Tag: 100-200

Manganese-Catalyzed Synthesis of Imines from Primary Alcohols and (Hetero)Aromatic Amines was written by Raydan, Daniel;Friaes, Sofia;Viduedo, Nuno;Santos, A. Sofia;Gomes, Clara S. B.;Royo, Beatriz;Marques, M. Manuel B.. And the article was included in Synlett in 2022.Reference of 105-13-5 This article mentions the following:

Herein, the synthesis of a wide variety of imines through oxidative coupling of alcs. and aromatic amines catalyzed by Mn complexes bearing NN triazole ligands was described. A wide variety of imines in excellent yields (up to 99%) was prepared Mn-based catalysts proved to be highly efficient and versatile, allowing for the first time the preparation of several imines containing N-based heterocycles. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Reference of 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hierarchy of relaxation times in supramolecular polymer model networks was written by Koziol, Martha Franziska;Nguyen, Phuong Loan;Gallo, Shannon;Olsen, Bradley D.;Seiffert, Sebastian. And the article was included in Physical Chemistry Chemical Physics in 2022.Application of 111-77-3 This article mentions the following:

Supramol. polymer gels are an evolving class of soft materials with a vast number of properties that can be tuned to desired applications. Despite continuous advances concerning polymer synthesis, sustainability or adaptability, a consistent understanding of the interplay between structure, dynamics, and diffusion processes within transient networks is lacking. In this study, the hierarchy of several relaxation processes is investigated, starting from a microscopic perspective of a single sticker dissociation event up to the center-of-mass diffusion of a star-shaped polymer building block on different length scales, as well as the resulting macroscopic mech. response to applied external stress. In addition to that, a second focus is placed on the gel micro-structure that is analyzed by light scattering. Conversion of the dynamic light scattering (DLS) inverse length scale into real space allows for a combination of relaxation times with those obtained by forced Rayleigh scattering (FRS). For these investigations, a model-type metallo-supramol. network consisting of narrowly dispersed tetra-arm poly(ethylene glycol)-terpyridine macromols. that are interconnected via complexation with zinc ions is chosen. Assembling the obtained activation energies reveals that all complex dissociation-governed relaxation processes exhibit similar activation energies. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Application of 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application of 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Facile synthesis of novel lithium β-diketonate glyme adducts: the effect of molecular engineering on the thermal properties was written by Peddagopu, Nishant;Rossi, Patrizia;Bonaccorso, Carmela;Bartasyte, Ausrine;Paoli, Paola;Malandrino, Graziella. And the article was included in Dalton Transactions in 2020.Name: 2,5,8,11-Tetraoxadodecane This article mentions the following:

Novel adducts of lithium hexafluoroacetylacetonato {Li(hfa)} with polyethers (monoglyme = {CH₃OCH₂CH₂OCH₃}, diglyme = {CH₃O(CH₂CH₂O)₂CH₃}, triglyme = {CH₃O(CH₂CH₂O)₃CH₃} and tetraglyme {CH₃O(CH₂CH₂O)₄CH₃}) were synthesized through a single step reaction and characterized by FTIR spectroscopy, ¹H, and ¹³C NMR, single crystal X-ray diffraction studies along with thermal anal. The prepared complexes are [Li₁₂(hfa)₁₂·monoglyme·4H₂O] (1), [Li₂(hfa)2·diglyme·H₂O] (2), Li(hfa)·triglyme (3), and Li(hfa)·tetraglyme (4). The complexes 1 and 2 were characterized by single crystal structure determination In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Name: 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Name: 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Theoretical Infrared Spectra: Quantitative Similarity Measures and Force Fields was written by Henschel, Henning;Andersson, Alfred T.;Jespers, Willem;Mehdi Ghahremanpour, Mohammad;van der Spoel, David. And the article was included in Journal of Chemical Theory and Computation in 2020.Product Details of 111-77-3 This article mentions the following:

IR spectroscopy can provide significant insight into the structures and dynamics of mols. of all sizes. The information that is contained in the spectrum is, however, often not easily extracted without the aid of theor. calculations or simulations. We present here the calculation of the IR spectra of a database of 703 gas phase compounds with four different force fields (CGenFF, GAFF-BCC, GAFF-ESP, and OPLS) using normal-mode anal. Modern force fields increasingly use virtual sites to describe, e.g., lone-pair electrons or the σ-holes on halogen atoms. This requires some adaptation of code to perform normal-mode anal. of such compounds,the implementation of which into the GROMACS software is briefly described as well. For the quant. comparison of the obtained spectra with exptl. reference data, we discuss the application of two different statistical correlation coefficients, Pearson and Spearman. The advantages and drawbacks of the different methods of comparison are discussed, and we find that both methods of comparison give the same overall picture, showing that present force field methods cannot match the performance of quantum chem. methods for the calculation of IR spectra. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Product Details of 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Product Details of 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kinetics and mechanism of oxidation of some meta- and para- substituted phenoxyacetic acids by N-chloropiperazine-2,5-dione in non-aqueous medium was written by Palaniappan, An.;Srinivasan, S.;Senthilkumar, S.. And the article was included in Asian Journal of Chemistry in 2002.Formula: C9H10O4 This article mentions the following:

The kinetics of oxidation of a number of meta- and para- substituted phenoxyacetic acids by N-chloropiperazine-2,5-dione (NCPD) were studied in methanol medium. The reaction shows unit order dependence with respect to oxidant and the order with respect to substrate varies depending on the nature of the substituent present in the ring. The rate is showing an inverse order of dependence with respect to [TsOH]. The rate increases with decrease in the percentage of methanol. Increase in ionic strength has no effect on the reaction rate. From the kinetic data obtained the activation parameters were computed and a suitable mechanism was proposed in accordance with multiparameter correlation anal. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effects of quinones and nitroazoles on free-radical fragmentation of glycerol-1-phosphate and 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol was written by Samovich, Svetlana N.;Sladkova, Anastasia A.;Sverdlov, Roman L.;Edimecheva, Irina P.;Shadyro, Oleg I.. And the article was included in Chemistry and Physics of Lipids in 2019.COA of Formula: C9H10O4 This article mentions the following:

Effects of quinones and azoles on the formation of steady-state radiolysis products in aqueous solutions of glycerol-1-phosphate and aqueous dispersions of 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol has been investigated. The data obtained by LC-MS-ESI and spectrophotometric measurements shows that the compounds having quinoid structures, including the antitumor agent doxorubicin, and azoles having nitro groups effectively inhibit free-radical fragmentation of glycerol-1-phosphate and 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol, decreasing the radiation-chem. yields of either inorganic phosphate or phosphatidic acid resp. The observed effects of blocking free-radical processes are believed to be related to the ability of the tested compounds to oxidize α-hydroxyl-containing carbon-centered radicals of starting substrates, which give rise to fragmentation reaction. The possibility of using the discovered properties of quinones, doxorubicin and nitroazoles to provide practical solutions in oncol. radiotherapy and pathophysiol. is discussed. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7COA of Formula: C9H10O4).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.COA of Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin was written by Hidaka, Koushi;Kimura, Tooru;Ruben, Adam J.;Uemura, Tsuyoshi;Kamiya, Mami;Kiso, Aiko;Okamoto, Tetsuya;Tsuchiya, Yumi;Hayashi, Yoshio;Freire, Ernesto;Kiso, Yoshiaki. And the article was included in Bioorganic & Medicinal Chemistry in 2008.COA of Formula: C9H10O4 This article mentions the following:

Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-dimethylthioproline scaffold to exhibit potent inhibitory activities against Plm II. Their activities against Plasmodium falciparum in the infected erythrocyte assay were largely different from those against the target enzyme. To improve the antimalarial activity of peptidomimetic Plm inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified alkylamino compounds such as 44 (KNI-10283) and 47 (KNI-10538) with more than 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining their potent Plm II inhibitory activity and low cytotoxicity. These results suggest that auxiliary substituents on a specific basic group contribute to deliver the inhibitors to the target Plm. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4COA of Formula: C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.COA of Formula: C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Access to sultams by rhodium(III)-catalyzed directed C-H activation was written by Pham, Manh V.;Ye, Baihua;Cramer, Nicolai. And the article was included in Angewandte Chemie, International Edition in 2012.Application of 16356-02-8 This article mentions the following:

Acylated sulfonamides were established as suitable directing groups for rhodium(III)-catalyzed C-H bond activations. The cyclo-metalated intermediates readily react with a broad range of internal alkynes and open a rapid and general access to aryl sultams. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Application of 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application of 16356-02-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Experimental investigation on the oxidation of printing ink wastewater under hydrothermal flames was written by Zhang, Fengming;Li, Yufeng;Liang, Zhaojian;Wu, Tong;Huang, Yingfei. And the article was included in Journal of Environmental Chemical Engineering in 2021.HPLC of Formula: 111-77-3 This article mentions the following:

Printing ink wastewater has a strong color and contains high salinity and high concentrations of complex organic compounds, posting a severe threat to the ecol. environment and human health. In this work, supercritical water oxidation of printing ink wastewater is performed within a transpiring wall reactor (TWR) to avoid corrosion and salt plugging issues. The high concentration of organic matter in printing ink wastewater is used to form hydrothermal flames for enhanced degradation Flame temperatures, gaseous and aqueous products characteristics, as well as the anti-corrosion and salt plugging performance of the reactor, are obtained. A remarkable temperature fluctuation due to the multi-component systems indicates the instability of hydrothermal flame. The salt recovery rate of 94.56% and the integrity of the porous tube inner wall indicate that TWR has a good performance in terms of anti-corrosion and salt plugging. Under typical conditions, the removal rates for COD, total nitrogen, and color are 99.52%, 70.07%, and 97.89%, resp. Alkanes, nitrogenous compounds, benzodiazepines, and heterocyclic compounds in the aqueous products, and CO, H₂, NH₃, and CH₄ in the gaseous products are the main intermediate products of printing ink wastewater under hydrothermal flames. Ammonia nitrogen, as the main intermediate product, inhibits the complete oxidation of nitrogenous organic compounds Addnl., higher KNO₃ concentrations promote the complete oxidation of nitrogenous organic compounds, while higher NaOH concentrations can increase the pH value and slightly facilitate degradation In addition, higher feed flow rates prevent deposition and adhesion of additives that occur at high concentrations In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3HPLC of Formula: 111-77-3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 111-77-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I was written by Uno, Shinpei;Masuya, Takahiro;Shinzawa-Itoh, Kyoko;Lasham, Jonathan;Haapanen, Outi;Shiba, Tomoo;Inaoka, Daniel Ken;Sharma, Vivek;Murai, Masatoshi;Miyoshi, Hideto. And the article was included in Journal of Biological Chemistry in 2020.Computed Properties of C9H10O4 This article mentions the following:

NADH-quinone oxidoreductase (complex I) couples electron transfer from NADH to quinone with proton translocation across the membrane. Quinone reduction is a key step for energy transmission from the site of quinone reduction to the remotely located proton-pumping machinery of the enzyme. Although structural biol. studies have proposed the existence of a long and narrow quinone-access channel, the physiol. relevance of this channel remains debatable. We investigated here whether complex I in bovine heart submitochondrial particles (SMPs) can catalytically reduce a series of oversized ubiquinones (OS-UQs), which are highly unlikely to transit the narrow channel because their side chain includes a bulky “block” that is ∼13 Å across. We found that some OS-UQs function as efficient electron acceptors from complex I, accepting electrons with an efficiency comparable with ubiquinone-2. The catalytic reduction and proton translocation coupled with this reduction were completely inhibited by different quinone-site inhibitors, indicating that the reduction of OS-UQs takes place at the physiol. reaction site for ubiquinone. Notably, the proton-translocating efficiencies of OS-UQs significantly varied depending on their side-chain structures, suggesting that the reaction characteristics of OS-UQs affect the predicted structural changes of the quinone reaction site required for triggering proton translocation. These results are difficult to reconcile with the current channel model; rather, the access path for ubiquinone may be open to allow OS-UQs to access the reaction site. Nevertheless, contrary to the observations in SMPs, OSUQs were not catalytically reduced by isolated complex I reconstituted into liposomes. We discuss possible reasons for these contradictory results. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Computed Properties of C9H10O4).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Computed Properties of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem