Tag: M.W=100-150

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Application In Synthesis of 111-90-0.

Wang, Yunhong;Chen, Jingcai;Yang, Yang;Gao, Sijia;Wang, Zhuzhu;Liu, Yating;Zhang, Xiaomei;Hua, Lei;Guo, Yanlei;Yang, Yong research published 《 Oil-water partition coefficient preparation and detection in the dihydroartemisinin self-emulsifying drug delivery system》, the research content is summarized as follows. Background: The aim of the present study is to increase the solubility of dihydroartemisinin (DHA) using the self-emulsifying drug delivery system (SEDDS). Methods: We first conducted solubility test and ternary phase diagram, then, in order to optimize the formulation of the DHA self-emulsifying agent, the design mixture method was selected in the design expert software. Next, optimal prescription validation and preliminary formulation evaluation were conducted. By comparing the oil-water partition coefficient in vitro, the improvement of the in vivo osmotic absorption of DHA via self-emulsification was evaluated. Results: The optimal prescription ratio of oleic acid polyethylene glycol glyceride, polyoxyethylene hydrogenated castor oil, and diethylene glycol monoethyl ether in the DHA self-emulsifying preparation = 0.511:0.2:0.289 (weight/weight/w), with a drug-loading capacity of 26.3634 mg/g, solubility of 2.5448 mg/mL, and self-emulsification time of 230 s. The solubility self-emulsification was approx. 20.52 x higher in DHA than in the crude drug. The self-emulsification could improve DHA permeability and promoting in vivo DHA absorption. Conclusion: The DHA SEDDS could significantly improve DHA solubility and in vivo absorption.

Application In Synthesis of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. COA of Formula: C6H14O3.

Welke, Juliane Elisa;Nicolli, Karine Primieri;Hernandes, Karolina Cardoso;Biasoto, Aline Camarao Telles;Zini, Claudia Alcaraz research published 《 Adaptation of an olfactometric system in a GC-FID in combination with GCxGC/MS to evaluate odor-active compounds of wine》, the research content is summarized as follows. A step-by-step approach to easily adapt and use a GC-FID as an olfactometer, as well as a detailed description of acquisition and interpretation of olfactometric data by the OSME (from the Greek word for odor, σμη) method. A Merlot wine was used to exemplifly this strategy and its volatiles were characterized, rendering 43 volatiles in 1D-GC/MS and 142 in GCxGC/MS. GC-O showed the presence of 24 odor-active compounds and GCxGC/MS indicated aditional 14 odor-active compounds, which were found as coelutions. Six compounds (isoamyl acetate, The adapted GC-O in combination with the use of GCxGC/MS may be a tool to more accurate investigation of the odor-active compounds of wine.

COA of Formula: C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. COA of Formula: C6H14O3.

Vasdev, Nupur;Handa, Mayank;Kesharwani, Prashant;Shukla, Rahul research published 《 Rosemary oil low energy nanoemulsion: optimization, μrheology, in silico, in vitro, and ex vivo characterization》, the research content is summarized as follows. Acetylcholine imbalance in the human brain causes dementia-related symptoms of Alzheimer′s disease. Acetylcholinesterase (AChE) inhibitors prevent the lysis of acetylcholine in the brain and prevent dementia. Therefore, the present study aims to investigate the in silico and in vitro AChE potential of rosemary oil and then formulate it into nanoemulsion as an adjuvant with co-administration of Donepezil (Dz) with a thought for futuristic target for Alzheimer′s diseases via the intranasal route. The aim for preparing this formulation was to add the AChE inhibition effect of the rosemary oil to the effect that acts as an additive effect along with Dz. The docking score of rosemary oil components on human cholinesterase 1GQR protein was found to be >-5 kcal/mol. In vitro AChE activity of rosemary oil confirms the prominent IC50 of oil at 0.001 μL/min. Nanoemulsion was prepared by low energy emulsification technique using Tween 80 as surfactant and ethanol or diethylene glycol monoethyl ether as cosurfactant. Droplet size, polydisperity index, and zeta potential of stable nanoemulsion was ∼16 nm, 0.1, and -6.05 mV for stable batch. High-resolution transmission electron microscopy microscopic studies depicted the spherical shape of the droplet. Micro rheol. investigation of nanoemulsion clearly attributes to gel-sol-gel behavior of formulated nanoemulsion. Thermal evaluation of nanoemulsion depicts the phase transition behavior of ethanol-based nanoemulsion at 60 °C. Ex vivo nasal ciliotoxicity and permeation studies of formulation establish the safety of ethanol-based rosemary oil-loaded nanoemulsion and permeation mechanism of Dz from the nanoemulsion. In vitro permeation studies showed more drug penetration from the nanoemulsion as compared to the plain drug. The prepared nanoemulsion was found to be stable for 3 mo at 4, 25, and 45 °C of storage. This low energy preparation method can be advantageous for the preparation of scalable nanoemulsion and can be a futuristic therapeutic for Alzheimer′s disease.

COA of Formula: C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Product Details of C6H14O3.

Venkatesan, Kumar;Haider, Nazima;Yusuf, Mohammad;Hussain, Afzal;Afzal, Obaid;Yasmin, Sabina;Altamimi, Abdulmalik S. A. research published 《 Water/transcutol/lecithin/M-812 green cationic nanoemulsion to treat oxytetracycline contaminated aqueous bulk solution》, the research content is summarized as follows. Oxytetracycline (OXT) has been recognized as the most common veterinary medicine discharge responsible to cause water contamination and subsequent health issues in aquatic animals and human health. The study addressed the use of cationic (water/transcutol/lecithin/M-812) green nanoemulsion as an efficient, effective, and cost effective approach. Components were selected based on the drug solubility and HSP (Hansen solubility parameter) software (HSPiP software). Several batches of green cationic nanoemulsions (GNE1-GNE5) were tailored using medium chain triglyceride, transcutol, and lecithin as dictated in pseudoternary phase diagrams followed by thermodn. stability study. These were characterized for globular size and size distribution, zeta potential, refractive index (RI), viscosity, and pH. Moreover, removal efficiency (%) and the impact of exposure time (5, 10, and 20 min) on removal efficiency were investigated. Finally, the treated water was assessed to ensure free from OXT using SEM-EDX (SEM- energy dispersive X-ray anal. mode) and ICP-OES (inductively coupled plasma-optical emission spectrometry). Result showed that removal efficiency was significantly dependent upon (a) globular size, (b) water content, (c) oil content, and (d) viscosity. However, the exposure time for emulsification had no considerable impact. The most optimized cationic GNE5 was characterized with low size (38 nm), optimal zeta potential (+26 mV), low viscosity (316.5 cP), and the highest removal efficiency (90.3% at 20 min) as compared to resp. anionic nanoemulsion. SEM-EDX and ICP-OES results corroborated the absence of OXT in the treated water. Hence, this approach is promising to decontaminate anionic OXT present in wastewater using cationic GNE5 (to get OXT loaded ONE5 after dispersion).

Product Details of C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Recommanded Product: Diethylene Glycol Monoethyl Ether.

Singh, Manmeet;Singh, Dilpreet;Mahajan, Sundar;Sheikh, Bilal Ahmed;Bedi, Neena research published 《 Polymeric Precipitation Inhibitor Assisted Supersaturable SMEDDS of Efavirenz Based on Experimental Observations and Molecular Mechanics》, the research content is summarized as follows. Supersaturable SMEDDS, a versatile dosage form, was investigated for improving the biopharmaceutical attributes and eradicating the food effect of poorly water soluble drug efavirenz. The present research pursues the development of efavirenz loaded Supersaturable Self- Microemulsifying Drug Delivery System (SS SMEDDS) for improving biopharmaceutical performance. Preformulation studies were carried out to determine the optimized range of lipid excipients to develop stable supersaturated SMEDDS (ST SMEDDS). The SS SMEDD formulation was prepared by adding hydroxypropyl methylcellulose as a polymeric precipitation inhibitor. The developed SS SMEDDS were evaluated for supersaturation behavior by performing in vitro supersaturation studies and mol. simulations by in silico docking. Dissolution was performed in biorelevant media to simulate fed/fasted conditions in gastrointestinal regions. Absorption behavior was determined through in vivo pharmacokinetics approach. The optimized ST SMEDDS formulation containing Maisine CC, Tween 80 and Transcutol-P exhibited thermodn. stability with quick rate of emulsification. The optimized SS SMEDDS containing suitable polymeric precipitation inhibitor exhibited enhanced efavirenz concentration in in vitro supersaturation test. The theor. simulations by mol. docking revealed strong intermol. interactions with a docking score of -3.004 KJ/mol. The dissolution performance of marketed product in biorelevant dissolution media inferred the existence of food effect in the dissolution of efavirenz. However, in SS SMEDDS, no significant differences in drug release behavior under different fasted/fed conditions signify that the food effect was neutralized. In vivo pharmacokinetics revealed a significant increase in the absorption profile of efavirenz from SS SMEDDS than that of ST SMEDDS and marketed product. The designed delivery system indicated promising results in developing an effectual EFV formulation for HIV treatment.

Recommanded Product: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Electric Literature of 111-90-0.

Singh, Tej Pratap;Ahmad, Farhan Jalees;Jain, Gaurav Kumar;Verma, Navneet research published 《 Formulation development and characterization of nanoemulsion-based gel for topical application of raloxifene hydrochloride》, the research content is summarized as follows. Nanoemulsion-gels are nanosized droplets, and thermodynamically stable oil-in-water dispersion. Raloxifene hydrochloride a selective estrogen receptor modulator currently its more research is being laid on in treatment of diseases in estrogen deficient postmenopausal women. The objective of this research was to formulate nanoemulsion-gel of raloxifene for topical delivery. The oil, surfactant and cosurfactant were selected on the basis of maximal solubility of raloxifene. The screening of surfactant and cosurfactant were on the basis of their emulsification efficacy with oil to form homogenization mixture on gentle shaking. The nanoemulsions were prepared by ternary phase diagram method using different ratio of oil and surfactant-cosurfactant mixture (Smix) and nanoemulsion region obtained by excel sheet design triangular software. The composition of the optimized nanoemulsion contains 0.072 %w/v raloxifene, 14.29 %volume/volume oil phase (Labrafil-M2125CS), 33.33%volume/volume Smix (Cremophor-RH40:Transcutol-P, 1:1), and 52.38%volume/volume distilled water. The optimized nanoemulsion was converted into gel form by addition of 1%w/v Carbopol-934. The formulation NEG2 possessed droplets size 56.73±0.58 nm, zeta-potential -22.20±0.02 mV, spreadability 18.35±0.45 gcm-1sec-1 and viscosity 98.54 ± 0.39 mPas. The ex vivo permeation of NEG2 (22.38%) was comparatively lower to the permeation of NE3 (26.68%). Also, flux of NEG2 (11.96 ± 0.4 μgcm-2h-1) significantly lower permeability than NE3(16.28 ± 0.7μgcm-2h-1). But nanoemulsion-gel form is maintained more effective concentration within skin due to adhesive nature of gel form remain contact on the applied area for a long duration. Nanoemulsion-gel found stable during six months. The outcome of this study points out the nanoemulsion-gel better than nanoemulsion because of adhesive nature and less permeability. Consequently, It maintain more raloxifene concentration at applied skin.

Electric Literature of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. SDS of cas: 111-90-0.

Singha, L. Ronibala;Das, Malay K. research published 《 Effect of Mesua ferrea Linn. seed kernel oil on percutaneous absorption of Diltiazem hydrochloride through pig ear epidermis: A mechanistic study》, the research content is summarized as follows. The present study reports the mechanistic investigation on Mesua ferrea L. seed kernel oil as a natural skin permeation enhancer. The natural oil was extracted by Soxhlation method. The permeation parameters resulting from the ex vivo skin permeation study of the model drug Diltiazem HCl across oil pre-treated pig ear epidermis revealed better transdermal flux of the test groups compared to the control one. Also, the investigated oil exhibited significantly higher penetration enhancement effect compared to the standard penetration enhancer Transcutol and the maximum permeation enhancement effect was observed at 15% volume/volume in PG. The permeation enhancement mechanistic studies by FT-IR, DSC and SEM suggested that the enhancement effect of the oil was due to the fluidization of lipids and interaction with keratinocytes of the stratum corneum maintaining morphol. integrity of the skin membrane. Furthermore, the test oil was found to be non-irritant in nature and safe for topical application. These findings suggests the Mesua ferrea L. seed oil is an efficient and safe natural skin permeation enhancer providing the scope for future research on its usage in the development of transdermal drug delivery devices.

SDS of cas: 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Reference of 111-90-0.

Sinico, Chiara;Fadda, Anna Maria;Valenti, Donatella;Pireddu, Rosa;Corrias, Francesco;Schlich, Michele;Pitzanti, Giulia;Lai, Francesco research published 《 Nanoliposomes@Transcutol for in vitro skin delivery of 8-methoxypsoralen》, the research content is summarized as follows. The 8-methoxypsoralen is the most common drug in psoralen plus UV light irradiation therapy for the treatment of severe psoriasis. Despite of the efficacy, its classic oral administration leads to several serious adverse effects. However, the topical psoralen application produces a drug skin accumulation lower than that obtained by oral administration, due to the drug low skin permeability. In this paper, 8-methoxypsoralen loaded Penetration Enhancer-contg Vesicles were prepared using soy phosphatidylcholine and the penetration enhancer Transcutol (5% or 10%) and characterized in terms of size, polydispersity index, zeta potential and encapsulation efficiency. No statistically significant differences in both size (∼135 nm) and encapsulation efficiency (∼65%) were found for different Transcutol concentration Transdermal delivery study assessed by Franz diffusion cells, showed that the 8-methoxypsoralen mainly accumulated into the stratum corneum. Moreover, after Penetration Enhancer-contg Vesicles application, the drug recovered in this layer is almost double of that delivered by conventional liposomes, while no significant difference was found from the different Transcutol concentrations Finally, biocompatibility checked by an MTT assay, demonstrated that the incubation of human keratinocytes for 24 h with 8-methoxypsoralen loaded Penetration Enhancer-contg Vesicles did not significantly reduce cell viability.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Reference of 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. COA of Formula: C6H14O3.

Subedi, Laxman;Pandey, Prashant;Shim, Jung-Hyun;Kim, Ki-Taek;Cho, Seung-Sik;Koo, Kyo-Tan;Kim, Beum Joon;Park, Jin Woo research published 《 Preparation of topical bimatoprost with enhanced skin infiltration and in vivo hair regrowth efficacy in androgenic alopecia》, the research content is summarized as follows. To prepare a topical formulation of bimatoprost (BIM) with high skin permeability, we designed a solvent mixture system composed of ethanol, diethylene glycol monoethyl ether, cyclomethicone, and butylated hydroxyanisole, serving as a volatile solvent, nonvolatile co-solvent, spreading agent, and antioxidant, resp. The ideal topical BIM formulation (BIM-TF#5) exhibited 4.60-fold higher human skin flux and a 529% increase in dermal drug deposition compared to BIM in ethanol. In addition, compared to the other formulations, BIM-TF#5 maximally activated human dermal papilla cell proliferation at a concentration of 5 muM BIM, equivalent to 10 muM minoxidil. Moreover, BIM-TF#5 (0.3% [weight/weight] BIM) significantly promoted hair regrowth in the androgenic alopecia mouse model and increased the area covered by hair at 10 days by 585% compared to the vehicle-treated mice, indicating that entire telogen area transitioned into the anagen phase. Furthermore, at day 14, the hair weight of mice treated with BIM-TF#5 (5% [weight/weight] BIM) was 8.45- and 1.30-fold greater than in the 5% (weight/weight) BIM in ethanol and 5% (w/v) minoxidil treated groups, resp. In the histol. examination, the number and diameter of hair follicles in the deep subcutis were significantly increased in the BIM-TF#5 (0.3 or 5% [weight/weight] BIM)-treated mice compared to the mice treated with vehicle or 5% (weight/weight) BIM in ethanol. Thus, our findings suggest that BIM-TF#5 is an effective formulation to treat scalp alopecia, as part of a novel therapeutic approach involving direct prostamide F2alpha receptor-mediated stimulation of dermal papilla cells within hair follicles.

COA of Formula: C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Category: ethers-buliding-blocks.

Sumimoto, Yusuke;Okawa, Shinya;Inoue, Tomoya;Masuda, Kazufumi;Maruyama, Masato;Higaki, Kazutaka research published 《 Extensive improvement of oral bioavailability of mebendazole, a brick dust, by polymer-containing SNEDDS preparation: Disruption of high crystallinity by utilizing its counter ion》, the research content is summarized as follows. Poorly water-soluble and poorly lipid-soluble drugs are called as ′brick dust′ and it is very hard for them to be formulated as some dosage form which can provide an effective bioavailability after oral administration. Mebendazole (MBZ), an anti-helminthic drug having anti-cancer properties, is one of the brick dusts and its poor bioavailability has been well known. The strategy of the current study was to improve the oral absorption of MBZ by SNEDDS formulation prepared by utilizing an MBZ-counter ion complex, of which the formation would disrupt the high crystallinity of MBZ. Among five different counter ions examined, (+)-10-camphorsulfonic acid (CSA), 2-naphthalene-sulfonic acid (NSA) and p-toluenesulfonic acid (TSA) largely improved MBZ solubility in the SNEDDS vehicle by forming the complex with MBZ. The solid state of these complexes, MBZ-CSA, MBZ-NSA and MBZ-TSA, was suggested to be amorphous by XRPD and DSC. SNEDDS formulations of the three complexes extensively improved MBZ dissolution under gastric and intestinal luminal conditions, compared with MBZ crystalline powder. However, since the dissolved concentrations of MBZ were time-dependently decreased so much by precipitation, we tried to maintain the high dissolution property by applying some polymer for SNEDDS preparation of MBZ-CSA which provided the highest solubility in the SNEDDS vehicle. Among ten different polymers examined, HPMCP-50 successfully maintained the high dissolution property of MBZ-CSA SNEDDS under both gastric and intestinal luminal conditions. In the in vivo oral administration study, SNEDDS preparations for the three MBZ complexes significantly improved MBZ absorption compared with MBZ crystalline powder, but 2% HPMCP-50-containing SNEDDS of MBZ-CSA provided further improvement of MBZ absorption, resulting in around 10-fold of crystalline powder in AUC.

Category: ethers-buliding-blocks, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem