Tag: M.W=100-150

Heilmann, S. M. published the artcileO-Hydroxyethylation of 1,1-dihydroperfluorinated alcohols, Name: 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Journal of Fluorine Chemistry (1992), 59(3), 387-96, database is CAplus.

A convenient transformation of 1,1-dihydroperfluorinated alcs. into O-hydroxyethyl derivatives (R_FCH₂OCH₂CH₂OH) is described in which ethylene carbonate is utilized as the alkylating agent. Tetraalkylammonium iodides and trialkylamines are effective catalysts.

Journal of Fluorine Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, Name: 2-(2,2,2-Trifluoroethoxy)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhu, Guanxin published the artcileSelective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite, Name: (2-Methoxyphenyl)methanamine, the publication is Chinese Chemical Letters (2022), 33(1), 266-270, database is CAplus.

Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites were designed, synthesized and carefully characterized by means of XPS, EDS, TEM and XRD. The resulting zinc composite showed good catalytic activity for the N-alkylation of amines 2-R-3-R¹-4-R²-5-R³-C₆HNH₂ (R = H, Cl, Me; R¹ = H, Cl; R² = H, Cl, OMe; R³ = H, Me) with amines R⁴CH₂NH₂ (R⁴ = Ph, 2-methylphenyl, thiophen-2-yl, etc.), ketones R⁵C(O)CH₃ (R⁵ = Ph, 3-bromophenyl, naphthalen-2-yl, etc.;) with alcs. R⁶CH₂OH (R⁶ = Ph, 3,4-difluorophenyl, thiophen-2-yl, etc.) in water under base-free conditions, while unsaturated carbonyl compounds R⁵C(O)CH=CHR⁶ and R⁵C(O)(CH₂)₂R⁶ could also be synthesized by tuning the reaction conditions. Importantly, it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives I (R⁷ = H, Cl, Me) by using this zinc composite under green conditions. Meanwhile, this zinc catalyst could be easily recovered and reused for at least five times.

Chinese Chemical Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C11H17BN2O2, Name: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Topolovcan, Nikola published the artcileChemoselective and Regioselective Synthesis of Spiroisoindolinone Indenes via an Intercepted Meyer-Schuster Rearrangement/Intramolecular Friedel-Crafts Alkylation Relay, SDS of cas: 91-16-7, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

A Bronsted acid-catalyzed reaction between isoindolinone-derived propargylic alcs. I [R = H, 2-Me, 3-Cl, 4-Me, etc.; R ₁ = Me, iso-Pr, benzyl, etc.] and external aromatic nucleophiles [such as 1,3,5-trimethoxybenzene, 1-naphthol, 1H-indole, etc.] for the construction of spiroisoindolinone indenes II [R ₂ = H, 7-Me, 6-Cl, 5-Me, etc.], e.g., III is described. The reaction proceeds rapidly with a broad range of substrates to generate spiroindenes II, e.g., III chemoselectively and regioselectively in moderate to high yields. Key to the success of this transformation is an intercepted Meyer-Schuster rearrangement/intramol. Friedel-Crafts alkylation relay that offers a modular approach in the synthesis of target compds II, e.g., III.

Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H17Br, SDS of cas: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kato, Kahoko published the artcilePrimary amine synthesis by hydrogen-involving reactions over heterogeneous cobalt catalysts, Computed Properties of 6850-57-3, the publication is Catalysis Science & Technology, database is CAplus.

A composite of metallic cobalt and silica particles that exhibits high catalytic performance for the selective synthesis of primary amines RNH₂ [R = heptyl, cyclohexyl, Bn, [5-(hydroxymethyl)oxolan-2-yl]methyl, etc.] via hydrogenation of nitriles RCN and reductive amination, even under mild conditions was reported. A mechanistic study revealed that the substrate nitrile and the product amine retarded the hydrogenation of secondary imine intermediates, which resulted in a selective reaction. On the basis of this knowledge, the selectivity for the primary amine was further improved by the addition of coordinating organic mols., which provided new insights into the control of selectivity toward primary amines unlike that with classical methods using ammonia.

Catalysis Science & Technology published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Computed Properties of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fu, Gui-Ming published the artcileAnalysis of microbial community, physiochemical indices, and volatile compounds of Chinese te-flavor baijiu daqu produced in different seasons, Safety of 1,2-Dimethoxybenzene, the publication is Journal of the Science of Food and Agriculture (2021), 101(15), 6525-6532, database is CAplus and MEDLINE.

Chinese te-flavor baijiu (CTF), the most famous Chinese baijiu in Jiangxi province, China, is made from a unique daqu. Its characteristic style is closely related to the daqu used for fermentation However, current studies on the effects of different production seasons on microbial communities, physicochem. indexes, and volatile compounds in CTF daqu are very rare. The relationships of microbial communities, physicochem. indexes, and volatile compounds in CTF daqu produced in summer (July and August) and autumn (Sept. and Oct.) were studied. The results of Illumina MiSeq sequencing indicated that there was greater bacterial diversity in the CTF daqu-7 (produced in July) and CTF daqu-8 (produced in August) and greater fungal diversity in the CTF daqu-9 (produced in Sept.) and CTF daqu-10 (produced in Oct.). The physicochem. indexes of CTF daqu produced in different seasons were significantly different. It was determined that CTF daqu-9 had the highest esterification and liquefaction abilities. A total of 44 volatile compounds, including alcs., esters, aldehydes, and ketones were identified in CTF daqu produced during different seasons. Among them, CTF daqu-9 had the greatest alc. content. Sept. (early autumn) is the best production period for CTF daqu. The results of the study provide a theor. basis for the standardized and uniform production of Chinese baijiu. 2021 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Peiyu published the artcileAn azine-linked 2D porphyrinic covalent organic framework for red light photocatalytic oxidative coupling of amines, HPLC of Formula: 6850-57-3, the publication is Materials Today Chemistry (2022), 100953, database is CAplus.

The construction of two-dimensional covalent organic frameworks (2D COFs) with robust stability for photocatalysis has gained intensive attention recently. Herein, we report the design and synthesis of a highly crystalline azine-linked porphyrinic 2D COF (Por-HZ-COF). Our results clearly show that Por-HZ-COF adopts an eclipsed AA stacking structure with a high Brunauer-Emmett-Teller (BET) sp. surface area of 1586 m2/g. In addition, Por-HZ-COF is chem. stable under various conditions, even in 12 M sodium hydroxide aqueous solution or 9 M hydrochloric acid. Moreover, Por-HZ-COF can be used for the photocatalytic aerobic oxidative coupling of benzylamines under red light irradiation with high activity and good reusability. This study demonstrates a novel robust 2D COF with azine linkage that has promising applications in photocatalysis.

Materials Today Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hu, Guishan published the artcilePyrazine-cored covalent organic frameworks for efficient CO₂ adsorption and removal of organic dyes, Related Products of ethers-buliding-blocks, the publication is Polymer Chemistry (2022), 13(25), 3827-3832, database is CAplus.

The rational introduction of nitrogen heterocycles into a linker of covalent organic frameworks (COFs) can effectively capture CO₂ and remove dyes in sewage. Here, we report the designed synthesis of COF-H1 and COF-H2, starting from integration reactions between a novel tetratopic 2,3,5,6-tetrakis(4-aminophenyl)pyrazine and ditopic aromatic aldehydes. They crystallize as 2D microporous pore structures with high stability in different environments, exhibiting good CO₂ uptake capacities of 56.8 and 66.2 mg g^-1 at 273 K, resp. COF-H1 and COF-H2 exhibit efficient adsorption performances for rhodamine B, methylene blue, Congo red and gentian violet, especially reaching the adsorption equilibrium for Congo red in 5 min together with an adsorption capacity of 470.3 and 362.9 mg g^-1, resp.

Polymer Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ma, Xuerui published the artcileTartramide Ligands for Copper-Catalyzed N-Arylation at Room Temperature, HPLC of Formula: 6850-57-3, the publication is Advanced Synthesis & Catalysis (2022), 364(12), 2023-2031, database is CAplus.

Readily accessible tartramide ligands R¹NHC(O)CH(OH)CH(OH) C(O)NHR (R = Ph, Bn, cyclohexyl, etc.)have been demonstrated to promote copper-catalyzed N-arylation under mild conditions. In addition, the coupling protocol employs cheap and readily available pre-catalyst, ligand, and base (NaOH), and overcomes many current limitations often associated with Ullmann coupling: it can be run with low catalyst loadings, does not require the use of excess amine, operates at room temperature, is fully homogeneous, and displays improved tolerance to air and moisture. Detailed kinetic studies using reaction progress kinetic anal. (RPKA) methods have provided insight into the factors influencing the reaction rate in terms of impact of ligand structure, reactant/catalyst dependence and catalyst (in)stability. These kinetic insights have been used in a quality-by-design approach for further optimization of the reaction protocol. The reaction scope was extended to 22 examples, showing broad applicability for a wide range of substituted aryl iodides ArI (Ar = 3,5-dimethylphenyl, 4-chlorophenyl, 3-cyanophenyl, etc.) with both primary and secondary amines R¹NHR² (R¹ = H); R² = -(CH₂)₂O(CH₂)₂-, -(CH₂)₂N(CH₃)(CH₂)₂-, -(CH₂)₅-, etc.

Advanced Synthesis & Catalysis published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wojcik-Pszczola, Katarzyna published the artcilePan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation, Application In Synthesis of 6850-57-3, the publication is Pharmaceuticals (2022), 15(4), 423, database is CAplus and MEDLINE.

Airway remodeling is a pathol. process that accompanies many chronic lung diseases. One of the important players in this process are epithelial cells, which under the influence of pro-inflammatory and pro-fibrotic factors present in the airway niche, actively participate in The remodeling process by increasing extracellular matrix secretion, acquiring migration properties, and overproducing pro-fibrotic transducers. Here, we investigated the effect of three new 8-arylalkylamino- and 8-alkoxy-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl-N-(5-(tertbutyl)-2-hydroxyphenyl)butanamides (1, 2, and 3), representing prominent pan-phosphodiesterase (pan-PDE) inhibitors on transforming growth factor type β (TGF-β)-induced alveolar epithelial type II cells (A549 cell line) of a pro-fibrotic phenotype. Our results demonstrate for the first time the strong activity of pan-PDE inhibitors in the prevention of TGF-β-induced mesenchymal markers′ expression and A549 cells′ migration. We also showed an increased p-CREB and decreased p-Smad-2 phosphorylation in TGF-β-induced A549 cells treated with 1, 2, and 3 derivatives, thereby confirming a pan-PDE inhibitor mesenchymal phenotype reducing effect in alveolar epithelial type II cells via suppression of the canonical Smad signaling pathway. Our observations confirmed that PDE inhibitors, and especially those active against various isoforms involved in the airway remodeling, constitute an interesting group of compounds modulating the pro-fibrotic response of epithelial cells.

Pharmaceuticals published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C15H16O3, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gopalaiah, Kovuru published the artcileSynthesis of Krohnke pyridines through iron-catalyzed oxidative condensation/double alkynylation/amination cascade strategy, HPLC of Formula: 6850-57-3, the publication is Tetrahedron (2021), 132429, database is CAplus.

An efficient protocol for the synthesis of sym. and unsym. 2,4,6-trisubstituted pyridines via oxidative cascade annulation of arylacetylenes with benzylamines was developed. The reaction proceeded smoothly by utilizing iron(II) triflate as a catalyst and mol. oxygen as an oxidant with broad substrate scope. Mechanistic studies revealed that the reaction may experience an oxidative condensation followed by double alkynylation and amination process.

Tetrahedron published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem