Tag: M.W=100-150

Kim, Jae Hyun published the artcileStructure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction, Product Details of C8H11NO, the publication is Bioorganic Chemistry (2021), 104907, database is CAplus and MEDLINE.

The enzyme leucyl-tRNA synthetase (LRS) and the amino acid leucine regulate the mechanistic target of rapamycin (mTOR) signaling pathway. Leucine-dependent mTORC1 activation depends on GTPase activating protein events mediated by LRS. In a prior study, compound BC-LI-0186 was discovered and shown to interfere with the mTORC1 signaling pathway by inhibiting the LRS-RagD interaction. However, BC-LI-0186 exhibited poor solubility and was metabolized by human liver microsomes. In this study, in silico physicochem. properties and metabolite anal. of BC-LI-0186 are used to investigate the addition of functional groups to improve solubility and microsomal stability. In vitro experiments demonstrated that 7b and 8a had improved chem. properties while still maintaining inhibitory activity against mTORC1. The results suggest a new strategy for the discovery of novel drug candidates and the treatment of diverse mTORC1-related diseases.

Bioorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Diao, Xinyong published the artcileFabricating high temperature stable Mo-Co₉S₈/Al₂O₃ catalyst for selective hydrodeoxygenation of lignin to arenes, Quality Control of 91-16-7, the publication is Applied Catalysis, B: Environmental (2022), 121067, database is CAplus.

Achieving high-temperature stability/duration without compromising the activity remains an arduous task in catalyst design, particularly for MoS₂ materials. Herein, a robust catalyst with Mo doped Co₉S₈ nanoparticles anchored on Al₂O₃ matrix is fabricated, which could selectively convert lignin to arenes with high hydrodeoxygenation activity, selectivity and particularly excellent stability. In the hydrodeoxygenation of di-Ph ether, this catalyst afforded 99.8% conversion and 91.0% yield of benzene at 265°C for at least 10 reaction runs. The resultant Mo-Co₉S₈ structure with chem. connection by covalent bonds of Mo-S-Co type on the Co₉S₈ surface demonstrates strong ability in the adsorption and activation of oxygen-containing substrates, which enables the effective C-O cleavage while avoids undesirable hydrogenation of benzene ring. The superior stability and water-resistance at elevated temperature was attributed to the anchoring effect of Al₂O₃ matrix and “protection” of surface-rich Co₉S₈ species to the active Mo-Co₉S₈ center. This strategy provides new sights for the rational design of efficient and stable sulfide catalysts toward the applications in demanding high-temperature reactions.

Applied Catalysis, B: Environmental published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Quality Control of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Jia, Zhichao published the artcileHighly Selective Hydrodeoxygenation of Lignin to Naphthenes over Three-Dimensional Flower-like Ni₂P Derived from Hydrotalcite, Category: ethers-buliding-blocks, the publication is ACS Catalysis (2022), 12(2), 1338-1356, database is CAplus.

A strategy for low-temperature synthesis of hydrotalcite-based nickel phosphide catalysts (Ni₂P-Al₂O₃) with flower-like porous structures was proposed. The in situ reduction of red phosphorus at 500°C enables Ni₂P catalysts with small particle size and abundant active and acidic sites, which facilitate the activation of substrates and H₂. In the hydrodeoxygenation of guaiacol, a 100% conversion and 94.5% yield of cyclohexane were obtained over the Ni₂P-Al₂O₃ catalyst under 5 MPa H₂ at 250°C for 3 h. Other lignin-derived phenolic compounds could also afford the corresponding alkanes with yields higher than 85%. Moreover, Ni₂P-Al₂O₃ exhibited high hydrodeoxygenation activity in the deconstruction of more complex wood structures, including lignin oil and real lignin. Among the two different types of Ni sites of Ni(1) and Ni(2) in Ni₂P, d. functional theory (DFT) calculations showed that the Ni(2) site, highly exposed on the Ni₂P-Al₂O₃ surface, possesses a stronger ability to break C-OH bonds during the hydrodeoxygenation of guaiacol in comparison with the Ni(1) site.

ACS Catalysis published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kushawaha, Ajay Kishor published the artcileA simple and efficient oxidation of primary and secondary benzylamines to acids using table salt in aqueous medium, Related Products of ethers-buliding-blocks, the publication is Tetrahedron (2021), 132502, database is CAplus.

A novel, simple, efficient method for the oxidation of aromatic benzylamines RCH₂NH₂ (R = C₆H₅, 4-FC₆H₄, 2-thienyl, etc.), R¹CH₂NHCH₂R¹ (R¹ = C₆H₅, 4-ClC₆H₄, 2-thienyl, etc.) and 4-OCH₃C₆H₄CH₂NHR₂ (R₂ = Me, Et, Pr, n-octyl, t-butyl) to corresponding acids RC(O)OH, R¹C(O)OH and 4-methoxybenzoic acid using common table salt in aqueous medium has been described. Oxidation of benzylamine was achieved by using NaCl (20 mol%) as a catalyst, NaOH (4 equiv) and TBHP (5 equiv) as oxidant, in moderate to good yields (34-84%). Control experiments revealed that in situ generated ClO₂^– ion is the active form of the catalyst. This methodol. can also be scaled up for easy accessibility to the industrially important terephthalic acid as well. This investigation provided a facile entry of various primary as well as secondary benzylamines with wide range of functional group tolerance.

Tetrahedron published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wojcik-Pszczola, Katarzyna published the artcileSynthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents, Safety of (2-Methoxyphenyl)methanamine, the publication is Bioorganic Chemistry (2021), 105409, database is CAplus and MEDLINE.

Phosphodiesterase inhibitors are currently an extensively studied group of compounds that can bring many benefits in the treatment of various inflammatory and fibrotic diseases, including asthma. Herein, we describe a series of novel N�phenyl- or N�benzylbutanamide and N�arylidenebutanehydrazide derivatives of 8-aminopurine-2,6-dione (27-43) and characterized them as prominent pan-PDE inhibitors. Most of the compounds exhibited antioxidant and anti-inflammatory activity in LPS-induced murine macrophages RAW264.7. The most active compounds (32-35 and 38) were evaluated in human bronchial epithelial cells derived from asthmatics. To better map the bronchial microenvironment in asthma, HBECs after exposure to selected 8-aminopurine-2,6-dione derivatives were incubated in the presence of two proinflammatory and/or profibrotic factors: TGF-beta and IL-13. Detailed anal. of their inhibition preferences for selected PDEs showed high affinity for isoenzymes important in the pathogenesis of asthma, including PDE1, PDE3, PDE4, PDE7, and PDE8. The presented data confirm that structural modifications within the 7 and 8 positions of the purine-2,6-dione core result in obtaining preferable pan-PDE inhibitors which in turn exert an excellent anti-inflammatory and anti-fibrotic effect in the bronchial epithelial cells derived from asthmatic patients. This dual-acting pan-PDE inhibitors constitute interesting and promising lead structures for further anti-asthmatic agent discovery.

Bioorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C4H10O2, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Keim, Michael published the artcile1,3-Bis(trifluoromethyl)prop-2-ene 1-Iminium Salts: Reactions with Alkoxybenzenes and Anilines, Formula: C8H10O2, the publication is Synthesis (2022), 54(6), 1587-1600, database is CAplus.

1,3-Bis(trifluoromethyl)prop-2-ene 1-iminium triflate salts were prepared for the first time and some synthetic applications as 1,3-biselectrophilic building blocks were established. They were found to react with dimethoxybenzenes or methylene-1,2-dioxybenzenes to furnish vinylogous trifluoroacetylation products (4-aryl-1,1,1,5,5,5-hexafluoropent-3-en-2-ones) and 1-dialkylamino-1,3-bis(trifluoromethyl)-1 H-indenes. With aniline and ring-substituted anilines, 2,4-bis(trifluoromethyl)quinolines were formed. An unusual 4 H-pyran, formally a condensation product of the N, N-dimethyl-1,3-bis(trifluoromethyl)prop-2-en-1-iminium ion and its enaminone precursor, is also reported.

Synthesis published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

DeSelm, Lizbeth published the artcileIdentification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers, Computed Properties of 6850-57-3, the publication is Journal of Medicinal Chemistry (2021), 64(19), 14603-14619, database is CAplus and MEDLINE.

The discovery of a novel class of quinazoline carboxamides such as I [R¹ = H, Me; R² = Ph, 3-FC₆H₄, 4-MeOC₆H₄, etc.] as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway was reported. Through the screening of inhouse proprietary kinase library, 4-benzylamino-quinazoline-8-carboxylic acid amide 1 stood out, with sub-micromolar p70S6k biochem. activity, as the starting point for a structurally enabled p70S6K/Akt dual inhibitor program that led to the discovery of M2698, a dual p70S6k/Akt inhibitor. Compound M2698 [II] is kinase selective, possesses favorable phys., chem., and DMPK profiles, was orally available and well tolerated, and displayed tumor control in multiple in vivo studies of PAM pathway-driven tumors.

Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Computed Properties of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kochurin, Matvei A. published the artcileReactions of linear conjugated dienone structures with arenes under superelectrophilic activation conditions. An experimental and theoretical study of intermediate multicentered electrophilic species, Quality Control of 91-16-7, the publication is New Journal of Chemistry (2022), 46(25), 12041-12053, database is CAplus.

Reactions of linear conjugated dienone structures ArCH=CHCHCHC(O)X, 1,5-diarylpenta-2,4-dien-1-ones (X = Ar’), 5-phenylpenta-2,4-dienoic acid (Ar = Ph, X = OH) and its Me ester (Ar = Ph, X = OMe), with arenes under superelectrophilic activation conditions by Bronsted superacids (CF₃SO₃H and FSO₃H) or strong Lewis acid (AlCl₃) result in the formation of various compounds, such as conjugated enones, indanes, and carbocyclic derivatives The formation of the reaction products depends on the structures of starting compounds (dienone and arene) and on the reaction conditions (temperature, time, and medium acidity). In these transformations, starting dienones are precursors of di- and tri-centered electrophilic synthons leading to target products. A NMR study and DFT calculations have shown that the most probable reactive intermediates should be O,C-diprotonated species Ar⁺CHCH₂CHCHC(O⁺H)X derived from the protonation of starting dienones. Plausible mechanisms of electrophilic transformations are discussed.

New Journal of Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Quality Control of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Qin published the artcileCharacterization of key aroma compounds and core functional microorganisms in different aroma types of Liupao tea, Application In Synthesis of 91-16-7, the publication is Food Research International (2022), 110925, database is CAplus and MEDLINE.

Liupao tea is a representative Chinese dark tea. Stale-aroma type, betelnut-aroma type and fungal-aroma type were the main aroma types of Liupao tea. In this study, aroma profiles and fungal communities of the three aroma types of Liupao tea were examined by HS-SPME/GC-MS and Illumina MiSeq anal. A total of 102 volatiles were identified and quantified in Liupao tea. Indicated by OPLS-DA anal., six aroma compounds with stale, woody, roasted notes in stale-aroma type samples, five aroma compounds possessing smoky, minty, pungent notes in betelnut-aroma type samples, and nine aroma compounds owned minty, floral, fruity, woody, green notes in fungal-aroma type samples were responsible for the different aroma characteristics formation of Liupao tea. In addition, a total of 60 fungal genera were identified in Liupao tea. Aspergillus, Wallemia, Xeromyces were the predominant fungal genera in Liupao tea. Ten fungal genera, including Wallemia, Tritirachium, Debaryomyces, Trichomonascus, unclassified_o_Hypocreales in betelnut-aroma type, Rasamsonia, Candida, Blastobotrys, Acremonium in stale-aroma type, and Xeromyces in fungal-aroma type, were identified as the biomarkers in the three aroma types of Liupao tea. Furthermore, fungal genera including Aspergillus, Wallemia, Xeromyces, and Blastobotrys were identified as the core functional microorganisms contributing to the variation of volatile profiles based on O2PLS anal. This study provided useful information on the key aroma compounds and core functional microorganisms that drive the different aroma characteristics formation of Liupao tea.

Food Research International published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xu, Haiyan published the artcileDABCO as a practical catalyst for aromatic halogenation with N-halosuccinimides, Quality Control of 91-16-7, the publication is RSC Advances (2022), 12(12), 7115-7119, database is CAplus and MEDLINE.

A simple and practical synthetic approach for synthesis of aromatic halides was developed. Simple Lewis base, DABCO, was used as the catalyst. This arene halogenation process proceeded conveniently and efficiently at ambient conditions, providing the desired products in good to excellent yields and selectivity.

RSC Advances published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C24H20Ge, Quality Control of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem