Tag: M.W=100-150

Tennie, Iris K. published the artcilePolymeric ¹⁹F MRI Contrast Agents Prepared by Ring-Opening Metathesis Polymerization/Dihydroxylation, Product Details of C4H7F3O2, the publication is Macromolecules (Washington, DC, United States) (2020), 53(23), 10386-10396, database is CAplus.

The capability of ring-opening metathesis polymerization (ROMP) to efficiently incorporate bulky monomers and conserve olefin bonds during polymerization was exploited to design water-soluble fluoropolymers, which were evaluated as potential quant. ¹⁹F magnetic resonance imaging (MRI) contrast agents. The fluoromonomeric units comprised 3, 6, 9, or 18 magnetically equivalent fluorine atoms. Aqueous solubility was achieved through dihydroxylation of the partially unsaturated polymeric backbone and by tetraethylene glycol (TEG)-based linker incorporation, ammonium quaternization, or copolymerization

Macromolecules (Washington, DC, United States) published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C20H12N2O2, Product Details of C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Meringdal, Jonas W. published the artcileModular Synthesis of Halogenated Xanthones by a Divergent Coupling Strategy, Application In Synthesis of 91-16-7, the publication is Journal of Organic Chemistry (2022), 87(14), 9375-9383, database is CAplus and MEDLINE.

A versatile strategy to halogenated xanthones I (R¹ = H, R² = Br; R¹ = Br, R² = H; R³ = H, Cl) that relied on a modular coupling of vanillin derivatives with a dibromoquinone has been developed. Depending on the reaction conditions, either the 6- or the 7-bromo heterocycles can be obtained in a divergent manner. These heterocycles were readily further elaborated by sequential Sonogashira couplings, and the sequence might be successfully applied to substructures of the antibiotic lysolipin.

Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bano, Kulsum published the artcileFacile Synthesis of Benzimidazole and Benzothiazole Compounds Mediated by a Zinc Precatalyst Supported by an Iminopyrrole-Morpholine Ligand, Application In Synthesis of 6850-57-3, the publication is European Journal of Inorganic Chemistry (2022), 2022(10), e202200023, database is CAplus.

Three zinc complexes, with the general formula {κ2-C₄H₃NH[2-CH=NCH₂CH₂N(CH₂CH₂)₂O]ZnX₂} [X = Cl, Br, I], supported by a neutral iminopyrrole-morpholine ligand, were synthesized by the reaction between {C₄H₃NH-2-[CH=NCH₂CH₂N (CH₂CH₂)₂O]} and anhydrous zinc dihalides (ZnCl₂, ZnBr₂, ZnI₂) at ambient temperature in dry methanol. The zinc complexes were fully characterized using multinuclear NMR spectroscopic techniques and the mol. structures of complexes in their solid states were determined by single-crystal X-ray diffraction anal. The zinc diiodo complex proved to be a competent precatalyst in the formation of a wide range of benzimidazole and benzothiazole compounds, via aerobic oxidative condensation of several benzylamines with o-phenylenediamine, N-phenyl-o-phenylene-diamine, and o-mercaptoaniline. The benzimidazole and benzothiazole derivatives were successfully characterized using ¹H and ¹³C{1H} NMR spectroscopy.

European Journal of Inorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Budeev, Anton published the artcileUgi reaction-derived 1H-pyrrol-2(5H)-ones proved as valid precursors to a new class of heterocyclic α-diazocarbonyl compounds, Synthetic Route of 6850-57-3, the publication is Tetrahedron Letters (2022), 153598, database is CAplus.

1H-Pyrrol-2(5H)-ones synthesized via a modified literature procedure from primary amines, 3-substituted propiolic acids, isocyanides and glyoxal underwent a facile Regitz diazo transfer to give novel heterocyclic α-diazocarbonyl compounds – polysubstituted diazo pyrrol-2-ones I [R¹ = Me, n-Pr, Ph, etc.; R² = n-Bu, Bn, 3-FC₆H₄CH₂, etc.; R³ = t-Bu, cyclohexyl] .

Tetrahedron Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kadu, Vikas D. published the artcileRapid One-Pot Aerobic Oxidative N-α-C(sp³)-H Functionalization of Arylmethylamines to Access Tetrasubstituted Imidazoles, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Asian Journal of Organic Chemistry (2022), 11(8), e202200162, database is CAplus.

A simple copper catalyzed “one-pot” process has been developed for synthesis of polysubstituted imidazoles via direct oxidative N-α-C(sp³)-H functionalization of arylmethylamines. The readily available arylmethylamines as substrates have afforded tetrasubstituted imidazoles products up to 94% yields under mild and environmentally benign conditions. The explored substrates scope with 1,2-diketones and α-hydroxyketones have shown great utility for synthesis of tetrasubstituted imidazoles.

Asian Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhou, Jun published the artcileEtherification of Fluoroarenes with Alkoxyboronic Acid Pinacol Esters via C-F Bond Cleavage, Synthetic Route of 91-16-7, the publication is Organic Letters (2022), 24(28), 5084-5089, database is CAplus and MEDLINE.

Potassium-base-mediated defluoroetherification of aryl and heteroaryl fluorides with alkoxyboronic acid pinacol esters under transition-metal-free conditions is reported. This protocol efficiently and safely provides a wide variety of aryl ethers in high yields without using metal catalysts, specific ligands, and harsh conditions to selectively forge C_sp2-O bonds via the C_sp2-F cleavage. This method can be applied to the late-stage etherification of structurally complex C_sp2-fluorides and bioactive alcs., such as β-estradiol, calciferol, and tocopherol.

Organic Letters published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C11H22N2O4, Synthetic Route of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yao, Chuansheng published the artcileHDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Bioorganic Chemistry (2022), 105724, database is CAplus and MEDLINE.

A series of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids inhibitors combining the typical pharmacophores of hydroxamic acid/o-aminobenzamide and propargylamine I [R = H, 2-Cl, 3-F, etc.] and II [R¹ = H, 2-CH₃, 4-F, etc.] were designed and synthesized as HDAC1/MAO-B dual inhibitors for the treatment of Alzheimer’s disease. Most of the hybrids displayed moderate to good MAO-B inhibitory activities. Among them, Hybrid I [R = 3-Cl] exhibited the most potent activity against MAO-B and HDAC1 (MAO-B, IC₅₀ = 99.0 nM; HDAC1, IC₅₀ = 21.4 nM) and excellent MAO selectively (MAO-A, IC₅₀ = 9923.0 nM; SI = 100.2). Moreover, compound I [R = 3-Cl] significantly reversed Aβ1-42-induced PC12 cell damage and decreased the production of intracellular ROS, exhibiting favorable antioxidant activity. More importantly, hybrid If instantly penetrated the BBB and accumulated in brain tissue as well as markedly ameliorated cognitive dysfunction in a Morris water maze ICR mice model. In summary, HDAC1/MAO-B dual inhibitor I [R = 3-Cl] was a promising potential agent for the therapy of Alzheimer’s disease.

Bioorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C9H5FO2, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lu, Xiaojie published the artcileEurotium cristatum produced β-hydroxy acid metabolite of monacolin K and improved bioactive compound contents as well as functional properties in fermented wheat bran, Computed Properties of 91-16-7, the publication is LWT–Food Science and Technology (2022), 113088, database is CAplus.

For the first time, wheat bran was fermented with Eurotium cristatum (E. cristatum), and alterations in the structural and functional characteristics were explored. The results showed that the soluble dietary fiber (SDF) content significantly increased in fermented bran, and the water and oil holding capacities improved. The total polyphenols, anthocyanin, and main flavor substance phenylethyl alc. were significantly increased by E. cristatum fermentation The ferulic acid content was approx. 12.06 times higher in fermented bran than in unfermented bran. These changes may be due to the release of hydrolytic enzymes during E. cristatum fermentation E. cristatum fermentation enhanced the antioxidant and anti-obesity activities of bran. Furthermore, this study showing that E. cristatum fermentation produced β-hydroxy acid metabolites of monacolin K (MKA) in wheat bran. Thus, this research suggests that E. cristatum can be a starter culture to produce functional foods.

LWT–Food Science and Technology published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Aykanat, Aylin published the artcileConductive Stimuli-Responsive Coordination Network Linked with Bismuth for Chemiresistive Gas Sensing, Formula: C8H10O2, the publication is ACS Applied Materials & Interfaces (2021), 13(50), 60306-60318, database is CAplus and MEDLINE.

This paper describes the design, synthesis, characterization, and performance of a novel semiconductive crystalline coordination network, synthesized using 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) ligands interconnected with bismuth ions, toward chemiresistive gas sensing. Bi(HHTP) exhibits two distinct structures upon hydration and dehydration of the pores within the network, Bi(HHTP)-α and Bi(HHTP)-β, resp., both with unprecedented network topol. (2,3-c and 3,4,4,5-c nodal net stoichiometry, resp.) and unique corrugated coordination geometries of HHTP mols. held together by bismuth ions, as revealed by a crystal structure resolved via microelectron diffraction (MicroED) (1.00 Å resolution). Good elec. conductivity (5.3 x 10^-3 S·cm^-1) promotes the utility of this material in the chem. sensing of gases (NH₃ and NO) and volatile organic compounds (VOCs: acetone, ethanol, methanol, and isopropanol). The chemiresistive sensing of NO and NH₃ using Bi(HHTP) exhibits limits of detection 0.15 and 0.29 ppm (ppm), resp., at low driving voltages (0.1-1.0 V) and operation at room temperature This material is also capable of exhibiting unique and distinct responses to VOCs at ppm concentrations Spectroscopic assessment via XPS and Fourier transform IR spectroscopic methods (i.e., attenuated total reflectance-IR spectroscopy (ATR-IR) and diffuse reflectance IR Fourier transformed spectroscopy (DRIFTS)), suggests that the sensing mechanisms of Bi(HHTP) to VOCs, NO, and NH₃ comprise a complex combination of steric, electronic, and protic properties of the targeted analytes.

ACS Applied Materials & Interfaces published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tu, Guangliang published the artcileLigand-Promoted Nickel-Catalyzed para-Selective Carboxylation of Anisoles, Application In Synthesis of 91-16-7, the publication is Organic Letters (2022), 24(11), 2155-2159, database is CAplus and MEDLINE.

It has always been a challenge in free radical chem. to control site selectivity during the reaction of free radicals with aromatic rings. Herein, the site-selective carboxylation of anisoles through the direct reaction of the bromoform radical with a benzene ring at the para position under the assistance of 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline with nickel(II) as the catalyst is reported. A wide variety of anisoles were compatible, leading to para-carboxylated products in moderate to good yields. A preliminary mechanistic study suggested that the Ni(II) complex coordinates with the methoxyl group of the aromatic ring, which may have increased the steric hindrance at the ortho and meta positions, while this weak interaction reduces the aromaticity of the aromatic ring, affording an activated Ph ring, thereby leading to highly para-selective carboxylation.

Organic Letters published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C7H8BrClFN, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem