethylene glycol ethers and esters in leather by GC-MS was written by Ma, He-Wei;Luo, Jian-Xun. And the article was included in Journal of the Society of Leather Technologists and Chemists in 2021.Reference of 112-49-2 This article mentions the following:

An anal. approach was developed for the simultaneous determination of the eight ethylene glycol ethers (EGEs) and esters (EGEEs) prohibited by European Union (EU) REACH regulation in leather samples. The analytes were extracted using methanol with ultrasonic assistance within 30 min. The extracts were cleaned up by passing the extraction solution through a cartridge containing alumina-N frits, and the eluate was injected into GC-MS which was fitted with a 60m length capillary DB-WAX column. Excellent separation of the eight EGEs/EGEEs was achieved by the capillary column within 25 min. The clean-up with Alumina-N cartridge presented desired efficiency for removing the co-extractives in the extracts The major advantages of this method are the simplicity and accuracy. Limitation of the detection, linear range, and reproducibility of the method were evaluated. Average recoveries in the range of 91.7%-102.5% (RSD, ≤6.1%) with detection limits at 3.0-9.4mg/kg for the eight targets were obtained. Anal. results showed that ethylene glycol di-Me ether (EGDME), ethylene glycol Et ether (EGEE), and diethylene glycol di-Me ether (DEGDME), were found in 22% of 95 leather samples at the concentration range of 35-82mg/kg, 12-285mg/kg and 28-66mg/kg, resp., while the other five EGEs/EGEEs were not detected. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Reference of 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Reference of 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Convergent reductive depolymerization of wood lignin to isolated phenol derivatives by metal-free catalytic hydrosilylation was written by Feghali, Elias;Carrot, Geraldine;Thuery, Pierre;Genre, Caroline;Cantat, Thibault. And the article was included in Energy & Environmental Science in 2015.COA of Formula: C11H16O3 This article mentions the following:

The first examples of reductive depolymerization of lignin are reported under metal-free conditions. Using hydrosilanes as reductants and B(C₆F₅)₃ as a Lewis acid catalyst, wood lignin is efficiently converted to a narrow distribution of phenol derivatives at room temperature A three-step methodol. based on the selection of the wood species and the lignin extraction method followed by a convergent reductive depolymerization enables the production of four structurally defined aromatic compounds The phenol products were successfully isolated in 7-24 wt% yield from lignin and 0.5-2.4 wt% yield from wood. The strategy is found to be robust and is applied to 15 different wood plants, including gymnosperm and angiosperm species. The efficiency of this novel methodol. has been evaluated based on spectroscopic characterization of the lignin preparations and isolated yields of mono-aromatic products. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3COA of Formula: C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.COA of Formula: C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The asarone-derived phenylpropanoids from the rhizome of Acorus calamus var. angustatus Besser was written by Bai, Yajun;Sun, Ying;Xie, Jing;Li, Bin;Bai, Yujun;Zhang, Dongxu;Liang, Jing;Xiao, Chaoni;Zhong, Aiguo;Cao, Yanjun;Zheng, Xiaohui. And the article was included in Phytochemistry (Elsevier) in 2020.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

Phenylpropanoids comprise a broad spectrum of biol. active natural products. As part of our ongoing research on antiepileptic active compounds from traditional Chinese herb, Acorus calamus var. angustatus Besser, three undescribed phenylpropanoids and twenty-two known ones were isolated. All the undescribed structures were determined by a combination of 1D and 2D NMR, HRMS. In addition, γ-asaronol was identified as racemates and its absolute configuration were determined by the modified Mosher′s method and ECD spectral data. Furthermore, some selected isolated compounds were evaluated for their cell viability and neuroprotective activities in H₂O₂-induced SH-SY5Y cells. α-Asaronol, β-asaronol, 3-(2,4,5-trimethoxyphenyl)propan-1-ol and 1,2,4-trimethoxy-5-(3-methoxypropyl)benzene exerted potential protective activity from neuronal oxidative stress in all test concentrations ranging from 0.01 to 100 μM, in which the neuroprotective activity of β-asaronol was the best. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application In Synthesis of 3-(3,4-Dimethoxyphenyl)propan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ruthenium(III)-catalyzed oxidation of phenoxyacetic acids by aqueous phenyliodoso acetate was written by Gurumurthy, R.;Karunakaran, K.;Sathiyanarayanan, K.. And the article was included in Oxidation Communications in 1993.Formula: C9H10O4 This article mentions the following:

The kinetics of oxidation of phenoxyacetic acid and its derivatives (19 compounds) by phenyliodoso acetate has been studied in 60% (volume/volume) aqueous acetic acid. The reaction is first order with respect to both phenoxyacetic acid and phenyliodoso acetate and is catalyzed by hydrogen ions. Catalysis by Ru(III) is observed A Hammett ρ value of -2.62 at 35° indicates an electron-deficient transition state. The oxidation rates of ortho-substituted compounds have been analyzed by applying Taft’s steric energy parameters. A suitable mechanism has been proposed. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photocatalytic pollutant removal in water at room temperature: case study of the total degradation of the insecticide fenitrothion (phosphorothioic acid O,O-dimethyl-O- (3-methyl-4-nitro-phenyl) ester) was written by Kerzhentsev, Mikhail;Guillard, Chantal;Herrmann, Jean-Marie;Pichat, Pierre. And the article was included in Catalysis Today in 1996.Application In Synthesis of 3-Methyl-4-nitroanisole This article mentions the following:

The photocatalytic purification of water containing fenitrothion was performed in TiO₂ aqueous suspensions. Mineralization into CO₂, H₂PO₄^–, SO₄^2-, NO₃^– was achieved. Several intermediates were identified by HPLC and gas chromatog.-mass spectrometry. They illustrate the transformation of P:S into P:0, the splitting between the P part and the aromatic moiety, and the transfer of Me or methoxy groups. Formate ions, principally produced from the CH₃O and CH₃ groups, and acetate ions were also detected as intermediate products. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Application In Synthesis of 3-Methyl-4-nitroanisole).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of 3-Methyl-4-nitroanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

New access to indoles by ylide-amide condensation was written by Le Corre, M.;Hercouet, A.;Le Stanc, Y.;Le Baron, H.. And the article was included in Tetrahedron in 1985.Related Products of 5367-32-8 This article mentions the following:

o-Acylaminobenzylidenephosphoranes lead to indoles in good yield by an intramol. Wittig reaction with the amide carbonyl group. Mechanistic aspects are discussed. A general method is described for the synthesis of indoles from o-nitrobenzyl bromides and o-aminobenzyl alcs. Thus, o-AcNHC₆H₄CH₂PPh₃, prepared in 3 steps from 2-O₂NC₆H₄Me, was treated with base to give the indole I in 96% yield. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Related Products of 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Radical addition of silanes to alkenes followed by oxidation was written by Palframan, Matthew J.;Parsons, Andrew F.;Johnson, Paul. And the article was included in Synlett in 2011.Category: ethers-buliding-blocks This article mentions the following:

Phenyldimethylsilane and trichlorosilane are shown to undergo efficient radical hydrosilylation reactions, on reaction with various alkenes, using triethylborane as the initiator. Adducts from the trichlorosilane reactions can be oxidized to afford alcs. in good yields. This two-step process leads to the anti-Markovnikov hydration of alkenes. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Category: ethers-buliding-blocks).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Novel Lead Structures for p38 MAP Kinase via FieldScreen Virtual Screening was written by Cheeseright, Timothy J.;Holm, Melanie;Lehmann, Frank;Luik, Sabine;Gottert, Marcia;Melville, James L.;Laufer, Stefan. And the article was included in Journal of Medicinal Chemistry in 2009.Related Products of 1877-75-4 This article mentions the following:

The p38 MAP kinase has received considerable interest in the pharmaceutical industry and remains a valid and interesting target for the treatment of inflammation. To discover novel p38 inhibitors, the ligand-based virtual screening technique, FieldScreen, was applied to 1.2 million com. available compounds Fifty-eight diverse compounds were selected for biol. anal., using mol. field similarity to known inhibitors, while explicitly removing any structure that shared a scaffold with previously reported p38 inhibitors. Of these, 11 (19%) showed ≥20% inhibition of p38 at 10 μM. Analogs of two distinct chem. series were prepared, resulting in a potential lead compound with pIC₅₀ of 6.4. Modeling of SAR using FieldAlign, a ligand alignment protocol, was used to rationalize the SAR of the series of thiadiazole based inhibitors. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemistry of Pyrrolo[1,2-a]indole- and Pyrido[1,2-a]indole-Based Quinone Methides. Mechanistic Explanations for Differences in Cytostatic/Cytotoxic Properties was written by Khdour, Omar;Skibo, Edward B.. And the article was included in Journal of Organic Chemistry in 2007.Product Details of 5367-32-8 This article mentions the following:

In the present study the authors investigate pyrido[1,2-a]indole- and pyrrolo[1,2-a]indole-based quinones capable of forming quinone methide and vinyl quinone species upon reduction and leaving group elimination. The goals were to determine the influence of the 6-membered pyrido and the 5-membered pyrrolo fused rings on quinone methide and vinyl quinone formation and fate as well as on cytostatic and cytotoxic activity. The authors used the technique of Spectral Global Fitting to study the fleeting quinone methide intermediate directly. Conclusions regarding quinone methide reactivity are that carbonyl O-protonation is required for nucleophile trapping and that the pK_a value of this protonated species is near neutrality. The abnormally high protonated carbonyl pK_a values are due to the formation of an aromatic carbocation species upon protonation. The fused pyrido ring promotes quinone methide and vinyl quinone formation but slows nucleophile trapping compared to the fused pyrrolo ring. These findings are explained by the presence of axial hydrogen atoms in the fused pyrido ring resulting in more steric congestion compared to the relatively flat fused pyrrolo ring. Consequently, pyrrolo[1,2-a]indole-based quinones exhibit more cytostatic activity than the pyrido[1,2-a]indole analogs due to their greater nucleophile trapping capability. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Product Details of 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Product Details of 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Superior coulombic efficiency of lithium anodes for rechargeable batteries utilizing high-concentration ether electrolytes was written by Xie, Jian-De;Liu, Weng-Jing;Li, Chi;Patra, Jagabandhu;Gandomi, Yasser Ashraf;Dong, Quan-Feng;Chang, Jeng-Kuei. And the article was included in Electrochimica Acta in 2019.Recommanded Product: 2,5,8,11-Tetraoxadodecane This article mentions the following:

This study adopts high-concentration ether electrolytes to improve high-rate capability, cycling stability, and Coulombic efficiency (CE) for lithium ion batteries with lithium anode. A series of ether-based electrolytes including lithium bis(fluorosulfonyl)imide (LiFSI)-glyme/ethylene carbonate (EC), LiFSI-glyme/EC, LiFSI-diglyme/EC, LiFSI-triglyme/EC, LiFSI-tetraglyme (G4)/EC, and LiFSI-1,3-dioxolane (DOL)/EC, along with commonly used LiPF₆-DEC/EC were prepared to delineate the influences of concentration, chain length, mol. structure (linear or ring ether), and EC additive on the electrochem. performance of Li anodes. An optimum composition for ether-based electrolyte was determined resulting in significant improvement in anti-flammability as well as CE at both low and high rates. At ultra-high c.d. operation (e.g. 6 mA cm^-2), the CE was 95.5 and 97.1% with 3 M LiFSI-G4/EC and 3 M LiFSI-DOL/EC, resp. Using 1 M LiPF₆ carbonate-based electrolyte tend to grow a needle-like dendritic structure when depositing lithium metal on Cu foils, whereas high-concentration ether electrolyte promotes a knot-like and rounded Li metal microstructure. High concentration EC-based electrolytes, are capable of facilitating Li⁺ almost in tandem with solvent mols., thereby reducing the number of free mols., reducing the chance of side reaction with Li metal, and subsequently inhibiting the formation of dendritic Li structures. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Recommanded Product: 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem