Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27191-09-9, name is 3-Methoxyaniline hydrochloride, A new synthetic method of this compound is introduced below., Computed Properties of C7H10ClNO

General procedure: To a solution of compound 27 (1 mmol) in 20 mL dried CH2Cl2 was added oxalyl chloride (4 mmol). The mixture was stirred at room temperature for 24 h under argon and then concentrated to dryness under reduced pressure. Hexane (3 * 10 mL) was added to the residue, then concentrated under vacuum to dryness. To a dried CH2Cl2 (20 mL) solution of aniline hydrochloride, 4-methoxyaniline hydrochloride, 4-(trifluoromethoxy)aniline hydrochloride, 4-fluoroaniline hydrochloride, 4-chloroaniline hydrochloride, 4-bromoaniline hydrochloride, 3-methoxyaniline hydrochloride, 3-chloroaniline hydrochloride, 2-methoxyaniline hydrochloride, 2-chloroaniline hydrochloride, benzylamine hydrochloride, 4-methoxybenzylamine hydrochloride, N,N-Dimethylethylenediamine, or pyrrolidine (1.5 mmol) was added to the above acid chloride in the presence of triethylamine (3.0 mmol). The reaction mixture was stirred at room temperature for 3 h under argon and then concentrated. The obtained residue was dissolved in 2:1 MeOH/CH2Cl2 (15 mL) and then NaOMe was added until pH = 10. After stirred at r.t. for 12 h, the solution was neutralized with Dowex 50 * 8 (H+) resin until pH = 7, filtered and concentrated under vacuum. Then the residue was purified by silica gel column chromatography (CH2Cl2-MeOH, 6:1) to give compounds 4-18, respectively.

The synthetic route of 27191-09-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liao, Yixian; Chen, Lizhu; Li, Sumei; Cui, Zi-ning; Lei, Zhiwei; Li, Hui; Liu, Shuwen; Song, Gaopeng; Bioorganic and Medicinal Chemistry; vol. 27; 18; (2019); p. 4048 – 4058;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1758-46-9, name is 2-Phenoxyethylamine, A new synthetic method of this compound is introduced below., Computed Properties of C8H11NO

General procedure: Et3N (4.3 mmol) and 97% EtOCOCl (4.3 mmol) in dry CHCl3(25 mL) were added to a solution of the suitable carboxylic acid 24a,24b or 25 (4.3 mmol) at 0 C. After 30 min at 0 C under stirring asolution of the suitable amine (2-phenoxyethanamine, 2-(2-methoxyphenoxy)ethanamine [37], 2-(2,6-dimethoxyphenoxy)ethanamine [38], or 1-(2-methoxyphenyl)piperazine) (4.3 mmol)in dry CHCl3 (10 mL) was added and the reaction mixture was left atroom temperature for 3 h. The solution was washed with 2 N HCl and 2 N NaOH. The organic layer was dried over Na2SO4. After evaporation of the solvent the residue was purified by column chromatography eluting with cyclohexane/EtOAc (7:3).

The synthetic route of 1758-46-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Del Bello, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Quaglia, Wilma; Amantini, Consuelo; Morelli, Maria Beatrice; Santoni, Giorgio; Battiti, Francisco O.; Vistoli, Giulio; Cilia, Antonio; Piergentili, Alessandro; European Journal of Medicinal Chemistry; vol. 168; (2019); p. 461 – 473;,
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Application of 946-80-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 946-80-5, name is Benzyl Phenyl Ether belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A. A 1.12 portion of anhydrous DMF is cooled to 0 C. and treated dropwise with 2.06 g of sulfuryl chloride. The resulting suspension is stirred for 30 min., then treated with 1.50 g of benzyl phenyl ether. The mixture is heated at 90 C. for 3 h, then cooled, extracted with brine and methylene chloride, and dried over MgSO4. Chormotography on silica gel (i-PrOH/hexanes) yields 4-benzyloxybenzenesulfonyl chloride.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Benzyl Phenyl Ether, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Vertex Pharmaceuticals Incorporated; US5723490; (1998); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 349-65-5, name is 2-Methoxy-5-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Safety of 2-Methoxy-5-(trifluoromethyl)aniline

The 1-(5-bromopyridin-2-yl)-3-(2-methoxy-5-trifluoromethylphenyl)urea can be prepared in the following way: A solution of 11.05 g (57.80 mmol) of 2-methoxy-5-trifluoromethylaniline in 100 ml of anhydrous tetrahydrofuran is added, at 0 C. over 3 minutes, to a solution of 6 g (20.23 mmol) of triphosgene in 500 ml of anhydrous tetrahydrofuran. 16.50 ml (116.80 mmol) of triethylamine are added at 0 C. The reaction is stirred at 0 C. for 10 minutes and then at ambient temperature for 1 h 45 min. A solution of 10 g (57.80 mmol) of 2-amino-5-bromopyridine in 100 ml of anhydrous tetrahydrofuran is then added at ambient temperature. The reaction is stirred at ambient temperature for 20 h. The mixture is filtered over sintered glass and the white solid obtained is washed with tetrahydrofuran and a small amount of ethyl acetate. The filtrate is evaporated to dryness under reduced pressure and a pale yellow solid is obtained. The latter is triturated with ethyl acetate and water and then, after filtration over sintered glass, 12.04 g of 1-(5-bromopyridin-2-yl)-3-(2-methoxy-5-trifluoromethylphenyl)urea are obtained in the form of a white solid. EI: m/z=389 (M+), m/z=191 (C8H8NOF3+), m/z=172 (C5H5N2Br+) base peak.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AVENTIS PHARMA S.A.; US2007/259910; (2007); A1;,
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Adding a certain compound to certain chemical reactions, such as: 22483-09-6, name is 2,2-Dimethoxyethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22483-09-6, Application In Synthesis of 2,2-Dimethoxyethanamine

To 3-thiophenecarboxaldehyde (8.75 mL) cooled to 0 C. was added aminoacetaldehyde dimethylacetal (14.2 mL). The clear solution was stirred at room temperature for 60 h. The solution was diluted with ethanol and hydrogenated at 56 psi in the presence of 10% Pd/C (5 g) overnight. The catalyst was filtered off and washed with MeOH. The solvent was removed by rotary evaporation and co-evaporated with toluene to afford an oil (19 g, 94% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2-Dimethoxyethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nagarathnam, Dhanapalan; Khire, Uday; Asgari, Davoud; Shao, Jianxing; Liu, Xiao-Gao; Wang, Chunguang; Hart, Barry; Weber, Olaf; Lynch, Mark; Zhang, Lei; Wang, Lei; US2004/14755; (2004); A1;,
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Adding a certain compound to certain chemical reactions, such as: 103-50-4, name is Benzyl ether, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103-50-4, 103-50-4

General procedure: To a stirred solution of ether (1.0 mmol) in AcOH (6 mL), was added 30 mol % of BF3·Et2O followed by the addition of cyanamide (1.0 mmol). The reaction mixture was refluxed at an elevated temperature (40-50 C) till the completion of the reaction as monitored by TLC. Upon complete consumption of the cyanamide, the reaction medium was diluted with EtOAc (15 mL). The organic layer was washed with water followed by 5% NaHCO3 (2 × 5 mL), water (2 × 5 mL), and brine (5 mL). The organic layer was then dried over anhydrous Na2SO4 and the solvent was evaporated in vacuo to afford the crude which was then purified through silica gel column chromatography (30-40% EtOAc/hexane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Benzyl ether, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Panduranga, Veladi; Basavaprabhu; Sureshbabu, Vommina V.; Tetrahedron Letters; vol. 54; 8; (2013); p. 975 – 979;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 216067-66-2, name is O-(2,4-Dimethoxybenzyl)hydroxylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 216067-66-2

General procedure: To a solution of 2a (0.200 g, 0.651 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC.HCl, 0.150 g, 0.781 mmol)and 4-dimethylaminopyridine (DMAP, 8 mg, 0.065 mmol) in CH2Cl2(30 mL) was added O-benzylhydroxylamine hydrochloride (0.125 g;0.781 mmol) and N-methylmorpholine (NMM, 0.086 mL, 0.781 mmol),and the mixture was stirred at room temperature (r.t.) for 16 h. Thefinal solution was evaporated, dissolved in EtOAc (25 mL) and washedwith 0.1 M HCl (3 × 25mL), 0.1 M NaOH (2 × 25 mL) and then H2O(1 × 25 mL). The final organic phase was dried over anhydrous Na2SO4,and the solvent evaporated. The crude was recrystallized from Et2O/n-hexane, affording the pure compound as white solid

The synthetic route of 216067-66-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Marques, Sergio M.; Abate, Claudia C.; Chaves, Silvia; Marques, Fernanda; Santos, Isabel; Nuti, Elisa; Rossello, Armando; Santos, M. Amelia; Journal of Inorganic Biochemistry; vol. 127; (2013); p. 188 – 202;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 767-91-9, name is 2′-Methoxyphenyl acetylene, A new synthetic method of this compound is introduced below., Product Details of 767-91-9

General procedure: To a mixture of alpha-azidoamide 16aa (34 mg, 0.20 mmol) and phenylacetylene (9a; 24 L,0.20 mmol) in t-BuOH/H2O (2 mL, 1:1) were added 0.5 M CuSO4 (0.020 mL, 0.010 mmol) and 1.0 M sodium ascorbate (0.020 mL, 0.020 mmol). The reaction mixture was stirred at room temperature for 1 day, and then the resulting reaction mixture was filtered. The separated solid was washed with H2O and hexanes, and triturated with hexane/EtOAc (10:1) to give the 1-morpholino-2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethanone (2aaa; 52 mg, 96%) as a white solid

The synthetic route of 767-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lee, Doohyun; Kim, Daehun; Lee, Seungyeon; Kim, Taegeum; Kim, Joobin; Kim, Sohee; Liu, Kwang-Hyeon; Lee, Sangkyu; Bae, Jong-Sup; Song, Kyung-Sik; Cho, Chang-Woo; Son, Youn Kyung; Baek, Dong Jae; Lee, Taeho; Molecules; vol. 20; 11; (2015); p. 19984 – 20013;,
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Synthetic Route of 93919-56-3, These common heterocyclic compound, 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Commercially available amines (20 mmol) were dissolved in dry DMF (40 ml) under nitrogen. To this solution, Et3N (20 mmol) was added and bromoacetyl bromide (20 mmol) via syringe at 0 C under nitrogen. The mixture was stirred at 0 C for 30 min and then at room temperature for another 2 h. Next, solid NaN3 (30 mmol) was added, and the reaction mixture was stirred overnight. The mixture was poured into water (100 ml) and extracted with EtOAc (3 x 100 ml). The combined extracts were washed with water (3 x 50 ml) and brine (50 ml). The organic layer was dried over Na2SO4, filtered, and evaporated under reduced pressure. Silica gel flash chromatography (10 % ethyl acetate in hexane) gave the desired azide product in 70-90 % isolated yield.

Statistics shows that (4-(Trifluoromethoxy)phenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 93919-56-3.

Reference:
Article; Kumbhare, Ravindra M.; Dadmal, Tulshiram L.; Pamanji; Kosurkar, Umesh B.; Velatooru; Appalanaidu; Rao, Y. Khageswara; Rao, J. Venkateswara; Medicinal Chemistry Research; vol. 23; 10; (2014); p. 4404 – 4413;,
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Reference of 7252-83-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A 100-mL, three-neck flask was charged with 2-bromo-l,l-dimethoxyethane 4 (23.2 g (16 mL, 137.2 mmol) and aqueous HBr (47.6% HBr by wt, 8.8 mmol/mL, 6.6 mL, 58.8 mmol), and the reaction mixture was heated to reflux (55C) for 2 hours. The mixture was allowed to cool to 40C, and solid NaHCC3 was added in small portions, until evolution of gas ceased. The resulting suspension was filtered, under vacuum, into a 500-mL, three-neck flask, and the filter cake was washed with isopropanol (200 mL). Solid 3,5-dibromopyrazin-2-amine (3) (12.0 g, 47.2 mmol) was added into the isopropanol filtrate, and the reaction mixture was heated at reflux (78C) for 16 hours. The resulting suspension was cooled to room temperature, filtered, the cake was washed with cold isopropanol (100 mL), and then the cake was dried under vacuum. The cake was transferred into a three-neck flask, into which, water (200 mL) was added, followed by solid K2CC3, in small portions, until gas evolution ceased, after which the reaction was stirred for 30 minutes. The resulting precipitate was isolated by filtration, and washed with water (200 mL). The solid was dried at 50C, to constant weight, then dissolved in THF, filtered through a plug (celite, silica gel, and charcoal). The solvent was removed under vacuum, to give 12.0 g of the desired product (5) as a white solid at 99% purity, as determined by NMR and LC-MS. IH NMR (500 MHz, CDC13) delta 8.26 (s, IH), 7.84 (d, J = 1.0 Hz, IH), 7.78 (d, J = 1.1 Hz, IH); 13C NMR (126 MHz, CDC13) delta 136.93, 134.06, 120.29, 119.26, 115.78.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1,1-dimethoxyethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DOW GLOBAL TECHNOLOGIES LLC; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; ONDARI, Mark E.; WELSH, Dean M.; FROESE, Robert DJ; NA, Hong-Yeop; (38 pag.)WO2016/209895; (2016); A1;,
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