Tag: M.W=100-150

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Application In Synthesis of 111-90-0.

Silva-Alvarez, Amanda F.;de Carvalho, Ana Clara Wada;Benassi-Zanqueta, Erica;Oliveira, Thalita Z.;Fonseca, Dyenefer P.;Ferreira, Maira P.;Vicentini, Fabiana T. M. C.;Ueda-Nakamura, Tania;Pedrazzi, Vinicius;de Freitas, Osvaldo research published 《 Herpes Labialis: A New Possibility for Topical Treatment with Well-Elucidated Drugs》, the research content is summarized as follows. Mucocutaneous infections caused by Herpes simplex virus (HSV-1 and HSV-2) are characterized by the appearance of vesicles that cause pain and embarrassment to the carrier. The standard treatment is based on the use of antivirals in gels or ointments, however, relapses are common. Local anesthetics decrease the pain caused by the lesion, in addition to showing antiviral properties. Semi-solid form facilitates application and its transformation into a thin film favors the maintenance of the formulation in place, with a more discreet final aspect. The objective of this study was to develop and evaluate formulations containing anesthetics for the treatment of cold sores. For this purpose, two semi-solid film-forming formulations were developed and evaluated, containing HPMC K100, lidocaine (LIDO) and prilocaine (PRILO) combined with adjuvants, in the presence (F1T) or not (F1) of the absorption promoter Transcutol. The mixture of PRILO and LIDO resulted in the formation of a eutectic mixture (EM), essential for penetration of drugs into the skin. The quantification of drugs was performed by HPLC (High Performance Liquid Chromatog.), and Transcutol did not influence the release of drugs from the formulation. The bioadhesiveness of the formulation was evaluate and the drugs did not impair the adhesive potential of the polymers used. The formulations were evaluated in vivo for skin irritation and did not show any neg. sign on macroscopic examination The in vivo efficacy test proved the anesthetics ability to decrease the lesions caused by HSV-1. Thus, the proposed formulations proved to be good alternatives to the treatment of oral lesions caused by HSV-1.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Application In Synthesis of 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Name: Diethylene Glycol Monoethyl Ether.

Ruokolainen, Joonas;Hyttinen, Marko;Sorvari, Jouni;Pasanen, Pertti research published 《 Exposure of cleaning workers to chemical agents and physical conditions in swimming pools and spas》, the research content is summarized as follows. Swimming pools and spas require a high hygiene level, and therefore constant cleaning. In this study, cleaning worker′s exposure to volatile organic compounds (VOCs), trichloramine (TCA), and particulate matter (PM) in the swimming pools and spas were evaluated. Also, statistical methods were employed to determine what activities affect the exposure to disinfection byproducts (DBPs). The study was conducted in 32 swimming pools and spas. The measurement locations were pool areas, bathrooms, and locker rooms, both during cleaning and opening hours. During the cleaning, the total volatile organic compound (TVOC) concentrations were low, on average 96, 251, and 91 μg/m³ for locker rooms, bathrooms, and pool areas, resp. Similarly, during the opening hours, the TVOC concentrations were on average 78, 125, and 83 μg/m3, for locker rooms, bathrooms, and pool areas, resp. This is in line with previous studies investigating cleaning work in other environments. The most prevalent compounds during the cleaning were 2-(2-butoxyethoxy)ethanol (DEGBE), 2-(2-ethoxyethoxy)ethanol (DEGEE), 2-butyl-1-octanol, trichloromethane (chloroform), decamethylcyclopentasiloxane (D5), and carbon tetrachloride. The most prevalent compounds during the opening hours were D5, D-limonene, carbon tetrachloride (bathrooms and pool areas), and trichloromethane (bathrooms and pool areas). The TCA concentrations during the cleaning in the bathrooms and pool areas were on average 60 and 67 μg/m³, resp., and during the opening hours, 28 and 122 μg/m³, resp. The use of disinfectants was found to increase the TCA concentration in the bathrooms, while the other cleaning products did not. Even though the TCA concentrations were below the WHO′s guideline and the Finnish occupational exposure limit value of 500 μg/m³, the measured TCA levels were occasionally high enough to pose a risk of irritative symptoms. The PM concentrations were low, both in the real-time monitoring (aerodynamic diameter, Dae ≤ 15 μm) and inhalable dust samples (Dae ≤ 100 μm). Highest measured inhalable dust concentration was 350 μg/m³, well below the Finnish occupational limit value of 5,000 μg/m³ for organic inhalable dust.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Name: Diethylene Glycol Monoethyl Ether

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Product Details of C6H14O3.

Sabater, Paula Querol;Santana, Oscar Diaz;Moreno, Daura Vega research published 《 Determining Intersecting Ball-Point Ink Strokes with Different Aging》, the research content is summarized as follows. Abstract: The order of laying down homogeneous intersecting strokes of ball-point inks has been assessed using a range of different spectroscopic and anal. techniques for recent inks and for inks with a time difference of 4 years. These techniques are IR reflectance photog. with luminescence, fluorescence micro-spectrophotometry, Fourier transform IR spectrometry, high resolution liquid chromatog. and gas chromatog. with mass spectrometry. This paper presents a combined method applicable to forensic cases aimed at resolving homogenous intersecting strokes of ball-point ink to determine whether they were made at the same time or, on the contrary, they were intersecting strokes laid down with an acute time difference, taking four years as an age reference

Product Details of C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Synthetic Route of 111-90-0.

Saha, Mithun;Sikder, Pallabi;Saha, Aditi;Shah, Sharha;Sultana, Sharmin;Emran, Tushar;Banik, Ananna;Islam, Zahidul;Islam, Muhammad Saiful;Sharker, Shazid Md.;Reza, Hasan Mahmud research published 《 QbD Approach towards Robust Design Space for Flutamide/PiperineSelf-Emulsifying Drug Delivery System with Reduced Liver Injury》, the research content is summarized as follows. Flutamide which is used to treat prostate cancer and other diseases induces liver damage during and after the therapy. The aim of this study was to develop a flutamide/piperineco-loaded self-emulsifying drug delivery system (FPSEDDS) to inhibit flutamide-induced liver injury by utilizing piperine as a metabolic inhibitor. The development of SEDDS was carried out following a quality by design (QbD) approach. The risk assessment study was performed to identify critical quality attributes (CQAs) and critical material attributes (CMAs)/critical process parameters (CPPs). I-optimal mixture design was executed with three CMAs as the independent variables and CQAs as the dependable variables. The effectiveness of optimized SEDDS to circumvent flutamide-induced hepatotoxicity was assessed in mice. The numerical optimization suggested an optimal formulation with a desirability value of 0.621, using CQAs targets as optimization goals with 95% prediction intervals (α = 0.05). The optimal formulation exhibited the grade A SEDDS characteristics with the guarantee of high payloads in self-formed oily droplets. The design space was also obtained from the same optimization goals. All CQA responses of verification points were found within the 95% prediction intervals of the polynomial models, indicating a good agreement between actual vs. predicted responses within the design space. These obtained responses also passed CQAs acceptance criteria. Finally, hematoxylin-eosin staining revealed the minimal flutamide-induced hepatotoxicity from the optimal SEDDS formulation as compared to the control and flutamide/piperine normal suspension. We demonstrate that the piperine containing optimized SEDDS formulation developed by QbD significantly reduces the flutamide-induced liver injury in mice.

Synthetic Route of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Electric Literature of 111-90-0.

Salabat, Alireza;Parsi, Elham research published 《 Ex vivo evaluation of celecoxib release from ionic liquid-based microemulsions and microemulgels for topical applications》, the research content is summarized as follows. The aim of this study was to introduce new ionic liquid (IL)-based microemulsions and microemulgels as topical delivery systems for celecoxib. Ex-vivo diffusion of celecoxib loaded in IL-based microemulsions and microemulgels through the rat skin by using Franz diffusion cell was investigated and compared with traditional microemulsions. The investigated systems composed of the same nonionic surfactant/co-surfactant of tween-80/transcutolP, and different oil phases of [BMIM][PF₆], [OMIM][PF₆] and iso-Pr myristate, for construction of ILs/W and O/W microemulsions. The particle size of the ILs/W and O/W microemulsion systems was determined by DLS method. The ex-vivo release results of ILs/W and O/W formulations, at similar conditions, showed that the celecoxib permeability of the ILs/W formulations is more than that of the O/W formulation, either as microemulsion or as microemulgel. As an interesting result, the celecoxib release percent and release rate from the ILs/W systems was more and faster than the O/W system. The kinetic mechanism for ILs/W systems had followed from first-order model and for O/W systems followed Higuchi zero-order model.

Electric Literature of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. COA of Formula: C6H14O3.

Sanders, Alyssa B.;Zangaro, Jacob T.;Webber, Nakoa K.;Calhoun, Ryan P.;Richards, Elizabeth A.;Ricci, Samuel L.;Work, Hannah M.;Yang, Daniel D.;Casey, Kaitlyn R.;Iovine, Joseph C.;Baker, Gabriela;Douglas, Taylor V.;Dutko, Sierra B.;Fasano, Thomas J.;Lofland, Sarah A.;Rajan, Ashley A.;Vasile, Mihaela A.;Carone, Benjamin R.;Nucci, Nathaniel V. research published 《 Optimization of Biocompatibility for a Hydrophilic Biological Molecule Encapsulation System》, the research content is summarized as follows. Despite considerable advances in recent years, challenges in delivery and storage of biol. drugs persist and may delay or prohibit their clin. application. Though nanoparticle-based approaches for small mol. drug encapsulation are mature, encapsulation of proteins remains problematic due to destabilization of the protein. Reverse micelles composed of decylmonoacyl glycerol (10MAG) and lauryldimethylamino-N-oxide (LDAO) in low-viscosity alkanes have been shown to preserve the structure and stability of a wide range of biol. macromols. Here, we present a first step on developing this system as a future platform for storage and delivery of biol. drugs by replacing the non-biocompatible alkane solvent with solvents currently used in small mol. delivery systems. Using a novel screening approach, we performed a comprehensive evaluation of the 10MAG/LDAO system using two preparation methods across seven biocompatible solvents with anal. of toxicity and encapsulation efficiency for each solvent. By using an inexpensive hydrophilic small mol. to test a wide range of conditions, we identify optimal solvent properties for further development. We validate the predictions from this screen with preliminary protein encapsulation tests. The insight provided lays the foundation for further development of this system toward long-term room-temperature storage of biologics or toward water-in-oil-in-water biol. delivery systems.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., COA of Formula: C6H14O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Recommanded Product: Diethylene Glycol Monoethyl Ether.

Sawale, Sunil Rambhau;Shete, R. V.;Bhagat, Vishwas C.;Deshmukh, Madhuri T. research published 《 Nanostuctured lipid based drug delivery system of lopinavir- optimization and evaluation》, the research content is summarized as follows. By using the high-shear homogenization method Nanostructured lipid carriers (NLCs) loaded with lopinavir (LOP) were prepared The LOPNLCs formulations were freeze-dried using POLOXOMER 188 as a cryoprotectant. A burst release is shown by in vitro release studies in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). The optimized freeze-dried formulation (LOP-NLC) had a particle size (PS), zeta potential (ZP) and % entrapment efficiency (%EE) of 159.5 _ 3.75 nm, 0.413 _ 0.017, -46 mV and 97.77 _ 4.46%, resp. A spherical shape was observed in the optimized formulation by transmission and scanning electron microscopes. The absence of chem. interaction between the drug and lipids is observed in Differential scanning Calorimetry study. In vitro study is performed using the bulk-equilibrium reverse dialysis technique, to investigate LOP release from optimized LOP-NLC and pure drug suspension in different media. The optimized formulations stored in amber glass container were found to be phys. and chem. stable for three months at room temperature The bioavailability of LOP following oral administration of LOP-NLC in male Wistar rats was found 4.52-fold higher than the LOP-suspension. So the conclusion is:- for improving the oral bioavailability of lopinavir, the nanostructure lipid carriers are potential carriers.

Recommanded Product: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Computed Properties of 111-90-0.

Sayed, Mohammed A.;Saini, Rajesh K.;AlAli, Eyad;Kalgaonkar, Rajendra;Arnous, Ahmed research published 《 Safer Dual-Functional Gas Hydrate Dissolver and Inhibitor to Replace Methanol》, the research content is summarized as follows. In the presence of free water and under certain conditions of temperature and pressure, low-mol.-weight gases such as methane and ethane present in the fluid stream flowing in pipelines cause the formation of gas hydrate crystals. These gas hydrate crystals may accumulate and cause a partial or complete plugging of pipelines in the vertical or horizontal section. Methanol has been used in the industry as an effective gas hydrate dissolver and inhibitor, but its low flashpoint temperature makes it unsafe to be stored and pumped in large volumes The objective of the current work is to develop a safer dissolver and inhibitor for gas hydrate plugs that form in pipelines. Methanol has a very low f.p. (-90°C) and it is completely miscible with water, which can shift the hydrate phase equilibrium to lower temperatures Solvent- and aqueous-based formulations were selected as alternatives to methanol, keeping in mind parameters such as higher flashpoint, miscibility with water, f.p., viscosity, and local availability. The performance of these formulations was evaluated in a see-through gas hydrate reactor. Representative gas and water compositions were used in the experiments to form the gas hydrate inside the reactor. Hydrate formation was detected by the change in torque or by visual inspection through the see-through window of the reactor. Methanol was able to mobilize the hydrate plug when used at 10 vol %, while complete dissolution was achieved at 30 vol %. In comparison, the potassium formate saturated solution achieved complete dissolution of the hydrate plugs at 10 vol % in a lesser time compared to methanol. The tested formulations worked not only as a dissolver but also as an inhibitor to prevent the formation of hydrates once they are melted or dissolved. These formulations enable safer operations in the field and improve the performance when it comes to melting gas hydrate plugs.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Computed Properties of 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Reference of 111-90-0.

Rahimpour, Elaheh;Acree, William E. Jr.;Jouyban, Abolghasem research published 《 Prediction of sulfonamides’ solubilities in the mixed solvents using solvation parameters》, the research content is summarized as follows. The exptl. solubility data of various sulfonamides in the binary solvent systems at various temperatures are collected from the literature and fitted to Jouyban-Acree model as an accurate cosolvency model for providing solubility prediction tools. In order to obtain predictive cosolvency models, the Jouyban-Acree model is combined with physicochem. parameters of the Abraham solvation parameters and the Hansen solubility parameters. Based on these computations, the generally trained versions of the combined models are proposed which enable one to predict the solubility of sulfonamides in the binary solvent mixtures at various temperatures with reasonable error levels.

Reference of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Related Products of 111-90-0.

Rahimpour, Elaheh;Alvani-Alamdari, Sima;Acree, Jr. William E.;Jouyban, Abolghasem research published 《 Drug Solubility Correlation Using the Jouyban-Acree Model: Effects of Concentration Units and Error Criteria》, the research content is summarized as follows. An important factor affecting the model accuracy is the unit expression type for solute and solvent concentrations One can report the solute and solvent concentration in various units and compare them with various error scales. In order to investigate the unit and error scale expression effects on the accuracy of the Jouyban-Acree model, in the current study, seventy-nine solubility data sets were collected randomly from the published articles and solute and solvent concentrations in the investigated systems were expressed in various units. Mass fraction, mole fraction, and volume fraction were the employed concentration units for the solvent compositions, and mole fraction, molar, and gram/L were the investigated concentration units for the solutes. The solubility data, with various solute/solvent concentration units, were correlated using the Jouyban-Acree model, and the accuracy of each model for correlating the data was investigated by calculating different error scales and discussed.

Related Products of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem