Tag: 100-200

Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer’s disease was written by Pan, Long-Fei;Wang, Xiao-Bing;Xie, Sai-Sai;Li, Su-Yi;Kong, Ling-Yi. And the article was included in MedChemComm in 2014.COA of Formula: C10H15NO The following contents are mentioned in the article:

Considering the complex pathogenesis factors of Alzheimer’s disease (AD), the multitarget-directed ligand strategy is expected to provide superior effects to fight AD, instead of the classic one-drug-one-target strategy. Resveratrol, exhibiting important properties against AD, was suggested to be used as a starting compound for the treatment of AD. Based on these reasons, a series of resveratrol derivatives were designed, synthesized and biol. evaluated. Among them, compound 6r, exhibiting moderate cholinesterase inhibition activity (AChE, IC₅₀ = 6.55 μM; BuChE, IC₅₀ = 8.04 μM; SI = 1.23), significant inhibition of Aβ₄₂ aggregation (57.78%, at 20 μM) and acceptable inhibitory activity against monoamine oxidases (MAO-A, IC₅₀ = 17.58 μM; MAO-B, IC₅₀ = 12.19 μM), was a potential anti-Alzheimer agent with balanced activities. Consequently, this study provided useful information for further development of resveratrol derivatives as multitarget-directed agents for AD therapy. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3COA of Formula: C10H15NO).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C10H15NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic hydrothermal liquefaction of lignin for production of aromatic hydrocarbon over metal supported mesoporous catalyst was written by Feng, Li;Li, Xuhao;Wang, Zizeng;Liu, Bingzhi. And the article was included in Bioresource Technology in 2021.Product Details of 2380-78-1 The following contents are mentioned in the article:

Catalytic hydrothermal liquefaction (HTL) of lignin was examined at various temperature (250-310°C) and reaction time in the presence of different solvents (water, methanol and ethanol) with different metal supported on MCM-41 mesoporous catalyst. In case of ethanol solvent, the maximum bio-oil yield of 56.2 wt% was obtained with Ni-Al/MCM-41. However in case of water, bio-oil yield was (44.3 wt%); while significantly improves bio-oil yield for methanol solvent (48.1 wt%). It is indicated that alc. solvents promoted the lignin decomposition, while in the presence of catalyst; water solvent significantly improves lignin degradation Loading of Ni and Al on MCM-41, the acid strength of the catalyst increased, which enhanced lignin degradation From the GC-MS anal., the main G-type (ca.54%) phenolic compounds were produced with higher percentage of aromatic hydrocarbon compounds CHNS and GPC anal. showed that catalytic liquefaction encouraged hydrodeoxygenation, which produced lower oxygen content bio-oil with lower mol. weight This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Product Details of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nutrition during pregnancy and lactation: New evidence for the vertical transmission of extra virgin olive oil phenolic compounds in rats was written by Lopez-Yerena, Anallely;Grases-Pinto, Blanca;Zhan-Dai, Sonia;Perez-Cano, Francisco J.;Lamuela-Raventos, Rosa M.;Rodriguez-Lagunas, Maria J.;Vallverdu-Queralt, Anna. And the article was included in Food Chemistry in 2022.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Maternal breast milk provides the newborn with passive immunity and stimulates the maturation of the infant immune system. The aim of the present study was to evaluate the vertical transmission of phenolic compounds and their metabolites to offspring in rats fed with extra virgin olive oil (EVOO) during pregnancy and lactation. For this purpose, plasma and lactic serum from dams and plasma from offspring were analyzed by LC-ESI-LTQ-Orbitrap-MS. Both enzymic and microbial metabolites of hydroxytyrosol and tyrosol were detected in dam plasma and lactic serum. In addition, significant levels of phenolic compounds and their metabolites were found in offspring plasma. The concentration and number of hydroxytyrosol derivatives was higher than those of tyrosol and the microbial metabolites were found in the highest concentration The observed vertical transmission of EVOO phenolic compounds, whose health benefits are widely reported, provides further support for the importance of the maternal diet during pregnancy and lactation. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effects of post-harvest fungal infection of apples on chemical characteristics of cider was written by Simonato, Barbara;Lorenzini, Marilinda;Zapparoli, Giacomo. And the article was included in LWT–Food Science and Technology in 2021.Product Details of 2380-78-1 The following contents are mentioned in the article:

The impact of fungal post-harvest infection of apple on the chem. composition of cider was investigated through a comparative anal. of ciders obtained from apples (Gala variety) sep. infected by five fungal species (Alternaria alternata, Botrytis cinerea, Diplodia seriata, Monilinia fructigena, and Penicillium expansum) and cider from sound apples. The content of several flavor-active mols. belonging to different chem. groups, such as alcs., esters, acids, aldehydes, phenols, and lactones, significantly varied among ciders. Particularly, cider from sound apples had a higher concentration of Et ester acetate, fatty acid Et esters and fatty acids, mols. that contribute to fruity and sweet scent. Principal component anal. well discriminated ciders, evidencing species-specific fungal effect. Differences in precursor availability in juices and biosynthesis pathways in fungi could explain changes in aroma profile of ciders. This study provides information on the potential risk to produce cider from infected apples due to the possible quality depreciation. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Product Details of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of New Tyrosol-Based Phosphodiester Derivatives: Effect on Amyloid β Aggregation and Metal Chelation Ability was written by Romanucci, Valeria;Giordano, Maddalena;De Tommaso, Gaetano;Iuliano, Mauro;Bernini, Roberta;Clemente, Mariangela;Garcia-Vinuales, Sara;Milardi, Danilo;Zarrelli, Armando;Di Fabio, Giovanni. And the article was included in ChemMedChem in 2021.COA of Formula: C9H12O3 The following contents are mentioned in the article:

Alzheimer’s disease (AD) is a multifactorial pathol. that requires multifaceted agents able to address its peculiar nature. Increasing evidence has shown that aggregation of amyloid β (Aβ) and oxidative stress are strictly interconnected, and their modulation might have a pos. and synergic effect in contrasting AD-related impairments. Herein, a new and efficient fragment-based approach towards tyrosol phosphodiester derivatives (TPDs) has been developed starting from suitable tyrosol building blocks and exploiting the well-established phosphoramidite chem. The antioxidant activity of new TPDs has been tested as well as their ability to inhibit Aβ protein aggregation. In addition, their metal chelating ability has been evaluated as a possible strategy to develop new natural-based entities for the prevention or therapy of AD. Interestingly, TPDs containing a catechol moiety have demonstrated highly promising activity in inhibiting the aggregation of Aβ₄₀ and a strong ability to chelate biometals such as Cu^II and Zn^II. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1COA of Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reproductive parasitism by worker honey bees suppressed by queens through regulation of worker mandibular secretions was written by Mumoki, Fiona N.;Pirk, Christian W. W.;Yusuf, Abdullahi A.;Crewe, Robin M.. And the article was included in Scientific Reports in 2018.Synthetic Route of C9H12O3 The following contents are mentioned in the article:

Social cohesion in social insect colonies can be achieved through the use of chem. signals whose production is caste-specific and regulated by social contexts. In honey bees, queen mandibular gland pheromones (QMP) maintain reproductive dominance by inhibiting ovary activation and production of queen-like mandibular gland signals in workers. We investigated whether honey bee queens can control reproductively active workers of the intraspecific social parasite Apis mellifera capensis, parasitising A. m. scutellata host colonies. Our results show that the queen’s QMP suppresses ovarian activation and inhibits the production of QMP pheromone signals by the parasitic workers, achieved through differential expression of enzymes involved in the biosynthesis of these pheromones at two points in the biosynthetic pathway. This is the first report showing that honey bee queens can regulate reproduction in intraspecific social parasites and deepens our understanding of the mol. mechanisms involved in the regulation of worker reproduction in social insects. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Synthetic Route of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Combinatorial libraries of diamidopyridine-derived ‘tweezer’ receptors and sequence selective binding of peptides was written by Arienzo, Rosa;Kilburn, Jeremy D.. And the article was included in Tetrahedron in 2002.Related Products of 112-59-4 The following contents are mentioned in the article:

A library of diamidopyridine derived tweezer receptors with peptidic side-arms has been prepared Screening experiments with the library and a dye-labeled tripeptide L-Glu-L-Ser-L-Val-OH showed excellent selectivity (strong binding of the dye-labeled guest to ∼0.2% of resin-bound library members was observed) and led to the identification of a tweezer receptor structure, which was shown to bind the tripeptide with good selectivity over related tripeptide sequences. Analogous screening experiments with the side-chain protected tripeptide L-Glu(O^tBu)-L-Ser(^tBu)-L-Val-OH, showed little selectivity for any particular library member. The results are discussed in relation to previous screening experiments, using the same tripeptide guests, with related tweezer receptor libraries, which differ by one methylene in the separation of the diamidopyridine unit from the peptidic side-arms of the tweezer receptors. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Related Products of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sensory descriptive and comprehensive GC-MS as suitable tools to characterize the effects of alternative procedures on wine aroma. Part II: BRS Rub́ea and BRS Cora was written by Bonatto Machado de Castilhos, Mauricio;Luiz Del Bianchi, Vanildo;Gomez-Alonso, Sergio;Garcia-Romero, Esteban;Hermosin-Gutierrez, Isidro. And the article was included in Food Chemistry in 2020.Product Details of 2380-78-1 The following contents are mentioned in the article:

The present manuscript assessed the volatile and sensory profiles of BRS Rub́ea and BRS Cora wines elaborated from traditional, grape pre-drying and submerged cap winemaking. The wines contained a higher concentration of acetates (257 mg L^-1 to 547 mg L^-1) and Et and Me esters (183 mg L^-1 to 456 mg L^-1) in comparison with Vitis vinifera wines. PCA was applied (explaining 68.43% of the total variance), and the higher concentration of Et decanoate and Et octanoate, di-Et succinate, hydroxylinalool, and 2-Ph ethanol was responsible for describing the BRS Rub́ea wines as fruity/foxy. They also presented an intense jam note, probably due to their higher concentration of syringol and guaiacol. BRS Cora wines exhibited a vegetal note, possibly due to their higher concentration of 1-hexanol and cis-3-hexenol. Wines from pre-dried grapes presented higher concentration of furfural, assuming a bitter/burned almond aroma. Alternative winemaking accounted for suitable changes in wine aroma, enhancing wine quality. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Product Details of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Directional and integrated conversion of whole components in biomass for levulinates and phenolics with biphasic system was written by Feng, Junfeng;Tong, Le;Ma, Changyue;Xu, Yangyang;Jiang, Jianchun;Yang, Zhongzhi;Pan, Hui. And the article was included in Bioresource Technology in 2020.COA of Formula: C9H12O3 The following contents are mentioned in the article:

Integrated conversion and stepwise extraction of whole components in biomass with biphasic system are introduced for producing chems.: levulinates and phenolics. When methanol/dimethoxymethane as biphasic solvent, 46.51% Me levulinate and 18.78% phenolics were obtained with a conversion of 80.59 wt% per 4 g rice straw under the mild reaction conditions. Levulinates were collected with a 87.5 wt% high purity of Me levulinate with stepwise precipitation and extraction from the cellulose and hemicellulose. The results of acid value, f.p., induction period, kinematic viscosity, and flash point supposed that the extracted Me levulinate could meet the requirements of fuel additives. Depolymerized lignin was consisted of many low-mol. phenolics. These results illustrated that the biphasic system can promote the conversion of cellulose and hemicellulose to the same product Me levulinate through different intermediate transition compounds, and the catalyst can contribute to directly cleave the glycosidic bonds, β-O-4, and 4-O-5 with adequate protons. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1COA of Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Influence of beta glucosidases from native yeast on the aroma of Muscat and Tannat wines was written by de Ovalle, Stefani;Brena, Beatriz;Gonzalez-Pombo, Paula. And the article was included in Food Chemistry in 2021.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

It is now well established that β-glucosidases (BGLs) from non-Saccharomyces yeasts are key enzymes that hydrolyze grape-derived aroma precursors enhancing the flavor of wines. This work reports on the specificity for wine glycosides and the impact on wine aroma, of three native yeast β-glucosidases. Volatile compounds were analyzed by gas-chromatog. and mass spectroscopy (GC-MS) and wine aroma was studied by sensory anal. Issatchenkia terricola β-glucosidase stood out from the other β-glucosidases studied. The I. terricola BGL showed remarkable specificity for norisoprenoid aglycons such as: 3-oxo-7, 8-dihydro-alpha-ionol, 3-oxo-α-ionol, vomifoliol. This different specificity was perceived in the sensory tests. The judges described pleasant fruity, sweet, honey and raisin notes in both Tannat and Muscat wines treated with I. terricola BGL. These results are particularly remarkable for Tannat wines, since there are few reports concerning the application of β-glucosidases to enhance its aroma of Tannat, and none with BGLs from native yeasts. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem