Tag: M.W=100-200

Synthetic Route of 3616-56-6, These common heterocyclic compound, 3616-56-6, name is 2,2-Diethoxy-N,N-dimethylethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of 3-bromo-12H-benzofuranyl[3,2-a]carbazole (compound 13); (13); Under nitrogen, compound 12 (3.2 g, 1 eq) is initially charged and dissolved with acetic acid (30 ml) while heating to reflux. Then (dimethylamino)acetaldehyde diethyl acetal (95percent; 21 .9 g, 10 eq.) is added dropwise to the reaction within 1 h and the mixture is stirred at reflux for 48 h. The mixture is cooled to room temperature and diluted with methylene chloride. Washed in a separating funnel with distilled water and then with saturated NaCI solution. The organic phase is dried with sodium sulfate and concentrated. LC (Si02, 3: 1 cyclohexane/methylene chloride) gives 0.98 g of product (28.6percent yield). 1H NMR (CD2CI2, 400 MHz): “5 = 8.75 (s, 1 H), 8.24 (s, 1 H), 8.1 (dd, 2H), 7.67 (d, 1 H), 7.48-7.55 (m, 6H).

The synthetic route of 3616-56-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; BASF (CHINA) COMPANY LIMITED; KONINKLIJKE PHILIPS ELECTRONICS N.V.; OSRAM OPTO SEMICONDUCTORS GMBH; PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH; LANGER, Nicolle; SCHILDKNECHT, Christian; WATANABE, Soichi; FUCHS, Evelyn; WAGENBLAST, Gerhard; LENNARTZ, Christian; MOLT, Oliver; DORMANN, Korinna; HUNZE, Arvid; KRAUSE, Ralf; SCHMID, Guenter; HEUSER, Karsten; VAN ELSBERGEN, Volker; BOERNER, Herbert Friedrich; WO2011/125020; (2011); A1;,
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Application of 2930-05-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2930-05-4, name is 2-((Benzyloxy)methyl)oxirane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred mixture of epoxide (1 equiv.) in glycerine was added the amine (1 equiv.) and CeCl3?7H2O (0.1 equiv.) at room temperature. The reaction mixture was stirred until the starting material was consumed as judged by TLC or LCMS analysis. The reaction mixture was then extracted with ethyl acetate (3x) and the combined organic layers were washed with water (2x) and brine before drying over sodium sulfate and concentrating under reduced pressure. The crude product was purified on silica to afford the ethanolamine derivative (Narsaiah, A. V.; Wadavrao, S. B.; Reddy, A. R.; Yadav, J. S.; Synthesis, 2011, 3, 485-489.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-((Benzyloxy)methyl)oxirane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; LAZARSKI, Kiel; MICHAEL, Ryan, E.; (771 pag.)WO2017/197036; (2017); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36865-41-5 as follows. category: ethers-buliding-blocks

b) To a solution of the compound obtained in the previous section (250 mg, 0.78 mmol) in DMF (10 ml_), potassium carbonate (217 mg, 1 .57 mmol) and 1 – bromo-3-methoxypropane (181 mg, 1 .18 mmol) were added. The reaction mixture was stirred at 60 5C overnight. The reaction mixture was diluted by adding EtAcO and saturated NH4CI aqueous solution (15 ml_) and extracted with EtAcO (3×15 ml_). The combined organic phases were dried over anhydrous Na2S04, filtered and concentrated. The crude residue was chromatographed on a silica gel flash system (Biotage SP1 ) using hexanes/EtAcO mixtures of increasing polarity as eluent, to afford the desired product in quantitative yield.LC-MS (method 4): tR = 3.09 [M+H]+= 390

According to the analysis of related databases, 36865-41-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; DRACONIS PHARMA, S.L.; ALMIRALL, S.A.; TORRENS JOVER, Andoni; MERCE VIDAL, Ramon; CALDENTEY FRONTERA, Francesc Xavier; RODRIGUEZ GARRIDO, Antonio, David; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi; WO2013/37960; (2013); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 107622-80-0, name is (4-Phenoxyphenyl)methanamine, A new synthetic method of this compound is introduced below., Recommanded Product: 107622-80-0

General procedure: A mixture of 5 (1 eq.) and amine (2 eq.) in ethanol was stirred at 85 C for 3 h. The mixture was concentrated and purified by flash column chromatography to give compound 6.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Park, Sun Jun; Kim, Eunjin; Yoo, Miyoun; Lee, Joo-Youn; Park, Chi Hoon; Hwang, Jong Yeon; Ha, Jae Du; Bioorganic and Medicinal Chemistry Letters; vol. 27; 18; (2017); p. 4399 – 4404;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 929-75-9, name is 1,11-Diamino-3,6,9-trioxaundecane, A new synthetic method of this compound is introduced below., Safety of 1,11-Diamino-3,6,9-trioxaundecane

General procedure: A two-neck flaskequipped with a magnetic stirrer and reflux condenser, flushed with dry argon, was charged withcorresponding triazacycloalkane derivative 8-10 (0.15-0.29 mmol), Pd(dba)2 (16 mol%),DavePhos (18 mol%), and absolute dioxane (10-15 ml). The mixture was stirred for 2-3 min,then corresponding oxadiamine (0.15-0.29 mmol) was added followed by tBuONa (0.45-0.9mmol). The reaction mixture was stirred at reflux for 24 h, cooled down to ambient temperature,the residue was filtered off, washed with dichloromethane (5 ml), combined organic fractionswere evaporated in vacuo, and the residue was chromatographed on silica gel using a sequenceof eluents CH2Cl2,CH2Cl2-MeOH 100:1-2:1, CH2Cl2-MeOH- NH3aq100:20:1-10:4:1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Chernichenko, Nataliya M.; Shevchuk, Vadim N.; Averin, Alexei D.; Maloshitskaya, Olga A.; Beletskaya, Irina P.; Synlett; vol. 28; 20; (2017); p. 2800 – 2806;,
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Related Products of 494-99-5,Some common heterocyclic compound, 494-99-5, name is 1,2-Dimethoxy-4-methylbenzene, molecular formula is C9H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1 ,2-Dimethoxy-5-methyl-3,4-dinitro-benzene was synthesized by adding 15.0 g of 3,4- dimethoxytoluene portionwise to a mixture of 60 mL fumic nitric acid and 300 mL water keeping the temperature < 200C with the aid of an ice bath. The reaction was stirred for 1 h at 00C, quenched by the addition of ice and stirred for another 1 h. The yellow solid was filtered off, washed with ice cold water and dried in vacuo to yield 9.2 g of 1 ,2-dimethoxy- 5-methyl-3,4-dinitro-benzene as yellow solid.1H-NMR (CDCI3): 6.88 (s, 1 H); 4.01 (s, 3H); 3.98 (s, 3H); 2.52 (s, 3H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dimethoxy-4-methylbenzene, its application will become more common. Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/132679; (2008); A1;,
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Adding a certain compound to certain chemical reactions, such as: 24332-20-5, name is 1,1,2-Trimethoxyethane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24332-20-5, COA of Formula: C5H12O3

Reaction of cis – cedimnylene glycol with methoxyacetaldehyde dimethylacetal24 g (0.1 mol) of cis-cedrylene glycol (using 26 g of a GC content of 92%), 127.6 g (1.45 mol)Methoxyacetaldehyde dimethyl acetal and 0.4 g of concentrated sulfuric acid were stirred at 10 C for 24 hours. At the end of the reaction, methyl tert-butyl was addedEther, washed with a 5% solution of sodium hydrogencarbonate, and the low boiling components removed by distillation. After the addition of n-hexane, unreacted cis-isomer was addedType – cypressane diol crystallization, filtration separation. After concentration of the filtrate by evaporation, 30.4 g of crude product was obtained. According toThe content of the compounds of formulas (X) and (XI) in the product obtained by GC analysis was 51% (corresponding to a theoretical yield of 50%). The originalThe material was dissolved in dipropylene glycol (DPG) to prepare a solution of the compound of formulas (X) and (XI) in an amount of 10% by weightExample (VIII): (IX) = 1: 6.2).For analytical purposes, cyclohexane / ethyl acetate eluant (60/1) was passed through silica gel 60 (0.04-0.063 mm)(X) and (XI) in the crude product were separated from each other by liquid chromatography on a liquid chromatograph. (X)Of the compound has a purity of 99.4% and the purity of the compound of formula (XI) is 96.9%.Compounds of formula (X): & lt; EMI ID =

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,2-Trimethoxyethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Simrose Corporation; Bei, Ende hhuoersiche; (41 pag.)CN105228993; (2016); A;,
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Related Products of 578-57-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 578-57-4, name is 1-Bromo-2-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: CuI (0.05 mmol), aryl halide (0.5 mmol), Na3PO4 (0.5 mmol), 25-28% aqueous ammonia (1 mL), and PEG-400 (2 mL) were added to a sealed tube. The reaction mixture was stirred at 100 C (aryl iodides for 15 h and aryl bromides for 24 h) and then cooled to room temperature and extracted with diethyl ether (3 times). The combined organic phase was then dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. The remaining residue was purified by column chromatography on silica gel to provide the desired aryl amines.

The synthetic route of 1-Bromo-2-methoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Junmin; Yuan, Tangjun; Hao, Wenyan; Cai, Mingzhong; Tetrahedron Letters; vol. 52; 29; (2011); p. 3710 – 3713;,
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366-99-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 366-99-4, name is 3-Fluoro-4-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation 66A: 4-Bromo-3-fluoro-N-(3-fluoro-4- methoxyphenyl)benzenecarboximidamide To a solution of EtMgBr (48 mL, 42.55 mmol, 0.9 M) in THF (24 mL) was added a solution of 3-fluoro-4-methoxyaniline (3 g, 21.28 mmol) in THF (30 mL) at r.t. The mixture was stirred for 30 min at r.t. A solution of 4-bromo-3-fluorobenzonitrile (4.657 g, 23.40 mmol) in THF (20 mL) was added dropwise at r.t. and stirred overnight at r.t. LC/MS showed the reaction was completed, H20 was added and extracted with EA, dried, concentrated and purified by flash chromatography on silica gel (PE/EA=3/1 to EA) to afford 4-bromo-3-fluoro-N-(3-fluoro-4-methoxyphenyl)benzenecarboximidamide (4.68 g, 65percent). [M+H] Calc’d for Ci4HnBrF2N20, 341; Found, 341.

The synthetic route of 3-Fluoro-4-methoxyaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; CHEN, Young, K.; KANOUNI, Toufike; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; (166 pag.)WO2016/4105; (2016); A1;,
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Electric Literature of 2106-18-5, These common heterocyclic compound, 2106-18-5, name is 2-(Trifluoromethoxy)fluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 20: 4-[2-FLUORO-3-(TRIFLUOROMETHOXY)PHENYL]-1-PROPYLPIPERIDIN-4-OL To a solution of 1-fluoro-2-(trifluoromethoxy)benzene (1.22 g, 6.77 mmol) in dry tetrahydrofurane (30 ml) at-78 C, under nitrogen, lithium diisopropylamide (2.5 M in hexane, 3.0 ml, 7.45 mmol) was added dropwise. The mixture was stirred for 1 h after which a solution of newly distilled 4-propyl-1-piperidone (0.96 g, 6.77 mmol) in dry tetrahydrofuran (20 ml) was added drop wise. The resulting mixture was stirred at-78 C for 30 min and then brought to ambient temperature. Water (100 ml) was added and the mixture was extracted with ethylacetate (3×100 ml). The combined organic phases was dried (MgS04), filtered and evaporated to dryness. The oily residue was purified by flash column chromatography (ethylacetate/methanol, 1: 1) to give the title compound (0.83 g). MS m/z (rel. intensity, 70 eV) 321 (M+, 5), 293 (14), 292 (bp), 274 (25), 207 (10).

Statistics shows that 2-(Trifluoromethoxy)fluorobenzene is playing an increasingly important role. we look forward to future research findings about 2106-18-5.

Reference:
Patent; A. CARLSSON RESEARCH AB; WO2005/121092; (2005); A1;,
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