Tag: 100-200

A new diversity oriented and metal-free approach to highly functionalized 3H-pyrimidin-4-ones was written by Riva, Renata;Banfi, Luca;Basso, Andrea;Zito, Paola. And the article was included in Organic & Biomolecular Chemistry in 2011.Recommanded Product: 1877-75-4 This article mentions the following:

A new synthesis of functionalized 3H-pyrimidin-4-ones is presented. The strategy is based on the synthetic elaboration of readily available α-substituted β-ketoesters that, upon transformation into the corresponding acyl enamines, have been cyclized to give 6H-1,3-oxazin-6-ones. These reactive intermediates have been in turn cleanly converted into highly functionalized pyrimidinones, by treatment with an appropriate primary amine. The whole sequence does not need the use of any metal mediator or catalyst. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Recommanded Product: 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Recommanded Product: 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kinetics and mechanism of oxidation of phenoxyacetic acids by chromic acid was written by Gurumurthy, R.;Sathiyanarayanan, K.;Anandabaskaran, T.;Karunakaran, K.. And the article was included in Asian Journal of Chemistry in 1994.Safety of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

The kinetics of oxidation of phenoxyacetic acid and several para- and meta-substituted phenoxyacetic acids by chromic acid in the presence of perchloric acid have been studied in 50% (volume/volume) aqueous acetic acid. The oxidation is fractional order (0.74) with respect to substrate. Increasing the concentration of perchloric acid increases the rate of oxidation with an order of 0.62. Added Mn²⁺ decreases the rate considerably, suggesting a two-electron transfer at the rate-limiting step. In general, electron-releasing substituents accelerate the rate while electron-attracting groups retard the rate. A good Hammett correlation is obtained. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Safety of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Safety of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In Vitro synergy of nisin and coenzyme Q₀ against Staphylococcus aureus was written by Zhao, Xingchen;Liu, Zonghui;Li, Wenli;Li, Xia;Shi, Ce;Meng, Rizeng;Cheng, Wei;Jin, Kunqi;Yang, Zhiqiang;Shi, Xiaochen;Guo, Na;Yu, Lu. And the article was included in Food Control in 2014.HPLC of Formula: 605-94-7 This article mentions the following:

Nisin has been widely used as a natural preservative in foods including dairy products, but the emergence of the nisin-resistant strains could compromise its use to control food-borne pathogens. It has been reported that coenzyme Q (CoQ) is a powerful antioxidant, but a small number of studies have described the antibacterial activity of CoQ. One of the most abundant forms of CoQ is CoQ₁₀. CoQ₀ is chosen for this study, which is the water-soluble homolog of CoQ₁₀. In the present study, the in vitro interaction of nisin and CoQ₀ against 15 food-borne isolates of Staphylococcus aureus was assessed using a checkerboard microdilution method. Synergism was observed in strains tested, the FICI values ranging from 0.25 to 0.375. No antagonistic interaction between nisin and CoQ₀ occurred. The pos. interactions were verified confirmed using the time-killing test and agar diffusion assay. Our discovery of efficacy of combining nisin with CoQ₀ might pave the way for a novel solution for spoilage problem in food industry and provide an alternative approach to overcome antimicrobial drug resistance. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7HPLC of Formula: 605-94-7).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).HPLC of Formula: 605-94-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template was written by Santra, Soumava;Sharma, Horrick;Vedachalam, Seenuvasan;Antonio, Tamara;Reith, Maarten;Dutta, Aloke. And the article was included in Bioorganic & Medicinal Chemistry in 2015.Application of 57179-35-8 This article mentions the following:

Current therapy of depression is less than ideal with remission rates of only 25-35% and response rates of 45-60%. It has been hypothesized that a dysfunctional dopaminergic system in the mesocorticolimbic pathway in depressive disorder may lead to development of anhedonia associated with loss of pleasure and interest along with loss of motivation. The current antidepressants do not address dopamine dysfunction which might explain their low efficacy. In this report, we have described an SAR study on our pyran-based triple reuptake inhibitors (TRIs) which are being investigated as the next-generation antidepressants. In the present work we demonstrate that our lead TRIs can be modified with appropriate aromatic substitutions to display a highly potent SSRI profile for compounds 2a and 4a (K_i (SERT); 0.71 and 2.68 nM, resp.) or a potent DNRI profile for compounds 6b and 6h (K_i (DAT/NET); 8.94/4.76 and 13/7.37 nM, resp.). Compounds 4g-4i exhibited potencies at all three monoamine transporters. The results provide insights into the structural requirements for developing selective dual- and triple-uptake inhibitors from a unique pyran mol. template for an effective management of depression and related disorders. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Application of 57179-35-8).

3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application of 57179-35-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Iron-catalyzed direct C-H arylation of heterocycles and quinones with arylboronic acids was written by Deb, Arghya;Manna, Srimanta;Maji, Arun;Dutta, Uttam;Maiti, Debabrata. And the article was included in European Journal of Organic Chemistry in 2013.COA of Formula: C9H10O4 This article mentions the following:

The arylation of C-H bonds to generate heteroaryl-aryl (Het-Ar) and arylated quinone (Quin-Ar) compounds has received great attention to achieve sustainable goals in synthetic chem. Despite significant advances, arylation of a broad range of Het-Ar and Quin-Ar derivatives remains a challenging task. Herein, a variety of heterocycles are arylated by using arylboronic acids in the presence of catalytic amounts of inexpensive Fe(NO₃)₃. The C-arylated quinone compounds can be prepared by reacting arylboronic acids with either quinone or hydroquinone. The present method is operationally simple, scalable, does not require prefunctionalization of the heterocycle or quinone, and can tolerate a wide variety of functional groups in the coupling partners. These qualities are expected to render this method attractive for academic and industrial use. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7COA of Formula: C9H10O4).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).COA of Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Construction of Self-Reporting Biodegradable CO₂-Based Polycarbonates for the Visualization of Thermoresponsive Behavior with Aggregation-Induced Emission Technology was written by Wang, Molin;Wang, Enhao;Cao, Han;Liu, Shunjie;Wang, Xianhong;Wang, Fosong. And the article was included in Chinese Journal of Chemistry in 2021.Quality Control of 2-(2-Methoxyethoxy)ethanol This article mentions the following:

Thermoresponsive polymers with simultaneous biodegradability and signal “self-reporting” outputs that meet for advanced applications are hard to obtain. To address this issue, we developed fluorescence signal “self-reporting” biodegradable thermoresponsive polycarbonates through the immortal copolymerization of CO₂ and oligoethylene glycol monomethyl ether-functionalized epoxides in the presence of hydroxyl-modified tetraphenylethylene (TPE-OH). TPE-OH was used as chain transfer agent to afford well-defined polycarbonates with controlled mol. weight (6000-17000 g·mol^-1) and aggregation-induced emission characteristics. Through temperature-dependent fluorescence intensity study, low critical solution transition of TPE-labeled polycarbonates were determined and the fine details of thermal-induced phase transition process were monitored. Further research indicated that temperature-controlled aggregation and dissociation of TPE moieties are the main reason for fluorescence intensity variations. We anticipate that this work could offer a method to visualize the thermal transition process of thermoresponsive polycarbonates and broaden their application fields as smart materials. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Quality Control of 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Development of Photoactivated Fluorescent N-Hydroxyoxindoles and Their Application for Cell-Selective Imaging was written by Lai, Jinping;Yu, An;Yang, Letao;Zhang, Yixiao;Shah, Birju P.;Lee, Ki Bum. And the article was included in Chemistry – A European Journal in 2016.Name: 3-Methyl-4-nitroanisole This article mentions the following:

Photoactivatable fluorophores are essential tools for studying the dynamic mol. interactions within important biol. systems with high spatiotemporal resolution However, currently developed photoactivatable fluorophores based on conventional dyes have several limitations including reduced photoactivation efficiency, cytotoxicity, large mol. size, and complicated organic synthesis. To overcome these challenges, we herein report a class of photoactivatable fluorescent N-hydroxyoxindoles formed through the intramol. photocyclization of substituted o-nitrophenyl ethanol (ONPE). These oxindole fluorophores afford excellent photoactivation efficiency with ultra-high fluorescence enhancement (up to 800-fold) and are small in size. Furthermore, the oxindole derivatives show exceptional biocompatibility by generating water as the only photolytic side product. Moreover, structure-activity relationship anal. clearly revealed the strong correlation between the fluorescent properties and the substituent groups, which can serve as a guideline for the further development of ONPE-based fluorescent probes with desired photophys. and biol. properties. As a proof-of-concept, we demonstrated the capability of a new substituted ONPE that has an uncaging wavelength of 365-405 nm and an excitation/emission at 515 and 620 nm, for the selective imaging of a cancer cell line (Hela cells) and a human neural stem cell line (hNSCs). In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Name: 3-Methyl-4-nitroanisole).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Name: 3-Methyl-4-nitroanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A New Approach To Predict the Biological Activity of Molecules Based on Similarity of Their Interaction Fields and the logP and logD Values: Application to Auxins was written by Bertosa, Branimir;Kojic-Prodic, Biserka;Wade, Rebecca C.;Ramek, Michael;Piperaki, Stavroula;Tsantili-Kakoulidou, Anna;Tomic, Sanja. And the article was included in Journal of Chemical Information and Computer Sciences in 2003.HPLC of Formula: 1877-75-4 This article mentions the following:

The activity of a biol. compound is dependent both on specific binding to a target receptor and its ADME (Absorption, Distribution, Metabolism, Excretion) properties. A challenge to predict biol. activity is to consider both contributions simultaneously in deriving quant. models. We present a novel approach to derive QSAR models combining similarity anal. of mol. interaction fields (MIFs) with prediction of logP and/or logD. This new classification method is applied to a set of about 100 compounds related to the auxin plant hormone. The classification based on similarity of their interaction fields is more successful for the indole than the phenoxy compounds The classification of the phenoxy compounds is however improved by taking into account the influence of the logP and/or the logD values on biol. activity. With the new combined method, the majority (8 out of 10) of the previously misclassified derivatives of phenoxy acetic acid are classified in accord with their bioassays. The recently determined crystal structure of the auxin-binding protein 1 (ABP1) enabled validation of our approach. The results of docking a few auxin related compounds with different biol. activity to ABP1 correlate well with the classification based on similarity of MIFs only. Biol. activity is, however, better predicted by a combined similarity of MIFs + logP/logD approach. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4HPLC of Formula: 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.HPLC of Formula: 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Melting synthesis of 2-[(aryloxy)methyl]benzimidazole derivatives was written by Li, Yingjun;Liu, Lijun;Jin, Kun;Wang, Wei;Zhao, Nan;Li, Lina;Li, Chunyan. And the article was included in Youji Huaxue in 2009.Safety of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

Several 2-[(aryloxy)methyl]benzimidazole derivatives were obtained by a reaction of benzenediamine with aryloxyacetic acid derivatives using a melting method. The products were confirmed by IR and NMR techniques. In this method, the molar ratio of o-phenylenediamine and aryloxyacetic acid is 1:1.1, and the reaction temperature is 180°. The above-mentioned method has the advantages of simple operation, short reaction time, easy purification, few byproducts, moderate to high yields and green synthesis. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Safety of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Juvenile hormone like substances. Part XIV. Synthesis and biological activities of some juvenile hormone analogues containing peptidic feature was written by Mahajan, R. K.;Sharma, G. C.. And the article was included in Journal of Indian Council of Chemists in 1998.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid This article mentions the following:

Juvenile hormone analogs which contain glycinate moiety, i.e. 4-RC₆H₄OCH₂CON(R¹)CH₂CO₂R³ (R = H, Cl, Me, OMe, NO₂, R¹ = H, R³ = CHMe₂; R = H, Cl, Me, OMe, R¹ = H, R³ = CH₂Me; R = H, Cl, Me, OMe, R¹ = H, R³ = CH₂CHMe₂;R = H, Cl, R¹ = Me, R³ = CH₂Me), were synthesized. Preliminary biol. screening of PhOCH₂CONHCH₂CO₂CHMe₂ showed a pos. juvenile hormonal activity against potato tuber moth Phthorimaea operculella. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Application In Synthesis of 2-(4-Methoxyphenoxy)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem