Tag: M.W=100-150

Diem Ferreira Xavier, Mauricio Carpe published the artcileDitelluride-Catalyzed synthesis of phosphoramidates: A design of experiment approach, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Tetrahedron (2022), 132879, database is CAplus.

Di-Ph ditelluride Ph₂Te₂ in aerial oxidative conditions catalyzes amidation of hydrophosphonates HP(O)(OR²)₂ (R² = Et, Me, Bu) with primary and secondary amines RR¹NH (R¹ = H, R = alkyl, aralkyl; R = R¹ = Et, RR¹NH = pyrrolidine, morpholine), giving phosphoramidates RR¹NP(O)(OR²)₂ with high yields in mild conditions (50°, 13 mol% of Ph₂Te₂). In this contribution, we describe a selective synthesis of phosphoramidates employing di-Ph ditelluride as a simple and readily available organic catalyst. To optimize the reaction conditions, a full factorial design was carried out, demonstrating that the temperature is the critical factor for the P(O)-N bonding formation. The products were obtained in moderate to excellent yields, in mild conditions. Addnl., ³¹P and ¹²⁵Te NMR spectroscopies were used to characterize the intermediate, confirming the reaction mechanism.

Tetrahedron published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mertens, R. Tyler published the artcileStable Au(I) catalysts for oxidant-free C-H functionalization with iodoarenes, Formula: C8H10O2, the publication is Journal of Catalysis (2022), 109-114, database is CAplus and MEDLINE.

Herein, the development of novel tricoordinate Au(I) catalysts supported by N,N-bidentate ligands and ligated by phosphine or arsine ligands for C-H functionalization without external oxidants to form biaryls with no homocoupling was reported. The unsym. character of the Au(I) catalyst was critical to facilitating this necessary orthogonal transformation. This study unveils yet another potential of Au(I) catalysis in biaryl synthesis.

Journal of Catalysis published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Saha, Argha published the artcilePhotoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites, Name: 1,2-Dimethoxybenzene, the publication is Journal of the American Chemical Society (2022), 144(4), 1929-1940, database is CAplus and MEDLINE.

Herein, a photoredox catalytic system constituting a merger of palladium/organo-photocatalyst that forges oxidative olefination in an explicit regioselective fashion with diverse arenes and heteroarenes has been established. Visible light plays a significant role in executing ‘regio-resolved’ Fujiwara-Moritani reaction without the requirement of silver salts and thermal energy. The catalytic system is also amenable toward proximal and distal olefination aided by resp. directing groups, which entails the versatility of the protocol in engaging the entire spectrum of C(sp²)-H olefination. Furthermore, streamlining the synthesis of natural products/chiral mols./drugs and diversification through late-stage functionalizations underscore the importance of this sustainable protocol. The photoinduced attainment of this regioselective transformation is mechanistically established through control reactions and kinetic studies.

Journal of the American Chemical Society published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ma, Lijuan published the artcileCharacterization of the key active aroma compounds in Pu-erh tea using gas chromatography-time of flight/mass spectrometry-olfactometry combined with five different evaluation methods, Synthetic Route of 91-16-7, the publication is European Food Research and Technology (2022), 248(1), 45-56, database is CAplus.

The aroma characteristics of Pu-erh tea were studied in this work. A total of 117 volatile compounds were identified by HSSPME combined with GC-TOF/MS, of which 29 active aroma compounds were identified by olfactometry. The active aroma compounds of Pu-erh tea were analyzed by intensity aroma (IA), aroma extraction dilution (AEDA), sensory quantification value (MF), detection frequency (DFA) and odor activity value (OAV). 24, 21 and 23 active aroma components were identified by DFA, AEDA and OAV, while 20 by IA and MF. Recombination of the obtained active aroma components indicated that OAV method was best for determining the active aroma compounds as the aroma profle of OAV recombination model was the most similar to that of Pu-erh tea sample. Omission test of the OAV recombination model furtherly identifed 19 characteristic active aroma compounds of Pu-erh tea, and linalool, 1,2,3-trimenthoxybenzebe, 1,2,4-trimethoxybenzene and α-ionone were the key characteristic active aromatic compounds

European Food Research and Technology published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zheng, Qiaoran published the artcileEffects of drying methods on colour, amino acids, phenolic profile, microstructure and volatile aroma components of Boletus aereus slices, Recommanded Product: 1,2-Dimethoxybenzene, the publication is International Journal of Food Science and Technology (2022), 57(8), 5164-5174, database is CAplus.

This study is to investigate the effects of hot air drying (HD) at 60-80°C (HD-60, HD-70 and HD-80), microwave pretreatment combined with HD (MHD), ultrasound pretreatment combined with HD (UHD) and vacuum freeze drying (FD) on the quality of Boletus aereus slices. Key characteristics, including color, free amino acids, microstructure, volatile aroma components, phenolic profile and antioxidant activity, were studied. Amongst these drying methods, FD was the best way to preserve color and volatiles of Boletus aereus slices. Fifteen amino acids were detected in Boletus aereus slices, and HD-60 showed a higher content of total amino acids than other drying regimes. Two phenolic acids were identified in Boletus aereus slices, namely, protocatechuic acid and p-hydroxybenzoic acid. MHD presented the highest content of phenolic compounds, followed by FD. Antioxidant capacity was pos. correlated with phenolic compounds of Boletus aereus slices. Moreover, the cell structure of Boletus aereus slices was damaged after drying, and FD had a more porous structure than other drying methods. These results will be beneficial to the further industrial production of Boletus aereus slices.

International Journal of Food Science and Technology published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C7H14N2, Recommanded Product: 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Luqing published the artcileSynthesis and Surface Activities of Novel Succinic Acid Double-Tailed Sulfonate Fluorinated Surfactants, Formula: C4H7F3O2, the publication is Journal of Surfactants and Detergents (2016), 19(3), 559-565, database is CAplus.

In this study, four environmentally friendly succinic acid double-tailed sulfonate fluorinated surfactants were synthesized from maleic anhydride, fluoroalkyl alcs., namely 1-(1H,1H,7H-Dodecafluoroheptyloxy) ethanol, 1-(1H,1H,5H-octafluoropentyloxy) ethanol, 1-(1H,1H,3H-tetrafluoropropoxy) ethanol, 1-(1H,1H-trifluoroethyloxy) ethanol, and sodium hydrogensulfite. The surfactant structure was characterized by FT-IR, ¹H NMR, and ¹⁹F NMR . Thermogravimetric results showed that the fluorinated surfactants were stable up to relatively high temperature The Krafft points of the four novel succinic acid double-tailed sulfonate fluorinated surfactants were all below 0°C. The lowest CMC value for the synthesized four double-tailed fluorine surfactants is about 0.076 mmol L^-1, far less than that of ammonium perfluorooctanoate (PFOA), demonstrating that double-tailed surfactants have higher surface activity than surfactants with one fluoroalkyl chain. The replacement of alkyl groups with oxyethylene groups enhances the hydrophilicity of the obtained fluorinated surfactants. Based on these findings, the synthesized surfactants may be environmentally friendly alternatives to PFOA and exhibit promising potential in industry applications.

Journal of Surfactants and Detergents published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C38H74Cl2N2O4, Formula: C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Montone, Carmela Maria published the artcileUntargeted analysis of contaminants in river water samples: Comparison between two different sorbents for solid-phase extraction followed by liquid chromatography-high-resolution mass spectrometry determination, SDS of cas: 91-16-7, the publication is Microchemical Journal (2022), 172(Part_A), 106979, database is CAplus.

In this work, an untargeted approach based on ultra-high performance liquid chromatog. coupled to high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) was employed for the anal. of contaminants in surface water samples, possibly deriving from an ineffective removal by wastewater treatment plants or illicit release. First, solid-phase extraction (SPE) conditions for 30 target compounds were optimized for two different sorbents, namely the com. Oasis HLB and graphitized carbon black (GCB), by Box-Behnken designs of experiments Upon identification of optimal conditions, the two SPE materials yielded comparable extraction recoveries, ranging between 52 and 110% and 55-100% for Oasis HLB and GCB, resp. Thereafter, river water samples collected in five locations near Rome (Italy) were extracted using both sorbents and then analyzed by UHPLC-HRMS/MS in both pos. and neg. electrospray (ESI) ion polarities. The retrieved raw data files were submitted to Compound Discoverer software and compound identification was tentatively assigned by matching their tandem mass spectra with the mzCloud mass spectral library and manual validation, resulting in a total of 241 identified compounds (211 and 40 in pos. and neg. ESI mode, resp.), mainly belonging to pharmaceuticals.

Microchemical Journal published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Haas, Brittany C. published the artcilePredicting relative efficiency of amide bond formation using multivariate linear regression, Safety of (2-Methoxyphenyl)methanamine, the publication is Proceedings of the National Academy of Sciences of the United States of America (2022), 119(16), e2118451119, database is CAplus and MEDLINE.

Herein, the development of statistical models correlating measured rates to phys. organic descriptors to enable the prediction of reaction rates for untested carboxylic acid/amine pairs was reported. The key to the success of this endeavor was the development of an end-to-end data science-based work flow to select a set of coupling partners that were appropriately distributed in chem. space to facilitate statistical model development. By using a parameterization, dimensionality reduction, and clustering protocol, a training set was identified. Reaction rates for a range of carboxylic acid and primary alkyl amine couplings utilizing carbonyldiimidazole (CDI) as the coupling reagent were measured. The collected rates span five orders of magnitude, confirming that the designed training set encompasses a wide range of chem. space necessary for effective model development. Regressing these rates with high-level d. functional theory (DFT) descriptors allowed for identification of a statistical model wherein the mol. features of the carboxylic acid are primarily responsible for the observed rates. Finally, out-of-sample amide couplings are used to determine the limitations and effectiveness of the model.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Taniya, Olga S. published the artcileAbnormal push-pull benzo[4,5]imidazo[1,2-a][1,2,3]triazolo[4,5-e]pyrimidine fluorophores in planarized intramolecular charge transfer (PLICT) state: Synthesis, photophysical studies and theoretical calculations, Quality Control of 91-16-7, the publication is Dyes and Pigments (2022), 110405, database is CAplus.

Herein, a series of novel 4-heteroaryl-substituted 2-aryl-2H-benzo[4,5]imidazo[1,2-a][1,2,3]triazolo[4,5-e]pyrimidine fluorophores possessing a planarized intramol. charge transfer (PLICT) state was designed. All these fluorophores exhibited high luminescence quantum yields (up to 60%) and large Stokes shift values of up to 7459 cm^-1. Among them, the fluorophore I was found to exhibit the most pronounced pos. solvatochromic effect and the probe II exhibited the most pronounced aggregation induced emission characteristics. This aggregation induced emission behavior was further confirmed by means of time-resolved fluorescence lifetime measurements as well as DFT-assisted geometry optimization studies. In the presence of trifluoroacetic acid (TFA) compound I exhibited a well-pronounced acidochromism via visible color change from yellow-green to orange which returned to the original yellow-green solution after the addition of triethylamine (TEA). The Stern-Volmer constant for the probe I towards TFA was 38 M^-1. Finally, for the compounds II, III, I theor. calculations in the ground and excited states in different solvents were carried out to confirm the PLICT process. Based on all above the herein reported PLICT fluorophores can be successfully applied as biol. probes and optical switches.

Dyes and Pigments published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C12H25Br, Quality Control of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ryan, Rachael Y. M. published the artcileThe medicinal plant Tabebuia impetiginosa potently reduces pro-inflammatory cytokine responses in primary human lymphocytes, HPLC of Formula: 91-16-7, the publication is Scientific Reports (2021), 11(1), 5519, database is CAplus and MEDLINE.

Bark from the Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) tree has long been used in traditional South American healing practises to treat inflammation. However, its anti-inflammatory activity has not been closely examined Here we use chem. extraction, qual. phytochem. examination, toxicity testing and quant. examination of anti-inflammatory activity on human cells ex vivo. All extracts were found to be nontoxic. We found different extracts exhibited unique cytokine profiles with some extracts outperforming a pos. control used in the clinic. These results verify the immunomodulatory activity of Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) tree bark-derived compounds Collectively, combining a lack of toxicity and potency in human immune cells supports further fractionation and research.

Scientific Reports published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem