Tag: M.W=100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis, characterization and photovoltaic behaviours of peripheral and non-peripheral tetra-[4-(4-octylpiperazin-1-yl)phenoxy] substituted zinc(II), cobalt(II), copper(II) and indium(III) phthalocyanines》. Authors are Artuc, Gamze Ozgul; Altindal, Ahmet; Eran, Belkiz Bilgin; Bulut, Mustafa.The article about the compound:4-(Piperazin-1-yl)phenolcas:56621-48-8,SMILESS:OC1=CC=C(N2CCNCC2)C=C1).Electric Literature of C10H14N2O. Through the article, more information about this compound (cas:56621-48-8) is conveyed.

The synthesis of zinc(II), cobalt(II), copper(II) and indium(III)(OAc) phthalocyanines carrying four 4-(4-octylpiperazin-1-yl)phenoxy moieties in peripheral/non-peripheral positions were performed by the cyclotetramerization of compounds 4-[4-(4-octylpiperazin-1-yl)phenoxy]phthalonitrile or 3-[4-(4-octylpiperazin-1-yl)phenoxy]phthalonitrile with resp. metal salts. The novel phthalonitriles and phthalocyanines were characterized by elemental and spectroscopic anal., including 1H NMR, 13C NMR, FTIR, UV-visible spectral and MALDI-TOF mass data. To clarify the influence of the position of substituent group and the variety of the central metal atom on the photovoltaic performance, bulk heterojunction devices by using phthalocyanines with different blend ratio, as donor was fabricated and characterized.

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Formula: C10H14N2O. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Ordered Layered Dendrimers Constructed from Two Known Dendrimer Families: Inheritance and Emergence of Properties. Author is Dib, Hanna; Rebout, Cyrille; Laurent, Regis; Mallet-Ladeira, Sonia; Sournia-Saquet, Alix; Sarosi, Menyhart B.; Hey-Hawkins, Evamarie; Majoral, Jean-Pierre; Delavaux-Nicot, Beatrice; Caminade, Anne-Marie.

A new concept is presented, namely the synthesis of dendrimers intrinsically composed in alternation of building blocks pertaining to two known families of dendrimers: phosphorhydrazone dendrimers and triazine-piperazine dendrimers. These mixed dendrimers with layered controlled architecture inherit their easy 31P NMR characterization and their thermal stability from the phosphorhydrazone family, and their decreased solubility from the triazine-piperazine family. However, they have also their own and original characteristics. Both parent families are white powders, whereas the mixed dendrimers are yellow, orange, or red powders, depending on the generation. DFT calculations were carried out on model dendrons to understand these special color features. Remarkably, these dendrimers incorporating redox-active organic entities allow for the first time the monitoring of the growth of an organic dendrimer by electrochem. while highlighting an even-odd generation behavior.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Synthetic Route of C10H14N2O.Ryu, Seong-Ryuall published the article 《Synthesis of cycloalkylcarbamoyl substituted ketoconazole derivatives as antifungal agents》 about this compound( cas:56621-48-8 ) in Kongop Hwahak. Keywords: cycloalkylcarbamoyl ketoconazole derivative fungicide preparation; antifungal cycloalkylcarbamoyl ketoconazole derivative preparation. Let’s learn more about this compound (cas:56621-48-8).

In an effort to prepare new antifungal agents, two new title derivatives I (R = cyclopropyl, cyclohexyl) were synthesized by the reaction of substituted piperazine II with N-cycloalkylcarbamoyl derivatives ClCH2CONHR.

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Pace, Jennifer R.; Teske, Kelly A.; Chau, Lianne Q.; Dash, Radha Charan; Zaino, Angela M.; Wechsler-Reya, Robert J.; Hadden, M. Kyle published an article about the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8,SMILESS:OC1=CC=C(N2CCNCC2)C=C1 ).Product Details of 56621-48-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:56621-48-8) through the article.

The Food and Drug Administration-approved antifungal agent, itraconazole (ITZ), has been increasingly studied for its novel biol. properties. In particular, ITZ inhibits the hedgehog (Hh) signaling pathway and has the potential to serve as an anticancer chemotherapeutic against several Hh-dependent malignancies. We have extended our studies on ITZ analogs as Hh pathway inhibitors through the design, synthesis, and evaluation of novel des-triazole ITZ analogs that incorporate modifications to the triazolone/side chain region of the scaffold. Our overall results suggest that the triazolone/side chain region can be replaced with various functionalities (hydrazine carboxamides and meta-substituted amides) resulting in improved potency when compared to ITZ. Our studies also indicate that the stereochem. orientation of the dioxolane ring is important for both potent Hh pathway inhibition and compound stability. Finally, our studies suggest that the ITZ scaffold can be successfully modified in terms of functionality and stereochem. to further improve its anti-Hh potency and physicochem. properties.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called New N,S-substituted dienes from mono(thio)substituted-2-nitrohalo-1,3-diene and some amines, published in 2006-03-31, which mentions a compound: 56621-48-8, mainly applied to nitrohalodiene substitution reaction amine; diene substituted preparation mol crystal structure, Category: ethers-buliding-blocks.

1-(4-Methoxyphenylthio)-2-nitro-1,3,4,4-tetrachloro-1,3-butadiene, (I) reacted with piperazine derivatives and yielded N,S-substituted chloronitrodienes in methylene chloride. Compound I gave dioxaspiro-piperidinyl-substituted chloronitrodiene by the reaction with 1,4-dioxa-8-azaspiro-4,5-decane. 4-Substituted piperidinyl chloronitrodiene derivatives were obtained by the reactions of piperidines with I. 1-(4-Methoxyphenylthio)-2-nitro-1-(4-(p-nitrophenyl)piperazin-1-yl)-1,3,4,4-tetrachloro-1,3-butadiene also was structurally characterized using single-crystal X-ray diffraction anal. [triclinic, P-1, a 7.8400(2), b 9.7030(3), c 16.9628(4) Å, α 93.898(3), β 93.879(2), γ 96.9296(13)°, V 1260.67(6) Å3, Z 2].

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Computed Properties of C10H14N2O. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Synthesis and characterization of phosphorus-containing dendrimers bearing rhodamine derivatives as terminal groups. Author is Wei, Yiqian; Laurent, Regis; Majoral, Jean-Pierre; Caminade, Anne-Marie.

The synthesis of two new derivatives of Rhodamine B functionalized by phenols is reported. For one rhodamine derivative, the equilibrium between the open form and the ring-closed (spirolactam) form is completely shifted toward the latter, whereas the constitution of the other rhodamine derivative precludes ring closure. The spirolactam derivative was grafted as terminal group to a first generation phosphorus-containing dendrimer. Attempts to open the spirolactam form by adding HCl failed and resulted only in protonation of the NEt2 substituent of rhodamine.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56621-48-8, is researched, Molecular C10H14N2O, about Synthesis of propargylamine mycophenolate analogues and their selective cytotoxic activity towards neuroblastoma SH-SY5Y cell line, the main research direction is propargylamine mycophenolate analog preparation mol docking neuroblastoma anticancer; A(3)-coupling reaction; Cytotoxic activity; Molecular docking; Mycophenolic Acid; Neuroblastoma SH-SY5Y cells; Propargylamine mycophenolate.Reference of 4-(Piperazin-1-yl)phenol.

Twenty six propargylamine mycophenolate analogs were designed and synthesized from mycophenolic acid 1 employing a key step A3-coupling reaction. Their cytotoxic activity was examined against six cancer cell lines. Four compounds exhibited selective cytotoxicity towards neuroblastoma (SH-SY5Y) cancer cells and were less toxic to normal cells in comparison to the lead compound, MPA 1 and a standard drug, ellipticine. Mol. docking results suggested that compound I is fit well in the key amino acid of three proteins (CDK9, EGFR, and VEGFR-2) as targets in cancer therapy. The propargylamine mycophenolate scaffold might be a valuable starting point for development of new neuroblastoma anticancer drugs.

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Application of 56621-48-8. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Discovery of a new potent inhibitor of mushroom tyrosinase (Agaricus bisporus) containing 4-(4-hydroxyphenyl)piperazin-1-yl moiety.

Tyrosinase (TYR, EC 1.14.18.1) plays a pivotal role in mammalian melanogenesis and enzymic browning of plant-derived food. Therefore, tyrosinase inhibitors (TYRIs) can be of interest in cosmetics and pharmaceutical industries as depigmentation compounds as well as anti-browning agents. Starting from 4-benzylpiperidine derivatives that showed good inhibitory properties toward tyrosinase from Agaricus bisporus (TyM), we synthesized a new series of TYRIs named 3-(4-benzyl-1-piperidyl)-1-(4-phenylpiperazin-1-yl)propan-1-one and 2-(4-benzyl-1-piperidyl)-1-(4-phenylpiperazin-1-yl)ethanone derivatives Among them, compound 4b proved to be the most potent inhibitor (IC50 = 3.80μM) and it also showed a good antioxidant activity. These new data furnished addnl. information about the SAR for this class of TYRIs.

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Reference of 4-(Piperazin-1-yl)phenol. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Synthesis and characterization of phosphorus-containing dendrimers bearing rhodamine derivatives as terminal groups. Author is Wei, Yiqian; Laurent, Regis; Majoral, Jean-Pierre; Caminade, Anne-Marie.

The synthesis of two new derivatives of Rhodamine B functionalized by phenols is reported. For one rhodamine derivative, the equilibrium between the open form and the ring-closed (spirolactam) form is completely shifted toward the latter, whereas the constitution of the other rhodamine derivative precludes ring closure. The spirolactam derivative was grafted as terminal group to a first generation phosphorus-containing dendrimer. Attempts to open the spirolactam form by adding HCl failed and resulted only in protonation of the NEt2 substituent of rhodamine.

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Franc, Gregory; Turrin, Cedric-Olivier; Cavero, Emma; Costes, Jean-Pierre; Duhayon, Carine; Caminade, Anne-Marie; Majoral, Jean-Pierre published the article 《gem-Bisphosphonate-Ended Group Dendrimers: Design and Gadolinium Complexing Properties》. Keywords: gem bisphosphonate terminated dendrimer gadolinium complex magnetic property; piperazino gem bisphosphonate functionalized gadolinium complex crystal structure.They researched the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ).Category: ethers-buliding-blocks. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:56621-48-8) here.

The synthesis of the first gem-bisphosphonate-ended group dendrimers is described using nucleophilic substitution of terminal P(S)Cl2 units of phosphorus dendrimers of generation 1 to 3 with protected aminophenols followed by deprotection of amino groups and Michael addition with vinylidene tetraisopropyl bisphosphonate. These dendrimers were found to act as chelating agents towards Gd ions. Contrary to the phosphonic acids that can introduce bridges between Gd ions, these synthons act as unique chelating agents toward the Gd ions. Furthermore, it appears that the number of Gd ions introduced in the isolated units is equal to the number of gem-bisphosphonate pairs. Eventually, the magnetic measurements demonstrate clearly that the Gd ions are not coordinated to these pairs as isolated ions but that at least some of these ions are bridged through oxygen atoms that are not P=O functions, as shown by the structural determination given in the paper. Studies concerning properties of these Gd dendrimers complexes are under active study. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009).

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